{ "uniprot_canonical_ac": "P53792-1", "uniprot_ac": "P53792", "uniprot_id": "SC5A2_RAT", "mass": { "chemical_mass": 72962.0, "monoisotopic_mass": 72962.0 }, "refseq": { "ac": "NP_072112", "name": "sodium/glucose cotransporter 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" }, "gene_names": [ { "name": "Slc5a2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P53792", "id": "P53792" }, { "name": "Sglt2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112", "id": "NP_072112" }, { "name": "Sglt2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P53792", "id": "P53792" }, { "name": "Slc5a2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112", "id": "NP_072112" } ], "protein_names": [ { "name": "Sodium/glucose cotransporter 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P53792" }, { "name": "Low affinity sodium-glucose cotransporter", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P53792" }, { "name": "Na(+)/glucose cotransporter 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P53792" }, { "name": "Solute carrier family 5 member 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P53792" }, { "name": "low affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 2; low affinity Na-dependent glucose transporter (SGLT2); solute carrier family 5 (sodium/glucose cotransporter), member 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112", "id": "NP_072112" }, { "name": "sodium/glucose cotransporter 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112", "id": "NP_072112" } ], "function": [ { "annotation": "Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:7493971). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P53792", "url": "https://www.uniprot.org/uniprot/P53792#function" }, { "database": "PubMed", "id": "7493971", "url": "https://glygen.org/publication/PubMed/7493971" }, { "database": "UniProtKB", "id": "Q923I7", "url": "https://www.uniprot.org/uniprot/Q923I7#function" } ] }, { "annotation": "Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves.", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" }, { "database": "PubMed", "id": "34789005", "url": "https://glygen.org/publication/PubMed/34789005" } ] }, { "annotation": "Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" }, { "database": "PubMed", "id": "33806551", "url": "https://glygen.org/publication/PubMed/33806551" } ] }, { "annotation": "In renovascular hypertension, angiotensin II induced SGLT2 via the AT1 receptor, which was evidenced at both the functional and expression levels, probably contributing to increased absorption of Na+ and thereby to the development of hypertension.", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" }, { "database": "PubMed", "id": "14506074", "url": "https://glygen.org/publication/PubMed/14506074" } ] }, { "annotation": "Preliminary mechanism of inhibitor of SGLT2 in fatty liver cold ischemia injury.", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" }, { "database": "PubMed", "id": "36708596", "url": "https://glygen.org/publication/PubMed/36708596" } ] }, { "annotation": "SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na(+) transport in Dahl SS rats.", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" }, { "database": "PubMed", "id": "35466690", "url": "https://glygen.org/publication/PubMed/35466690" } ] }, { "annotation": "SGLT2 is not expressed in pancreatic alpha- and beta-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" }, { "database": "PubMed", "id": "32896668", "url": "https://glygen.org/publication/PubMed/32896668" } ] } ], "disease": [ { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "evidence": [ { "id": "10763", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] }, { "disease_id": "DOID:9432", "recommended_name": { "id": "DOID:9432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9432", "name": "renal glycosuria", "description": "" }, "synonyms": [ { "id": "DOID:9432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9432", "name": "renal diabetes", "description": "" }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "familial renal glucosuria", "description": "Familial Renal Glucosuria (FRG) is characterized by the presence of persistent isolated glucosuria in the absence of both generalized proximal tubular dysfunction and hyperglycemia. FRG is usually considered a benign entity as most patients are not affected by severe clinical consequences. Polyuria and enuresis and later a mild growth and pubertal maturation delay are the only manifestations that have been reported during a follow-up period of 30 years. Episodic dehydration and ketosis during pregnancy and starvation and an increased incidence of urinary tract infections have occasionally been reported in severe cases. FRG is caused by loss-of-function mutations in the gene SLC5A2 (16p11.2)." }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "SGLT2 deficiency", "description": "" }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "familial renal