{ "uniprot_canonical_ac": "P43596-1", "uniprot_ac": "P43596", "uniprot_id": "IOC3_YEAST", "mass": { "chemical_mass": 90897.0, "monoisotopic_mass": 90897.0 }, "refseq": { "ac": "NP_116668", "name": "Ioc3p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116668" }, "gene_names": [ { "name": "IOC3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P43596", "id": "P43596" }, { "name": "IOC3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116668", "id": "NP_116668" } ], "protein_names": [ { "name": "ISWI one complex protein 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P43596" }, { "name": "Ioc3p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116668", "id": "NP_116668" } ], "function": [ { "annotation": "Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome.", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596#function" }, { "database": "PubMed", "id": "12482963", "url": "https://glygen.org/publication/PubMed/12482963" }, { "database": "PubMed", "id": "14622597", "url": "https://glygen.org/publication/PubMed/14622597" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "common_name": "Yeast" } ], "gene": [ { "name": "IOC3", "url": "https://www.uniprot.org/uniprot/P43596", "locus": {} } ], "crossref": [ { "id": "850567", "url": "https://www.ncbi.nlm.nih.gov/gene/850567", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P43596", "url": "https://www.ebi.ac.uk/intact/interactors/id:P43596*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR028942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YFR013W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YFR013W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YWYEMCH", "url": "https://omabrowser.org/oma/group/YWYEMCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2037049at2759", "url": "http://www.orthodb.org/?query=2037049at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "2Y9Y", "url": "https://www.rcsb.org/structure/2Y9Y", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2Y9Z", "url": "https://www.rcsb.org/structure/2Y9Z", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF15612", "url": "http://pfam.xfam.org/family/PF15612", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P43596", "url": "http://purl.obolibrary.org/obo/PR_P43596", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_116668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116668", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000001909", "url": "https://www.yeastgenome.org/locus/S000001909", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P43596-1", "url": "https://www.uniprot.org/uniprot/P43596-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSPSNSIQNLQQEAQGSSSAQLADHDHDRVSMAMPLQTDQSVSVSQSSDNLRRSRRVPKPRTSIYDEYEEELKERANKPKRKRPAPPKKKAPSTQNSKSNDKVEKKKTTSIAKDGKPTLKTNDKKVAPKPKPAHEQVEPALIPSNWTSVIPLLTSDFKNQYSVISRLKNPNMKPVPYAGDIIKLMAFINKFSSFFHSDLQNLSFQDFEVGLDLYPGDPNGSAAGIVKGPEDTSLLLYPDFMAIKDIVYCQDKMNLLFLSLLDLTFTENFDGKSAKKKGPLTTWENLKSSSKKVFSNPLYRLRLVAREWGYPREWRQQLPSDQDISKPKTALFEQDEQTPVVDPSHPEILTPNIYTWNANEPLPLESNPLYNREMDKNGILALKPMDRVVLLRALTDWCASHSSAIHDEIYKLTHGKKDPVFGIQTQQVPRYTIEGVDNTINQFKKLCSLIQSRYEIRSKKKHFVKQLKEGKKPDLSRKLEILKEIKAELKNAVKSEKDELLFSLYDKWVPLFEGELPDQPLANPFSERLYKLRLQEFFLGRVPHIGDFYMPRLHSYGDSLEMSTFTDLRNLQALLSKFKNNEYNAFTLFENDGQSMSAQFKLFYHDTPSLAHDVARGRNTSGKVYWYELCHDSATLLEFLEFLDYKIVKPQDEKKEGNEKEKEALNNEAHILEQKSTTDNNPSINTNPLPKDAKYNTARKKLQILKEFLSDYYFILRQFEQMKVQFADMKPGKRQLRRIQRQTVNYNTEYDSEEYVDDEEDDEADIYDDNDNDSSFDDGRVKRQRT", "length": 787, "header": "sp|P43596-1|IOC3_YEAST