{ "uniprot_canonical_ac": "P53135-1", "uniprot_ac": "P53135", "uniprot_id": "SLD3_YEAST", "mass": { "chemical_mass": 77298.0, "monoisotopic_mass": 77298.0 }, "refseq": { "ac": "NP_011402", "name": "Sld3p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011402" }, "gene_names": [ { "name": "SLD3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P53135", "id": "P53135" }, { "name": "G2980", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P53135", "id": "P53135" }, { "name": "SLD3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011402", "id": "NP_011402" } ], "protein_names": [ { "name": "DNA replication regulator SLD3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P53135" }, { "name": "Sld3p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011402", "id": "NP_011402" } ], "function": [ { "annotation": "Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins.", "evidence": [ { "database": "UniProtKB", "id": "P53135", "url": "https://www.uniprot.org/uniprot/P53135#function" }, { "database": "PubMed", "id": "21487389", "url": "https://glygen.org/publication/PubMed/21487389" }, { "database": "PubMed", "id": "11296242", "url": "https://glygen.org/publication/PubMed/11296242" }, { "database": "PubMed", "id": "12730134", "url": "https://glygen.org/publication/PubMed/12730134" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P53135", "url": "https://www.uniprot.org/uniprot/P53135" } ], "common_name": "Yeast" } ], "gene": [ { "name": "SLD3", "url": "https://www.uniprot.org/uniprot/P53135", "locus": {} } ], "crossref": [ { "id": "852765", "url": "https://www.ncbi.nlm.nih.gov/gene/852765", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P53135", "url": "https://www.ebi.ac.uk/intact/interactors/id:P53135*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR013948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YGL113W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YGL113W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "P53135", "url": "https://oglcnac.org/atlas/detail/P53135", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P53135", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P53135", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "SLDYCEQ", "url": "https://omabrowser.org/oma/group/SLDYCEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2028603at2759", "url": "http://www.orthodb.org/?query=2028603at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28067", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28067", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28067:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28067:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3WI3", "url": "https://www.rcsb.org/structure/3WI3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF08639", "url": "http://pfam.xfam.org/family/PF08639", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18523", "url": "http://pfam.xfam.org/family/PF18523", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P53135", "url": "http://purl.obolibrary.org/obo/PR_P53135", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_011402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011402", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000003081", "url": "https://www.yeastgenome.org/locus/S000003081", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P53135", "url": "https://www.uniprot.org/uniprot/P53135", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P53135-1", "url": "https://www.uniprot.org/uniprot/P53135-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METWEVIASVKEATKGLDLSLDHPLIIKSEDVPSNILQLLQQKNRRQLKHICMKSRKEYFLLEEYGPGFWVKWPYNYFNGYSLPERRTEVVTTVERERAKRETLKTWDELKFKELLHLWSEEPKGSCKLEKDKDLKLDMNPPDMKGESKINDYYSDPKEYIESKYYDALFSIHTPLAYFVKSNLVRLKNTCRTKYGSDSYKIAYQAMLQKFLLSIVQFKDRHDNRLLLEPFSSPIADEKRKNCLTKFVIQDENKNSSTIADLCVVLKSREIKLQILLLLEIIGLNDLDWNFRDFEKKYKLKLKKRSLNLTKKGLVRRRSKKKTSEKDKGIERITTSLDYCEQLDLYLDRACILDILLSSETPNPDAIEASNGTIQEHKKNILDKSKEASLVGFINYVLIPYFNKKVPHAVEFIIQKLKGPSMRPKRALKKVNDSTNVSSPNTVETYNRLSTSQRASRSSIINSVPSSPALRRVDANLFSRKSIASPTPELLNSRTNSNLNEFLESETRSLKRPSQLGRTKSDLTMNHLQKRQFSVSDLSTTRVPNSSTITLKTPFSHSTINAYKTMNNSFRRVGKRKDINETIRLHERVDSEENVQVQATPAVKKRTVTPNKKAQLQSIIESPLNFKDDDTHEGRKNTSNITSTPTNKPPENSSKRRVRRRLFAPEST", "length": 668, "header": "sp|P53135-1|SLD3_YEAST Isoform 1 of DNA replication regulator SLD3 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SLD3 PE=1 SV=1 CANONICAL=P53135-1" }, "isoforms": [ { "isoform_ac": "P53135-1", "url": "", "sequence": { "sequence": "METWEVIASVKEATKGLDLSLDHPLIIKSEDVPSNILQLLQQKNRRQLKHICMKSRKEYFLLEEYGPGFWVKWPYNYFNGYSLPERRTEVVTTVERERAKRETLKTWDELKFKELLHLWSEEPKGSCKLEKDKDLKLDMNPPDMKGESKINDYYSDPKEYIESKYYDALFSIHTPLAYFVKSNLVRLKNTCRTKYGSDSYKIAYQAMLQKFLLSIVQFKDRHDNRLLLEPFSSPIADEKRKNCLTKFVIQDENKNSSTIADLCVVLKSREIKLQILLLLEIIGLNDLDWNFRDFEKKYKLKLKKRSLNLTKKGLVRRRSKKKTSEKDKGIERITTSLDYCEQLDLYLDRACILDILLSSETPNPDAIEASNGTIQEHKKNILDKSKEASLVGFINYVLIPYFNKKVPHAVEFIIQKLKGPSMRPKRALKKVNDSTNVSSPNTVETYNRLSTSQRASRSSIINSVPSSPALRRVDANLFSRKSIASPTPELLNSRTNSNLNEFLESETRSLKRPSQLGRTKSDLTMNHLQKRQFSVSDLSTTRVPNSSTITLKTPFSHSTINAYKTMNNSFRRVGKRKDINETIRLHERVDSEENVQVQATPAVKKRTVTPNKKAQLQSIIESPLNFKDDDTHEGRKNTSNITSTPTNKPPENSSKRRVRRRLFAPEST", "length": 668, "header": "sp|P53135-1|SLD3_YEAST Isoform 1 of DNA replication regulator SLD3 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SLD3 PE=1 SV=1 CANONICAL=P53135-1" }, "locus": { "chromosome": "VII", "start_pos": 297935, "end_pos": 295932, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YGL113W_mRNA", "url": "https://www.ensembl.org/id/YGL113W_mRNA" }, { "database": "Ensembl Peptide", "id": "YGL113W", "url": "https://www.ensembl.org/id/YGL113W" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 556, "start_aa": "Ser", "end_pos": 556, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser556", "evidence": [ { "id": "P53135", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P53135" }, { "id": "33229814", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33229814" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 558, "start_aa": "Ser", "end_pos": 558, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser558", "evidence": [ { "id": "P53135", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P53135" }, { "id": "33229814", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33229814" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P53135", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P53135" }, { "id": "33229814", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33229814" } ] } ], "phosphorylation": [ { "start_pos": 153, "end_pos": 153, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20865002", "url": "https://glygen.org/publication/PubMed/20865002" } ], "site_lbl": "Tyr153" }, { "start_pos": 154, "end_pos": 154, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20865002", "url": "https://glygen.org/publication/PubMed/20865002" } ], "site_lbl": "Tyr154" }, { "start_pos": 306, "end_pos": 306, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser306" }, { "start_pos": 310, "end_pos": 310, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Thr310" }, { "start_pos": 370, "end_pos": 370, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20865002", "url": "https://glygen.org/publication/PubMed/20865002" } ], "site_lbl": "Ser370" }, { "start_pos": 373, "end_pos": 373, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20865002", "url": "https://glygen.org/publication/PubMed/20865002" } ], "site_lbl": "Thr373" }, { "start_pos": 421, "end_pos": 421, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser421" }, { "start_pos": 434, "end_pos": 434, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser434" }, { "start_pos": 435, "end_pos": 435, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Thr435" }, { "start_pos": 438, "end_pos": 438, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser438" }, { "start_pos": 439, "end_pos": 439, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P53135", "url": "https://www.yeastgenome.org/locus/P53135" }, { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser439" }, { "start_pos": 442, "end_pos": 442, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Thr442" }, { "start_pos": 445, "end_pos": 445, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Thr445" }, { "start_pos": 450, "end_pos": 450, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser450" }, { "start_pos": 451, "end_pos": 451, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" }, { "database": "PubMed", "id": "20865002", "url": "https://glygen.org/publication/PubMed/20865002" } ], "site_lbl": "Thr451" }, { "start_pos": 452, "end_pos": 452, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser452" }, { "start_pos": 456, "end_pos": 456, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" }, { "database": "PubMed", "id": "20865002", "url": "https://glygen.org/publication/PubMed/20865002" } ], "site_lbl": "Ser456" }, { "start_pos": 458, "end_pos": 458, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser458" }, { "start_pos": 459, "end_pos": 459, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser459" }, { "start_pos": 463, "end_pos": 463, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "20865002", "url": "https://glygen.org/publication/PubMed/20865002" }, { "database": "SGD", "id": "P53135", "url": "https://www.yeastgenome.org/locus/P53135" } ], "site_lbl": "Ser463" }, { "start_pos": 466, "end_pos": 466, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20865002", "url": "https://glygen.org/publication/PubMed/20865002" } ], "site_lbl": "Ser466" }, { "start_pos": 467, "end_pos": 467, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "P53135", "url": "https://www.yeastgenome.org/locus/P53135" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser467" }, { "start_pos": 479, "end_pos": 479, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser479" }, { "start_pos": 482, "end_pos": 482, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20835227", "url": "https://glygen.org/publication/PubMed/20835227" } ], "site_lbl": "Ser482" }, { "start_pos": 493, "end_pos": 493, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P53135", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P53135" }, { "database": "PubMed", "id": "20865002", "url": 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