{
    "uniprot_canonical_ac": "P50102-1",
    "uniprot_ac": "P50102",
    "uniprot_id": "UBP8_YEAST",
    "mass": {
        "chemical_mass": 53623.0,
        "monoisotopic_mass": 53623.0
    },
    "refseq": {
        "ac": "NP_013950",
        "name": "ubiquitin-specific protease UBP8",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013950"
    },
    "gene_names": [
        {
            "name": "UBP8",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P50102",
            "id": "P50102"
        },
        {
            "name": "UBP8",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013950",
            "id": "NP_013950"
        },
        {
            "name": "YM9959.05",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P50102",
            "id": "P50102"
        }
    ],
    "protein_names": [
        {
            "name": "Ubiquitin carboxyl-terminal hydrolase 8",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P50102"
        },
        {
            "name": "3.4.19.12",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50102"
        },
        {
            "name": "Deubiquitinating enzyme 8",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50102"
        },
        {
            "name": "Ubiquitin thioesterase 8",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50102"
        },
        {
            "name": "Ubiquitin-specific-processing protease 8",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P50102"
        },
        {
            "name": "ubiquitin-specific protease UBP8",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013950",
            "id": "NP_013950"
        }
    ],
    "function": [
        {
            "annotation": "Functions as histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. Together with SGF11, is required for histone H2B deubiquitination.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50102",
                    "url": "https://www.uniprot.org/uniprot/P50102#function"
                },
                {
                    "database": "PubMed",
                    "id": "15657441",
                    "url": "https://glygen.org/publication/PubMed/15657441"
                },
                {
                    "database": "PubMed",
                    "id": "14660634",
                    "url": "https://glygen.org/publication/PubMed/14660634"
                },
                {
                    "database": "PubMed",
                    "id": "10026213",
                    "url": "https://glygen.org/publication/PubMed/10026213"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0112036",
            "recommended_name": {
                "id": "DOID:0112036",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112036",
                "name": "non-syndromic X-linked intellectual disability 105",
                "description": "A non-syndromic X-linked intellectual disability characterized by borderline to moderate intellectual disability, variable poor or absent speech, and behavioral problems that has_material_basis_in hemizygous mutation in the USP27X gene on chromosome Xp11.23."
            },
            "synonyms": [
                {
                    "id": "DOID:0112036",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112036",
                    "name": "MRX105",
                    "description": ""
                },
                {
                    "id": "DOID:0112036",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112036",
                    "name": "X-linked mental retardation 105",
                    "description": ""
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "intellectual disability, X-linked 105",
                    "description": "Any non-syndromic X-linked intellectual disability in which the cause of the disease is a mutation in the USP27X gene."
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "MRX105",
                    "description": ""
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "USP27X non-syndromic X-linked intellectual disability",
                    "description": ""
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "intellectual developmental disorder, X-linked 105, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "intellectual disability, X-linked 105",
                    "description": ""
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "intellectual disability, X-linked type 105",
                    "description": ""
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "mental retardation, X-linked 105",
                    "description": ""
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "mental retardation, X-linked type 105",
                    "description": ""
                },
                {
                    "id": "MONDO:0010510",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010510",
                    "name": "non-syndromic X-linked intellectual disability caused by mutation in USP27X",
                    "description": ""
                },
                {
                    "id": "MIM:300984",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/300984",
                    "name": "Intellectual developmental disorder, X-linked 105",
                    "description": "Intellectual developmental disorder, X-linked 105"
                }
            ],
            "evidence": [
                {
                    "id": "0112036",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112036"
                }
            ]
        },
        {
            "disease_id": "DOID:3068",
            "recommended_name": {
                "id": "DOID:3068",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:3068",
                "name": "glioblastoma",
                "description": "A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes."
            },
            "synonyms": [
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "glioblastoma multiforme",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "GBM",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "adult glioblastoma multiforme",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "grade IV adult Astrocytic tumor",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "primary glioblastoma multiforme",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "spongioblastoma multiforme",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "3068",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:3068"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 146,
            "end_pos": 146,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "Lowers histone H2B deubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50102",
                    "url": "https://www.uniprot.org/uniprot/P50102"
                },
                {
                    "database": "PubMed",
                    "id": "15657441",
                    "url": "https://glygen.org/publication/PubMed/15657441"
                }
            ]
        },
        {
            "start_pos": 419,
            "end_pos": 419,
            "sequence_org": "H",
            "sequence_mut": "A",
            "comment": "Lowers histone H2B deubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50102",
                    "url": "https://www.uniprot.org/uniprot/P50102"
                },
                {
                    "database": "PubMed",
                    "id": "15657441",
                    "url": "https://glygen.org/publication/PubMed/15657441"
                }
            ]
        },
        {
            "start_pos": 46,
            "end_pos": 46,
            "sequence_org": "C",
            "sequence_mut": "A",
            "comment": "Lowers histone H2B deubiquitination activity; when associated with A-49.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50102",
                    "url": "https://www.uniprot.org/uniprot/P50102"
                },
                {
                    "database": "PubMed",
                    "id": "15657441",
                    "url": "https://glygen.org/publication/PubMed/15657441"
                }
            ]
        },
        {
            "start_pos": 49,
            "end_pos": 49,
            "sequence_org": "C",
            "sequence_mut": "A",
            "comment": "Lowers histone H2B deubiquitination activity; when associated with A-46.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50102",
                    "url": "https://www.uniprot.org/uniprot/P50102"
                },
                {
                    "database": "PubMed",
                    "id": "15657441",
                    "url": "https://glygen.org/publication/PubMed/15657441"
                }
            ]
        },
        {
            "start_pos": 77,
            "end_pos": 77,
            "sequence_org": "H",
            "sequence_mut": "A",
            "comment": "Lowers histone H2B deubiquitination activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50102",
                    "url": "https://www.uniprot.org/uniprot/P50102"
                },
                {
                    "database": "PubMed",
                    "id": "15657441",
                    "url": "https://glygen.org/publication/PubMed/15657441"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50102",
                    "url": "https://www.uniprot.org/uniprot/P50102"
                }
            ],
            "common_name": "Yeast"
        }
    ],
    "gene": [
        {
            "name": "UBP8",
            "url": "https://www.uniprot.org/uniprot/P50102",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "cd02660",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02660",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "855263",
            "url": "https://www.ncbi.nlm.nih.gov/gene/855263",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P50102",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P50102*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001394",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001394",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001607",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001607",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018200",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018200",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR028889",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028889",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR038765",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YMR223W",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YMR223W",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "NVSCNCI",
            "url": "https://omabrowser.org/oma/group/NVSCNCI/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "74526at2759",
            "url": "http://www.orthodb.org/?query=74526at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21646",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21646",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21646:SF33",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21646:SF33",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3M99",
            "url": "https://www.rcsb.org/structure/3M99",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "3MHH",
            "url": "https://www.rcsb.org/structure/3MHH",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "3MHS",
            "url": "https://www.rcsb.org/structure/3MHS",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "4FIP",
            "url": "https://www.rcsb.org/structure/4FIP",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "4FJC",
            "url": "https://www.rcsb.org/structure/4FJC",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "4FK5",
            "url": "https://www.rcsb.org/structure/4FK5",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "4WA6",
            "url": "https://www.rcsb.org/structure/4WA6",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "4ZUX",
            "url": "https://www.rcsb.org/structure/4ZUX",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6AQR",
            "url": "https://www.rcsb.org/structure/6AQR",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6T9L",
            "url": "https://www.rcsb.org/structure/6T9L",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF00443",
            "url": "http://pfam.xfam.org/family/PF00443",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02148",
            "url": "http://pfam.xfam.org/family/PF02148",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P50102",
            "url": "http://purl.obolibrary.org/obo/PR_P50102",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_013950",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013950",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000004836",
            "url": "https://www.yeastgenome.org/locus/S000004836",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P50102",
            "url": "https://www.uniprot.org/uniprot/P50102",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P50102-1",
            "url": "https://www.uniprot.org/uniprot/P50102-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMCLQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDDVCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN",
        "length": 471,
        "header": "sp|P50102-1|UBP8_YEAST Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 8  OS=Saccharomyces cerevisiae S288C OX=559292 GN=UBP8 PE=1 SV=1 CANONICAL=P50102-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P50102-1",
            "url": "",
            "sequence": {
                "sequence": "MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMCLQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDDVCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN",
                "length": 471,
                "header": "sp|P50102-1|UBP8_YEAST Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 8  OS=Saccharomyces cerevisiae S288C OX=559292 GN=UBP8 PE=1 SV=1 CANONICAL=P50102-1"
            },
            "locus": {
                "chromosome": "XIII",
                "start_pos": 718127,
                "end_pos": 716715,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YMR223W_mRNA",
                        "url": "https://www.ensembl.org/id/YMR223W_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YMR223W",
                        "url": "https://www.ensembl.org/id/YMR223W"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Expanded lysine acetylation specificity of Gcn5 in native complexes.",
            "journal": "J. Biol. Chem.",
            "date": "1999",
            "authors": "Workman J.L., Cook R.G., John S., Turner B.M., Grant P.A., Eberharter A.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P50102",
                    "url": "https://www.uniprot.org/uniprot/P50102"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10026213",
                    "url": "https://glygen.org/publication/PubMed/10026213"
                }
            ]
        },
        {
            "title": "The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.",
            "journal": "Mol. Cell. Biol.",
            "date": "2002",
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