{ "uniprot_canonical_ac": "P51656-1", "uniprot_ac": "P51656", "uniprot_id": "DHB1_MOUSE", "mass": { "chemical_mass": 36785.0, "monoisotopic_mass": 36785.0 }, "refseq": { "ac": "NP_034605", "name": "17-beta-hydroxysteroid dehydrogenase type 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605" }, "gene_names": [ { "name": "Hsd17b1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P51656", "id": "P51656" }, { "name": "17beta-HSD; 17HSDB1; E2DH; Hsd17ba", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605", "id": "NP_034605" }, { "name": "Edh17b1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P51656", "id": "P51656" }, { "name": "Hsd17b1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605", "id": "NP_034605" } ], "protein_names": [ { "name": "17-beta-hydroxysteroid dehydrogenase type 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P51656" }, { "name": "1.1.1.51", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P51656" }, { "name": "1.1.1.62", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P51656" }, { "name": "17-beta-HSD 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P51656" }, { "name": "17-beta-hydroxysteroid dehydrogenase type 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605", "id": "NP_034605" }, { "name": "Estradiol 17-beta-dehydrogenase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P51656" }, { "name": "estradiol 17-beta-dehydrogenase 1; 17-beta-HSD 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605", "id": "NP_034605" } ], "function": [ { "annotation": "Based on the data we propose that the Hsd17b1 gene includes a regulatory element controlling Naglu expression and the metabolic phenotype in mice lacking the Hsd17b1 genomic region is caused by the reduced expression of Naglu rather than the lack of Hsd17b1. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_034605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605" }, { "database": "PubMed", "id": "29180785", "url": "https://glygen.org/publication/PubMed/29180785" } ] }, { "annotation": "Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:9658408). Also has 20-alpha-HSD activity. Uses preferentially NADH (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656#function" }, { "database": "PubMed", "id": "9658408", "url": "https://glygen.org/publication/PubMed/9658408" }, { "database": "UniProtKB", "id": "P14061", "url": "https://www.uniprot.org/uniprot/P14061#function" } ] }, { "annotation": "Mammary-restricted HSD17B1 expression induced lesions at the sites of ducts and alveoli, accompanied by peri- and intraductal inflammation and disruption of the myoepithelial cell layer.", "evidence": [ { "database": "RefSeq", "id": "NP_034605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605" }, { "database": "PubMed", "id": "29371331", "url": "https://glygen.org/publication/PubMed/29371331" } ] }, { "annotation": "These results revealed a novel role for HSD17B1 in the control of spermatogenesis and male fertility, and that Sertoli cells significantly contribute to steroid synthesis in the testis.", "evidence": [ { "database": "RefSeq", "id": "NP_034605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605" }, { "database": "PubMed", "id": "29401623", "url": "https://glygen.org/publication/PubMed/29401623" } ] } ], "disease": [ { "disease_id": "DOID:3008", "recommended_name": { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "invasive ductal carcinoma", "description": "A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated." }, "synonyms": [ { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "Infiltrating ductal carcinoma of breast", "description": "" }, { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "Invasive ductal carcinoma, NST", "description": "" }, { "id": "DOID:3008", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3008", "name": "ductal adenocarcinoma", "description": "" } ], "evidence": [ { "id": "3008", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3008" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Hsd17b1", "url": "https://www.uniprot.org/uniprot/P51656", "locus": { "chromosome": "11", "start_pos": 100971353, "end_pos": 100969237, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000019301", "url": "https://www.ensembl.org/id/ENSMUSG00000019301" } ] } } ], "crossref": [ { "id": "ENSMUSG00000019301", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000019301", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "CHEMBL1914269", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL1914269", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "15485", "url": "https://www.ncbi.nlm.nih.gov/gene/15485", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:15485", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:15485", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "105077", "url": "http://www.informatics.jax.org/marker/MGI:105077", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "FFGWHQL", "url": "https://omabrowser.org/oma/group/FFGWHQL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2898074at2759", "url": "http://www.orthodb.org/?query=2898074at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43391", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43391", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43391:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43391:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "http://pfam.xfam.org/family/PF00106", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P51656", "url": "http://purl.obolibrary.org/obo/PR_P51656", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193144", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_034605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "14981", "url": "https://www.rhea-db.org/rhea/14981", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "24612", "url": "https://www.rhea-db.org/rhea/24612", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "24616", "url": "https://www.rhea-db.org/rhea/24616", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P51656-1", "url": "https://www.uniprot.org/uniprot/P51656-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPTVVLITGCSSGIGMHLAVRLASDRSQSFKVYATLRDLKAQGPLLEAARTQGCPPGSLEILELDVRDSKSVAAAQACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFYEKLVGGPGGALERADAQTRHLFAHYLRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVAAMHQEAFSNLQTQENAKAGAQVPGVSDTASSALICLPECAIPRVASELGWSASDKPGQDNSCYQQKI", "length": 344, "header": "sp|P51656-1|DHB1_MOUSE Isoform 1 of 17-beta-hydroxysteroid dehydrogenase type 1 OS=Mus musculus OX=10090 GN=Hsd17b1 PE=1 SV=1 CANONICAL=P51656-1" }, "isoforms": [ { "isoform_ac": "P51656-1", "url": "", "sequence": { "sequence": "MDPTVVLITGCSSGIGMHLAVRLASDRSQSFKVYATLRDLKAQGPLLEAARTQGCPPGSLEILELDVRDSKSVAAAQACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFYEKLVGGPGGALERADAQTRHLFAHYLRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVAAMHQEAFSNLQTQENAKAGAQVPGVSDTASSALICLPECAIPRVASELGWSASDKPGQDNSCYQQKI", "length": 344, "header": "sp|P51656-1|DHB1_MOUSE Isoform 1 of 17-beta-hydroxysteroid dehydrogenase type 1 OS=Mus musculus OX=10090 GN=Hsd17b1 PE=1 SV=1 CANONICAL=P51656-1" }, "locus": { "chromosome": "11", "start_pos": 100971077, "end_pos": 100969268, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000019445", "url": "https://www.ensembl.org/id/ENSMUST00000019445" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000019445", "url": "https://www.ensembl.org/id/ENSMUSP00000019445" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 135, "end_pos": 135, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "site_lbl": "Ser135" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease.", "journal": "Scientific reports", "date": "2017", "authors": "Jokela H, Hakkarainen J, Katkanaho L, Pakarinen P, Ruohonen ST, Tena-Sempere M, Zhang FP, Poutanen M", "evidence": [ { "database": "RefSeq", "id": "NP_034605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605" } ], "reference": [ { "type": "PubMed", "id": "29180785", "url": "https://glygen.org/publication/PubMed/29180785" } ] }, { "title": "HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium.", "journal": "Endocrine-related cancer", "date": "2018", "authors": "Jarvensivu P, Heinosalo T, Hakkarainen J, Kronqvist P, Saarinen N, Poutanen M", "evidence": [ { "database": "RefSeq", "id": "NP_034605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605" } ], "reference": [ { "type": "PubMed", "id": "29371331", "url": "https://glygen.org/publication/PubMed/29371331" } ] }, { "title": "Hydroxysteroid (17beta) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2018", "authors": "Hakkarainen J, Zhang FP, Jokela H, Mayerhofer A, Behr R, Cisneros-Montalvo S, Nurmio M, Toppari J, Ohlsson C, Kotaja N, Sipila P, Poutanen M", "evidence": [ { "database": "RefSeq", "id": "NP_034605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034605" } ], "reference": [ { "type": "PubMed", "id": "29401623", "url": "https://glygen.org/publication/PubMed/29401623" } ] }, { "title": "Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity.", "journal": "Eur. J. Biochem.", "date": "1996", "authors": "Nokelainen P, Puranen T, Peltoketo H, Orava M, Vihko P, Vihko R", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "reference": [ { "type": "PubMed", "id": "8612620", "url": "https://glygen.org/publication/PubMed/8612620" } ] }, { "title": "Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat.", "journal": "Mol. Endocrinol.", "date": "1998", "authors": "Nokelainen P, Peltoketo H, Vihko R, Vihko P", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "reference": [ { "type": "PubMed", "id": "9658408", "url": "https://glygen.org/publication/PubMed/9658408" } ] } ], "pathway": [ { "id": "mmu:15485", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:15485", "resource": "KEGG Pathway" }, { "id": "R-MMU-193144", "name": "Estrogen biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193144", "resource": "Reactome", "description": "Estrogen biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "P14061-1", "protein_name": "17-beta-hydroxysteroid dehydrogenase type 1", "gene_name": "HSD17B1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ", "length": 328 }, "evidence": [ { "id": "45226367", "url": "http://www.informatics.jax.org/homology/45226367", "database": "MGI" }, { "id": "P51656", "url": "https://omabrowser.org/oma/group/P51656/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P51657-1", "protein_name": "Estradiol 17-beta-dehydrogenase 1", "gene_name": "Hsd17b1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSTVVLITGCSSGIGLHLAVRLASDRSQSFKVYATLRDLKSQGPLLEAARAQGCPPGSLEILELDVRDSESVAAARACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFHEKLEGGPGGALERADAQTRHLFAHYQRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVEAMHREAFSDLQVQEGAKAGAQVSGDPDTPPRALICLPECAIPRVTAELGWSASDKPGQNKSCYQQKI", "length": 344 }, "evidence": [ { "id": "45226367", "url": "http://www.informatics.jax.org/homology/45226367", "database": "MGI" }, { "id": "P51656", "url": "https://omabrowser.org/oma/group/P51656/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "17-beta-hydroxysteroid dehydrogenase (NADP+) activity", "id": "GO:0072582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072582", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "steroid binding", "id": "GO:0005496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005496", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "estradiol 