Isoform 1 of ISWI one complex protein 3 OS=Saccharomyces cerevisiae S288C OX=559292 GN=IOC3 PE=1 SV=1 CANONICAL=P43596-1" }, "isoforms": [ { "isoform_ac": "P43596-1", "url": "", "sequence": { "sequence": "MDSPSNSIQNLQQEAQGSSSAQLADHDHDRVSMAMPLQTDQSVSVSQSSDNLRRSRRVPKPRTSIYDEYEEELKERANKPKRKRPAPPKKKAPSTQNSKSNDKVEKKKTTSIAKDGKPTLKTNDKKVAPKPKPAHEQVEPALIPSNWTSVIPLLTSDFKNQYSVISRLKNPNMKPVPYAGDIIKLMAFINKFSSFFHSDLQNLSFQDFEVGLDLYPGDPNGSAAGIVKGPEDTSLLLYPDFMAIKDIVYCQDKMNLLFLSLLDLTFTENFDGKSAKKKGPLTTWENLKSSSKKVFSNPLYRLRLVAREWGYPREWRQQLPSDQDISKPKTALFEQDEQTPVVDPSHPEILTPNIYTWNANEPLPLESNPLYNREMDKNGILALKPMDRVVLLRALTDWCASHSSAIHDEIYKLTHGKKDPVFGIQTQQVPRYTIEGVDNTINQFKKLCSLIQSRYEIRSKKKHFVKQLKEGKKPDLSRKLEILKEIKAELKNAVKSEKDELLFSLYDKWVPLFEGELPDQPLANPFSERLYKLRLQEFFLGRVPHIGDFYMPRLHSYGDSLEMSTFTDLRNLQALLSKFKNNEYNAFTLFENDGQSMSAQFKLFYHDTPSLAHDVARGRNTSGKVYWYELCHDSATLLEFLEFLDYKIVKPQDEKKEGNEKEKEALNNEAHILEQKSTTDNNPSINTNPLPKDAKYNTARKKLQILKEFLSDYYFILRQFEQMKVQFADMKPGKRQLRRIQRQTVNYNTEYDSEEYVDDEEDDEADIYDDNDNDSSFDDGRVKRQRT", "length": 787, "header": "sp|P43596-1|IOC3_YEAST Isoform 1 of ISWI one complex protein 3 OS=Saccharomyces cerevisiae S288C OX=559292 GN=IOC3 PE=1 SV=1 CANONICAL=P43596-1" }, "locus": { "chromosome": "VI", "start_pos": 172282, "end_pos": 169922, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YFR013W_mRNA", "url": "https://www.ensembl.org/id/YFR013W_mRNA" }, { "database": "Ensembl Peptide", "id": "YFR013W", "url": "https://www.ensembl.org/id/YFR013W" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Yeast Isw1p forms two separable complexes in vivo.", "journal": "Mol. Cell. Biol.", "date": "2003", "authors": "Qin J., Tsukiyama T., Bartholomew B., Kooperberg C., Gangaraju V.K., Landel C.C., Vary J.C. Jr.", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "reference": [ { "type": "PubMed", "id": "12482963", "url": "https://glygen.org/publication/PubMed/12482963" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II.", "journal": "Cell", "date": "2003", "authors": "O'Sullivan J., Karabetsou N., Mellor J., Morillon A., Kent N., Proudfoot N.", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "reference": [ { "type": "PubMed", "id": "14622597", "url": "https://glygen.org/publication/PubMed/14622597" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.", "journal": "Nat. Genet.", "date": "1995", "authors": "Soeda E., Tashiro H., Yamazaki M., Yokoyama K., Hagiwara H., Murakami Y., Shibata T., Ozawa M., Eki T., Tsuchiya Y., Sasanuma S., Naitou M., Sasanuma M.", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "reference": [ { "type": "PubMed", "id": "7670463", "url": "https://glygen.org/publication/PubMed/7670463" } ] } ], "pathway": [ { "id": "sce:YFR013W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YFR013W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "pmid": "" }, { "name": "sister chromatid cohesion", "id": "GO:0007062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007062", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Isw1 complex", "id": "GO:0016587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016587", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "pmid": "" }, { "name": "Isw1a complex", "id": "GO:0036436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036436", "evidence": [ { "database": "UniProtKB", "id": "P43596", "url": "https://www.uniprot.org/uniprot/P43596" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 773, "end_pos": 775, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }