{ "uniprot_canonical_ac": "P54867-1", "uniprot_ac": "P54867", "uniprot_id": "SLG1_YEAST", "mass": { "chemical_mass": 39270.0, "monoisotopic_mass": 39270.0 }, "refseq": { "ac": "NP_014650", "name": "Slg1p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014650" }, "gene_names": [ { "name": "SLG1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P54867", "id": "P54867" }, { "name": "HCS77; WSC1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014650", "id": "NP_014650" }, { "name": "SLG1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014650", "id": "NP_014650" }, { "name": "UNF378", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P54867", "id": "P54867" }, { "name": "WSC1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P54867", "id": "P54867" } ], "protein_names": [ { "name": "Protein SLG1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P54867" }, { "name": "Cell wall integrity and stress response component 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P54867" }, { "name": "Slg1p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014650", "id": "NP_014650" }, { "name": "Synthetic lethal with GAP protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P54867" } ], "function": [ { "annotation": "Plays a role during G1 to regulate entering or exiting the cell cycle. Involved in stress responses. Has a role in cell wall integrity signaling. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1. Important regulator of the actin cytoskeleton rearrangements in conditions of cell wall expansion and membrane stretching. Specifically required for the actin reorganization induced by hypo-osmotic shock. Multicopy suppressor of 1,3-beta-glucan synthase (GS). Activates GS upstream of RHO1. Acts positively on the PKC1-MAPK pathway. Activates transiently SLT2 during alkaline stress, which leads to an increase in the expression of several specific genes.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867#function" }, { "database": "PubMed", "id": "10430578", "url": "https://glygen.org/publication/PubMed/10430578" }, { "database": "PubMed", "id": "15484288", "url": "https://glygen.org/publication/PubMed/15484288" }, { "database": "PubMed", "id": "11113201", "url": "https://glygen.org/publication/PubMed/11113201" }, { "database": "PubMed", "id": "12399379", "url": "https://glygen.org/publication/PubMed/12399379" }, { "database": "PubMed", "id": "10660075", "url": "https://glygen.org/publication/PubMed/10660075" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 303, "end_pos": 303, "sequence_org": "Y", "sequence_mut": "A", "comment": "Sensitive to alkali. Fails to restore normal levels of SLT2 phosphorylation upon alkaline stress.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "PubMed", "id": "17088254", "url": "https://glygen.org/publication/PubMed/17088254" } ] }, { "start_pos": 319, "end_pos": 319, "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation; when associated with A-320.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "PubMed", "id": "15470108", "url": "https://glygen.org/publication/PubMed/15470108" } ] }, { "start_pos": 320, "end_pos": 320, "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation; when associated with A-319.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "PubMed", "id": "15470108", "url": "https://glygen.org/publication/PubMed/15470108" } ] }, { "start_pos": 322, "end_pos": 322, "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation; when associated with A-323.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "PubMed", "id": "15470108", "url": "https://glygen.org/publication/PubMed/15470108" } ] }, { "start_pos": 323, "end_pos": 323, "sequence_org": "S", "sequence_mut": "A", "comment": "No phosphorylation; when associated with A-322.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "PubMed", "id": "15470108", "url": "https://glygen.org/publication/PubMed/15470108" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "common_name": "Yeast" } ], "gene": [ { "name": "SLG1", "url": "https://www.uniprot.org/uniprot/P54867", "locus": { "chromosome": "XV", "start_pos": 341278, "end_pos": 342414, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YOR008C", "url": "https://www.ensembl.org/id/YOR008C" } ] } } ], "crossref": [ { "id": "854170", "url": "https://www.ncbi.nlm.nih.gov/gene/854170", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P54867", "url": "https://www.ebi.ac.uk/intact/interactors/id:P54867*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOR008C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOR008C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HINMKRE", "url": "https://omabrowser.org/oma/group/HINMKRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1425255at2759", "url": "http://www.orthodb.org/?query=1425255at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24269", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24269", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24269:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24269:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01822", "url": "http://pfam.xfam.org/family/PF01822", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P54867", "url": "http://purl.obolibrary.org/obo/PR_P54867", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014650", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005534", "url": "https://www.yeastgenome.org/locus/S000005534", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P54867-1", "url": "https://www.uniprot.org/uniprot/P54867-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPNKTSLLLALLSILSQANAYEYVNCFSSLPSDFSKADSYNWQSSSHCNSECSAKGASYFALYNHSECYCGDTNPSGSESTSSSCNTYCFGYSSEMCGGEDAYSVYQLDSDTNSNSISSSDSSTESTSASSSTTSSTTSSTTSTTSSTTSSTTSSMASSSTVQNSPESTQAAASISTSQSSSTVTSESSLTSDTLATSSTSSQSQDATSIIYSTTFHTEGGSTIFVTNTITASAQNSGSATGTAGSDSTSGSKTHKKKANVGAIVGGVVGGVVGAVAIALCILLIVRHINMKREQDRMEKEYQEAIKPVEYPDKLYASSFSSNHGPSSGSFEEEHTKGQTDINPFDDSRRISNGTFINGGPGGKNNVLTVVNPDEAD", "length": 