17-beta-dehydrogenase [NAD(P)] activity", "id": "GO:0004303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004303", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "small molecule binding", "id": "GO:0036094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036094", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "dihydrotestosterone 17-beta-dehydrogenase activity", "id": "GO:0035410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035410", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "testosterone dehydrogenase (NAD+) activity", "id": "GO:0047035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047035", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "testosterone 17-beta-dehydrogenase (NADP+) activity", "id": "GO:0047045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047045", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "NADP binding", "id": "GO:0050661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050661", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "NADP+ binding", "id": "GO:0070401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070401", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "estradiol binding", "id": "GO:1903924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903924", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "testosterone dehydrogenase [NAD(P)] activity", "id": "GO:0030283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030283", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "adipose tissue development", "id": "GO:0060612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060612", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "estrogen biosynthetic process", "id": "GO:0006703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006703", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "testosterone biosynthetic process", "id": "GO:0061370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061370", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "skeletal muscle tissue development", "id": "GO:0007519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" }, { "name": "cellular response to metal ion", "id": "GO:0071248", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071248", "evidence": [ { "database": "UniProtKB", "id": "P51656", "url": "https://www.uniprot.org/uniprot/P51656" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14981", "name": "", "equation": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54939-1", "C9JRZ8-1", "P42330-1", "P37058-1", "P17516-1", "Q04828-1", "P14061-1", "Q96LJ7-1", "P70385-1", "P51656-1", "Q99L04-1" ], "evidence": [ { "id": "14981", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14981" } ] }, { "id": "24612", "name": "", "equation": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5M875-1", "Q62730-1", "Q6MGB5-1", "Q6P7R8-1", "Q6AYS8-1", "O54753-1", "P51657-1", "O70351-1", "Q8NBQ5-1", "Q6UWP2-1", "P14061-1", "Q53GQ0-1", "Q92506-1", "P37059-1", "O14756-1", "P52895-1", "P17516-1", "Q04828-1", "P42330-1", "Q7Z5P4-1", "Q5T2L2-1", "Q9BPX1-1", "Q99714-1", "P50171-1", "P51656-1", "P51658-1", "O70503-1", "Q3U0B3-1", "Q9EQ06-1", "Q9R092-1", "O08756-1", "Q8VCR2-1", "O18404-1" ], "evidence": [ { "id": "24612", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24612" } ] }, { "id": "24616", "name": "", "equation": "17beta-estradiol + NADP(+) = estrone + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7R8-1", "Q62904-1", "Q6AYS8-1", "O54753-1", "P51657-1", "O54939-1", "C9JRZ8-1", "Q8NBQ5-1", "Q6UWP2-1", "P14061-1", "Q53GQ0-1", "P56937-1", "O14756-1", "P52895-1", "P17516-1", "Q04828-1", "P42330-1", "Q5T2L2-1", "P37058-1", "P51656-1", "O70503-1", "O88736-1", "Q3U0B3-1", "Q9EQ06-1", "Q9R092-1", "P70385-1" ], "evidence": [ { "id": "24616", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24616" } ] }, { "id": "R-MMU-804969", "name": "HSD17B1 hydrogenates E1 to EST17b", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51656-1" ], "evidence": [ { "id": "R-MMU-804969", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-804969" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "C9JRZ8", "gene_name": "AKR1B15", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.216", "activity": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] } ] }, { "uniprot_ac": "O08756", "gene_name": "Hsd17b10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] } ] }, { "uniprot_ac": "O14756", "gene_name": "HSD17B6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] } ] }, { "uniprot_ac": "O18404", "gene_name": "scu", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.201", "activity": "a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.36", "activity": "a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] } ] }, { "uniprot_ac": "O54753", "gene_name": "Hsd17b6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] } ] }, { "uniprot_ac": "O54939", "gene_name": "Hsd17b3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] } ] }, { "uniprot_ac": "O70351", "gene_name": "Hsd17b10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] } ] }, { "uniprot_ac": "O70503", "gene_name": "Hsd17b12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] } ] }, { "uniprot_ac": "O88736", "gene_name": "Hsd17b7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.270", "activity": "", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] } ] }, { "uniprot_ac": "P14061", "gene_name": "HSD17B1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] } ] }, { "uniprot_ac": "P17516", "gene_name": "AKR1C4", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.225", "activity": "chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] } ] }, { "uniprot_ac": "P37058", "gene_name": "HSD17B3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] } ] }, { "uniprot_ac": "P37059", "gene_name": "HSD17B2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P37059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37059" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P37059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37059" } ] } ] }, { "uniprot_ac": "P42330", "gene_name": "AKR1C3", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.188", "activity": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] } ] }, { "uniprot_ac": "P50171", "gene_name": "Hsd17b8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] } ] }, { "uniprot_ac": "P51656", "gene_name": "Hsd17b1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] } ] }, { "uniprot_ac": "P51657", "gene_name": "Hsd17b1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51657" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P51657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51657" } ] } ] }, { "uniprot_ac": "P51658", "gene_name": "Hsd17b2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] } ] }, { "uniprot_ac": "P52895", "gene_name": "AKR1C2", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.112", "activity": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.3.1.20", "activity": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.3.1.20", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.112", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] } ] }, { "uniprot_ac": "P56937", "gene_name": "HSD17B7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] } ] }, { "uniprot_ac": "P70385", "gene_name": "Hsd17b3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] } ] }, { "uniprot_ac": "Q04828", "gene_name": "AKR1C1", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.112", "activity": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.149", "activity": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.3.1.20", "activity": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.112", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.357", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.3.1.20", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] } ] }, { "uniprot_ac": "Q3U0B3", "gene_name": "Dhrs11", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q3U0B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0B3" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q3U0B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0B3" } ] } ] }, { "uniprot_ac": "Q53GQ0", "gene_name": "HSD17B12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] } ] }, { "uniprot_ac": "Q5M875", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] } ] }, { "uniprot_ac": "Q5T2L2", "gene_name": "AKR1C8", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5T2L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T2L2" } ] } ] }, { "uniprot_ac": "Q62730", "gene_name": "Hsd17b2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] } ] }, { "uniprot_ac": "Q62904", "gene_name": "Hsd17b7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.270", "activity": "", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] } ] }, { "uniprot_ac": "Q6AYS8", "gene_name": "Hsd17b11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6AYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS8" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q6AYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS8" } ] } ] }, { "uniprot_ac": "Q6MGB5", "gene_name": "Hsd17b8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] } ] }, { "uniprot_ac": "Q6P7R8", "gene_name": "Hsd17b12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] } ] }, { "uniprot_ac": "Q6UWP2", "gene_name": "DHRS11", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q6UWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6UWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ] } ] }, { "uniprot_ac": "Q7Z5P4", "gene_name": "HSD17B13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] } ] }, { "uniprot_ac": "Q8NBQ5", "gene_name": "HSD17B11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8NBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBQ5" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8NBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBQ5" } ] } ] }, { "uniprot_ac": "Q8VCR2", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] } ] }, { "uniprot_ac": "Q92506", "gene_name": "HSD17B8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] } ] }, { "uniprot_ac": "Q96LJ7", "gene_name": "DHRS1", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q96LJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LJ7" } ] } ] }, { "uniprot_ac": "Q99714", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] } ] }, { "uniprot_ac": "Q99L04", "gene_name": "Dhrs1", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q99L04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99L04" } ] } ] }, { "uniprot_ac": "Q9BPX1", "gene_name": "HSD17B14", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q9BPX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BPX1" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q9BPX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BPX1" } ] } ] }, { "uniprot_ac": "Q9EQ06", "gene_name": "Hsd17b11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q9EQ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQ06" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q9EQ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQ06" } ] } ] }, { "uniprot_ac": "Q9R092", "gene_name": "Hsd17b6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { 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