{ "uniprot_canonical_ac": "P55283-1", "uniprot_ac": "P55283", "uniprot_id": "CADH4_HUMAN", "mass": { "chemical_mass": 100281.0, "monoisotopic_mass": 100281.0 }, "refseq": { "ac": "NP_001239268", "name": "cadherin-4 isoform 3", "summary": "This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268" }, "gene_names": [ { "name": "CDH4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P55283", "id": "P55283" }, { "name": "CAD4; R-CAD; RCAD", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268", "id": "NP_001239268" }, { "name": "CDH4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268", "id": "NP_001239268" } ], "protein_names": [ { "name": "Cadherin-4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P55283" }, { "name": "R-CAD", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P55283" }, { "name": "R-cadherin; retinal cadherin; cadherin 4, type 1, R-cadherin (retinal); cadherin 4, type 1, preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268", "id": "NP_001239268" }, { "name": "R-cadherin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P55283" }, { "name": "Retinal cadherin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P55283" }, { "name": "cadherin-4 isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268", "id": "NP_001239268" } ], "function": [ { "annotation": "Alu Deletions in LAMA2 and CDH4 Genes Are Key Components of Polygenic Predictors of Longevity. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001239268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268" }, { "database": "PubMed", "id": "36362280", "url": "https://glygen.org/publication/PubMed/36362280" } ] }, { "annotation": "CDH4 inhibits ferroptosis in oral squamous cell carcinoma cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001239268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268" }, { "database": "PubMed", "id": "37237299", "url": "https://glygen.org/publication/PubMed/37237299" } ] }, { "annotation": "Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression.", "evidence": [ { "database": "RefSeq", "id": "NP_001239268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268" }, { "database": "PubMed", "id": "35064910", "url": "https://glygen.org/publication/PubMed/35064910" } ] }, { "annotation": "Cadherins are calcium-dependent cell adhesion proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0A087WX99", "url": "https://www.uniprot.org/uniprot/A0A087WX99#function" }, { "database": "UniProtKB", "id": "RU004357", "url": "https://www.uniprot.org/uniprot/RU004357#function" }, { "database": "UniProtKB", "id": "A0A0G2JRA4", "url": "https://www.uniprot.org/uniprot/A0A0G2JRA4#function" } ] }, { "annotation": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.", "evidence": [ { "database": "UniProtKB", "id": "P55283", "url": "https://www.uniprot.org/uniprot/P55283#function" } ] }, { "annotation": "Expression and Prognostic Significance of Cadherin 4 (CDH4) in Renal Cell Carcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001239268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268" }, { "database": "PubMed", "id": "32511216", "url": "https://glygen.org/publication/PubMed/32511216" } ] }, { "annotation": "Regulatory CDH4 Genetic Variants Associate With Risk to Develop Capecitabine-Induced Hand-Foot Syndrome.", "evidence": [ { "database": "RefSeq", "id": "NP_001239268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268" }, { "database": "PubMed", "id": "32757270", "url": "https://glygen.org/publication/PubMed/32757270" } ] }, { "annotation": "This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_001239268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239268" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs867274930", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs867274930" }, { "id": "rs867274930", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs867274930" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 24, "end_pos": 24, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DLT->NLT).", "chr_id": "20", "chr_pos": "61254838", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D24", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs953377525", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs953377525" }, { "id": "rs953377525", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs953377525" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 273, "end_pos": 273, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDN->NDS).", "chr_id": "20", "chr_pos": "61894959", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N273", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs35817343", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs35817343" }, { "id": "rs35817343", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs35817343" }, { "id": "rs35817343", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs35817343#frequency_tab" }, { "id": "rs35817343", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs35817343" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 283, "end_pos": 283, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NGS->SGS).", "chr_id": "20", "chr_pos": "61852869", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N283", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs35817343", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs35817343" }, { "id": "rs35817343", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs35817343" }, { "id": "rs35817343", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs35817343#frequency_tab" }, { "id": "rs35817343", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs35817343" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 283, "end_pos": 283, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NGS->TGS).", "chr_id": "20", "chr_pos": "61852869", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N283", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1463730085", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1463730085" }, { "id": "rs1463730085", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1463730085#frequency_tab" }, { "id": "rs1463730085", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1463730085" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 298, "end_pos": 298, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TVT->NVT).", "chr_id": "20", "chr_pos": "61873743", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T298", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs758952645", "database": "dbSNP", "url": 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"start_pos": 388, "end_pos": 388, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDN->NDT).", "chr_id": "20", "chr_pos": "61895022", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N388", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1293547144", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1293547144" }, { "id": "rs1293547144", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1293547144#frequency_tab" }, { "id": "rs1293547144", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1293547144" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 39, "end_pos": 39, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DYT->NYT).", "chr_id": "20", "chr_pos": "61254883", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D39", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1200506111", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1200506111" }, { "id": "rs1200506111", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1200506111" }, { "id": "rs1200506111", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1200506111#frequency_tab" }, { "id": "rs1200506111", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1200506111" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 414, "end_pos": 414, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->NLM).", "chr_id": "20", "chr_pos": "61910474", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T414", "keywords": [ "ebi", "germline" ] }, { "evidence": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P55283", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P55283" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"https://www.uniprot.org/uniprot/A0A087WX99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JRA4", "url": "https://www.uniprot.org/uniprot/A0A0G2JRA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JRA4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JRA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P55283", "url": "https://www.uniprot.org/uniprot/P55283", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P55283-1", "url": "https://www.uniprot.org/uniprot/P55283-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P55283-2", "url": "https://www.uniprot.org/uniprot/P55283-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED", "length": 916, "header": "sp|P55283-1|CADH4_HUMAN Isoform 1 of Cadherin-4 OS=Homo sapiens OX=9606 GN=CDH4 PE=2 SV=2 CANONICAL=P55283-1" }, "isoforms": [ { "isoform_ac": "A0A087WX99-1", "url": "", "sequence": { "sequence": "MPKSTGMLHGGRENAGVKFSSCVGTKGTQYETNSMDFKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED", "length": 822, "header": "tr|A0A087WX99-1|A0A087WX99_HUMAN Computationally mapped isoform of Cadherin 4 OS=Homo sapiens OX=9606 GN=CDH4 PE=1 SV=1 CANONICAL=P55283-1" }, "locus": { "chromosome": "20", "start_pos": 61936940, "end_pos": 61570695, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000611855.4", "url": "https://www.ensembl.org/id/ENST00000611855.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000480844.1", "url": "https://www.ensembl.org/id/ENSP00000480844.1" } ] } }, { "isoform_ac": "A0A0G2JRA4-1", "url": "", "sequence": { "sequence": "KVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICERPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED", "length": 566, "header": "tr|A0A0G2JRA4-1|CADH4_HUMAN Computationally mapped isoform of Cadherin-4 OS=Homo sapiens OX=9606 GN=CDH4 PE=2 SV=1 CANONICAL=P55283-1" }, "locus": { "chromosome": "CHR_HSCHR20_1_CTG2", "start_pos": 61936895, "end_pos": 61894910, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000625686.1", "url": "https://www.ensembl.org/id/ENST00000625686.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000486568.1", "url": "https://www.ensembl.org/id/ENSP00000486568.1" } ] } }, { "isoform_ac": "P55283-1", "url": "", "sequence": { "sequence": "MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED", "length": 916, "header": "sp|P55283-1|CADH4_HUMAN Isoform 1 of Cadherin-4 OS=Homo sapiens OX=9606 GN=CDH4 PE=2 SV=2 CANONICAL=P55283-1" }, "locus": { "chromosome": "20", "start_pos": 61936940, "end_pos": 61252514, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000614565.5", "url": "https://www.ensembl.org/id/ENST00000614565.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000484928.1", "url": "https://www.ensembl.org/id/ENSP00000484928.1" } ] } }, { "isoform_ac": "P55283-2", "url": "", "sequence": { "sequence": "MDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED", "length": 842, "header": "sp|P55283-2|CADH4_HUMAN Isoform 2 of Cadherin-4 OS=Homo sapiens OX=9606 GN=CDH4 PE=2 SV=2 CANONICAL=P55283-1" }, "locus": { "chromosome": "20", "start_pos": 61936940, "end_pos": 61743616, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000543233.2", "url": "https://www.ensembl.org/id/ENST00000543233.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000443301.1", "url": "https://www.ensembl.org/id/ENSP00000443301.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 283, "start_aa": "Asn", "end_pos": 283, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn283", "evidence": [ { "id": "P55283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55283#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 412, "start_aa": "Asn", "end_pos": 412, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn412", "evidence": [ { "id": "P55283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55283#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 557, "start_aa": "Asn", "end_pos": 557, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn557", "evidence": [ { "id": "P55283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55283#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 632, "start_aa": "Asn", "end_pos": 632, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn632", "evidence": [ { "id": "P55283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55283#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 661, "start_aa": "Asn", "end_pos": 661, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn661", "evidence": [ { "id": "P55283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55283#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 702, "start_aa": "Asn", "end_pos": 702, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn702", "evidence": [ { "id": "P55283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55283#ptm_processing" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "VGADGTVFATR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 79, "start_aa": "Val", "end_pos": 89, "end_aa": "Arg", "evidence": [ { "id": "P55283", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 84, "start_aa": "Thr", "end_pos": 84, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr84", "evidence": [ { "id": "P55283", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 88, "start_aa": "Thr", "end_pos": 88, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr88", "evidence": [ { "id": "P55283", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_predicted" ], "publication": [ { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology", "journal": "EMBO J", "date": "2013", "authors": "Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen .H", "evidence": [ { "database": "UniCarbKB", "id": "P55283", "url": "" } ], "reference": [ { "type": "DOI", "id": "10.1038/emboj.2013.79", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "title": "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein.", "journal": "The Journal of cell biology", "date": "1999", "authors": "Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418990" } ], "reference": [ { "type": "PubMed", "id": "10225955", "url": "https://glygen.org/publication/PubMed/10225955" } ] }, { "title": "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Yang SH, Galanis A, Sharrocks AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-525793" } ], "reference": [ { "type": "PubMed", "id": "10330143", "url": "https://glygen.org/publication/PubMed/10330143" } ] }, { "title": "A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase.", "journal": "The Journal of cell biology", "date": "1999", "authors": "Blanco-Aparicio C, Torres J, Pulido R", "evidence": [ { "database": "Reactome", "id": "R-HSA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-525793" } ], "reference": [ { "type": "PubMed", "id": "10601328", "url": "https://glygen.org/publication/PubMed/10601328" } ] }, { "title": "p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Wu Z, Woodring PJ, Bhakta KS, Tamura K, Wen F, Feramisco JR, Karin M, Wang JY, Puri PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-525793" } ], "reference": [ { "type": "PubMed", "id": "10805738", "url": "https://glygen.org/publication/PubMed/10805738" } ] }, { "title": "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation.", "journal": "The EMBO journal", "date": "2002", "authors": "Kang JS, Mulieri PJ, Hu Y, Taliana L, Krauss RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-525793" } ], "reference": [ { "type": "PubMed", "id": "11782431", "url": "https://glygen.org/publication/PubMed/11782431" } ] }, { "title": "The tumor suppressor protein TSLC1 is involved in cell-cell adhesion.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Masuda M, Yageta M, Fukuhara H, Kuramochi M, Maruyama T, Nomoto A, Murakami Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418990" } ], "reference": [ { "type": "PubMed", "id": "12050160", "url": "https://glygen.org/publication/PubMed/12050160" } ] }, { "title": "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-525793" } ], "reference": [ { "type": "PubMed", "id": "12634428", "url": "https://glygen.org/publication/PubMed/12634428" } ] }, { "title": "Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Dong X, Xu F, Gong Y, Gao J, Lin P, Chen T, Peng Y, Qiang B, Yuan J, Peng X, Rao Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418990" } ], "reference": [ { "type": "PubMed", "id": "16467305", "url": "https://glygen.org/publication/PubMed/16467305" } ] }, { "title": "The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion.", "journal": "BMC neuroscience", "date": "2007", "authors": "Pellissier F, Gerber A, Bauer C, Ballivet M, Ossipow V", "evidence": [ { "database": "Reactome", "id": "R-HSA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418990" } ], "reference": [ { "type": "PubMed", "id": "17967169", "url": "https://glygen.org/publication/PubMed/17967169" } ] }, { "title": "Ribonuclease inhibitor regulates neovascularization by human angiogenin.", "journal": "Biochemistry", "date": "2009", "authors": "Dickson KA, Kang DK, Kwon YS, Kim JC, Leland PA, Kim BM, Chang SI, Raines RT", "evidence": [ { "database": "Reactome", "id": "R-HSA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418990" } ], "reference": [ { "type": "PubMed", "id": "19354288", "url": "https://glygen.org/publication/PubMed/19354288" } ] }, { "title": "Nuclear localization of p38 MAPK in response to DNA damage.", "journal": "International journal of biological sciences", "date": "2009", "authors": "Wood CD, Thornton TM, Sabio G, Davis RA, Rincon M", "evidence": [ { "database": "Reactome", "id": "R-HSA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-525793" } ], "reference": [ { "type": "PubMed", "id": "19564926", "url": "https://glygen.org/publication/PubMed/19564926" } ] }, { "title": "N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010", "authors": "Lu M, Krauss RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-525793", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-525793" } ], "reference": [ { "type": "PubMed", "id": "20160094", "url": "https://glygen.org/publication/PubMed/20160094" } ] }, { "title": "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.", "journal": "Cell Regul.", "date": "1991", "authors": "Suzuki S., Sano K., Tanihara H.", "evidence": [ { "database": "UniProtKB", "id": "P55283", "url": "https://www.uniprot.org/uniprot/P55283" } ], "reference": [ { "type": "PubMed", "id": "2059658", "url": "https://glygen.org/publication/PubMed/2059658" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome 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