glucosuria", "description": "" }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "renal diabetes", "description": "" }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "GLYS", "description": "" }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "Glys1", "description": "" }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "glycosuria, renal", "description": "" }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "renal glucosuria", "description": "" }, { "id": "MONDO:0009297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009297", "name": "renal glycosuria", "description": "" }, { "id": "MIM:233100", "resource": "MIM", "url": "https://www.omim.org/entry/233100", "name": "Renal glucosuria", "description": "Renal glucosuria" } ], "evidence": [ { "id": "9432", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9432" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P53792", "url": "https://www.uniprot.org/uniprot/P53792" } ], "common_name": "Rat" } ], "gene": [ { "name": "Slc5a2", "url": "https://www.uniprot.org/uniprot/P53792", "locus": { "chromosome": "1", "start_pos": 182853306, "end_pos": 182847106, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000020039", "url": "https://www.ensembl.org/id/ENSRNOG00000020039" } ] } } ], "crossref": [ { "id": "ENSRNOG00000020039", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020039", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "CHEMBL4316", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4316", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "64522", "url": "https://www.ncbi.nlm.nih.gov/gene/64522", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038377", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038377", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:64522", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64522", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AYMTMVT", "url": "https://omabrowser.org/oma/group/AYMTMVT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "74094at2759", "url": "http://www.orthodb.org/?query=74094at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11819", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11819:SF145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819:SF145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00474", "url": "http://pfam.xfam.org/family/PF00474", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P53792", "url": "http://purl.obolibrary.org/obo/PR_P53792", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189200", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "620217", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620217", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "70571", "url": "https://www.rhea-db.org/rhea/70571", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JZF9", "url": "https://www.uniprot.org/uniprot/A0A0G2JZF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JZF9-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JZF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LMI6", "url": "https://www.uniprot.org/uniprot/F1LMI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LMI6-1", "url": "https://www.uniprot.org/uniprot/F1LMI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P53792", "url": "https://www.uniprot.org/uniprot/P53792", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P53792-1", "url": "https://www.uniprot.org/uniprot/P53792-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGGLPWPALLLGLTIVSGWHWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISRCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA", "length": 670, "header": "sp|P53792-1|SC5A2_RAT Isoform 1 of Sodium/glucose cotransporter 2 OS=Rattus norvegicus OX=10116 GN=Slc5a2 PE=1 SV=1 CANONICAL=P53792-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JZF9-1", "url": "", "sequence": { "sequence": "MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPGNVCITPRPSLTAAAHSSPWISTHACGLGRVIGSCCWLEGFGWCSLWQCPWLGCQWCRQHRAASSSITFSLSPATWRLQCPLSLCWHSLCPVLMRSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISLCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA", "length": 596, "header": "tr|A0A0G2JZF9-1|SC5A2_RAT Computationally mapped isoform of Sodium/glucose cotransporter 2 OS=Rattus norvegicus OX=10116 GN=Slc5a2 PE=1 SV=1 CANONICAL=P53792-1" }, "locus": { "chromosome": "1", "start_pos": 182853067, "end_pos": 182847190, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000080872.2", "url": "https://www.ensembl.org/id/ENSRNOT00000080872.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000071031.2", "url": "https://www.ensembl.org/id/ENSRNOP00000071031.2" } ] } }, { "isoform_ac": "F1LMI6-1", "url": "", "sequence": { "sequence": "MLERMEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISLCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA", "length": 674, "header": "tr|F1LMI6-1|F1LMI6_RAT Computationally mapped isoform of Solute carrier family 5 member 2 OS=Rattus norvegicus OX=10116 GN=Slc5a2 PE=3 SV=2 CANONICAL=P53792-1" }, "locus": { "chromosome": "1", "start_pos": 182853067, "end_pos": 182847178, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000027265.4", "url": "https://www.ensembl.org/id/ENSRNOT00000027265.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000027265.2", "url": "https://www.ensembl.org/id/ENSRNOP00000027265.2" } ] } }, { "isoform_ac": "P53792-1", "url": "", "sequence": { "sequence": "MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGGLPWPALLLGLTIVSGWHWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISRCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA", "length": 670, "header": "sp|P53792-1|SC5A2_RAT Isoform 1 of Sodium/glucose cotransporter 2 OS=Rattus norvegicus OX=10116 GN=Slc5a2 PE=1 SV=1 CANONICAL=P53792-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 248, "start_aa": "Asn", "end_pos": 248, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn248", "evidence": [ { "id": "P53792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53792#ptm_processing" }, { "id": "7493971", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7493971" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension.", "journal": "American journal of physiology. Renal physiology", "date": "2004", "authors": "Bautista R, Manning R, Martinez F, Avila-Casado Mdel C, Soto V, Medina A, Escalante B", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" } ], "reference": [ { "type": "PubMed", "id": "14506074", "url": "https://glygen.org/publication/PubMed/14506074" } ] }, { "title": "SGLT2 is not expressed in pancreatic alpha- and beta-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.", "journal": "Molecular metabolism", "date": "2020", "authors": "Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" } ], "reference": [ { "type": "PubMed", "id": "32896668", "url": "https://glygen.org/publication/PubMed/32896668" } ] }, { "title": "Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.", "journal": "International journal of molecular sciences", "date": "2021", "authors": "Pruett JE, Torres Fernandez ED, Everman SJ, Vinson RM, Davenport K, Logan MK, Ye SA, Romero DG, Yanes Cardozo LL", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" } ], "reference": [ { "type": "PubMed", "id": "33806551", "url": "https://glygen.org/publication/PubMed/33806551" } ] }, { "title": "Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves.", "journal": "Circulation. Heart failure", "date": "2021", "authors": "Katsurada K, Nandi SS, Sharma NM, Patel KP", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" } ], "reference": [ { "type": "PubMed", "id": "34789005", "url": "https://glygen.org/publication/PubMed/34789005" } ] }, { "title": "SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na(+) transport in Dahl SS rats.", "journal": "American journal of physiology. Renal physiology", "date": "2022", "authors": "Kravtsova O, Bohovyk R, Levchenko V, Palygin O, Klemens CA, Rieg T, Staruschenko A", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" } ], "reference": [ { "type": "PubMed", "id": "35466690", "url": "https://glygen.org/publication/PubMed/35466690" } ] }, { "title": "Preliminary mechanism of inhibitor of SGLT2 in fatty liver cold ischemia injury.", "journal": "Biochemical and biophysical research communications", "date": "2023-02-26", "authors": "Yang Hanwen, Wang Qiang, Zhang Pengpeng, Cheng Ke, Li Hao, Wang Huan, Cai Mingxin, Ming Yingzi, Zhao Yujun", "evidence": [ { "database": "RefSeq", "id": "NP_072112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072112" } ], "reference": [ { "type": "PubMed", "id": "36708596", "url": "https://glygen.org/publication/PubMed/36708596" } ] }, { "title": "Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidney.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "You G, Lee WS, Barros EJ, Kanai Y, Huo TL, Khawaja S, Wells RG, Nigam SK, Hediger MA", "evidence": [ { "database": "UniProtKB", "id": "P53792", "url": "https://www.uniprot.org/uniprot/P53792#ptm_processing" }, { "database": "UniProtKB", "id": "P53792", "url": "https://www.uniprot.org/uniprot/P53792" } ], "reference": [ { "type": "PubMed", "id": "7493971", "url": "https://glygen.org/publication/PubMed/7493971" } ] } ], "pathway": [ { "id": "rno:64522", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:64522", "resource": "KEGG Pathway" }, { "id": "R-RNO-189200", "name": "Cellular hexose transport", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189200", "resource": "Reactome", "description": "Cellular hexose transport" } ], "orthologs": [ { "uniprot_canonical_ac": "P31639-1", "protein_name": "Sodium/glucose cotransporter 2", "gene_name": "SLC5A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA", "length": 672 }, "evidence": [ { "id": "45236528", "url": "http://www.informatics.jax.org/homology/45236528", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q923I7-1", "protein_name": "Sodium/glucose cotransporter 2", 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