{
    "uniprot_canonical_ac": "P54370-1",
    "uniprot_ac": "P54370",
    "uniprot_id": "OAZ1_RAT",
    "mass": {
        "chemical_mass": 25228.0,
        "monoisotopic_mass": 25228.0
    },
    "refseq": {
        "ac": "NP_620781",
        "name": "ornithine decarboxylase antizyme 1 isoform 1",
        "summary": "The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014].",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781"
    },
    "gene_names": [
        {
            "name": "Oaz1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P54370",
            "id": "P54370"
        },
        {
            "name": "Oaz1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781",
            "id": "NP_620781"
        },
        {
            "name": "Oaz; ODC-Az; ODCAC",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781",
            "id": "NP_620781"
        },
        {
            "name": "Oaz",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P54370",
            "id": "P54370"
        }
    ],
    "protein_names": [
        {
            "name": "Ornithine decarboxylase antizyme 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P54370"
        },
        {
            "name": "ODC-Az",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P54370"
        },
        {
            "name": "ornithine decarboxylase antizyme 1 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781",
            "id": "NP_620781"
        }
    ],
    "function": [
        {
            "annotation": "Antizyme expression requires programmed,+1 ribosomal frameshifting",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_620781",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781"
                },
                {
                    "database": "PubMed",
                    "id": "7813017",
                    "url": "https://glygen.org/publication/PubMed/7813017"
                }
            ]
        },
        {
            "annotation": "Corticosterone treatment induces antizyme 1 protein synthesis in early regenerating rat liver. However, it has little effect on antizyme 1 gene transcription.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_620781",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781"
                },
                {
                    "database": "PubMed",
                    "id": "21861313",
                    "url": "https://glygen.org/publication/PubMed/21861313"
                }
            ]
        },
        {
            "annotation": "Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination (By similarity). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter (PubMed:8166639). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P54370",
                    "url": "https://www.uniprot.org/uniprot/P54370#function"
                },
                {
                    "database": "PubMed",
                    "id": "8166639",
                    "url": "https://glygen.org/publication/PubMed/8166639"
                },
                {
                    "database": "UniProtKB",
                    "id": "P54368",
                    "url": "https://www.uniprot.org/uniprot/P54368#function"
                }
            ]
        },
        {
            "annotation": "The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_620781",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P54370",
                    "url": "https://www.uniprot.org/uniprot/P54370"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Oaz1",
            "url": "https://www.uniprot.org/uniprot/P54370",
            "locus": {
                "chromosome": "7",
                "start_pos": 8883851,
                "end_pos": 8886310,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000019459",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000019459"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000019459",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019459",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "25502",
            "url": "https://www.ncbi.nlm.nih.gov/gene/25502",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR002993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002993",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR016181",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038581",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038581",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:25502",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25502",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HVDHVFI",
            "url": "https://omabrowser.org/oma/group/HVDHVFI/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3678762at2759",
            "url": "http://www.orthodb.org/?query=3678762at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10279",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10279",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10279:SF8",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10279:SF8",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1ZO0",
            "url": "https://www.rcsb.org/structure/1ZO0",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF02100",
            "url": "http://pfam.xfam.org/family/PF02100",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P54370",
            "url": "http://purl.obolibrary.org/obo/PR_P54370",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-350562",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-350562",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_620781",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "3219",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=3219",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6AEN8",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AEN8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AEN8-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AEN8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1M8D8",
            "url": "https://www.uniprot.org/uniprot/F1M8D8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1M8D8-1",
            "url": "https://www.uniprot.org/uniprot/F1M8D8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P54370",
            "url": "https://www.uniprot.org/uniprot/P54370",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P54370-1",
            "url": "https://www.uniprot.org/uniprot/P54370-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALHCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQCTLTEAKQVTWRAVWNGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLRADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED",
        "length": 227,
        "header": "sp|P54370-1|OAZ1_RAT Isoform 1 of Ornithine decarboxylase antizyme 1  OS=Rattus norvegicus OX=10116 GN=Oaz1 PE=1 SV=3 CANONICAL=P54370-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6AEN8-1",
            "url": "",
            "sequence": {
                "sequence": "NPPCSGSSTATASPERKKGTNAAPRFTPAAPCRFLVSTAAAAAAARGLPFIAVVTWVRGLGGAPDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQCTLTEAKQVTWRAVWNGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLRADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED",
                "length": 223,
                "header": "tr|A0A8I6AEN8-1|OAZ1_RAT Computationally mapped isoform of Ornithine decarboxylase antizyme 1  OS=Rattus norvegicus OX=10116 GN=Oaz1 PE=1 SV=1 CANONICAL=P54370-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 8886229,
