{ "uniprot_canonical_ac": "P48525-1", "uniprot_ac": "P48525", "uniprot_id": "SYEM_YEAST", "mass": { "chemical_mass": 61603.0, "monoisotopic_mass": 61603.0 }, "refseq": { "ac": "NP_014609", "name": "glutamate--tRNA ligase MSE1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014609" }, "gene_names": [ { "name": "MSE1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P48525", "id": "P48525" }, { "name": "MSE1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014609", "id": "NP_014609" } ], "protein_names": [ { "name": "Glutamate--tRNA ligase, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P48525" }, { "name": "6.1.1.17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P48525" }, { "name": "GluRS", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P48525" }, { "name": "Glutamyl-tRNA synthetase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P48525" }, { "name": "glutamate--tRNA ligase MSE1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014609", "id": "NP_014609" } ], "function": [ { "annotation": "Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525#function" } ] } ], "disease": [ { "disease_id": "DOID:0111493", "recommended_name": { "id": "DOID:0111493", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111493", "name": "combined oxidative phosphorylation deficiency 12", "description": "A combined oxidative phosphorylation deficiency characterized by infantile onset of hypotonia and delayed psychomotor development or developmental regression that has_material_basis_in homozygous or compound heterozygous mutation in the EARS2 gene on chromosome 16p12.2." }, "synonyms": [ { "id": "DOID:0111493", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111493", "name": "COXPD12", "description": "" }, { "id": "DOID:0111493", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111493", "name": "LTBL", "description": "" }, { "id": "DOID:0111493", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111493", "name": "leukoencephalopathy with thalamus and brainstem involvement and high lactate", "description": "" }, { "id": "DOID:0111493", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111493", "name": "leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome", "description": "Leukoencephalopathy-thalamus and brainstem anomalies-high lactate (LTBL) syndrome is a rare, genetic neurological disorder defined by early-onset of neurologic symptoms, biphasic clinical course, unique MRI features (incl. extensive, symmetrical, deep white matter abnormalities), and increased lactate in body fluids. The severe form is characterized by delayed psychomotor development, seizures, early-onset hypotonia, and persistently increased lactate levels. The mild form usually presents with irritability, psychomotor regression after six months of age, and temporary high lactate levels, with overall clinical improvement from the second year onward." }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "COXPD12", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "EARS2 combined oxidative phosphorylation deficiency", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "LTBL", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "combined oxidative phosphorylation defect type 12", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "combined oxidative phosphorylation deficiency caused by mutation in EARS2", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "combined oxidative phosphorylation deficiency type 12", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "leukoencephalopathy-thalamus and brainstem anomalies-high lactate syndrome", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "combined oxidative phosphorylation deficiency 12", "description": "" }, { "id": "MONDO:0013971", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013971", "name": "leukoencephalopathy with thalamus and brainstem involvement and high lactate", "description": "" }, { "id": "MIM:614924", "resource": "MIM", "url": "https://www.omim.org/entry/614924", "name": "Combined oxidative phosphorylation deficiency 12", "description": "Combined oxidative phosphorylation deficiency 12" } ], "evidence": [ { "id": "0111493", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111493" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "common_name": "Yeast" } ], "gene": [ { "name": "MSE1", "url": "https://www.uniprot.org/uniprot/P48525", "locus": {} } ], "crossref": [ { "id": "cd00808", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00808", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "854124", "url": "https://www.ncbi.nlm.nih.gov/gene/854124", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P48525", "url": "https://www.ebi.ac.uk/intact/interactors/id:P48525*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000924", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000924", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOL033W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOL033W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETQMANG", "url": "https://omabrowser.org/oma/group/ETQMANG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5404395at2759", "url": "http://www.orthodb.org/?query=5404395at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43311", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43311", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43311:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43311:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00749", "url": "http://pfam.xfam.org/family/PF00749", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19269", "url": "http://pfam.xfam.org/family/PF19269", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P48525", "url": "http://purl.obolibrary.org/obo/PR_P48525", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014609", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005393", "url": "https://www.yeastgenome.org/locus/S000005393", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P48525-1", "url": "https://www.uniprot.org/uniprot/P48525-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIMLRIPTRSYCSPSKLIKGVGLSPLKKSLLSKKIKEDIHPSLPVRTRFAPSPTGFLHLGSLRTALYNYLLARNTNGQFLLRLEDTDQKRLIEGAEENIYEILKWCNINYDETPIKQSERKLIYDKYVKILLSSGKAYRCFCSKERLNDLRHSAMELKPPSMASYDRCCAHLGEEEIKSKLAQGIPFTVRFKSPERYPTFTDLLHGQINLQPQVNFNDKRYDDLILVKSDKLPTYHLANVVDDHLMGITHVIRGEEWLPSTPKHIALYNAFGWACPKFIHIPLLTTVGDKKLSKRKGDMSISDLKRQGVLPEALINFCALFGWSPPRDLASKKHECFSMEELETIFNLNGLTKGNAKVDDKKLWFFNKHFLQKRILNPSTLRELVDDIMPSLESIYNTSTISREKVAKILLNCGGSLSRINDFHDEFYYFFEKPKYNDNDAVTKFLSKNESRHIAHLLKKLGQFQEGTDAQEVESMVETMYYENGFSRKVTYQAMRFALAGCHPGAKIAAMIDILGIKESNKRLSEGLQFLQREKK", "length": 536, "header": "sp|P48525-1|SYEM_YEAST Isoform 1 of Glutamate--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae S288C OX=559292 GN=MSE1 PE=1 SV=2 CANONICAL=P48525-1" }, "isoforms": [ { "isoform_ac": "P48525-1", "url": "", "sequence": { "sequence": "MIMLRIPTRSYCSPSKLIKGVGLSPLKKSLLSKKIKEDIHPSLPVRTRFAPSPTGFLHLGSLRTALYNYLLARNTNGQFLLRLEDTDQKRLIEGAEENIYEILKWCNINYDETPIKQSERKLIYDKYVKILLSSGKAYRCFCSKERLNDLRHSAMELKPPSMASYDRCCAHLGEEEIKSKLAQGIPFTVRFKSPERYPTFTDLLHGQINLQPQVNFNDKRYDDLILVKSDKLPTYHLANVVDDHLMGITHVIRGEEWLPSTPKHIALYNAFGWACPKFIHIPLLTTVGDKKLSKRKGDMSISDLKRQGVLPEALINFCALFGWSPPRDLASKKHECFSMEELETIFNLNGLTKGNAKVDDKKLWFFNKHFLQKRILNPSTLRELVDDIMPSLESIYNTSTISREKVAKILLNCGGSLSRINDFHDEFYYFFEKPKYNDNDAVTKFLSKNESRHIAHLLKKLGQFQEGTDAQEVESMVETMYYENGFSRKVTYQAMRFALAGCHPGAKIAAMIDILGIKESNKRLSEGLQFLQREKK", "length": 536, "header": "sp|P48525-1|SYEM_YEAST Isoform 1 of Glutamate--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae S288C OX=559292 GN=MSE1 PE=1 SV=2 CANONICAL=P48525-1" }, "locus": { "chromosome": "XV", "start_pos": 265082, "end_pos": 263475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YOL033W_mRNA", "url": "https://www.ensembl.org/id/YOL033W_mRNA" }, { "database": "Ensembl Peptide", "id": "YOL033W", "url": "https://www.ensembl.org/id/YOL033W" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Mewes H.-W., Wambutt R., Wedler H., Wiemann S., Pujol A., Uhlen M., Camasses A., Poch O., Benes V., Durand P., Vlcek C., Winsor B., Landt O., Portetelle D., Casas C., Lafuente M.J., Paces V., Delius H., Michaux G., Schweizer M., Feldmann H., Kleine K., Martin R.P., Hofmann B., Schwager C., Voss H., Cziepluch C., Jauniaux J.-C., Hughes B., Galisson F., Volckaert G., Hattenhorst U., Cheret G., Sor F., Herrero E., Arino J., Vetter I., Casamayor A., Bordonne R., Perrin A., Thierry A., Kordes E., Louis E.J., Hollenberg C.P., Maarse A.C., Marck C., Vandenbol M., Pohl T.M., Tobiasch E., Pearson B.M., Poirey R., Hand N.J., Goulding S.E., Daignan-Fornier B., Dujon B., Goffeau A., Grivell L.A., Hani J., Hernando Y., Hilger F., Madania A., Mannhaupt G., Zollner A., Aldea M., Alexandraki D., Bolotin-Fukuhara M., Fairhead C., Gancedo C., Purnelle B., Ramezani Rad M., Tarassov I.A., Tzermia M., Voet M., Albermann K., Bohn C., Boyer J., Dang V.-D., Gaillon L., Gamo F.-J., Habbig B., Hebling U., Heumann K., Hiesel R., Kalogeropoulos A., Katsoulou C., Parle-McDermott A.G., Pettersson B., Rechmann S., Sterky F., Teodoru C., Tettelin H., Unseld M., Valens M., Wolfe K.H., Zumstein E., de Haan M.", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "reference": [ { "type": "PubMed", "id": "9169874", "url": "https://glygen.org/publication/PubMed/9169874" } ] } ], "pathway": [ { "id": "sce:YOL033W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOL033W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" }, { "name": "glutamate-tRNA ligase activity", "id": "GO:0004818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004818", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "glutamyl-tRNA aminoacylation", "id": "GO:0006424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006424", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" }, { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" }, { "name": "mitochondrial glutamyl-tRNA aminoacylation", "id": "GO:0070149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070149", "evidence": [ { "database": "UniProtKB", "id": "P48525", "url": "https://www.uniprot.org/uniprot/P48525" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23540", "name": "", "equation": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8I6GJ92-1", "M0RAI4-1", "P07814-1", "Q5JPH6-1", "Q8CGC7-1", "Q9CXJ1-1", "P46655-1", "P48525-1", "Q54KB8-1", "Q869Z3-1", "P28668-1", "Q9VV59-1" ], "evidence": [ { "id": "23540", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23540" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6GJ92", "gene_name": "Eprs1", "activity": [ { "ec_number": "6.1.1.15", "activity": "ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).", "evidence": [ { "id": "A0A8I6GJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ92" } ] }, { "ec_number": "6.1.1.15", "activity": "", "evidence": [ { "id": "A0A8I6GJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ92" } ] } ] }, { "uniprot_ac": "M0RAI4", "gene_name": "Ears2", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "M0RAI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RAI4" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "M0RAI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RAI4" } ] } ] }, { "uniprot_ac": "P07814", "gene_name": "EPRS1", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "P07814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07814" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "P07814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07814" } ] }, { "ec_number": "6.1.1.15", "activity": "ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).", "evidence": [ { "id": "P07814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07814" } ] } ] }, { "uniprot_ac": "P28668", "gene_name": "GluProRS", "activity": [ { "ec_number": "6.1.1.15", "activity": "ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).", "evidence": [ { "id": "P28668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28668" } ] }, { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "P28668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28668" } ] } ] }, { "uniprot_ac": "P46655", "gene_name": "GUS1", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "P46655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46655" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "P46655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46655" } ] } ] }, { "uniprot_ac": "P48525", "gene_name": "MSE1", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "P48525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48525" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "P48525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48525" } ] } ] }, { "uniprot_ac": "Q54KB8", "gene_name": "gluS", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "Q54KB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54KB8" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "Q54KB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54KB8" } ] } ] }, { "uniprot_ac": "Q5JPH6", "gene_name": "EARS2", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "Q5JPH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JPH6" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "Q5JPH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JPH6" } ] } ] }, { "uniprot_ac": "Q869Z3", "gene_name": "mgluS", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "Q869Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869Z3" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "Q869Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869Z3" } ] } ] }, { "uniprot_ac": "Q8CGC7", "gene_name": "Eprs1", "activity": [ { "ec_number": "6.1.1.15", "activity": "ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).", "evidence": [ { "id": "Q8CGC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGC7" } ] }, { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "Q8CGC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGC7" } ] } ] }, { "uniprot_ac": "Q9CXJ1", "gene_name": "Ears2", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "Q9CXJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CXJ1" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "Q9CXJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CXJ1" } ] } ] }, { "uniprot_ac": "Q9VV59", "gene_name": "GluRS-m", "activity": [ { "ec_number": "6.1.1.17", "activity": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).", "evidence": [ { "id": "Q9VV59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VV59" } ] }, { "ec_number": "6.1.1.17", "activity": "", "evidence": [ { "id": "Q9VV59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VV59" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }