{
    "uniprot_canonical_ac": "P53812-1",
    "uniprot_ac": "P53812",
    "uniprot_id": "PIPNB_RAT",
    "mass": {
        "chemical_mass": 31450.0,
        "monoisotopic_mass": 31450.0
    },
    "refseq": {
        "ac": "NP_446194",
        "name": "phosphatidylinositol transfer protein beta isoform",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194"
    },
    "gene_names": [
        {
            "name": "Pitpnb",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P53812",
            "id": "P53812"
        },
        {
            "name": "Pitpnb",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194",
            "id": "NP_446194"
        }
    ],
    "protein_names": [
        {
            "name": "Phosphatidylinositol transfer protein beta isoform",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P53812"
        },
        {
            "name": "PI-TP-beta; ptdIns transfer protein beta; ptdInsTP beta; phosphotidylinositol transfer protein, beta",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194",
            "id": "NP_446194"
        },
        {
            "name": "PI-TP-beta",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P53812"
        },
        {
            "name": "PtdIns transfer protein beta",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P53812"
        },
        {
            "name": "PtdInsTP beta",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P53812"
        },
        {
            "name": "phosphatidylinositol transfer protein beta isoform",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194",
            "id": "NP_446194"
        }
    ],
    "function": [
        {
            "annotation": "Catalyzes the transfer of phosphatidylinositol between membranes (PubMed:18636990). Also catalyzes the transfer of phosphatidylcholine and sphingomyelin between membranes (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P53812",
                    "url": "https://www.uniprot.org/uniprot/P53812#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "P48739",
                    "url": "https://www.uniprot.org/uniprot/P48739#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9TR36",
                    "url": "https://www.uniprot.org/uniprot/Q9TR36#function"
                },
                {
                    "database": "PubMed",
                    "id": "18636990",
                    "url": "https://glygen.org/publication/PubMed/18636990"
                }
            ]
        },
        {
            "annotation": "In rat liver, the single gene for PITPbeta gives rise to seven distinct protein species that can be resolved on the basis of their charge differences",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_446194",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194"
                },
                {
                    "database": "PubMed",
                    "id": "16780419",
                    "url": "https://glygen.org/publication/PubMed/16780419"
                }
            ]
        },
        {
            "annotation": "Lower protein expression of PI-TP(alpha and beta) in aged brain and in PD.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_446194",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194"
                },
                {
                    "database": "PubMed",
                    "id": "16779671",
                    "url": "https://glygen.org/publication/PubMed/16779671"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 202,
            "end_pos": 203,
            "sequence_org": "WW",
            "sequence_mut": "AA",
            "comment": "Loss of Golgi membrane localization.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P53812",
                    "url": "https://www.uniprot.org/uniprot/P53812"
                },
                {
                    "database": "PubMed",
                    "id": "18636990",
                    "url": "https://glygen.org/publication/PubMed/18636990"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P53812",
                    "url": "https://www.uniprot.org/uniprot/P53812"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Pitpnb",
            "url": "https://www.uniprot.org/uniprot/P53812",
            "locus": {
                "chromosome": "12",
                "start_pos": 45249333,
                "end_pos": 45298314,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000000665",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000000665"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000000665",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000000665",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd08888",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08888",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "114561",
            "url": "https://www.ncbi.nlm.nih.gov/gene/114561",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001666",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001666",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023393",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023393",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:114561",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:114561",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "FIIESRH",
            "url": "https://omabrowser.org/oma/group/FIIESRH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3946034at2759",
            "url": "http://www.orthodb.org/?query=3946034at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10658",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10658",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10658:SF27",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10658:SF27",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2A1L",
            "url": "https://www.rcsb.org/structure/2A1L",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF02121",
            "url": "http://pfam.xfam.org/family/PF02121",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P53812",
            "url": "http://purl.obolibrary.org/obo/PR_P53812",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-1483196",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1483196",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_446194",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "620143",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620143",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "38571",
            "url": "https://www.rhea-db.org/rhea/38571",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "38691",
            "url": "https://www.rhea-db.org/rhea/38691",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "43776",
            "url": "https://www.rhea-db.org/rhea/43776",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A8I6ARL3",
            "url": "https://www.uniprot.org/uniprot/A0A8I6ARL3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6ARL3-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6ARL3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8L2UMX1",
            "url": "https://www.uniprot.org/uniprot/A0A8L2UMX1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8L2UMX1-1",
            "url": "https://www.uniprot.org/uniprot/A0A8L2UMX1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZCD4",
            "url": "https://www.uniprot.org/uniprot/D3ZCD4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3ZCD4-1",
            "url": "https://www.uniprot.org/uniprot/D3ZCD4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P53812",
            "url": "https://www.uniprot.org/uniprot/P53812",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P53812-1",
            "url": "https://www.uniprot.org/uniprot/P53812-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P53812-2",
            "url": "https://www.uniprot.org/uniprot/P53812-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANTPDCPKMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA",
        "length": 271,
        "header": "sp|P53812-1|PIPNB_RAT Isoform 1 of Phosphatidylinositol transfer protein beta isoform  OS=Rattus norvegicus OX=10116 GN=Pitpnb PE=1 SV=2 CANONICAL=P53812-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6ARL3-1",
            "url": "",
            "sequence": {
                "sequence": "NLVLKHLRIVYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTSKLNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANTPDCPKMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETVSLAVVAVSALYNCTCLARLFLFPCLFSPEWSFPDTNALRPS",
                "length": 291,
                "header": "tr|A0A8I6ARL3-1|PIPNB_RAT Computationally mapped isoform of Phosphatidylinositol transfer protein beta isoform  OS=Rattus norvegicus OX=10116 GN=Pitpnb PE=1 SV=1 CANONICAL=P53812-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 45292827,
                "end_pos": 45254336,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000115109.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000115109.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000091407.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000091407.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8L2UMX1-1",
            "url": "",
            "sequence": {
                "sequence": "NLVLKHLRIVYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTSKLNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANTPDCPKMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETVSLAVVAVESKACPGPSKQSS",
                "length": 270,
                "header": "tr|A0A8L2UMX1-1|A0A8L2UMX1_RAT Computationally mapped isoform of Phosphatidylinositol transfer protein, beta  OS=Rattus norvegicus OX=10116 GN=Pitpnb PE=1 SV=1 CANONICAL=P53812-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 45292827,
                "end_pos": 45253914,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000066892.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000066892.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000058957.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000058957.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3ZCD4-1",
            "url": "",
            "sequence": {
                "sequence": "MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTILQNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANTPDCPKMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETLRSQGQVRGTSAACDD",
                "length": 272,
                "header": "tr|D3ZCD4-1|PIPNB_RAT Computationally mapped isoform of Phosphatidylinositol transfer protein beta isoform  OS=Rattus norvegicus OX=10116 GN=Pitpnb PE=1 SV=3 CANONICAL=P53812-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "P53812-1",
            "url": "",
            "sequence": {
                "sequence": "MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANTPDCPKMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA",
                "length": 271,
                "header": "sp|P53812-1|PIPNB_RAT Isoform 1 of Phosphatidylinositol transfer protein beta isoform  OS=Rattus norvegicus OX=10116 GN=Pitpnb PE=1 SV=2 CANONICAL=P53812-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 45298258,
                "end_pos": 45252104,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000115325",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000115325"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000078649",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000078649"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P53812-2",
            "url": "",
            "sequence": {
                "sequence": "MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANTPDCPKMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETLRSQGQVRGTSAACDD",
                "length": 272,
                "header": "sp|P53812-2|PIPNB_RAT Isoform 2 of Phosphatidylinositol transfer protein beta isoform  OS=Rattus norvegicus OX=10116 GN=Pitpnb PE=1 SV=2 CANONICAL=P53812-1"
            },
            "locus": {
                "chromosome": "12",
                "start_pos": 45298258,
                "end_pos": 45251057,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000052202",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000052202"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000050368",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000050368"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 262,
            "end_pos": 262,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P53812",
                    "url": "https://www.uniprot.org/uniprot/P53812"
                }
            ],
            "site_lbl": "Ser262"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Phosphatidylinositol transfer protein expression altered by aging and Parkinson disease.",
            "journal": "Cellular and molecular neurobiology",
            "date": "2006",
            "authors": "Chalimoniuk M, Snoek GT, Adamczyk A, Malecki A, Strosznajder JB",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_446194",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16779671",
                    "url": "https://glygen.org/publication/PubMed/16779671"
                }
            ]
        },
        {
            "title": "Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment.",
            "journal": "The Biochemical journal",
            "date": "2006",
            "authors": "Morgan CP, Allen-Baume V, Radulovic M, Li M, Skippen A, Cockcroft S",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_446194",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446194"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16780419",
                    "url": "https://glygen.org/publication/PubMed/16780419"
                }
            ]
        },
        {
            "title": "Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells.",
            "journal": "Traffic",
            "date": "2008",
            "authors": "Shadan S, Holic R, Carvou N, Ee P, Li M, Murray-Rust J, Cockcroft S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P53812",
                    "url": "https://www.uniprot.org/uniprot/P53812"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18636990",
                    "url": "https://glygen.org/publication/PubMed/18636990"
                }
            ]
        },
        {
            "title": "Cloning of a cDNA encoding a second phosphatidylinositol transfer protein of rat brain by complementation of the yeast sec14 mutation.",
            "journal": "J. Biochem.",
            "date": "1994",
            "authors": "Tanaka S., Hosaka K.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P53812",
                    "url": "https://www.uniprot.org/uniprot/P53812"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7961615",
                    "url": "https://glygen.org/publication/PubMed/7961615"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:114561",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:114561",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1483196",
            "name": "PI and PC transport between ER and Golgi membranes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1483196",
            "resource": "Reactome",
            "description": "PI and PC transport between ER and Golgi membranes"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P48739-1",
            "protein_name": "Phosphatidylinositol transfer protein beta isoform",
            "gene_name": "PITPNB",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKRGSVRGTSAADV",
                "length": 271
            },
            "evidence": [
                {
                    "id": "45232691",
                    "url": "http://www.informatics.jax.org/homology/45232691",
                    "database": "MGI"
                },
                {
                    "id": "P53812",
                    "url": "https://omabrowser.org/oma/group/P53812/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P53811-1",
            "protein_name": "Phosphatidylinositol transfer protein beta isoform",
            "gene_name": "Pitpnb",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFHSVKTKRGPLGPNWKKELANTPDCPRMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA",
                "length": 271
            },
            "evidence": [
                {
                    "id": "45232691",
                    "url": "http://www.informatics.jax.org/homology/45232691",
                    "database": "MGI"
                },
                {
                    "id": "P53812",
                    "url": "https://omabrowser.org/oma/group/P53812/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 7,
                "go_terms": [
                    {
                        "name": "phospholipid transporter activity",
                        "id": "GO:0005548",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005548",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylcholine binding",
                        "id": "GO:0031210",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylinositol binding",
                        "id": "GO:0035091",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylinositol transfer activity",
                        "id": "GO:0008526",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008526",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylcholine transporter activity",
                        "id": "GO:0008525",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008525",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylcholine transfer activity",
                        "id": "GO:0120019",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120019",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sphingomyelin transfer activity",
                        "id": "GO:0140338",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140338",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "Golgi membrane",
                        "id": "GO:0000139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "in utero embryonic development",
                        "id": "GO:0001701",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phospholipid transport",
                        "id": "GO:0015914",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015914",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum",
                        "id": "GO:0006890",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P53812",
                                "url": "https://www.uniprot.org/uniprot/P53812"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 32,
            "end_pos": 34,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P53812",
                    "url": "https://www.uniprot.org/uniprot/P53812"
                },
                {
                    "database": "PubMed",
                    "id": "P53811",
                    "url": "https://glygen.org/publication/PubMed/P53811"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [
        {
            "id": "38571",
            "name": "",
            "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P58195-1",
                "O15162-1",
                "Q9JJ00-1"
            ],
            "evidence": [
                {
                    "id": "38571",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/38571"
                }
            ]
        },
        {
            "id": "38691",
            "name": "",
            "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "38691",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/38691"
                }
            ]
        },
        {
            "id": "43776",
            "name": "",
            "equation": "an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)-sphingosylphosphocholine(out)",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "43776",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/43776"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "O15162",
            "gene_name": "PLSCR1",
            "activity": [
                {
                    "ec_number": "3.1.-.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O15162",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O15162"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P58195",
            "gene_name": "Plscr1",
            "activity": [
                {
                    "ec_number": "3.1.-.-",
                    "activity": "",
                    "evidence": [
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                            "id": "P58195",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P58195"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9JJ00",
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                {
                    "ec_number": "3.1.-.-",
                    "activity": "",
                    "evidence": [
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                            "id": "Q9JJ00",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9JJ00"
                        }
                    ]
                }
            ]
        }
    ],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
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                {
                    "field": "n_linked_glycan_sites",
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                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
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                }
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        {
            "table_id": "glycosylation_reported_with_glycan",
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                    "field": "o_linked_glycan_sites",
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        {
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                {
                    "field": "o_linked_glycans",
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            "sort_fields": []
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        {
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                {
                    "field": "o_linked_glycan_sites",
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            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
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                    "field": "total",
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                },
                {
                    "field": "total_sites",
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                }
            ],
            "sort_fields": [
                "start_pos",
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                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
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                "comment",
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            ]
        },
        {
            "table_id": "snv",
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                    "field": "total",
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                },
                {
                    "field": "total_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
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                    "field": "total",
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                {
                    "field": "total_sites",
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        {
            "table_id": "snv_non_disease",
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        {
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                    "field": "total",
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            "sort_fields": [
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    ]
}
