{ "uniprot_canonical_ac": "P54654-1", "uniprot_ac": "P54654", "uniprot_id": "CAP_DICDI", "mass": { "chemical_mass": 49641.0, "monoisotopic_mass": 49641.0 }, "refseq": { "ac": "XP_636512", "name": "cyclase associated protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_636512" }, "gene_names": [ { "name": "cap", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P54654", "id": "P54654" }, { "name": "DDB_G0288769", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P54654", "id": "P54654" }, { "name": "cap", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_636512", "id": "XP_636512" } ], "protein_names": [ { "name": "Adenylyl cyclase-associated protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P54654" }, { "name": "CAP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P54654" }, { "name": "cyclase associated protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_636512", "id": "XP_636512" } ], "function": [ { "annotation": "May have a regulatory bifunctional role. Binds G-actin and PIP2. Involved in microfilament reorganization near the plasma membrane in a PIP2-regulated manner.", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "common_name": "Dictyostelium discoideum" } ], "gene": [ { "name": "cap", "url": "https://www.uniprot.org/uniprot/P54654", "locus": {} } ], "crossref": [ { "id": "DDB_G0288769", "url": "", "database": "", "categories": [ "Organism-specific" ] }, { "id": "8626797", "url": "https://www.ncbi.nlm.nih.gov/gene/8626797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0288769", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0288769", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KPESMRA", "url": "https://omabrowser.org/oma/group/KPESMRA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10652:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10652:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1S0P", "url": "https://www.rcsb.org/structure/1S0P", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1TJF", "url": "https://www.rcsb.org/structure/1TJF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01213", "url": "http://pfam.xfam.org/family/PF01213", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08603", "url": "http://pfam.xfam.org/family/PF08603", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P54654", "url": "http://purl.obolibrary.org/obo/PR_P54654", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_636512", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_636512", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P54654-1", "url": "https://www.uniprot.org/uniprot/P54654-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEATIVELLKRLDQATTRLEAVEKSIASGVASSSSSSSPSSGAAGPSSASVKEFQNLVDQHITPFVALSKKLAPEVGNQVEQLVKAIDAEKALINTASQSKKPSQETLLELIKPLNNFAAEVGKIRDSNRSSKFFNNLSAISESIGFLSWVVVEPTPGPHVAEMRGSAEFYTNRILKEFKGVNQDQVDWVSNYVNFLKDLEKYIKQYHTTGLTWNPKGGDAKSATPAPASSAPAAPVAPAVSSTPVESKKGPGLGAVFGELSKGDGVTSGLKKVTNDMKSKNFTDKSSVVKAADTKVAKVDAPSRPAVFALQGNKWSIEYQVNNKEIVIAEPDSRQTVYIFQCVNSLVQIKGKVNAITLDGCKKTSIVFENAISSCEVVNCNGVEIQVTGRVPSIAIDKTSGCQIYLSKDSLETEIVSSKSSEMNVLIPGATENDDLVELAIPEQYKTSVKGNKLHTESTSHI", "length": 464, "header": "sp|P54654-1|CAP_DICDI Isoform 1 of Adenylyl cyclase-associated protein OS=Dictyostelium discoideum OX=44689 GN=cap PE=1 SV=1 CANONICAL=P54654-1" }, "isoforms": [ { "isoform_ac": "P54654-1", "url": "", "sequence": { "sequence": "MSEATIVELLKRLDQATTRLEAVEKSIASGVASSSSSSSPSSGAAGPSSASVKEFQNLVDQHITPFVALSKKLAPEVGNQVEQLVKAIDAEKALINTASQSKKPSQETLLELIKPLNNFAAEVGKIRDSNRSSKFFNNLSAISESIGFLSWVVVEPTPGPHVAEMRGSAEFYTNRILKEFKGVNQDQVDWVSNYVNFLKDLEKYIKQYHTTGLTWNPKGGDAKSATPAPASSAPAAPVAPAVSSTPVESKKGPGLGAVFGELSKGDGVTSGLKKVTNDMKSKNFTDKSSVVKAADTKVAKVDAPSRPAVFALQGNKWSIEYQVNNKEIVIAEPDSRQTVYIFQCVNSLVQIKGKVNAITLDGCKKTSIVFENAISSCEVVNCNGVEIQVTGRVPSIAIDKTSGCQIYLSKDSLETEIVSSKSSEMNVLIPGATENDDLVELAIPEQYKTSVKGNKLHTESTSHI", "length": 464, "header": "sp|P54654-1|CAP_DICDI Isoform 1 of Adenylyl cyclase-associated protein OS=Dictyostelium discoideum OX=44689 GN=cap PE=1 SV=1 CANONICAL=P54654-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum.", "journal": "Structure", "date": "2003", "authors": "Janssen K.P., Bourenkov G.P., Holak T.A., Bartunik H.D., Noegel A.A., Brandstetter H., Schleicher M., Israel L., Katchalova G., Ksiazek D.", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "reference": [ { "type": "PubMed", "id": "12962635", "url": "https://glygen.org/publication/PubMed/12962635" } ] }, { "title": "Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP).", "journal": "Proteins", "date": "2005", "authors": "Hofmann A., Wlodawer A., Hu N.J., Yusof A.M.", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "reference": [ { "type": "PubMed", "id": "15558566", "url": "https://glygen.org/publication/PubMed/15558566" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin.", "journal": "Mol. Biol. Cell", "date": "1996", "authors": "Noegel A.A., Gottwald U., Schleicher M., Karakesisoglou I., Brokamp R.", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "reference": [ { "type": "PubMed", "id": "8688557", "url": "https://glygen.org/publication/PubMed/8688557" } ] } ], "pathway": [ { "id": "ddi:DDB_G0288769", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0288769", "resource": "KEGG Pathway" }, { "id": "R-DDI-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "phagocytic cup", "id": "GO:0001891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001891", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "phagocytic vesicle membrane", "id": "GO:0030670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030670", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "vacuolar membrane", "id": "GO:0005774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005774", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "pseudopodium", "id": "GO:0031143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031143", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "macropinosome", "id": "GO:0044354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044354", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "adenylate cyclase binding", "id": "GO:0008179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008179", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "response to osmotic stress", "id": "GO:0006970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006970", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "cAMP-mediated signaling", "id": "GO:0019933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019933", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "establishment or maintenance of cell polarity", "id": "GO:0007163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007163", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "pinocytosis", "id": "GO:0006907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006907", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "aggregation involved in sorocarp development", "id": "GO:0031152", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031152", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" }, { "name": "contractile vacuole organization", "id": "GO:0033298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033298", "evidence": [ { "database": "UniProtKB", "id": "P54654", "url": "https://www.uniprot.org/uniprot/P54654" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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}, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }