{ "uniprot_canonical_ac": "P53388-1", "uniprot_ac": "P53388", "uniprot_id": "DIP5_YEAST", "mass": { "chemical_mass": 68097.0, "monoisotopic_mass": 68097.0 }, "refseq": { "ac": "NP_015058", "name": "dicarboxylic amino acid permease", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015058" }, "gene_names": [ { "name": "DIP5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P53388", "id": "P53388" }, { "name": "DIP5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015058", "id": "NP_015058" } ], "protein_names": [ { "name": "Dicarboxylic amino acid permease", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P53388" }, { "name": "dicarboxylic amino acid permease", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015058", "id": "NP_015058" } ], "function": [ { "annotation": "Can transport glutamate, aspartate, glutamine, asparagine, serine, alanine and glycine.", "evidence": [ { "database": "UniProtKB", "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388#function" }, { "database": "PubMed", "id": "10654085", "url": "https://glygen.org/publication/PubMed/10654085" } ] } ], "disease": [ { "disease_id": "DOID:0110374", "recommended_name": { "id": "DOID:0110374", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110374", "name": "retinitis pigmentosa 68", "description": "A retinitis pigmentosa that has_material_basis_in mutation in the SLC7A14 gene on chromosome 3q26." }, "synonyms": [ { "id": "DOID:0110374", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110374", "name": "RP68", "description": "" }, { "id": "MONDO:0014323", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014323", "name": "retinitis pigmentosa 68", "description": "Any retinitis pigmentosa in which the cause of the disease is a mutation in the SLC7A14 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pigmentosa 68" } ], "evidence": [ { "id": "0110374", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110374" } ] }, { "disease_id": "DOID:10003", "recommended_name": { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "sensorineural hearing loss", "description": "An inner ear disease that is characterized by hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem." }, "synonyms": [ { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "High Frequency Hearing Loss", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "High frequency deafness", "description": "" }, { "id": "DOID:10003", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10003", "name": "Perceptive deafness", 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"description": "" } ], "evidence": [ { "id": "10003", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10003" } ] }, { "disease_id": "DOID:1432", "recommended_name": { "id": "DOID:1432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1432", "name": "blindness", "description": "An eye disease characterized by a lack or loss of vision." }, "synonyms": [ { "id": "DOID:1432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1432", "name": "vision impairment", "description": "" }, { "id": "DOID:1432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1432", "name": "vision loss", "description": "" }, { "id": "DOID:1432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1432", "name": "visual impairment", "description": "" } ], "evidence": [ { "id": "1432", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1432" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388" } ], "common_name": "Yeast" } ], "gene": [ { "name": "DIP5", "url": "https://www.uniprot.org/uniprot/P53388", "locus": {} } ], "crossref": [ { "id": "855863", "url": "https://www.ncbi.nlm.nih.gov/gene/855863", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P53388", "url": "https://www.ebi.ac.uk/intact/interactors/id:P53388*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR004762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004840", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004840", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YPL265W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YPL265W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MGEMLYV", "url": "https://omabrowser.org/oma/group/MGEMLYV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2048216at2759", "url": "http://www.orthodb.org/?query=2048216at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43341", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43341", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43341:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43341:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00324", "url": "http://pfam.xfam.org/family/PF00324", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P53388", "url": "http://purl.obolibrary.org/obo/PR_P53388", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_015058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015058", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000006186", "url": "https://www.yeastgenome.org/locus/S000006186", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P53388-1", "url": "https://www.uniprot.org/uniprot/P53388-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMPLKKMFTSTSPRNSSSLDSDHDAYYSKQNPDNFPVKEQEIYNIDLEENNVSSRSSTSTSPSARDDSFAVPDGKDENTRLRKDLKARHISMIAIGGSLGTGLLIGTGTALLTGGPVAMLIAYAFVGLLVFYTMACLGEMASYIPLDGFTSYASRYVDPALGFAIGYTYLFKYFILPPNQLTAAALVIQYWISRDRVNPGVWITIFLVVIVAINVVGVKFFGEFEFWLSSFKVMVMLGLILLLFIIMLGGGPNHDRLGFRYWRDPGAFKEYSTAITGGKGKFVSFVAVFVYSLFSYTGIELTGIVCSEAENPRKSVPKAIKLTVYRIIVFYLCTVFLLGMCVAYNDPRLLSTKGKSMSAAASPFVVAIQNSGIEVLPHIFNACVLVFVFSACNSDLYVSSRNLYALAIDGKAPKIFAKTSRWGVPYNALILSVLFCGLAYMNVSSGSAKIFNYFVNVVSMFGILSWITILIVYIYFDKACRAQGIDKSKFAYVAPGQRYGAYFALFFCILIALIKNFTVFLGHKFDYKTFITGYIGLPVYIISWAGYKLIYKTKVIKSTDVDLYTFKEIYDREEEEGRMKDQEKEERLKSNGKNMEWFYEKFLGNIF", "length": 608, "header": "sp|P53388-1|DIP5_YEAST Isoform 1 of Dicarboxylic amino acid permease OS=Saccharomyces cerevisiae S288C OX=559292 GN=DIP5 PE=1 SV=1 CANONICAL=P53388-1" }, "isoforms": [ { "isoform_ac": "P53388-1", "url": "", "sequence": { "sequence": "MKMPLKKMFTSTSPRNSSSLDSDHDAYYSKQNPDNFPVKEQEIYNIDLEENNVSSRSSTSTSPSARDDSFAVPDGKDENTRLRKDLKARHISMIAIGGSLGTGLLIGTGTALLTGGPVAMLIAYAFVGLLVFYTMACLGEMASYIPLDGFTSYASRYVDPALGFAIGYTYLFKYFILPPNQLTAAALVIQYWISRDRVNPGVWITIFLVVIVAINVVGVKFFGEFEFWLSSFKVMVMLGLILLLFIIMLGGGPNHDRLGFRYWRDPGAFKEYSTAITGGKGKFVSFVAVFVYSLFSYTGIELTGIVCSEAENPRKSVPKAIKLTVYRIIVFYLCTVFLLGMCVAYNDPRLLSTKGKSMSAAASPFVVAIQNSGIEVLPHIFNACVLVFVFSACNSDLYVSSRNLYALAIDGKAPKIFAKTSRWGVPYNALILSVLFCGLAYMNVSSGSAKIFNYFVNVVSMFGILSWITILIVYIYFDKACRAQGIDKSKFAYVAPGQRYGAYFALFFCILIALIKNFTVFLGHKFDYKTFITGYIGLPVYIISWAGYKLIYKTKVIKSTDVDLYTFKEIYDREEEEGRMKDQEKEERLKSNGKNMEWFYEKFLGNIF", "length": 608, "header": "sp|P53388-1|DIP5_YEAST Isoform 1 of Dicarboxylic amino acid permease OS=Saccharomyces cerevisiae S288C OX=559292 GN=DIP5 PE=1 SV=1 CANONICAL=P53388-1" }, "locus": { "chromosome": "XVI", "start_pos": 42866, "end_pos": 41043, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YPL265W_mRNA", "url": "https://www.ensembl.org/id/YPL265W_mRNA" }, { "database": "Ensembl Peptide", "id": "YPL265W", "url": "https://www.ensembl.org/id/YPL265W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 10, "end_pos": 10, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" }, { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" } ], "site_lbl": "Thr10" }, { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" } ], "site_lbl": "Ser11" }, { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" } ], "site_lbl": "Thr12" }, { "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "11875433", "url": "https://glygen.org/publication/PubMed/11875433" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser13" }, { "start_pos": 17, "end_pos": 17, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser17" }, { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "11875433", "url": "https://glygen.org/publication/PubMed/11875433" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser18" }, { "start_pos": 19, "end_pos": 19, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser19" }, { "start_pos": 22, "end_pos": 22, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "11875433", "url": "https://glygen.org/publication/PubMed/11875433" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser22" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Tyr27" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Tyr28" }, { "start_pos": 69, "end_pos": 69, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "P53388", "url": "https://www.yeastgenome.org/locus/P53388" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser69" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.", "journal": "Curr. Genet.", "date": "1999", "authors": "Holmberg S., Kielland-Brandt M.C., Regenberg B., During-Olsen L.", "evidence": [ { "database": "UniProtKB", "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388" } ], "reference": [ { "type": "PubMed", "id": "10654085", "url": "https://glygen.org/publication/PubMed/10654085" } ] }, { "title": "Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.", "journal": "Nature biotechnology", "date": "2002-03", "authors": "Ficarro Scott B, McCleland Mark L, Stukenberg P Todd, Burke Daniel J, Ross Mark M, Shabanowitz Jeffrey, Hunt Donald F, White Forest M", "evidence": [ { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" } ], "reference": [ { "type": "PubMed", "id": "11875433", "url": "https://glygen.org/publication/PubMed/11875433" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "A global topology map of the Saccharomyces cerevisiae membrane proteome.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Kim H., von Heijne G., Melen K., Oesterberg M.", "evidence": [ { "database": "UniProtKB", "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388" } ], "reference": [ { "type": "PubMed", "id": "16847258", "url": "https://glygen.org/publication/PubMed/16847258" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388" }, { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "P53388", "url": "https://www.uniprot.org/uniprot/P53388" }, { "database": "iPTMnet", "id": "P53388", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53388" } ], "reference": [ { "type": 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