378, "header": "sp|P54867-1|SLG1_YEAST Isoform 1 of Protein SLG1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SLG1 PE=1 SV=1 CANONICAL=P54867-1" }, "isoforms": [ { "isoform_ac": "P54867-1", "url": "", "sequence": { "sequence": "MRPNKTSLLLALLSILSQANAYEYVNCFSSLPSDFSKADSYNWQSSSHCNSECSAKGASYFALYNHSECYCGDTNPSGSESTSSSCNTYCFGYSSEMCGGEDAYSVYQLDSDTNSNSISSSDSSTESTSASSSTTSSTTSSTTSTTSSTTSSTTSSMASSSTVQNSPESTQAAASISTSQSSSTVTSESSLTSDTLATSSTSSQSQDATSIIYSTTFHTEGGSTIFVTNTITASAQNSGSATGTAGSDSTSGSKTHKKKANVGAIVGGVVGGVVGAVAIALCILLIVRHINMKREQDRMEKEYQEAIKPVEYPDKLYASSFSSNHGPSSGSFEEEHTKGQTDINPFDDSRRISNGTFINGGPGGKNNVLTVVNPDEAD", "length": 378, "header": "sp|P54867-1|SLG1_YEAST Isoform 1 of Protein SLG1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SLG1 PE=1 SV=1 CANONICAL=P54867-1" }, "locus": { "chromosome": "XV", "start_pos": 342414, "end_pos": 341281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YOR008C_mRNA", "url": "https://www.ensembl.org/id/YOR008C_mRNA" }, { "database": "Ensembl Peptide", "id": "YOR008C", "url": "https://www.ensembl.org/id/YOR008C" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 65, "start_aa": "Asn", "end_pos": 65, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn65", "evidence": [ { "id": "P54867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54867#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 319, "end_pos": 319, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "P54867", "url": "https://www.yeastgenome.org/locus/P54867" } ], "site_lbl": "Ser319" }, { "start_pos": 323, "end_pos": 323, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "SGD", "id": "P54867", "url": "https://www.yeastgenome.org/locus/P54867" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser323" }, { "start_pos": 328, "end_pos": 328, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" } ], "site_lbl": "Ser328" }, { "start_pos": 331, "end_pos": 331, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "P54867", "url": "https://www.yeastgenome.org/locus/P54867" } ], "site_lbl": "Ser331" }, { "start_pos": 353, "end_pos": 353, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" }, { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "P54867", "url": "https://www.yeastgenome.org/locus/P54867" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser353" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "P54867", "url": "https://www.yeastgenome.org/locus/P54867" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Thr356" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae.", "journal": "Genetics", "date": "1999", "authors": "Lodder A L, Lee T K, Ballester R", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "reference": [ { "type": "PubMed", "id": "10430578", "url": "https://glygen.org/publication/PubMed/10430578" } ] }, { "title": "SLG1 plays a role during G1 in the decision to enter or exit the cell cycle.", "journal": "Mol. Gen. Genet.", "date": "2000", "authors": "Ivanovska I., Rose M.D.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "reference": [ { "type": "PubMed", "id": "10660075", "url": "https://glygen.org/publication/PubMed/10660075" } ] }, { "title": "Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1.", "journal": "Mol. Cell. Biol.", "date": "2001", "authors": "Philip B., Levin D.E.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "reference": [ { "type": "PubMed", "id": "11113201", "url": "https://glygen.org/publication/PubMed/11113201" } ] }, { "title": "Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae.", "journal": "Genetics", "date": "2002", "authors": "Sekiya-Kawasaki Mariko, Abe Mitsuhiro, Saka Ayaka, Watanabe Daisuke, Kono Keiko, Minemura-Asakawa Masayo, Ishihara Satoru, Watanabe Takahide, Ohya Yoshikazu", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "reference": [ { "type": "PubMed", "id": "12399379", "url": "https://glygen.org/publication/PubMed/12399379" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Mutational analysis of the cytoplasmic domain of the Wsc1 cell wall stress sensor.", "journal": "Microbiology", "date": "2004", "authors": "Vay Heather A, Philip Bevin, Levin David E", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "reference": [ { "type": "PubMed", "id": "15470108", "url": "https://glygen.org/publication/PubMed/15470108" } ] }, { "title": "The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae.", "journal": "Yeast", "date": "2004", "authors": "Mizzi L., Popolo L., Ragni E., Fascio U., Gualtieri T.", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "reference": [ { "type": "PubMed", "id": "15484288", "url": "https://glygen.org/publication/PubMed/15484288" } ] }, { "title": "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.", "journal": "Molecular & cellular proteomics : MCP", "date": "2005-03", "authors": "Gruhler Albrecht, Olsen Jesper V, Mohammed Shabaz, Mortensen Peter, Faergeman Nils J, Mann Matthias, Jensen Ole N", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" } ], "reference": [ { "type": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" } ] }, { "title": "Signaling alkaline pH stress in the yeast Saccharomyces cerevisiae through the Wsc1 cell surface sensor and the Slt2 MAPK pathway.", "journal": "J. Biol. Chem.", "date": "2006", "authors": "Serrano Raquel, Mart\u00edn Humberto, Casamayor Antonio, Ari\u00f1o Joaqu\u00edn", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" } ], "reference": [ { "type": "PubMed", "id": "17088254", "url": "https://glygen.org/publication/PubMed/17088254" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "P54867", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P54867" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008-07", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P54867", "url": "https://www.uniprot.org/uniprot/P54867" }, { "database": "iPTMnet", "id": "P54867", "url": 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