{ "uniprot_canonical_ac": "P53749-1", "uniprot_ac": "P53749", "uniprot_id": "YN92_YEAST", "mass": { "chemical_mass": 69663.0, "monoisotopic_mass": 69663.0 }, "refseq": { "ac": "NP_014461", "name": "Pul4p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014461" }, "gene_names": [ { "name": "N3531", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P53749", "id": "P53749" }, { "name": "PUL4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014461", "id": "NP_014461" } ], "protein_names": [ { "name": "Uncharacterized transcriptional regulatory protein YNR063W", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P53749" }, { "name": "Pul4p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014461", "id": "NP_014461" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749" } ], "common_name": "Yeast" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprot/P53749", "locus": {} } ], "crossref": [ { "id": "cd00067", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00067", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12148", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12148", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "855800", "url": "https://www.ncbi.nlm.nih.gov/gene/855800", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P53749", "url": "https://www.ebi.ac.uk/intact/interactors/id:P53749*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YNR063W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YNR063W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LMANFMT", "url": "https://omabrowser.org/oma/group/LMANFMT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2313372at2759", "url": "http://www.orthodb.org/?query=2313372at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47424", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47424", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47424:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47424:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00172", "url": "http://pfam.xfam.org/family/PF00172", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF04082", "url": "http://pfam.xfam.org/family/PF04082", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P53749", "url": "http://purl.obolibrary.org/obo/PR_P53749", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014461", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005346", "url": "https://www.yeastgenome.org/locus/S000005346", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P53749-1", "url": "https://www.uniprot.org/uniprot/P53749-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRSKDARKRSISLACTVCRKRKLKCDGNKPCGRCIRLNTPKECIYNIDKRKDKRKIKNGSKVFLFKNNTIDNGNNSILENKGLNEDLSSHIYEKEAPKFDSDIDISRFGTNDAVIFNNDGWDTSLPIDFDFDEFNTETTDFDDFLKLLGDNSPSKEQKSLSYSPTATGLSGVVKETESEDNAPTRSRLIDVLFENKLHSVPGISKWHLYELESQYPNLECTEGNSDEKFLLSTVLCLGSLTIRKRELLNHSNIDNRPLLPENSISKLTTDAFKYYNAAKTLVPDLLSHPTIDGFCGLVLMANFMTMMISLEHQLYLSINALQLAVALNLNNNTKCKELLESNSDGIGVILLFWNIWCSSCMLATIHGKNPFITLEQITTPLPCEISPRNKTNKLLIDFMQIRIKLATLQSKIFQRLYTSSTANEVPFVNLEREFEEVSLQITRLKGFPIFEEHLFYRSRVLMLELSCLRAQASFLLYRPYLITGESLQAVTMAKSIIHEIWSQYTKQFPDNEKERHERLDWNFCYPLRTASLTLCISCIILLRYKQVVQFLKGTELFEYILALEILQDLVQVLPIEQNLIDIIKYPISPVQLSGDSFVEFWGRILY", "length": 607, "header": "sp|P53749-1|YN92_YEAST Isoform 1 of Uncharacterized transcriptional regulatory protein YNR063W OS=Saccharomyces cerevisiae S288C OX=559292 GN= PE=1 SV=1 CANONICAL=P53749-1" }, "isoforms": [ { "isoform_ac": "P53749-1", "url": "", "sequence": { "sequence": "MDRSKDARKRSISLACTVCRKRKLKCDGNKPCGRCIRLNTPKECIYNIDKRKDKRKIKNGSKVFLFKNNTIDNGNNSILENKGLNEDLSSHIYEKEAPKFDSDIDISRFGTNDAVIFNNDGWDTSLPIDFDFDEFNTETTDFDDFLKLLGDNSPSKEQKSLSYSPTATGLSGVVKETESEDNAPTRSRLIDVLFENKLHSVPGISKWHLYELESQYPNLECTEGNSDEKFLLSTVLCLGSLTIRKRELLNHSNIDNRPLLPENSISKLTTDAFKYYNAAKTLVPDLLSHPTIDGFCGLVLMANFMTMMISLEHQLYLSINALQLAVALNLNNNTKCKELLESNSDGIGVILLFWNIWCSSCMLATIHGKNPFITLEQITTPLPCEISPRNKTNKLLIDFMQIRIKLATLQSKIFQRLYTSSTANEVPFVNLEREFEEVSLQITRLKGFPIFEEHLFYRSRVLMLELSCLRAQASFLLYRPYLITGESLQAVTMAKSIIHEIWSQYTKQFPDNEKERHERLDWNFCYPLRTASLTLCISCIILLRYKQVVQFLKGTELFEYILALEILQDLVQVLPIEQNLIDIIKYPISPVQLSGDSFVEFWGRILY", "length": 607, "header": "sp|P53749-1|YN92_YEAST Isoform 1 of Uncharacterized transcriptional regulatory protein YNR063W OS=Saccharomyces cerevisiae S288C OX=559292 GN= PE=1 SV=1 CANONICAL=P53749-1" }, "locus": { "chromosome": "XIV", "start_pos": 748763, "end_pos": 746943, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YNR063W_mRNA", "url": "https://www.ensembl.org/id/YNR063W_mRNA" }, { "database": "Ensembl Peptide", "id": "YNR063W", "url": "https://www.ensembl.org/id/YNR063W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 102, "end_pos": 102, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P53749", "url": "https://www.yeastgenome.org/locus/P53749" }, { "database": "iPTMnet", "id": "P53749", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53749" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser102" }, { "start_pos": 153, "end_pos": 153, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P53749", "url": "https://www.yeastgenome.org/locus/P53749" }, { "database": "iPTMnet", "id": "P53749", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53749" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser153" }, { "start_pos": 164, "end_pos": 164, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53749", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53749" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P53749", "url": "https://www.yeastgenome.org/locus/P53749" } ], "site_lbl": "Ser164" } ], "glycation": [], "keywords": [], "publication": [ { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749" }, { "database": "iPTMnet", "id": "P53749", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53749" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", "evidence": [ { "database": "iPTMnet", "id": "P53749", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53749" } ], "reference": [ { "type": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.", "journal": "Nature", "date": "1997", "authors": "Duesterhoeft A., Mewes H.-W., Obermaier B., Wambutt R., Wedler H., Verhasselt P., Lanfranchi G., Valle G., Planta R.J., Jacquet M., Kleine K., Floeth M., Mallet L., Jimenez A., Dubois E., Volckaert G., Andre B., De Antoni A., Baladron V., Boskovic J., Nasr F., Pandolfo D., Philippsen P., Poehlmann R., Domdey H., D'Angelo M., Pohl T.M., Lyck R., Sartorello F., Ballesta J.P.G., Becam A.-M., Bussereau F., Crouzet M., Doignon F., Fleig U., Gaillardin C., Glansdorff N., Goffeau A., Gueldener U., Hani J., Hegemann J.H., Herbert C.J., Messenguy F., Pierard A., Remacha M.A., Revuelta J.L., Scherens B., Vissers S., Wach A., Zollner A., del Rey F., Fiedler T.A., Jonniaux J.-L., Lepingle A., Niedenthal R.K., Purnelle B., Saiz J.E., Urrestarazu L.A., Vierendeels F., Voet M., Aert R., Albermann K., Altmann R., Beinhauer J.D., Buitrago M.J., Coster F., Dal Pero F., Fritz C., Garcia-Cantalejo J.M., Hamberg K., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Karpfinger-Hartl L., Levesque H., Maftahi M., Maurer C.T.C., Moestl D., Nicaud J.-M., Piravandi E., Rebischung C., Rinke M., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Van Dyck L.", "evidence": [ { "database": "UniProtKB", "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749" } ], "reference": [ { "type": "PubMed", "id": "9169873", "url": "https://glygen.org/publication/PubMed/9169873" } ] } ], "pathway": [ { "id": "sce:YNR063W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YNR063W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "P53749", "url": "https://www.uniprot.org/uniprot/P53749" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": 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