{ "uniprot_canonical_ac": "P46824-1", "uniprot_ac": "P46824", "uniprot_id": "KLC_DROME", "mass": { "chemical_mass": 58044.0, "monoisotopic_mass": 58044.0 }, "refseq": { "ac": "NP_001261780", "name": "kinesin light chain, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261780" }, "gene_names": [ { "name": "Klc", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P46824", "id": "P46824" }, { "name": "CG5433; DKLC; Dmel\\CG5433; kinesin; klc; KLC", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261780", "id": "NP_001261780" }, { "name": "CG5433", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46824", "id": "P46824" }, { "name": "DKLC", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46824", "id": "P46824" }, { "name": "Dmel\\CG5433", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46824", "id": "P46824" }, { "name": "Dmel_CG5433", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46824", "id": "P46824" }, { "name": "KLC", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46824", "id": "P46824" }, { "name": "Klc", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261780", "id": "NP_001261780" }, { "name": "kinesin", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46824", "id": "P46824" }, { "name": "klc", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46824", "id": "P46824" } ], "protein_names": [ { "name": "Kinesin light chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P46824" }, { "name": "CG5433-PB; Klc-PB; kinesin light chain subunit of kinesin-1; kinesin 1 light chain; kinesin I; kinesin-1 light chain", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261780", "id": "NP_001261780" }, { "name": "CG5433-PC; Klc-PC; kinesin light chain subunit of kinesin-1; kinesin 1 light chain; kinesin I; kinesin-1 light chain", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261781", "id": "NP_001261781" }, { "name": "KLC", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P46824" }, { "name": "kinesin light chain, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261780", "id": "NP_001261780" }, { "name": "kinesin light chain, isoform C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261781", "id": "NP_001261781" } ], "function": [ { "annotation": "Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.", "evidence": [ { "database": "UniProtKB", "id": "P46824", "url": "https://www.uniprot.org/uniprot/P46824#function" } ] }, { "annotation": "Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.", "evidence": [ { "database": "UniProtKB", "id": "M9PFG7", "url": "https://www.uniprot.org/uniprot/M9PFG7#function" }, { "database": "UniProtKB", "id": "RU367020", "url": "https://www.uniprot.org/uniprot/RU367020#function" }, { "database": "UniProtKB", "id": "M9PF24", "url": "https://www.uniprot.org/uniprot/M9PF24#function" } ] } ], "disease": [ { "disease_id": "DOID:0060491", "recommended_name": { "id": "DOID:0060491", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060491", "name": "SPOAN syndrome", "description": "A neurodegenerative disease characterized by spastic paraplegia, axonal neuropathy, dysarthria, acoustic startle, and congenital optical atrophy and that has_material_basis_in homozygous mutation in the KLC2 gene on chromosome 11q13.2." }, "synonyms": [ { "id": "DOID:0060491", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060491", "name": "spastic paraplegia, optic atropy, and neuropathy syndrome", "description": "" }, { "id": "DOID:0060491", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060491", "name": "spastic paraplegia, optic atropy, and neuropathy", "description": "" }, { "id": "MONDO:0012297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012297", "name": "SPOAN syndrome", "description": "A rare, complex type of hereditary spastic paraplegia characterized by early-onset progressive spastic paraplegia presenting in infancy, associated with optic atrophy, fixation nystagmus, polyneuropathy occurring in late childhood/early adolescence leading to severe motor disability and progressive joint contractures and scoliosis. SPOAN syndrome is caused by mutations in the KLC2 gene (11q13.1), encoding kinesin light chain 2." }, { "id": "MONDO:0012297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012297", "name": "SPOAN", "description": "" }, { "id": "MONDO:0012297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012297", "name": "spastic paraplegia, optic atropy, and neuropathy", "description": "" }, { "id": "MONDO:0012297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012297", "name": "spastic paraplegia, optic atropy, and neuropathy syndrome", "description": "" }, { "id": "MONDO:0012297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012297", "name": "spastic paraplegia, optic atrophy, and neuropathy", "description": "" }, { "id": "MONDO:0012297", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012297", "name": "spastic paraplegia-optic atrophy-neuropathy syndrome", "description": "" }, { "id": "MIM:609541", "resource": "MIM", "url": "https://www.omim.org/entry/609541", "name": "Spastic paraplegia, optic atrophy, and neuropathy", "description": "Spastic paraplegia, optic atrophy, and neuropathy" } ], "evidence": [ { "id": "0060491", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060491" } ] }, { "disease_id": "DOID:0080348", "recommended_name": { "id": "DOID:0080348", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080348", "name": "Alzheimer's disease 1", "description": "An Alzheimer's disease that has_material_basis_in mutation heterozygous mutation in the APP gene, which encodes the amyloid precursor protein, on chromosome 21q21." }, "synonyms": [ { "id": "DOID:0080348", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080348", "name": "Alzheimer's disease 1, early onset", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease type 1", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "early-onset familial form of Alzheimer disease", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease 1, familial", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "AD", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "AD1", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease 1", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, early-onset, with cerebral amyloid angiopathy", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, familial, 1", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, late-onset, susceptibility to", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, protection against", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, susceptibility to", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "presenile and senile dementia", "description": "" }, { "id": "MIM:104300", "resource": "MIM", "url": "https://www.omim.org/entry/104300", "name": "Alzheimer disease 1", "description": "Alzheimer disease 1" } ], "evidence": [ { "id": "0080348", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080348" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:2378", "recommended_name": { "id": "DOID:2378", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2378", "name": "relapsing-remitting multiple sclerosis", "description": "A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles." }, "synonyms": [ { "id": "DOID:2378", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2378", "name": "RRMS", "description": "" }, { "id": "DOID:2378", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2378", "name": "Relapsing-remitting MS", "description": "" } ], "evidence": [ { "id": "2378", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2378" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "P46824", "url": "https://www.uniprot.org/uniprot/P46824" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Klc", "url": "https://www.uniprot.org/uniprot/P46824", "locus": { "chromosome": "3L", "start_pos": 12746616, "end_pos": 12750056, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0010235", "url": "https://www.ensembl.org/id/FBgn0010235" } ] } } ], "crossref": [ { "id": "FBgn0010235", "url": "https://bgee.org/?page=gene&gene_id=FBgn0010235", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0010235", "url": "https://flybase.org/reports/FBgn0010235", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "39445", "url": "https://www.ncbi.nlm.nih.gov/gene/39445", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P46824", "url": "https://www.ebi.ac.uk/intact/interactors/id:P46824*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG5433", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG5433", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YEEVEMY", "url": "https://omabrowser.org/oma/group/YEEVEMY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5392083at2759", "url": "http://www.orthodb.org/?query=5392083at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45783", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45783", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45783:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45783:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13374", "url": "http://pfam.xfam.org/family/PF13374", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13424", "url": "http://pfam.xfam.org/family/PF13424", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P46824", "url": "http://purl.obolibrary.org/obo/PR_P46824", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6811434", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-983189", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-983189", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001261780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261780", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "M9PF24", "url": "https://www.uniprot.org/uniprot/M9PF24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9PF24-1", "url": "https://www.uniprot.org/uniprot/M9PF24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9PFG7", "url": "https://www.uniprot.org/uniprot/M9PFG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9PFG7-1", "url": "https://www.uniprot.org/uniprot/M9PFG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P46824", "url": "https://www.uniprot.org/uniprot/P46824", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P46824-1", "url": "https://www.uniprot.org/uniprot/P46824-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTQMSQDEIITNTKTVLQGLEALRVEHVSIMNGIAEVQKDNEKSDMLRKNIENIELGLSEAQVMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMASVKKYDENQEQDDACDKSRTDPVVELFPDEENEDRHNMSPTPPSQFANQTSGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVLTRAHEREFGAIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKVDSPTVTTTLKNLGALYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLTSNEKRRSKAIKEDLDFSEEKNAKP", "length": 508, "header": "sp|P46824-1|KLC_DROME Isoform 1 of Kinesin light chain OS=Drosophila melanogaster OX=7227 GN=Klc PE=1 SV=1 CANONICAL=P46824-1" }, "isoforms": [ { "isoform_ac": "M9PF24-1", "url": "", "sequence": { "sequence": "MTQMSQDEIITNTKTVLQGLEALRVEHVSIMNGIAEVQKDNEKSDMLRKNIENIELGLSEAQVMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMASVKKYDENQEQDDACDKSRTDPVVELFPDEENEDRHNMSPTPPSQFANQTSGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVLTRAHEREFGAIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKVDSPTVTTTLKNLGALYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLTSNEKRRSKAIKEDLDFSEEKNAKP", "length": 508, "header": "tr|M9PF24-1|KLC_DROME Computationally mapped isoform of Kinesin light chain OS=Drosophila melanogaster OX=7227 GN=Klc PE=1 SV=1 CANONICAL=P46824-1" }, "locus": { "chromosome": "3L", "start_pos": 12748657, "end_pos": 12746816, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0075951", "url": "https://www.ensembl.org/id/FBtr0075951" }, { "database": "Ensembl Peptide", "id": "FBpp0075683", "url": "https://www.ensembl.org/id/FBpp0075683" } ] } }, { "isoform_ac": "M9PFG7-1", "url": "", "sequence": { "sequence": "MTQMSQDEIITNTKTVLQGLEALRVEHVSIMNGIAEVQKDNEKSDMLRKNIENIELGLSEAQVMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMASVKKYDENQEQDDACDKSRTDPVVELFPDEENEDRHNMSPTPPSQFANQTSGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVLTRAHEREFGAIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKVDSPTVTTTLKNLGALYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLTSNEKRRSKAIKEDLDFSEENAKP", "length": 507, "header": "tr|M9PFG7-1|KLC_DROME Computationally mapped isoform of Kinesin light chain OS=Drosophila melanogaster OX=7227 GN=Klc PE=1 SV=1 CANONICAL=P46824-1" }, "locus": { "chromosome": "3L", "start_pos": 12748657, "end_pos": 12746816, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0331556", "url": "https://www.ensembl.org/id/FBtr0331556" }, { "database": "Ensembl Peptide", "id": "FBpp0303946", "url": "https://www.ensembl.org/id/FBpp0303946" } ] } }, { "isoform_ac": "P46824-1", "url": "", "sequence": { "sequence": "MTQMSQDEIITNTKTVLQGLEALRVEHVSIMNGIAEVQKDNEKSDMLRKNIENIELGLSEAQVMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMASVKKYDENQEQDDACDKSRTDPVVELFPDEENEDRHNMSPTPPSQFANQTSGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVLTRAHEREFGAIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKVDSPTVTTTLKNLGALYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLTSNEKRRSKAIKEDLDFSEEKNAKP", "length": 508, "header": "sp|P46824-1|KLC_DROME Isoform 1 of Kinesin light chain OS=Drosophila melanogaster OX=7227 GN=Klc PE=1 SV=1 CANONICAL=P46824-1" }, "locus": { "chromosome": "3L", "start_pos": 12748657, "end_pos": 12746816, "strand": "+", "evidence": [ { 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