{ "uniprot_canonical_ac": "P46997-1", "uniprot_ac": "P46997", "uniprot_id": "JJJ2_YEAST", "mass": { "chemical_mass": 67389.0, "monoisotopic_mass": 67389.0 }, "refseq": { "ac": "NP_012373", "name": "Jjj2p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012373" }, "gene_names": [ { "name": "JJJ2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P46997", "id": "P46997" }, { "name": "J0549", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46997", "id": "P46997" }, { "name": "JJJ2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012373", "id": "NP_012373" } ], "protein_names": [ { "name": "J protein JJJ2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P46997" }, { "name": "Jjj2p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012373", "id": "NP_012373" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "common_name": "Yeast" } ], "gene": [ { "name": "JJJ2", "url": "https://www.uniprot.org/uniprot/P46997", "locus": {} } ], "crossref": [ { "id": "cd06257", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "853277", "url": "https://www.ncbi.nlm.nih.gov/gene/853277", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P46997", "url": "https://www.ebi.ac.uk/intact/interactors/id:P46997*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001623", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YJL162C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YJL162C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ARSKFEC", "url": "https://omabrowser.org/oma/group/ARSKFEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2040036at2759", "url": "http://www.orthodb.org/?query=2040036at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43908", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43908", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43908:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43908:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "http://pfam.xfam.org/family/PF00226", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P46997", "url": "http://purl.obolibrary.org/obo/PR_P46997", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_012373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012373", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000003698", "url": "https://www.yeastgenome.org/locus/S000003698", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P46997-1", "url": "https://www.uniprot.org/uniprot/P46997-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQVIEPQLDRTTYYSILGLTSNATSSEVHKSYLKLARLLHPDKTKSDKSEELFKAVVHAHSILTDEDQKLRYDRDLKIKGLHTYQPKKNCHIFKTKAKESQGASPTLGQSEAYHRQNKPYEQQPYGFGVGKKMTSSSKSKVPIFKSFNLKSYQRNHYYSSKKERKHGSPDIDSLFHETNGASKVRMTDAGKMDTNSQFQEIWEILGKNAYTHKSYSEDPNSCLGSALSDHEEEEEAGKQQQQQQQQQQQQQHYGMTSKSSSPDEEKKNNKEPKRESRVSPEENGEEETGHKQFKLPKTSTFSSGSHDSNLQSPFYNHEYRHYARSKFECKNQFRKSVSPIKEIPATTSANEGWNILRDIIEKLNISNVDDRNKDLLFRRDEIGDKNHSDSIDIENLSIKEPKGMKRRKKDDISLEELFQSLPREKDYFMMDAINDSLESINLFKKPKTTQSHEQGGTFAQAESNRAKFKPLLEQCGITPEILDLEIPEIPEFDAVADLETLKLNVQLFNNQCNKLKETIHQVSLQRLRADTQFSDMLTQKQSIMVWKTYLEFDKSLMDKLNILQERQMQVIKIFSERCDGKV", "length": 583, "header": "sp|P46997-1|JJJ2_YEAST Isoform 1 of J protein JJJ2 OS=Saccharomyces cerevisiae S288C OX=559292 GN=JJJ2 PE=1 SV=2 CANONICAL=P46997-1" }, "isoforms": [ { "isoform_ac": "P46997-1", "url": "", "sequence": { "sequence": "MSQVIEPQLDRTTYYSILGLTSNATSSEVHKSYLKLARLLHPDKTKSDKSEELFKAVVHAHSILTDEDQKLRYDRDLKIKGLHTYQPKKNCHIFKTKAKESQGASPTLGQSEAYHRQNKPYEQQPYGFGVGKKMTSSSKSKVPIFKSFNLKSYQRNHYYSSKKERKHGSPDIDSLFHETNGASKVRMTDAGKMDTNSQFQEIWEILGKNAYTHKSYSEDPNSCLGSALSDHEEEEEAGKQQQQQQQQQQQQQHYGMTSKSSSPDEEKKNNKEPKRESRVSPEENGEEETGHKQFKLPKTSTFSSGSHDSNLQSPFYNHEYRHYARSKFECKNQFRKSVSPIKEIPATTSANEGWNILRDIIEKLNISNVDDRNKDLLFRRDEIGDKNHSDSIDIENLSIKEPKGMKRRKKDDISLEELFQSLPREKDYFMMDAINDSLESINLFKKPKTTQSHEQGGTFAQAESNRAKFKPLLEQCGITPEILDLEIPEIPEFDAVADLETLKLNVQLFNNQCNKLKETIHQVSLQRLRADTQFSDMLTQKQSIMVWKTYLEFDKSLMDKLNILQERQMQVIKIFSERCDGKV", "length": 583, "header": "sp|P46997-1|JJJ2_YEAST Isoform 1 of J protein JJJ2 OS=Saccharomyces cerevisiae S288C OX=559292 GN=JJJ2 PE=1 SV=2 CANONICAL=P46997-1" }, "locus": { "chromosome": "X", "start_pos": 115629, "end_pos": 113881, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YJL162C_mRNA", "url": "https://www.ensembl.org/id/YJL162C_mRNA" }, { "database": "Ensembl Peptide", "id": "YJL162C", "url": "https://www.ensembl.org/id/YJL162C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 105, "end_pos": 105, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P46997", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P46997" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "SGD", "id": "P46997", "url": "https://www.yeastgenome.org/locus/P46997" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser105" }, { "start_pos": 229, "end_pos": 229, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "iPTMnet", "id": "P46997", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P46997" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "P46997", "url": "https://www.yeastgenome.org/locus/P46997" } ], "site_lbl": "Ser229" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Sequencing and comparison of yeast species to identify genes and regulatory elements.", "journal": "Nature", "date": "2003", "authors": "Birren B.W., Lander E.S., Kellis M., Patterson N., Endrizzi M.", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "reference": [ { "type": "PubMed", "id": "12748633", "url": "https://glygen.org/publication/PubMed/12748633" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The J-protein family: modulating protein assembly, disassembly and translocation.", "journal": "EMBO Rep.", "date": "2004", "authors": "Lithgow T., Walsh P., Cyr D., Bursac D., Law Y.C.", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "reference": [ { "type": "PubMed", "id": "15170475", "url": "https://glygen.org/publication/PubMed/15170475" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "P46997", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P46997" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008-07", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" }, { "database": "iPTMnet", "id": "P46997", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P46997" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science", "date": "2009", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" }, { "database": "iPTMnet", "id": "P46997", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P46997" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", "evidence": [ { "database": "iPTMnet", "id": "P46997", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P46997" } ], "reference": [ { "type": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.", "journal": "EMBO J.", "date": "1996", "authors": "Mewes H.-W., Obermaier B., Wambutt R., Wedler H., Pujol A., Galibert F., Rose M., Boles E., Durand P., Portetelle D., Zagulski M., Kleine K., Manus V., Rossau R., Cziepluch C., Jauniaux J.-C., Soriano N., Chuat J.-C., Koetter P., Entian K.-D., Kordes E., Louis E.J., Hollenberg C.P., Vandenbol M., Domdey H., Pohl T.M., Scarcez T., Goffeau A., Grivell L.A., Herbert C.J., Hilger F., Jacq C., Miosga T., Perea J., Schaaff-Gerstenschlaeger I., Zollner A., Alexandraki D., Huang M.-E., Kirchrath L., Purnelle B., Ramezani Rad M., Tzermia M., Baur A., Chalwatzis N., Coster F., Gatius M., Hennemann A., Heumann K., Karpfinger-Hartl L., Katsoulou C., Liebl S., Rasmussen S.W., Smits P.H.M., To Van D., Van Broekhoven A., de Haan M., von Wettstein D.", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "reference": [ { "type": "PubMed", "id": "8641269", "url": "https://glygen.org/publication/PubMed/8641269" } ] } ], "pathway": [ { "id": "sce:YJL162C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YJL162C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein refolding", "id": "GO:0042026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "pmid": "" }, { "name": "chaperone cofactor-dependent protein refolding", "id": "GO:0051085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051085", "evidence": [ { "database": "UniProtKB", "id": "P46997", "url": "https://www.uniprot.org/uniprot/P46997" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 396, "end_pos": 398, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }