{ "uniprot_canonical_ac": "P54100-1", "uniprot_ac": "P54100", "uniprot_id": "VAV_RAT", "mass": { "chemical_mass": 97954.0, "monoisotopic_mass": 97954.0 }, "refseq": { "ac": "NP_036891", "name": "proto-oncogene vav", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891" }, "gene_names": [ { "name": "Vav1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P54100", "id": "P54100" }, { "name": "Vav1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891", "id": "NP_036891" }, { "name": "Vav", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891", "id": "NP_036891" }, { "name": "Vav", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P54100", "id": "P54100" } ], "protein_names": [ { "name": "Proto-oncogene vav", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P54100" }, { "name": "p95; vav 1 oncogene; vav 1 guanine nucleotide exchange factor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891", "id": "NP_036891" }, { "name": "p95", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P54100" }, { "name": "proto-oncogene vav", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891", "id": "NP_036891" } ], "function": [ { "annotation": "Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.", "evidence": [ { "database": "UniProtKB", "id": "P54100", "url": "https://www.uniprot.org/uniprot/P54100#function" } ] }, { "annotation": "Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury.", "evidence": [ { "database": "RefSeq", "id": "NP_036891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891" }, { "database": "PubMed", "id": "34147481", "url": "https://glygen.org/publication/PubMed/34147481" } ] }, { "annotation": "These results highlight the importance of the signaling pathway involving epistasis between Themis1 and Vav1 in the control of Treg suppressive function and susceptibility to IBD development.", "evidence": [ { "database": "RefSeq", "id": "NP_036891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891" }, { "database": "PubMed", "id": "26163585", "url": "https://glygen.org/publication/PubMed/26163585" } ] } ], "disease": [ { "disease_id": "DOID:289", "recommended_name": { "id": "DOID:289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:289", "name": "endometriosis", "description": "A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body." }, "synonyms": [], "evidence": [ { "id": "289", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:289" } ] }, { "disease_id": "DOID:614", "recommended_name": { "id": "DOID:614", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:614", "name": "lymphopenia", "description": "A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood." }, "synonyms": [ { "id": "DOID:614", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:614", "name": "Lymphocytopenia", "description": "" } ], "evidence": [ { "id": "614", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:614" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] }, { "disease_id": "DOID:9744", "recommended_name": { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production." }, "synonyms": [ { 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"https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:25156", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25156", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PYISRPT", "url": "https://omabrowser.org/oma/group/PYISRPT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2911406at2759", "url": "http://www.orthodb.org/?query=2911406at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45818:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45818:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "http://pfam.xfam.org/family/PF00017", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "http://pfam.xfam.org/family/PF00018", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00130", "url": "http://pfam.xfam.org/family/PF00130", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "http://pfam.xfam.org/family/PF00169", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "http://pfam.xfam.org/family/PF00307", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "http://pfam.xfam.org/family/PF00621", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11971", "url": "http://pfam.xfam.org/family/PF11971", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P54100", "url": "http://purl.obolibrary.org/obo/PR_P54100", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-114604", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-114604", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1257604", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1257604", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1433557", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1433557", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-193648", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193648", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2029482", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2871796", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871796", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2871809", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-389359", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-389359", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416482", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-4420097", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4420097", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-512988", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-512988", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5218920", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5218920", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6811558", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811558", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8980692", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013404", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013408", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9027284", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9027284", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-912631", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9748787", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9748787", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-983695", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "3951", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=3951", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZTA6", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZTA6-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A1G3", "url": "https://www.uniprot.org/uniprot/A0A8I6A1G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A1G3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A1G3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0R4H8", "url": "https://www.uniprot.org/uniprot/M0R4H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0R4H8-1", "url": "https://www.uniprot.org/uniprot/M0R4H8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P54100", "url": "https://www.uniprot.org/uniprot/P54100", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P54100-1", "url": "https://www.uniprot.org/uniprot/P54100-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BK91", "url": "https://www.uniprot.org/uniprot/Q5BK91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5BK91-1", "url": "https://www.uniprot.org/uniprot/Q5BK91-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKERFLVYGRYCSQVESAIKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKDKLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHTWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC", "length": 843, "header": "sp|P54100-1|VAV_RAT Isoform 1 of Proto-oncogene vav OS=Rattus norvegicus OX=10116 GN=Vav1 PE=2 SV=1 CANONICAL=P54100-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZTA6-1", "url": "", "sequence": { "sequence": "MDPQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKDKLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC", "length": 779, "header": "tr|A0A8I5ZTA6-1|A0A8I5ZTA6_RAT Computationally mapped isoform of Vav guanine nucleotide exchange factor 1 OS=Rattus norvegicus OX=10116 GN=Vav1 PE=1 SV=1 CANONICAL=P54100-1" }, "locus": { "chromosome": "9", "start_pos": 2208701, "end_pos": 2157964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000111335.1", "url": "https://www.ensembl.org/id/ENSRNOT00000111335.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081960.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081960.1" } ] } }, { "isoform_ac": "A0A8I6A1G3-1", "url": "", "sequence": { "sequence": "MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLWPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKDKLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC", "length": 804, "header": "tr|A0A8I6A1G3-1|VAV_RAT Computationally mapped isoform of Proto-oncogene vav OS=Rattus norvegicus OX=10116 GN=Vav1 PE=2 SV=1 CANONICAL=P54100-1" }, "locus": { "chromosome": "9", "start_pos": 2208701, "end_pos": 2162042, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000094489.1", "url": "https://www.ensembl.org/id/ENSRNOT00000094489.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000086561.1", "url": "https://www.ensembl.org/id/ENSRNOP00000086561.1" } ] } }, { "isoform_ac": "M0R4H8-1", "url": "", "sequence": { "sequence": "MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLWPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLHSFQVRDDSSGERDNKKVSSFRDWPSTFFFFWRQGLSLTWSWVQLKHLWMDVQICCDTFILSNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKLFHLPPSGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC", "length": 842, "header": "tr|M0R4H8-1|VAV_RAT Computationally mapped isoform of Proto-oncogene vav OS=Rattus norvegicus OX=10116 GN=Vav1 PE=2 SV=3 CANONICAL=P54100-1" }, "locus": { "chromosome": "9", "start_pos": 2208701, "end_pos": 2162042, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000073294.3", "url": "https://www.ensembl.org/id/ENSRNOT00000073294.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000064264.3", "url": "https://www.ensembl.org/id/ENSRNOP00000064264.3" } ] } }, { "isoform_ac": "P54100-1", "url": "", "sequence": { "sequence": "MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKERFLVYGRYCSQVESAIKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKDKLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHTWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC", "length": 843, "header": "sp|P54100-1|VAV_RAT Isoform 1 of Proto-oncogene vav OS=Rattus norvegicus OX=10116 GN=Vav1 PE=2 SV=1 CANONICAL=P54100-1" }, "locus": {} }, { "isoform_ac": "Q5BK91-1", "url": "", "sequence": { "sequence": "MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLWPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVNLHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKDKLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFAISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEYC", "length": 843, "header": "tr|Q5BK91-1|Q5BK91_RAT Computationally mapped isoform of Vav guanine nucleotide exchange factor 1 OS=Rattus norvegicus OX=10116 GN=Vav1 PE=4 SV=1 CANONICAL=P54100-1" }, "locus": { "chromosome": "9", "start_pos": 2208701, "end_pos": 2162042, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096076.1", "url": "https://www.ensembl.org/id/ENSRNOT00000096076.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000077767.1", "url": "https://www.ensembl.org/id/ENSRNOP00000077767.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 824, "end_pos": 824, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P54100", "url": "https://www.uniprot.org/uniprot/P54100" } ], "site_lbl": "Tyr824" }, { "start_pos": 842, "end_pos": 842, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P54100", "url": "https://www.uniprot.org/uniprot/P54100" } ], "site_lbl": "Tyr842" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway.", "journal": "J. Immunol.", "date": "1999", "authors": "Song JS, Haleem-Smith H, Arudchandran R, Gomez J, Scott PM, Mill JF, Tan TH, Rivera J", "evidence": [ { "database": "UniProtKB", "id": "P54100", "url": "https://www.uniprot.org/uniprot/P54100" } ], "reference": [ { "type": "PubMed", "id": "10395673", "url": "https://glygen.org/publication/PubMed/10395673" } ] }, { "title": "An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2015", "authors": "Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, Andreoletti O, Dejean AS, Lesourne R, Fournie GJ, Saoudi A", "evidence": [ { "database": "RefSeq", "id": "NP_036891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891" } ], "reference": [ { "type": "PubMed", "id": "26163585", "url": "https://glygen.org/publication/PubMed/26163585" } ] }, { "title": "Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury.", "journal": "Experimental neurology", "date": "2021", "authors": "Wang Q, Gong L, Mao S, Yao C, Liu M, Wang Y, Yang J, Yu B, Chen G, Gu X", "evidence": [ { "database": "RefSeq", "id": "NP_036891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036891" } ], "reference": [ { "type": "PubMed", "id": "34147481", "url": "https://glygen.org/publication/PubMed/34147481" } ] } ], "pathway": [ { "id": "rno:25156", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25156", "resource": "KEGG Pathway" }, { "id": "R-RNO-114604", "name": "GPVI-mediated activation cascade", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-114604", "resource": "Reactome", "description": "GPVI-mediated activation cascade" }, { "id": "R-RNO-1257604", "name": "PIP3 activates AKT signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1257604", "resource": "Reactome", "description": "PIP3 activates AKT signaling" }, { "id": "R-RNO-1433557", 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