{ "uniprot_canonical_ac": "P51583-1", "uniprot_ac": "P51583", "uniprot_id": "PUR6_RAT", "mass": { "chemical_mass": 47096.0, "monoisotopic_mass": 47096.0 }, "refseq": { "ac": "XP_006250914", "name": "bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250914" }, "gene_names": [ { "name": "Paics", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P51583", "id": "P51583" }, { "name": "Ade2h1; Airc", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250914", "id": "XP_006250914" }, { "name": "Ade2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P51583", "id": "P51583" }, { "name": "Airc", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P51583", "id": "P51583" }, { "name": "Paics", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250914", "id": "XP_006250914" } ], "protein_names": [ { "name": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P51583" }, { "name": "AIR carboxylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P51583" }, { "name": "AIRC", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P51583" }, { "name": "PAICS", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P51583" }, { "name": "SAICAR synthetase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P51583" }, { "name": "bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250914", "id": "XP_006250914" } ], "function": [ { "annotation": "Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583#function" }, { "database": "UniProtKB", "id": "P22234", "url": "https://www.uniprot.org/uniprot/P22234#function" } ] } ], "disease": [ { "disease_id": "DOID:5419", "recommended_name": { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness." }, "synonyms": [ { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality." }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia 12", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia (disease)", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "SCZD", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizoaffective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia with or without an affective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia, susceptibility to", "description": "" }, { "id": "MIM:181500", "resource": "MIM", "url": "https://www.omim.org/entry/181500", "name": "Schizophrenia", "description": "Schizophrenia" } ], "evidence": [ { "id": "5419", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "common_name": "Rat" } ], "gene": [ { "name": "Paics", "url": "https://www.uniprot.org/uniprot/P51583", "locus": { "chromosome": "14", "start_pos": 31173541, "end_pos": 31232635, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000002101", "url": "https://www.ensembl.org/id/ENSRNOG00000002101" } ] } } ], "crossref": [ { "id": "ENSRNOG00000002101", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002101", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSRNOG00000046308", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000046308", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01416", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01416", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "140946", "url": "https://www.ncbi.nlm.nih.gov/gene/140946", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P51583", "url": "https://www.ebi.ac.uk/intact/interactors/id:P51583*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:140946", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:140946", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FQEMARC", "url": "https://omabrowser.org/oma/group/FQEMARC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2898120at2759", "url": "http://www.orthodb.org/?query=2898120at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43599:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43599:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00731", "url": "http://pfam.xfam.org/family/PF00731", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01259", "url": "http://pfam.xfam.org/family/PF01259", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13837", "url": "http://pfam.xfam.org/family/PF13837", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P51583", "url": "http://purl.obolibrary.org/obo/PR_P51583", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-73817", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73817", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_006250914", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250914", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "620066", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620066", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "10792", "url": "https://www.rhea-db.org/rhea/10792", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "22628", "url": "https://www.rhea-db.org/rhea/22628", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I6A960", "url": "https://www.uniprot.org/uniprot/A0A8I6A960", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A960-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A960-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WFR8", "url": "https://www.uniprot.org/uniprot/F8WFR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WFR8-1", "url": "https://www.uniprot.org/uniprot/F8WFR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P51583-1", "url": "https://www.uniprot.org/uniprot/P51583-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL", "length": 