                "end_pos": 8884143,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000110971.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000110971.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000090905.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000090905.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F1M8D8-1",
            "url": "",
            "sequence": {
                "sequence": "NPPCSGSSTATASPERKKGTNAAPRFTPAAPCRFLVSTAAAAAAARVLGLPFIAVVTWVRGLGGAPDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQCTLTEAKQVTWRAVWNGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLRADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED",
                "length": 225,
                "header": "tr|F1M8D8-1|OAZ1_RAT Computationally mapped isoform of Ornithine decarboxylase antizyme 1  OS=Rattus norvegicus OX=10116 GN=Oaz1 PE=1 SV=2 CANONICAL=P54370-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 8886229,
                "end_pos": 8884143,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000026341.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000026341.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000026341.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000026341.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P54370-1",
            "url": "",
            "sequence": {
                "sequence": "MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALHCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQCTLTEAKQVTWRAVWNGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLRADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED",
                "length": 227,
                "header": "sp|P54370-1|OAZ1_RAT Isoform 1 of Ornithine decarboxylase antizyme 1  OS=Rattus norvegicus OX=10116 GN=Oaz1 PE=1 SV=3 CANONICAL=P54370-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Solution structure of a conserved domain of antizyme: a protein regulator of polyamines.",
            "journal": "Biochemistry",
            "date": "2005",
            "authors": "Hackert M.L., Martinez N., Hoffman D.W., Carroll D.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P54370",
                    "url": "https://www.uniprot.org/uniprot/P54370"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16128579",
                    "url": "https://glygen.org/publication/PubMed/16128579"
                }
            ]
        },
        {
            "title": "The influence of corticosterone on antizyme gene expression in early regenerating rat liver.",
            "journal": "Acta gastro-enterologica Belgica",
            "date": "2011",
            "authors": "Ma JM, Yang H, Dong JF, Ning QJ, Li JK",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_620781",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21861313",
                    "url": "https://glygen.org/publication/PubMed/21861313"
                }
            ]
        },
        {
            "title": "Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme.",
            "journal": "Cell",
            "date": "1995",
            "authors": "Matsufuji S, Matsufuji T, Miyazaki Y, Murakami Y, Atkins JF, Gesteland RF, Hayashi S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P54370",
                    "url": "https://www.uniprot.org/uniprot/P54370"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_620781",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620781"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7813017",
                    "url": "https://glygen.org/publication/PubMed/7813017"
                }
            ]
        },
        {
            "title": "Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells.",
            "journal": "Biochem. J.",
            "date": "1994",
            "authors": "Mitchell JL, Judd GG, Bareyal-Leyser A, Ling SY",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P54370",
                    "url": "https://www.uniprot.org/uniprot/P54370"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8166639",
                    "url": "https://glygen.org/publication/PubMed/8166639"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:25502",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25502",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-350562",
            "name": "Regulation of ornithine decarboxylase (ODC)",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-350562",
            "resource": "Reactome",
            "description": "Regulation of ornithine decarboxylase (ODC)"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P54368-1",
            "protein_name": "Ornithine decarboxylase antizyme 1",
            "gene_name": "OAZ1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLHCCSNPGPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE",
                "length": 228
            },
            "evidence": [
                {
                    "id": "45225024",
                    "url": "http://www.informatics.jax.org/homology/45225024",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P54369-1",
            "protein_name": "Ornithine decarboxylase antizyme 1",
            "gene_name": "Oaz1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALNCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQSTLTEAKQVTWRAVWSGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLQADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED",
                "length": 227
            },
            "evidence": [
                {
                    "id": "45225024",
                    "url": "http://www.informatics.jax.org/homology/45225024",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "ornithine decarboxylase inhibitor activity",
                        "id": "GO:0008073",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008073",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P54370",
                                "url": "https://www.uniprot.org/uniprot/P54370"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "enzyme binding",
                        "id": "GO:0019899",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P54370",
                                "url": "https://www.uniprot.org/uniprot/P54370"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein-containing complex binding",
                        "id": "GO:0044877",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P54370",
                                "url": "https://www.uniprot.org/uniprot/P54370"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "positive regulation of protein catabolic process",
                        "id": "GO:0045732",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P54370",
                                "url": "https://www.uniprot.org/uniprot/P54370"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of polyamine transmembrane transport",
                        "id": "GO:1902268",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902268",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P54370",
                                "url": "https://www.uniprot.org/uniprot/P54370"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of intracellular protein transport",
                        "id": "GO:0090316",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090316",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P54370",
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