{ "uniprot_canonical_ac": "P46471-1", "uniprot_ac": "P46471", "uniprot_id": "PRS7_MOUSE", "mass": { "chemical_mass": 48648.0, "monoisotopic_mass": 48648.0 }, "refseq": { "ac": "NP_035318", "name": "26S proteasome regulatory subunit 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035318" }, "gene_names": [ { "name": "Psmc2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P46471", "id": "P46471" }, { "name": "Mss1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P46471", "id": "P46471" }, { "name": "Psmc2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035318", "id": "NP_035318" } ], "protein_names": [ { "name": "26S proteasome regulatory subunit 7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P46471" }, { "name": "26S protease regulatory subunit 7; proteasome 26S subunit ATPase 2; 26S proteasome AAA-ATPase subunit RPT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035318", "id": "NP_035318" }, { "name": "26S proteasome AAA-ATPase subunit RPT1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P46471" }, { "name": "26S proteasome regulatory subunit 7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035318", "id": "NP_035318" }, { "name": "Proteasome 26S subunit ATPase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P46471" } ], "function": [ { "annotation": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. 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"Protein Classification" ] }, { "id": "R-MMU-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9755511", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9762114", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9762114", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_035318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035318", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P46471", "url": "https://www.uniprot.org/uniprot/P46471", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P46471-1", "url": "https://www.uniprot.org/uniprot/P46471-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BVQ9", "url": "https://www.uniprot.org/uniprot/Q8BVQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BVQ9-1", "url": "https://www.uniprot.org/uniprot/Q8BVQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPDYLGADQRKTKEEEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN", "length": 433, "header": "sp|P46471-1|PRS7_MOUSE Isoform 1 of 26S proteasome regulatory subunit 7 OS=Mus musculus OX=10090 GN=Psmc2 PE=1 SV=5 CANONICAL=P46471-1" }, "isoforms": [ { "isoform_ac": "P46471-1", "url": "", "sequence": { "sequence": "MPDYLGADQRKTKEEEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN", "length": 433, "header": "sp|P46471-1|PRS7_MOUSE Isoform 1 of 26S proteasome regulatory subunit 7 OS=Mus musculus OX=10090 GN=Psmc2 PE=1 SV=5 CANONICAL=P46471-1" }, "locus": { "chromosome": "5", "start_pos": 22008699, "end_pos": 21991813, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000030769", "url": "https://www.ensembl.org/id/ENSMUST00000030769" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000030769", "url": "https://www.ensembl.org/id/ENSMUSP00000030769" } ] } }, { "isoform_ac": "Q8BVQ9-1", "url": "", "sequence": { "sequence": "MSREPAPGRGATSGGEEKGKTPAEAGKVLCNHRDAEALAASKMPDYLGADQRKTKEEEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN", "length": 475, "header": "tr|Q8BVQ9-1|PRS7_MOUSE Computationally mapped isoform of 26S proteasome regulatory subunit 7 OS=Mus musculus OX=10090 GN=Psmc2 PE=1 SV=1 CANONICAL=P46471-1" }, "locus": { "chromosome": "5", "start_pos": 22008699, "end_pos": 21991813, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000030769", "url": "https://www.ensembl.org/id/ENSMUST00000030769" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000030769", "url": "https://www.ensembl.org/id/ENSMUSP00000030769" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P46471", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P46471" }, { "id": "36288343", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36288343" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Mapping the murine cardiac 26S proteasome complexes.", "journal": "Circ. Res.", "date": "2006", "authors": "Gomes AV, Zong C, Edmondson RD, Li X, Stefani E, Zhang J, Jones RC, Thyparambil S, Wang GW, Qiao X, Bardag-Gorce F, Ping P", "evidence": [ { "database": "UniProtKB", "id": "P46471", "url": "https://www.uniprot.org/uniprot/P46471" } ], "reference": [ { "type": "PubMed", "id": "16857966", "url": "https://glygen.org/publication/PubMed/16857966" } ] }, { "title": "TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions.", "journal": "Retrovirology", "date": "2011", "authors": "Lukic Z, Hausmann S, Sebastian S, Rucci J, Sastri J, Robia SL, Luban J, Campbell EM", "evidence": [ { "database": "UniProtKB", "id": "P46471", "url": "https://www.uniprot.org/uniprot/P46471" } ], "reference": [ { "type": "PubMed", "id": "22078707", "url": "https://glygen.org/publication/PubMed/22078707" } ] }, { "title": "Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.", "journal": "Calcified tissue international", "date": "2021", "authors": "Zhou B, Peng K, Wang G, Chen W, Kang Y", "evidence": [ { "database": "RefSeq", "id": "NP_035318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035318" } ], "reference": [ { "type": "PubMed", "id": "33625534", "url": "https://glygen.org/publication/PubMed/33625534" } ] }, { "title": "First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.", "journal": "PloS one", "date": "2022", "authors": "Zhu Wei Zhong, Palazzo Teresa, Zhou Mowei, Ledee Dolena, Olson Heather M, Pa\u0161a-Toli\u0107 Ljiljana, Olson Aaron K", "evidence": [ { "database": "O-GlcNAc Database", "id": "P46471", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P46471" } ], "reference": [ { "type": "PubMed", "id": "36288343", "url": "https://glygen.org/publication/PubMed/36288343" } ] }, { "title": "Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit.", "journal": "Nature", "date": "1993", "authors": "Hastie N.D., Rosen C., Dillon P., Gordon C.B., McGurk G.", "evidence": [ { "database": "UniProtKB", "id": "P46471", "url": "https://www.uniprot.org/uniprot/P46471" } ], "reference": [ { "type": "PubMed", "id": "8247131", "url": "https://glygen.org/publication/PubMed/8247131" } ] }, { "title": "Uptake of pathogenic intracellular bacteria into human and murine macrophages downregulates the eukaryotic 26S protease complex ATPase gene.", "journal": "Infect. 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