425, "header": "sp|P51583-1|PUR6_RAT Isoform 1 of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Rattus norvegicus OX=10116 GN=Paics PE=1 SV=3 CANONICAL=P51583-1" }, "isoforms": [ { "isoform_ac": "A0A8I6A960-1", "url": "", "sequence": { "sequence": "MESGPGKHWTEEEVKALLSVWAERNIRKQLYGTLRNREIFIYVAKRLRSLGVYRDWKQCRAKYKNLKYEYRTVKHAHRSGDSSRTMKFFHVLDAILQSEPTARLTEESDGNIKCLVTLSSSSAPEITEGNRIPLEGAESHTHTVTSNDPGAGRHQPENEVTALVQIWHGERVRQTPEETTRNKGTSEETAQRPIQFGIDRDWKQCHDATHKTPNREQRVLQKTNDSPWRKRRFHDETDCILKSRTPGITKRKHESPEGHFGSLGTGSNKRKAQEGETMSTPLKKMSPEIITNWFPQSLIDLEGSTGCFFHQDPHLHQIAASFSRAVCSSSSPRIMATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL", "length": 759, "header": "tr|A0A8I6A960-1|A0A8I6A960_RAT Computationally mapped isoform of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Rattus norvegicus OX=10116 GN=Paics PE=1 SV=1 CANONICAL=P51583-1" }, "locus": { "chromosome": "14", "start_pos": 31232560, "end_pos": 31199682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096789.1", "url": "https://www.ensembl.org/id/ENSRNOT00000096789.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000089961.1", "url": "https://www.ensembl.org/id/ENSRNOP00000089961.1" } ] } }, { "isoform_ac": "F8WFR8-1", "url": "", "sequence": { "sequence": "MESGPGKHWTEEEVKALLSVWAERNIRKQLYGTLRNREIFIYVAKRLRSLGVYRDWKQCRAKYKNLKYEYRTVKHAHRSGDSSRTMKFFHVLDAILQSEPTARLTEESDGNIKCLVTLSSSSAPEITEGNRIPLEGAESHTHTVTSNDPGAGRHQPENEVTALVQIWHGERVRQTPEETTRNKGTSEETAQRPIQFGIDRDWKQCHDATHKTPNREQRVLQKTNDSPWRKRRFHDETDCILKSRTPGITKRKHETMSTPLKKMSPEIITNWFPQSLIDLEGSTGCFFHQDPHLHQIAASFSRAVCSSSSPRIMATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL", "length": 737, "header": "tr|F8WFR8-1|F8WFR8_RAT Computationally mapped isoform of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Rattus norvegicus OX=10116 GN=Paics PE=1 SV=3 CANONICAL=P51583-1" }, "locus": { "chromosome": "14", "start_pos": 31232560, "end_pos": 31199682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000002890.7", "url": "https://www.ensembl.org/id/ENSRNOT00000002890.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000002890.7", "url": "https://www.ensembl.org/id/ENSRNOP00000002890.7" } ] } }, { "isoform_ac": "P51583-1", "url": "", "sequence": { "sequence": "MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFGLNNHLVWAKLRASKLNTWISLKQADKKIRECNL", "length": 425, "header": "sp|P51583-1|PUR6_RAT Isoform 1 of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Rattus norvegicus OX=10116 GN=Paics PE=1 SV=3 CANONICAL=P51583-1" }, "locus": { "chromosome": "14", "start_pos": 31215565, "end_pos": 31199682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000063942", "url": "https://www.ensembl.org/id/ENSRNOT00000063942" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000061495", "url": "https://www.ensembl.org/id/ENSRNOP00000061495" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "site_lbl": "Ser107" }, { "start_pos": 22, "end_pos": 22, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "site_lbl": "Tyr22" }, { "start_pos": 238, "end_pos": 238, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "site_lbl": "Thr238" }, { "start_pos": 274, "end_pos": 274, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "site_lbl": "Ser274" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "P51583", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P51583" } ], "site_lbl": "Ser27" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" }, { "database": "iPTMnet", "id": "P51583", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P51583" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes.", "journal": "Biochim. Biophys. Acta", "date": "1995", "authors": "Iwahana H, Honda S, Tsujisawa T, Takahashi Y, Adzuma K, Katashima R, Yamaoka T, Moritani M, Yoshimoto K, Itakura M", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "reference": [ { "type": "PubMed", "id": "7742366", "url": "https://glygen.org/publication/PubMed/7742366" } ] } ], "pathway": [ { "id": "rno:140946", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:140946", "resource": "KEGG Pathway" }, { "id": "R-RNO-73817", "name": "Purine ribonucleoside monophosphate biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-73817", "resource": "Reactome", "description": "Purine ribonucleoside monophosphate biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "P22234-1", "protein_name": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase", "gene_name": "PAICS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL", "length": 425 }, "evidence": [ { "id": "45231875", "url": "http://www.informatics.jax.org/homology/45231875", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DCL9-1", "protein_name": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase", "gene_name": "Paics", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATAVVVNIGKKLYEGKTKEVYELLDTPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVQEGYKFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQDCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSDSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVSVAGRSNGLGPVLSGNTAYPVISCPPITPDWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFGLNNHLVWAKLRASILNTWISLKQADKKVRQCNL", "length": 425 }, "evidence": [ { "id": "45231875", "url": "http://www.informatics.jax.org/homology/45231875", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity", "id": "GO:0004639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004639", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "phosphoribosylaminoimidazole carboxylase activity", "id": "GO:0004638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004638", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "5-amino-4-imidazole carboxylate lyase activity", "id": "GO:0043727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043727", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "carboxy-lyase activity", "id": "GO:0016831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016831", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "GMP biosynthetic process", "id": "GO:0006177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006177", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "purine nucleobase biosynthetic process", "id": "GO:0009113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009113", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "'de novo' IMP biosynthetic process", "id": "GO:0006189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006189", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "'de novo' AMP biosynthetic process", "id": "GO:0044208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044208", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" }, { "name": "'de novo' XMP biosynthetic process", "id": "GO:0097294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097294", "evidence": [ { "database": "UniProtKB", "id": "P51583", "url": "https://www.uniprot.org/uniprot/P51583" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10792", "name": "", "equation": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51583-1", "P22234-1", "Q9DCL9-1", "P21264-1", "Q54QE4-1", "Q9I7S8-1" ], "evidence": [ { "id": "10792", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10792" } ] }, { "id": "22628", "name": "", "equation": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51583-1", "P22234-1", "Q9DCL9-1", "P27616-1", "Q54QE4-1", "Q9I7S8-1" ], "evidence": [ { "id": "22628", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22628" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P21264", "gene_name": "ADE2", "activity": [ { "ec_number": "4.1.1.21", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2.", "evidence": [ { "id": "P21264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21264" } ] }, { "ec_number": "4.1.1.21", "activity": "", "evidence": [ { "id": "P21264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21264" } ] } ] }, { "uniprot_ac": "P22234", "gene_name": "PAICS", "activity": [ { "ec_number": "4.1.1.21", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2.", "evidence": [ { "id": "P22234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22234" } ] }, { "ec_number": "6.3.2.6", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.", "evidence": [ { "id": "P22234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22234" } ] } ] }, { "uniprot_ac": "P27616", "gene_name": "ADE1", "activity": [ { "ec_number": "6.3.2.6", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.", "evidence": [ { "id": "P27616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27616" } ] }, { "ec_number": "6.3.2.6", "activity": "", "evidence": [ { "id": "P27616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27616" } ] } ] }, { "uniprot_ac": "P51583", "gene_name": "Paics", "activity": [ { "ec_number": "4.1.1.21", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2.", "evidence": [ { "id": "P51583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51583" } ] }, { "ec_number": "6.3.2.6", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.", "evidence": [ { "id": "P51583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51583" } ] } ] }, { "uniprot_ac": "Q54QE4", "gene_name": "E", "activity": [ { "ec_number": "4.1.1.21", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2.", "evidence": [ { "id": "Q54QE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QE4" } ] }, { "ec_number": "6.3.2.6", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.", "evidence": [ { "id": "Q54QE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QE4" } ] } ] }, { "uniprot_ac": "Q9DCL9", "gene_name": "Paics", "activity": [ { "ec_number": "6.3.2.6", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.", "evidence": [ { "id": "Q9DCL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DCL9" } ] }, { "ec_number": "6.3.2.6", "activity": "", "evidence": [ { "id": "Q9DCL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DCL9" } ] }, { "ec_number": "4.1.1.21", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2.", "evidence": [ { "id": "Q9DCL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DCL9" } ] } ] }, { "uniprot_ac": "Q9I7S8", "gene_name": "Paics", "activity": [ { "ec_number": "6.3.2.6", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.", "evidence": [ { "id": "Q9I7S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7S8" } ] }, { "ec_number": "4.1.1.21", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2.", "evidence": [ { "id": "Q9I7S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7S8" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }