{
    "uniprot_canonical_ac": "P48743-1",
    "uniprot_ac": "P48743",
    "uniprot_id": "RFX1_YEAST",
    "mass": {
        "chemical_mass": 90584.0,
        "monoisotopic_mass": 90584.0
    },
    "refseq": {
        "ac": "NP_013277",
        "name": "Rfx1p",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013277"
    },
    "gene_names": [
        {
            "name": "RFX1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P48743",
            "id": "P48743"
        },
        {
            "name": "CRT1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013277",
            "id": "NP_013277"
        },
        {
            "name": "CRT1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P48743",
            "id": "P48743"
        },
        {
            "name": "L9470.18",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P48743",
            "id": "P48743"
        },
        {
            "name": "RFX1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013277",
            "id": "NP_013277"
        }
    ],
    "protein_names": [
        {
            "name": "RFX-like DNA-binding protein RFX1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P48743"
        },
        {
            "name": "Rfx1p",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013277",
            "id": "NP_013277"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0050545",
            "recommended_name": {
                "id": "DOID:0050545",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050545",
                "name": "visceral heterotaxy",
                "description": "A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen."
            },
            "synonyms": [
                {
                    "id": "DOID:0050545",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050545",
                    "name": "heterotaxia",
                    "description": ""
                },
                {
                    "id": "DOID:0050545",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050545",
                    "name": "situs ambiguus",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "heterotaxy, visceral, 2, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "DTGA2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "heterotaxy, visceral, 2, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "transposition of the great arteries, dextro-looped 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "HTX2",
                    "description": ""
                },
                {
                    "id": "MONDO:0011546",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011546",
                    "name": "Htx",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "heterotaxy, visceral, 3, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "HTX3",
                    "description": ""
                },
                {
                    "id": "MONDO:0011659",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011659",
                    "name": "heterotaxy, visceral, 3, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked",
                    "description": "X-linked visceral heterotaxy type 1 is a very rare form of heterotaxy that has only been reported in a few families. Heterotaxy is the right/left transposition of thoracic and/or abdominal organs. This condition is caused by mutations in the ZIC3 gene, is inherited in an X-linked recessive fashion, and is usually seen in males. Physical features include heart abnormalities such as dextrocardia, transposition of great vessels, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis ; situs inversus, and missing (asplenia) and/or extra spleens (polysplenia).Affected individualscan also experience abnormalities in the development of the midline of the body, which can cause holoprosencephaly, myelomeningocele, urological anomalies, widely spaced eyes (hypertelorism), cleft palate, and abnormalities of the sacral spine and anus. Heterotaxia with recurrent respiratory infections are called primary ciliary dyskinesia."
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "ZIC3 visceral heterotaxy",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "congenital heart defects, nonsyndromic, 1, X-linked, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, 1, X-linked, X-linked recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "visceral heterotaxy caused by mutation in ZIC3",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "HTX1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "X-linked visceral heterotaxy 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "congenital heart defects, multiple types, 1, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "dextrocardia with Other Cardiac malformations",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "heterotaxy, visceral, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "laterality, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010607",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010607",
                    "name": "situs inversus, Complex Cardiac defects, and splenic defects, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "heterotaxy, visceral, 6, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0013887",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013887",
                    "name": "HTX6",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "heterotaxy, visceral, 4, autosomal",
                    "description": "Any visceral heterotaxy in which the cause of the disease is a mutation in the ACVR2B gene."
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "ACVR2B visceral heterotaxy",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "heterotaxy, visceral, 4, autosomal",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "visceral heterotaxy caused by mutation in ACVR2B",
                    "description": ""
                },
                {
                    "id": "MONDO:0013403",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0013403",
                    "name": "HTX4",
                    "description": ""
                },
                {
                    "id": "MIM:605376",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/605376",
                    "name": "Heterotaxy, visceral, 2, autosomal",
                    "description": "Heterotaxy, visceral, 2, autosomal"
                },
                {
                    "id": "MIM:306955",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/306955",
                    "name": "Heterotaxy, visceral, 1, X-linked",
                    "description": "Heterotaxy, visceral, 1, X-linked"
                },
                {
                    "id": "MIM:614779",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/614779",
                    "name": "Heterotaxy, visceral, 6, autosomal",
                    "description": "Heterotaxy, visceral, 6, autosomal"
                },
                {
                    "id": "MIM:613751",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/613751",
                    "name": "Heterotaxy, visceral, 4, autosomal",
                    "description": "Heterotaxy, visceral, 4, autosomal"
                }
            ],
            "evidence": [
                {
                    "id": "0050545",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050545"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P48743",
                    "url": "https://www.uniprot.org/uniprot/P48743"
                }
            ],
            "common_name": "Yeast"
        }
    ],
    "gene": [
        {
            "name": "RFX1",
            "url": "https://www.uniprot.org/uniprot/P48743",
            "locus": {
                "chromosome": "XII",
                "start_pos": 507797,
                "end_pos": 510232,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "YLR176C",
                        "url": "https://www.ensembl.org/id/YLR176C"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "850873",
            "url": "https://www.ncbi.nlm.nih.gov/gene/850873",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P48743",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P48743*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR003150",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003150",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036388",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036390",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039779",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039779",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YLR176C",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YLR176C",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "AQYASSC",
            "url": "https://omabrowser.org/oma/group/AQYASSC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5489658at2759",
            "url": "http://www.orthodb.org/?query=5489658at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12619",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12619:SF5",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619:SF5",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF02257",
            "url": "http://pfam.xfam.org/family/PF02257",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P48743",
            "url": "http://purl.obolibrary.org/obo/PR_P48743",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_013277",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013277",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000004166",
            "url": "https://www.yeastgenome.org/locus/S000004166",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P48743",
            "url": "https://www.uniprot.org/uniprot/P48743",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P48743-1",
            "url": "https://www.uniprot.org/uniprot/P48743-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MVIFKERKPTENLFTRKIPAKYFIFSPSFLSVHYFEFYLPMSGDNNIEPTSRGSNDNSNGPSNGSSVNSNRYSLNAPKYSSQPPPASHTYLPPMSVNIPPIASKSSSIYSLLHQSSPRPETPNPILPPLIGSGPGSHKPSPTPTQPPAQPATQRQPATYSVYPASISLNRSNSSAYPLSFKSEETLNNNPPTAAKRTNTFPSIPSSTKKQKTSQEKRISSISRRNTQEIIAKQIAENNKSKTIEEYAQIVKHAEIKVLSMDSQNTSKAALQLAEQNRERERQVFALLWLMKNCKSQHDSYVPRGKIFAQYASSCSQNNLKPLSQASLGKLIRTVFPDLTTRRLGMRGQSKYHYCGLKLTVNESGSVSLNNNNASLSLVHNNDPISPLSSPSPSSPSPQVPNVSSPFSLNRKSLSRTGSPVKQSSNDNPNEPELESQHPNETEANKLDSLPPAANNPTGTLSSDELTFTHDLIEKVFNCNDKLSDNYNTQILSNTEHPLLTSYKLDFPKIPAGVLPTDTDSDVISSLESLYHIHCNSVYECIKFLKSDNISNALFFSNSNSISPTMFNLFISEPLIDWVTKCDLITYTGLIKFFSQFIIHSNEISDSIIQKLESMIKLLPEQINKAVLELPKALVQRKLSIINNFTKLVKKLIKLLKFILNFLKSFPIFKSGMNNDWKNIVNLDDILEMMINEDDTNSETNTIMQHLQGFCQVFVTKFLNSSMSVSNDPSVSIECKSLNEMIKDFCSFISLQSKFSCLKLIDCSTRFRNAIIGDISLKSNENLLSWLFLNNVMGQLLNYCFEVMKFVNGLKV",
        "length": 811,
        "header": "sp|P48743-1|RFX1_YEAST Isoform 1 of RFX-like DNA-binding protein RFX1  OS=Saccharomyces cerevisiae S288C OX=559292 GN=RFX1 PE=1 SV=2 CANONICAL=P48743-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P48743-1",
            "url": "",
            "sequence": {
                "sequence": "MVIFKERKPTENLFTRKIPAKYFIFSPSFLSVHYFEFYLPMSGDNNIEPTSRGSNDNSNGPSNGSSVNSNRYSLNAPKYSSQPPPASHTYLPPMSVNIPPIASKSSSIYSLLHQSSPRPETPNPILPPLIGSGPGSHKPSPTPTQPPAQPATQRQPATYSVYPASISLNRSNSSAYPLSFKSEETLNNNPPTAAKRTNTFPSIPSSTKKQKTSQEKRISSISRRNTQEIIAKQIAENNKSKTIEEYAQIVKHAEIKVLSMDSQNTSKAALQLAEQNRERERQVFALLWLMKNCKSQHDSYVPRGKIFAQYASSCSQNNLKPLSQASLGKLIRTVFPDLTTRRLGMRGQSKYHYCGLKLTVNESGSVSLNNNNASLSLVHNNDPISPLSSPSPSSPSPQVPNVSSPFSLNRKSLSRTGSPVKQSSNDNPNEPELESQHPNETEANKLDSLPPAANNPTGTLSSDELTFTHDLIEKVFNCNDKLSDNYNTQILSNTEHPLLTSYKLDFPKIPAGVLPTDTDSDVISSLESLYHIHCNSVYECIKFLKSDNISNALFFSNSNSISPTMFNLFISEPLIDWVTKCDLITYTGLIKFFSQFIIHSNEISDSIIQKLESMIKLLPEQINKAVLELPKALVQRKLSIINNFTKLVKKLIKLLKFILNFLKSFPIFKSGMNNDWKNIVNLDDILEMMINEDDTNSETNTIMQHLQGFCQVFVTKFLNSSMSVSNDPSVSIECKSLNEMIKDFCSFISLQSKFSCLKLIDCSTRFRNAIIGDISLKSNENLLSWLFLNNVMGQLLNYCFEVMKFVNGLKV",
                "length": 811,
                "header": "sp|P48743-1|RFX1_YEAST Isoform 1 of RFX-like DNA-binding protein RFX1  OS=Saccharomyces cerevisiae S288C OX=559292 GN=RFX1 PE=1 SV=2 CANONICAL=P48743-1"
            },
            "locus": {
                "chromosome": "XII",
                "start_pos": 510232,
                "end_pos": 507800,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YLR176C_mRNA",
                        "url": "https://www.ensembl.org/id/YLR176C_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YLR176C",
                        "url": "https://www.ensembl.org/id/YLR176C"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 171,
            "end_pos": 171,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P48743",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P48743"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                },
                {
                    "database": "PubMed",
                    "id": "21126336",
                    "url": "https://glygen.org/publication/PubMed/21126336"
                },
                {
                    "database": "SGD",
                    "id": "P48743",
                    "url": "https://www.yeastgenome.org/locus/P48743"
                }
            ],
            "site_lbl": "Ser171"
        },
        {
            "start_pos": 173,
            "end_pos": 173,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P48743",
                    "url": "https://www.uniprot.org/uniprot/P48743"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "iPTMnet",
                    "id": "P48743",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P48743"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                },
                {
                    "database": "PubMed",
                    "id": "20190278",
                    "url": "https://glygen.org/publication/PubMed/20190278"
                },
                {
                    "database": "SGD",
                    "id": "P48743",
                    "url": "https://www.yeastgenome.org/locus/P48743"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser173"
        },
        {
            "start_pos": 174,
            "end_pos": 174,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P48743",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P48743"
                },
                {
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