{
    "uniprot_canonical_ac": "P50543-1",
    "uniprot_ac": "P50543",
    "uniprot_id": "S10AB_MOUSE",
    "mass": {
        "chemical_mass": 11083.0,
        "monoisotopic_mass": 11083.0
    },
    "refseq": {
        "ac": "NP_058020",
        "name": "protein S100-A11",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020"
    },
    "gene_names": [
        {
            "name": "S100a11",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P50543",
            "id": "P50543"
        },
        {
            "name": "S100a11",
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            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020",
            "id": "NP_058020"
        },
        {
            "name": "S100c",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P50543",
            "id": "P50543"
        },
        {
            "name": "cal; Emap1; EMAPI; S100a14; S100c",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020",
            "id": "NP_058020"
        }
    ],
    "protein_names": [
        {
            "name": "Protein S100-A11",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P50543"
        },
        {
            "name": "Calgizzarin",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50543"
        },
        {
            "name": "EMAP",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50543"
        },
        {
            "name": "Endothelial monocyte-activating polypeptide",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50543"
        },
        {
            "name": "Protein S100-C",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50543"
        },
        {
            "name": "S100 calcium-binding protein A11",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50543"
        },
        {
            "name": "calizzarin; EMAP; protein S100-C; endothelial monocyte-activating polypeptide; endothelial monocyte activating polypeptide 1; calgizzarin; S100 calcium binding protein A14",
            "resource": "RefSeq",
            "type": "synonym",
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            "id": "NP_058020"
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        {
            "name": "protein S100-A11",
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            "id": "NP_058020"
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            "annotation": "Dicalcin suppresses in vitro trophoblast attachment in human cell lines.",
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                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020"
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                    "database": "PubMed",
                    "id": "34311201",
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                }
            ]
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        {
            "annotation": "Facilitates the differentiation and the cornification of keratinocytes.",
            "evidence": [
                {
                    "database": "UniProtKB",
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                    "url": "https://www.uniprot.org/uniprot/P50543#function"
                }
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        {
            "annotation": "S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.",
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                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020"
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                    "database": "PubMed",
                    "id": "33075563",
                    "url": "https://glygen.org/publication/PubMed/33075563"
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                {
                    "database": "RefSeq",
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                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020"
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                {
                    "database": "PubMed",
                    "id": "30455460",
                    "url": "https://glygen.org/publication/PubMed/30455460"
                }
            ]
        }
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    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
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        {
            "name": "Mus musculus",
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    ],
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            "name": "S100a11",
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        {
            "id": "ENSMUSG00000027907",
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        },
        {
            "id": "cd05023",
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        },
        {
            "id": "20195",
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            "database": "IntAct",
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        {
            "id": "IPR001751",
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        },
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            "id": "IPR002048",
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            "id": "IPR011992",
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        {
            "id": "IPR013787",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013787",
            "database": "InterPro",
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            ]
        },
        {
            "id": "IPR018247",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "IPR028482",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:20195",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20195",
            "database": "KEGG Pathway",
            "categories": [
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            ]
        },
        {
            "id": "1338798",
            "url": "http://www.informatics.jax.org/marker/MGI:1338798",
            "database": "MGI",
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            ]
        },
        {
            "id": "MACEKCY",
            "url": "https://omabrowser.org/oma/group/MACEKCY/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5310603at2759",
            "url": "http://www.orthodb.org/?query=5310603at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11639",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11639:SF60",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF60",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00036",
            "url": "http://pfam.xfam.org/family/PF00036",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01023",
            "url": "http://pfam.xfam.org/family/PF01023",
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            ]
        },
        {
            "id": "PR_P50543",
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            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-6798695",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_058020",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020",
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            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P50543",
            "url": "https://www.uniprot.org/uniprot/P50543",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P50543-1",
            "url": "https://www.uniprot.org/uniprot/P50543-1",
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            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MPTETERCIESLIAVFQKYSGKDGNNTQLSKTEFLSFMNTELAAFTKNQKDPGVLDRMMKKLDLNCDGQLDFQEFLNLIGGLAIACHDSFIQTSQKRI",
        "length": 98,
        "header": "sp|P50543-1|S10AB_MOUSE Isoform 1 of Protein S100-A11  OS=Mus musculus OX=10090 GN=S100a11 PE=1 SV=1 CANONICAL=P50543-1"
    },
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        {
            "isoform_ac": "P50543-1",
            "url": "",
            "sequence": {
                "sequence": "MPTETERCIESLIAVFQKYSGKDGNNTQLSKTEFLSFMNTELAAFTKNQKDPGVLDRMMKKLDLNCDGQLDFQEFLNLIGGLAIACHDSFIQTSQKRI",
                "length": 98,
                "header": "sp|P50543-1|S10AB_MOUSE Isoform 1 of Protein S100-A11  OS=Mus musculus OX=10090 GN=S100a11 PE=1 SV=1 CANONICAL=P50543-1"
            },
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                "end_pos": 93431366,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000029515",
                        "url": "https://www.ensembl.org/id/ENSMUST00000029515"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000029515",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000029515"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 5,
            "end_pos": 5,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50543",
                    "url": "https://www.uniprot.org/uniprot/P50543"
                },
                {
                    "database": "PRO",
                    "id": "P50543",
                    "url": "http://purl.obolibrary.org/obo/P50543"
                },
                {
                    "database": "iPTMnet",
                    "id": "P50543",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P50543"
                }
            ],
            "site_lbl": "Thr5"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.",
            "journal": "Mol. Cell",
            "date": "2013",
            "authors": "Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50543",
                    "url": "https://www.uniprot.org/uniprot/P50543"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23806337",
                    "url": "https://glygen.org/publication/PubMed/23806337"
                }
            ]
        },
        {
            "title": "Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii.",
            "journal": "Nature immunology",
            "date": "2019",
            "authors": "Safronova A, Araujo A, Camanzo ET, Moon TJ, Elliott MR, Beiting DP, Yarovinsky F",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_058020",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30455460",
                    "url": "https://glygen.org/publication/PubMed/30455460"
                }
            ]
        },
        {
            "title": "S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.",
            "journal": "Cellular and molecular gastroenterology and hepatology",
            "date": "2021",
            "authors": "Zhang L, Zhang Z, Li C, Zhu T, Gao J, Zhou H, Zheng Y, Chang Q, Wang M, Wu J, Ran L, Wu Y, Miao H, Zou X, Liang B",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_058020",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33075563",
                    "url": "https://glygen.org/publication/PubMed/33075563"
                }
            ]
        },
        {
            "title": "Dicalcin suppresses in vitro trophoblast attachment in human cell lines.",
            "journal": "Biochemical and biophysical research communications",
            "date": "2021",
            "authors": "Saito R, Satoh H, Aoba K, Hirasawa H, Miwa N",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_058020",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058020"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34311201",
                    "url": "https://glygen.org/publication/PubMed/34311201"
                }
            ]
        }
    ],
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        {
            "id": "mmu:20195",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20195",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-6798695",
            "name": "Neutrophil degranulation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695",
            "resource": "Reactome",
            "description": "Neutrophil degranulation"
        }
    ],
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        {
            "uniprot_canonical_ac": "P31949-1",
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                "length": 105
            },
            "evidence": [
                {
                    "id": "45229095",
                    "url": "http://www.informatics.jax.org/homology/45229095",
                    "database": "MGI"
                },
                {
                    "id": "P50543",
                    "url": "https://omabrowser.org/oma/group/P50543/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6B345-1",
            "protein_name": "Protein S100-A11",
            "gene_name": "S100a11",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MPTETERCIESLIAVFQKYSGKDGNSCHLSKTEFLSFMNTELAAFTKNQKDPGVLDRMMKKLDLNSDGQLDFQEFLNLIGGLAIACHESFLQTSQKRI",
                "length": 98
            },
            "evidence": [
                {
                    "id": "45229095",
                    "url": "http://www.informatics.jax.org/homology/45229095",
                    "database": "MGI"
                },
                {
                    "id": "P50543",
                    "url": "https://omabrowser.org/oma/group/P50543/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        }
    ],
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        "categories": [
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "extracellular space",
                        "id": "GO:0005615",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ruffle",
                        "id": "GO:0001726",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "collagen-containing extracellular matrix",
                        "id": "GO:0062023",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "regulation of cell population proliferation",
                        "id": "GO:0042127",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of smooth muscle cell migration",
                        "id": "GO:0014911",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014911",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "protein homodimerization activity",
                        "id": "GO:0042803",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium-dependent protein binding",
                        "id": "GO:0048306",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium ion binding",
                        "id": "GO:0005509",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "S100 protein binding",
                        "id": "GO:0044548",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044548",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P50543",
                                "url": "https://www.uniprot.org/uniprot/P50543"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 25,
            "end_pos": 27,
            "annotation": "n_glycosylation_sequon"
        }
    ],
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