{ "uniprot_canonical_ac": "P47026-1", "uniprot_ac": "P47026", "uniprot_id": "GWT1_YEAST", "mass": { "chemical_mass": 55466.0, "monoisotopic_mass": 55466.0 }, "refseq": { "ac": "NP_012444", "name": "glucosaminyl-phosphotidylinositol O-acyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012444" }, "gene_names": [ { "name": "GWT1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P47026", "id": "P47026" }, { "name": "GWT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012444", "id": "NP_012444" }, { "name": "J0916", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P47026", "id": "P47026" } ], "protein_names": [ { "name": "GPI-anchored wall transfer protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P47026" }, { "name": "2.3.-.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P47026" }, { "name": "glucosaminyl-phosphotidylinositol O-acyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012444", "id": "NP_012444" } ], "function": [ { "annotation": "Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026#function" }, { "database": "PubMed", "id": "12714589", "url": "https://glygen.org/publication/PubMed/12714589" }, { "database": "PubMed", "id": "12753194", "url": "https://glygen.org/publication/PubMed/12753194" } ] } ], "disease": [ { "disease_id": "DOID:0070432", "recommended_name": { "id": "DOID:0070432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070432", "name": "hyperphosphatasia with impaired intellectual development syndrome 5", "description": "A hyperphosphatasia with impaired intellectual development syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the PIGW gene on chromosome 17q12." }, "synonyms": [ { "id": "DOID:0070432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070432", "name": "HPMRS5", "description": "" }, { "id": "DOID:0070432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070432", "name": "GPIBD11", "description": "" }, { "id": "DOID:0070432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070432", "name": "hyperphosphatasia with mental retardation syndrome 5", "description": "" }, { "id": "DOID:0070432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070432", "name": "glycosylphosphatidylinositol biosynthesis defect 11", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "hyperphosphatasia with intellectual disability syndrome 5", "description": "Any hyperphosphatasia-intellectual disability syndrome in which the cause of the disease is a mutation in the PIGW gene." }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "PIGW hyperphosphatasia-intellectual disability syndrome", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "hyperphosphatasia with intellectual disability syndrome 5", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "hyperphosphatasia with intellectual disability syndrome type 5", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "hyperphosphatasia with mental retardation syndrome 5", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "hyperphosphatasia with mental retardation syndrome type 5", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "hyperphosphatasia-intellectual disability syndrome caused by mutation in PIGW", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "GPIBD11", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "HPMRS5", "description": "" }, { "id": "MONDO:0014457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014457", "name": "glycosylphosphatidylinositol biosynthesis defect 11", "description": "" }, { "id": "MIM:616025", "resource": "MIM", "url": "https://www.omim.org/entry/616025", "name": "Glycosylphosphatidylinositol biosynthesis defect 11", "description": "Glycosylphosphatidylinositol biosynthesis defect 11" } ], "evidence": [ { "id": "0070432", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070432" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 132, "end_pos": 132, "sequence_org": "G", "sequence_mut": "R", "comment": "Resistant to the drug 1-[4-butylbenzyl]isoquinoline (BIQ).", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "12753194", "url": "https://glygen.org/publication/PubMed/12753194" } ] }, { "start_pos": 209, "end_pos": 209, "sequence_org": "L", "sequence_mut": "P", "comment": "In gwt1-28; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with D-259.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "12714589", "url": "https://glygen.org/publication/PubMed/12714589" } ] }, { "start_pos": 259, "end_pos": 259, "sequence_org": "V", "sequence_mut": "D", "comment": "In gwt1-28; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with P-209.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "12714589", "url": "https://glygen.org/publication/PubMed/12714589" } ] }, { "start_pos": 330, "end_pos": 330, "sequence_org": "N", "sequence_mut": "S", "comment": "In gwt1-16; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with P-362 and A-479.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "12714589", "url": "https://glygen.org/publication/PubMed/12714589" } ] }, { "start_pos": 362, "end_pos": 362, "sequence_org": "L", "sequence_mut": "P", "comment": "In gwt1-16; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with S-330 and A-479.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "12714589", "url": "https://glygen.org/publication/PubMed/12714589" } ] }, { "start_pos": 397, "end_pos": 397, "sequence_org": "V", "sequence_mut": "I", "comment": "Resistant to the drug 1-[4-butylbenzyl]isoquinoline (BIQ).", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "12753194", "url": "https://glygen.org/publication/PubMed/12753194" } ] }, { "start_pos": 479, "end_pos": 479, "sequence_org": "V", "sequence_mut": "A", "comment": "In gwt1-16; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins; when associated with S-330 and P-362.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "12714589", "url": "https://glygen.org/publication/PubMed/12714589" } ] }, { "start_pos": 63, "end_pos": 64, "sequence_org": "WV", "sequence_mut": "RA", "comment": "In gwt1-20; temperature sensitive mutant that induces a delay in export of GPI-anchored proteins.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "12714589", "url": "https://glygen.org/publication/PubMed/12714589" } ] }, { "start_pos": 8, "end_pos": 8, "sequence_org": "K", "sequence_mut": "E", "comment": "In gwt1-10; impairs the transport of detergent-resistant microdomain-associated membrane proteins TAT2 and FUR4.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" }, { "database": "PubMed", "id": "16361252", "url": "https://glygen.org/publication/PubMed/16361252" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "common_name": "Yeast" } ], "gene": [ { "name": "GWT1", "url": "https://www.uniprot.org/uniprot/P47026", "locus": {} } ], "crossref": [ { "id": "853354", "url": "https://www.ncbi.nlm.nih.gov/gene/853354", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P47026", "url": "https://www.ebi.ac.uk/intact/interactors/id:P47026*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR009447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YJL091C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YJL091C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GLYVMQP", "url": "https://omabrowser.org/oma/group/GLYVMQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "228697at2759", "url": "http://www.orthodb.org/?query=228697at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20661", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20661", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20661:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20661:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06423", "url": "http://pfam.xfam.org/family/PF06423", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P47026", "url": "http://purl.obolibrary.org/obo/PR_P47026", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_012444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012444", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000003627", "url": "https://www.yeastgenome.org/locus/S000003627", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P47026-1", "url": "https://www.uniprot.org/uniprot/P47026-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTLKQRKEDFVTGLNGGSITEINAVTSIALVTYISWNLLKNSNLMPPGISSVQYIIDFALNWVALLLSITIYASEPYLLNTLILLPCLLAFIYGKFTSSSKPSNPIYNKKKMITQRFQLEKKPYITAYRGGMLILTAIAILAVDFPIFPRRFAKVETWGTSLMDLGVGSFVFSNGIVSSRALLKNLSLKSKPSFLKNAFNALKSGGTLLFLGLLRLFFVKNLEYQEHVTEYGVHWNFFITLSLLPLVLTFIDPVTRMVPRCSIAIFISCIYEWLLLKDDRTLNFLILADRNCFFSANREGIFSFLGYCSIFLWGQNTGFYLLGNKPTLNNLYKPSTQDVVAASKKSSTWDYWTSVTPLSGLCIWSTIFLVISQLVFQYHPYSVSRRFANLPYTLWVITYNLLFLTGYCLTDKIFGNSSEYYKVAECLESINSNGLFLFLLANVSTGLVNMSMVTIDSSPLKSFLVLLAYCSFIAVISVFLYRKRIFIKL", "length": 490, "header": "sp|P47026-1|GWT1_YEAST Isoform 1 of GPI-anchored wall transfer protein 1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=GWT1 PE=1 SV=2 CANONICAL=P47026-1" }, "isoforms": [ { "isoform_ac": "P47026-1", "url": "", "sequence": { "sequence": "MSTLKQRKEDFVTGLNGGSITEINAVTSIALVTYISWNLLKNSNLMPPGISSVQYIIDFALNWVALLLSITIYASEPYLLNTLILLPCLLAFIYGKFTSSSKPSNPIYNKKKMITQRFQLEKKPYITAYRGGMLILTAIAILAVDFPIFPRRFAKVETWGTSLMDLGVGSFVFSNGIVSSRALLKNLSLKSKPSFLKNAFNALKSGGTLLFLGLLRLFFVKNLEYQEHVTEYGVHWNFFITLSLLPLVLTFIDPVTRMVPRCSIAIFISCIYEWLLLKDDRTLNFLILADRNCFFSANREGIFSFLGYCSIFLWGQNTGFYLLGNKPTLNNLYKPSTQDVVAASKKSSTWDYWTSVTPLSGLCIWSTIFLVISQLVFQYHPYSVSRRFANLPYTLWVITYNLLFLTGYCLTDKIFGNSSEYYKVAECLESINSNGLFLFLLANVSTGLVNMSMVTIDSSPLKSFLVLLAYCSFIAVISVFLYRKRIFIKL", "length": 490, "header": "sp|P47026-1|GWT1_YEAST Isoform 1 of GPI-anchored wall transfer protein 1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=GWT1 PE=1 SV=2 CANONICAL=P47026-1" }, "locus": { "chromosome": "X", "start_pos": 262552, "end_pos": 261083, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YJL091C_mRNA", "url": "https://www.ensembl.org/id/YJL091C_mRNA" }, { "database": "Ensembl Peptide", "id": "YJL091C", "url": "https://www.ensembl.org/id/YJL091C" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Umemura M, Okamoto M, Nakayama K, Sagane K, Tsukahara K, Hata K, Jigami Y", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "12714589", "url": "https://glygen.org/publication/PubMed/12714589" } ] }, { "title": "Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly.", "journal": "Mol. Microbiol.", "date": "2003", "authors": "Tsukahara Kappei, Hata Katsura, Nakamoto Kazutaka, Sagane Koji, Watanabe Nao-Aki, Kuromitsu Junro, Kai Junko, Tsuchiya Mamiko, Ohba Fuminori, Jigami Yoshifumi, Yoshimatsu Kentaro, Nagasu Takeshi", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "12753194", "url": "https://glygen.org/publication/PubMed/12753194" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Assigning function to yeast proteins by integration of technologies.", "journal": "Mol. Cell", "date": "2003", "authors": "Anderson S., Yates J.R. III, Baker D., Fields S., Bradley P., Fox B., Hazbun T.R., Davis T.N., Chiu C.-H., Malmstroem L., Aranda J.D., Graczyk B.J., McDonald W.H., Muller E.G.D., Riffle M., Snydsman B.E., Sundin B.A.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "14690591", "url": "https://glygen.org/publication/PubMed/14690591" } ] }, { "title": "Glycosylphosphatidylinositol-anchored proteins are required for the transport of detergent-resistant microdomain-associated membrane proteins Tat2p and Fur4p.", "journal": "J. Biol. Chem.", "date": "2006", "authors": "Okamoto Michiyo, Yoko-o Takehiko, Umemura Mariko, Nakayama Ken-Ichi, Jigami Yoshifumi", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "16361252", "url": "https://glygen.org/publication/PubMed/16361252" } ] }, { "title": "A global topology map of the Saccharomyces cerevisiae membrane proteome.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Kim H., von Heijne G., Melen K., Oesterberg M.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "16847258", "url": "https://glygen.org/publication/PubMed/16847258" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site.", "journal": "Yeast", "date": "1995", "authors": "Boles E., Schmitt S., Miosga T., Schaaff-Gerstenschlaeger I., Zimmermann F.K., Wilhelm N., Baur A., Chalwatzis N., Fournier C., Velten C.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "7483841", "url": "https://glygen.org/publication/PubMed/7483841" } ] }, { "title": "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.", "journal": "EMBO J.", "date": "1996", "authors": "Mewes H.-W., Obermaier B., Wambutt R., Wedler H., Pujol A., Galibert F., Rose M., Boles E., Durand P., Portetelle D., Zagulski M., Kleine K., Manus V., Rossau R., Cziepluch C., Jauniaux J.-C., Soriano N., Chuat J.-C., Koetter P., Entian K.-D., Kordes E., Louis E.J., Hollenberg C.P., Vandenbol M., Domdey H., Pohl T.M., Scarcez T., Goffeau A., Grivell L.A., Herbert C.J., Hilger F., Jacq C., Miosga T., Perea J., Schaaff-Gerstenschlaeger I., Zollner A., Alexandraki D., Huang M.-E., Kirchrath L., Purnelle B., Ramezani Rad M., Tzermia M., Baur A., Chalwatzis N., Coster F., Gatius M., Hennemann A., Heumann K., Karpfinger-Hartl L., Katsoulou C., Liebl S., Rasmussen S.W., Smits P.H.M., To Van D., Van Broekhoven A., de Haan M., von Wettstein D.", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "reference": [ { "type": "PubMed", "id": "8641269", "url": "https://glygen.org/publication/PubMed/8641269" } ] } ], "pathway": [ { "id": "sce:YJL091C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YJL091C", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q7Z7B1-1", "protein_name": "Phosphatidylinositol-glycan biosynthesis class W protein", "gene_name": "PIGW", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEKQMKEAFVSNLNGTTVLEITQGLCFPAFCILCRGFLIIFSQYLCSFSPTWKTRFLTDFVVLIVPMVATLTIWASFILLELLGVIIFGAGLLYQIYRRRTCYARLPFLKILEKFLNISLESEYNPAISCFRVITSAFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFVFGSAMVCLEVRRRKYMEGSKLHYFTNSLYSVWPLVFLGIGRLAIIKSIGYQEHLTEYGVHWNFFFTIIVVKLITPLLLIIFPLNKSWIIALGITVLYQLALDFTSLKRLILYGTDGSGTRVGLLNANREGIISTLGYVAIHMAGVQTGLYMHKNRSHIKDLIKVACFLLLAAISLFISLYVVQVNVEAVSRRMANLAFCIWIVASSLILLSSLLLGDIILSFAKFLIKGALVPCSWKLIQSPVTNKKHSESLVPEAERMEPSLCLITALNRKQLIFFLLSNITTGLINLMVDTLHSSTLWALFVVNLYMFSNCLIVYVLYLQDKTVQFW", "length": 504 }, "evidence": [ { "id": "P47026", "url": "https://omabrowser.org/oma/group/P47026/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C398-1", "protein_name": "Phosphatidylinositol-glycan biosynthesis class W protein", "gene_name": "Pigw", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQKQLKEAFVRNLSGTSVLEVTQGLCFPAFCILCRGLWIIFSQHVCSFSNTWSTRFLMDFVVLIVPLVITLTVLSSFILLENLTVIVWGAWLLYQIYHRRTCYAKVPVQKVFANFLKISLESEYNPAITCYRVINSVFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFIFGAAMVCPEVRRKSIEESRFNYLRKSLYSVWPLVFLGMGRLVIIKSIGYQEHSTEYGIHWNFFFTIIVVRLVTSLLLIIFPLNKSWIVAVSITVVYQLALDYTPLKRILLYGTDGSGTRVGFLNANREGIISTLGYVTIHMAGVQTGLYVLKGRAQVRDWIKATCWVFSVAVGFFISLHIVQVNIEAVSRRMANLAFCLWVVASSLMLLSCLLLSGIILSFAQFLIKGSLVPCSWKLIQSPTTHKNHSESLILEAEKNQPSLCLITALNRNQLFFFLLSNITTGLINLTMDTLHTGALWTLVVLSIYMFTNCLVIYVLDLQGKTIKFW", "length": 503 }, "evidence": [ { "id": "P47026", "url": "https://omabrowser.org/oma/group/P47026/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "pmid": "" }, { "name": "nuclear outer membrane-endoplasmic reticulum membrane network", "id": "GO:0042175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042175", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "pmid": "" }, { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glucosaminyl-phosphatidylinositol O-acyltransferase activity", "id": "GO:0032216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032216", "evidence": [ { "database": "UniProtKB", "id": "P47026", "url": "https://www.uniprot.org/uniprot/P47026" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-SCE-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-75967" ], "output_participant_list": [ "R-ALL-8855666" ], "enzyme_list": [ "P47026-1" ], "evidence": [ { "id": "R-SCE-162683", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-162683" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-75967", "participant_name": "FACoA [cytosol]", "crossref": [ { "id": "C00040", "database": "COMPOUND", "url": "" }, { "id": "77636", "database": "ChEBI", "url": "" }, { "id": "C00040", "database": "COMPOUND", "url": "" }, { "id": "77636", "database": "ChEBI", "url": "" }, { "id": "77636", "database": "ChEBI", "url": "" }, { "id": "C00040", "database": "COMPOUND", "url": "" }, { "id": "C00040", "database": "COMPOUND", "url": "" }, { "id": "77636", "database": "ChEBI", "url": "" }, { "id": "C00040", "database": "COMPOUND", "url": "" }, { "id": "77636", "database": "ChEBI", "url": "" }, { "id": "C00040", "database": "COMPOUND", "url": "" }, { "id": "77636", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-8855666", "participant_name": "glucosaminyl-acyl-PI [integral component of cytoplasmic side of endoplasmic reticulum membrane]", "crossref": [ { "id": "52572", "database": "ChEBI", "url": "" }, { "id": "52572", "database": "ChEBI", "url": "" }, { "id": "52572", "database": "ChEBI", "url": "" }, { "id": "52572", "database": "ChEBI", "url": "" }, { "id": "52572", "database": "ChEBI", "url": "" }, { "id": "52572", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P47026", "gene_name": "GWT1", "activity": [ { "ec_number": "2.3.-.-", "activity": "", "evidence": [ { "id": "P47026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47026" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 9 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }