{ "uniprot_canonical_ac": "P43428-1", "uniprot_ac": "P43428", "uniprot_id": "G6PC1_RAT", "mass": { "chemical_mass": 40556.0, "monoisotopic_mass": 40556.0 }, "refseq": { "ac": "NP_037230", "name": "glucose-6-phosphatase catalytic subunit 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037230" }, "gene_names": [ { "name": "G6pc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P43428", "id": "P43428" }, { "name": "Psme3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P43428", "id": "P43428" }, { "name": "Ab2-371", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011894", "id": "NP_001011894" }, { "name": "G6pc1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P43428", "id": "P43428" }, { "name": "G6pc", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P43428", "id": "P43428" }, { "name": "G6pt", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P43428", "id": "P43428" }, { "name": "Psme3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011894", "id": "NP_001011894" }, { "name": "Psme3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P43428", "id": "P43428" } ], "protein_names": [ { "name": "Glucose-6-phosphatase catalytic subunit 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P43428" }, { "name": "3.1.3.9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P43428" }, { "name": "G-6-Pase; glucose-6-phosphatase, catalytic subunit; proteasome activator subunit 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037230", "id": "NP_037230" }, { "name": "G-6-Pase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P43428" }, { "name": "G6Pase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P43428" }, { "name": "Glucose-6-phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P43428" }, { "name": "glucose-6-phosphatase catalytic subunit 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037230", "id": "NP_037230" }, { "name": "proteaseome (prosome, macropain) 28 subunit, 3; proteasome (prosome, macropain) activator subunit 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011894", "id": "NP_001011894" }, { "name": "proteasome activator complex subunit 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011894", "id": "NP_001011894" } ], "function": [ { "annotation": "Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428#function" }, { "database": "UniProtKB", "id": "P35575", "url": "https://www.uniprot.org/uniprot/P35575#function" } ] } ], "disease": [ { "disease_id": "DOID:2749", "recommended_name": { "id": "DOID:2749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2749", "name": "glycogen storage disease Ia", "description": "A glycogen storage disease I that has_material_basis_in homozygous or compound heterozygous mutation in the G6PC gene, which encodes glucose-6-phosphatase (G6Pase), on chromosome 17q21." }, "synonyms": [ { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogen storage disease due to glucose-6-phosphatase deficiency type IA", "description": "Glycogenosis due to glucose-6-phosphatase deficiency (G6P) type a, or glycogen storage disease (GSD) type 1a, is a type of glycogenosis due to G6P deficiency." }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "G6P deficiency type 1a", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "G6PC glycogen storage disease", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "GSD due to G6P deficiency type 1a", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "GSD due to G6P deficiency type Ia", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "GSD type 1a", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "GSDIa", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogen storage disease caused by mutation in G6PC", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogen storage disease due to G6P deficiency type Ia", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogen storage disease type 1a", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogen storage disease type Ia", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogenosis due to glucose-6-phosphatase deficiency type 1a", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogenosis due to glucose-6-phosphatase deficiency type Ia", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogenosis type Ia", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "GSD Ia", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "GSD1", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "GSD1A", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "Von Gierke disease", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glucose-6-phosphatase deficiency", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glucose-6-phosphatase deficiency glycogen storage disease", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogen storage disease 1", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogen storage disease 1A", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "glycogen storage disease Ia", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "hepatorenal form of glycogen storage disease", "description": "" }, { "id": "MONDO:0009287", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009287", "name": "hepatorenal glycogenosis", "description": "" }, { "id": "MIM:232200", "resource": "MIM", "url": "https://www.omim.org/entry/232200", "name": "Glycogen storage disease 1A", "description": "Glycogen storage disease 1A" } ], "evidence": [ { "id": "2749", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2749" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 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"https://www.reactome.org/PathwayBrowser/#R-RNO-5668541", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5676590", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5676590", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5687128", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5687128", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5689603", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689603", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-68867", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-68867", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-68949", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-68949", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-69017", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69017", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-69481", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69481", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-69601", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69601", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-70263", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-70263", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-75815", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75815", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8852276", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852276", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8854050", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8854050", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8939236", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8939236", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8941858", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8941858", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8951664", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9755511", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9755511", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9762114", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9762114", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_037230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037230", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1306996", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306996", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "2644", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2644", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "16689", "url": "https://www.rhea-db.org/rhea/16689", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A096MKF4", "url": "https://www.uniprot.org/uniprot/A0A096MKF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MKF4-1", "url": "https://www.uniprot.org/uniprot/A0A096MKF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JWZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JWZ2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZP59", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZP59-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2QF08", "url": "https://www.uniprot.org/uniprot/A0A8L2QF08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2QF08-1", "url": "https://www.uniprot.org/uniprot/A0A8L2QF08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R069", "url": "https://www.uniprot.org/uniprot/A0A8L2R069", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R069-1", "url": "https://www.uniprot.org/uniprot/A0A8L2R069-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7EVD4", "url": "https://www.uniprot.org/uniprot/F7EVD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7EVD4-1", "url": "https://www.uniprot.org/uniprot/F7EVD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P43428-1", "url": "https://www.uniprot.org/uniprot/P43428-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5FVM2", "url": "https://www.uniprot.org/uniprot/Q5FVM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5FVM2-1", "url": "https://www.uniprot.org/uniprot/Q5FVM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEERMNVLHDFGIQSTRYLQVNYEDSQDWFVLVSVIADLRNAFYVLFPIWFHIQETVGINLLWVAVVGDWFNLVFKWILFGQRPYWWVLDTDYYSNSSVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLAIFRGKKKSTYGFRCLNVVLWLGYWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLQRYCLITFFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMYRKSCKGELRKSLPFRLACIVASLGLLHLFDSLKPPSQIESIFYILSFCKSATVPFASVSLIPYCLARLLGQTHKKSL", "length": 357, "header": "sp|P43428-1|G6PC1_RAT Isoform 1 of Glucose-6-phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=2 SV=1 CANONICAL=P43428-1" }, "isoforms": [ { "isoform_ac": "A0A096MKF4-1", "url": "", "sequence": { "sequence": "MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGQNVGSALDSQDRRWEQLRGVDSGGNSCRAKNCRE", "length": 132, "header": "tr|A0A096MKF4-1|G6PC1_RAT Computationally mapped isoform of Glucose-6-phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=2 SV=1 CANONICAL=P43428-1" }, "locus": { "chromosome": "10", "start_pos": 86262217, "end_pos": 86257872, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076727.2", "url": "https://www.ensembl.org/id/ENSRNOT00000076727.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068494.1", "url": "https://www.ensembl.org/id/ENSRNOP00000068494.1" } ] } }, { "isoform_ac": "A0A0G2JWZ2-1", "url": "", "sequence": { "sequence": "MASLLKVDQEVKLKVAAQLRPPHPSFRTPSSRICSPLPMSSLSPWGHQEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLIHSWTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGLPPVRAALAIIFFGGQPKPNVILNPGSPVQHTGKLSDISLWTFTFGHGVFGDLRIFDIRFKGSGGLGDSQFPAHPPMLGTYQHSDCGKHVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEHSNAIPNKDPWPLPKVGGSIRLLGREIEEYYLPPPGSLETHSHDAQLWTEELQCEYVVVSSVLASKREGMSGLYSAEGGSLDIVLLKGGTDCTFWPLSLMFSQTPGYLSVEKCPVTSLRPTAGVEQSLPEIAGGDEKPDLTSRCKEHIPEDVRVDRFQCGMLILFGQRPYWWVLDTDYYSNSSVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLAIFRGKKKSTYGFRICKMKQDPTHTTGKLNSVGRCM", "length": 1358, "header": "tr|A0A0G2JWZ2-1|A0A0G2JWZ2_RAT Computationally mapped isoform of Amine oxidase OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=1 SV=1 CANONICAL=P43428-1" }, "locus": { "chromosome": "10", "start_pos": 86316932, "end_pos": 86257872, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000077603.2", "url": "https://www.ensembl.org/id/ENSRNOT00000077603.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070071.1", "url": "https://www.ensembl.org/id/ENSRNOP00000070071.1" } ] } }, { "isoform_ac": "A0A8I5ZP59-1", "url": "", "sequence": { "sequence": "MEKWILKKMKYLQSGGLSPSNYNFKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 265, "header": "tr|A0A8I5ZP59-1|G6PC1_RAT Computationally mapped isoform of Glucose-6-phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=2 SV=1 CANONICAL=P43428-1" }, "locus": { "chromosome": "10", "start_pos": 86263803, "end_pos": 86258449, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000117234.1", "url": "https://www.ensembl.org/id/ENSRNOT00000117234.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000080141.1", "url": "https://www.ensembl.org/id/ENSRNOP00000080141.1" } ] } }, { "isoform_ac": "A0A8L2QF08-1", "url": "", "sequence": { "sequence": "MEERMNVLHDFGIQSTRYLQVNYEDSQDWFVLVSVIADLRNAFYVLFPIWFHIQETVGINLLWVAVVGDWFNLVFKWILFGQRPYWWVLDTDYYSNSSVPLIKQFPVTCETGPGEQPSGSPSGFWSGCLLSCRCLNVVLWLGYWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLQRYCLITFFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMYRKSCKGELRKSLPFRLACIVASLGLLHLFDSLKPPSQIESIFYILSFCKSATVPFASVSLIPYCLARLLGQTHKKSL", "length": 341, "header": "tr|A0A8L2QF08-1|G6PC1_RAT Computationally mapped isoform of Glucose-6-phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=2 SV=1 CANONICAL=P43428-1" }, "locus": { "chromosome": "10", "start_pos": 86317634, "end_pos": 86307466, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000028033.7", "url": "https://www.ensembl.org/id/ENSRNOT00000028033.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000028033.5", "url": "https://www.ensembl.org/id/ENSRNOP00000028033.5" } ] } }, { "isoform_ac": "A0A8L2R069-1", "url": "", "sequence": { "sequence": "MASLLKVDQEVKLKVAAQLRPPHPSFRTPSSRICSPLPMSSLSPWGHQEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLIHSWTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGLPPVRAALAIIFFGGQPKPNVILNPGSPVQHTGKLSDISLWTFTFGHGVFGDLRIFDIRFKGELSQPLHCPSVLPSVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEHSNAIPNKDPWPLPKVGGSIRLLGREIEEYYLPPPGSLETHSHDAQLWTEELQCEYVVVSSVLASKREGMSGLYSAEGGSLDIVLLKGGTDCTFWPLSLMFSQTPGYLSVEKCPVTSLRPTAGVEQSLPEIAGGDEKPDLTSRCKEHIPEDVRVDRFQCGMLILFGQRPYWWVLDTDYYSNSSVPLIKQFPVTCETGPGEQPSGLRTAIMKQDPTHTTGKLNSMKQDPTHTTGKLNSAHLWNDGRLPVATPIPHRSFSHTGIAVAETFSHIRGIYNASLQRYCLITFFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMYRKSCKGELRKSLPFRLACIVASLGLLHLFDSLKPPSQIESIFYILSFCKSATVPFASHVSPRIKYRLSGCQRRRQERAHSALCCSITRDGFLGLILLKDPEVGKQLKKQKKRKALYEIPDELTRLDHNTVSEEAKGLNFATMMVFQTF", "length": 1590, "header": "tr|A0A8L2R069-1|G6PC1_RAT Computationally mapped isoform of Glucose-6-phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=2 SV=1 CANONICAL=P43428-1" }, "locus": { "chromosome": "10", "start_pos": 86333801, "end_pos": 86257872, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076820.2", "url": "https://www.ensembl.org/id/ENSRNOT00000076820.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068449.2", "url": "https://www.ensembl.org/id/ENSRNOP00000068449.2" } ] } }, { "isoform_ac": "F7EVD4-1", "url": "", "sequence": { "sequence": "MASLLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 246, "header": "tr|F7EVD4-1|G6PC1_RAT Computationally mapped isoform of Glucose-6-phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=2 SV=1 CANONICAL=P43428-1" }, "locus": { "chromosome": "10", "start_pos": 86263803, "end_pos": 86257872, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000027957.8", "url": "https://www.ensembl.org/id/ENSRNOT00000027957.8" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000027957.6", "url": "https://www.ensembl.org/id/ENSRNOP00000027957.6" } ] } }, { "isoform_ac": "P43428-1", "url": "", "sequence": { "sequence": "MEERMNVLHDFGIQSTRYLQVNYEDSQDWFVLVSVIADLRNAFYVLFPIWFHIQETVGINLLWVAVVGDWFNLVFKWILFGQRPYWWVLDTDYYSNSSVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLAIFRGKKKSTYGFRCLNVVLWLGYWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLQRYCLITFFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMYRKSCKGELRKSLPFRLACIVASLGLLHLFDSLKPPSQIESIFYILSFCKSATVPFASVSLIPYCLARLLGQTHKKSL", "length": 357, "header": "sp|P43428-1|G6PC1_RAT Isoform 1 of Glucose-6-phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=2 SV=1 CANONICAL=P43428-1" }, "locus": { "chromosome": "10", "start_pos": 86317634, "end_pos": 86307466, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085831", "url": "https://www.ensembl.org/id/ENSRNOT00000085831" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000071453", "url": "https://www.ensembl.org/id/ENSRNOP00000071453" } ] } }, { "isoform_ac": "Q5FVM2-1", "url": "", "sequence": { "sequence": "MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY", "length": 254, "header": "tr|Q5FVM2-1|G6PC1_RAT Computationally mapped isoform of Glucose-6-phosphatase catalytic subunit 1 OS=Rattus norvegicus OX=10116 GN=G6pc1 PE=2 SV=1 CANONICAL=P43428-1" }, "locus": { "chromosome": "10", "start_pos": 86263803, "end_pos": 86257872, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000101325.1", "url": "https://www.ensembl.org/id/ENSRNOT00000101325.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091678.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091678.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 96, "start_aa": "Asn", "end_pos": 96, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn96", "evidence": [ { "id": "P43428", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43428#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes.", "journal": "J. Clin. Invest.", "date": "1995", "authors": "Chin S., Naji A., Haber B.A., Buikuisen W., Chuang E., Taub R.A.", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "reference": [ { "type": "PubMed", "id": "7860767", "url": "https://glygen.org/publication/PubMed/7860767" } ] }, { "title": "Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1994", "authors": "Lange AJ, Argaud D, el-Maghrabi MR, Pan W, Maitra SR, Pilkis SJ", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "reference": [ { "type": "PubMed", "id": "8198588", "url": "https://glygen.org/publication/PubMed/8198588" } ] }, { "title": "Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state.", "journal": "Res. Commun. Mol. Pathol. Pharmacol.", "date": "1996", "authors": "Hamaguchi T., Matsuzawa Y., Horikawa Y., Nakajima H., Miyagawa J., Yamasaki T., Namba M., Hanafusa T., Shingu R.", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "reference": [ { "type": "PubMed", "id": "8865366", "url": "https://glygen.org/publication/PubMed/8865366" } ] } ], "pathway": [ { "id": "rno:25634", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:25634", "resource": "KEGG Pathway" }, { "id": "rno:287716", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:287716", "resource": "KEGG Pathway" }, { "id": "R-RNO-1169091", "name": "Activation of NF-kappaB in B cells", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169091", "resource": "Reactome", "description": "Activation of NF-kappaB in B cells" }, { "id": "R-RNO-1234176", "name": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", 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"name": "Degradation of beta-catenin by the destruction complex", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-195253", "resource": "Reactome", "description": "Degradation of beta-catenin by the destruction complex" }, { "id": "R-RNO-2467813", "name": "Separation of Sister Chromatids", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-RNO-349425", "name": "Autodegradation of the E3 ubiquitin ligase COP1", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349425", "resource": "Reactome", "description": "Autodegradation of the E3 ubiquitin ligase COP1" }, { "id": "R-RNO-350562", "name": "Regulation of ornithine decarboxylase (ODC)", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-350562", "resource": "Reactome", "description": "Regulation of ornithine decarboxylase (ODC)" }, { "id": "R-RNO-382556", "name": "ABC-family proteins mediated transport", "url": 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"name": "MDM2/MDM4 family protein binding", "id": "GO:0097371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097371", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "glucose-6-phosphatase activity", "id": "GO:0004346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004346", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "copper ion binding", "id": "GO:0005507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "primary amine oxidase activity", "id": "GO:0008131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008131", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "quinone binding", "id": "GO:0048038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048038", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "phosphate ion binding", "id": "GO:0042301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042301", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "phosphotransferase activity, alcohol group as acceptor", "id": "GO:0016773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016773", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 24, "go_terms": [ { "name": "gluconeogenesis", "id": "GO:0006094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006094", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "positive regulation of endopeptidase activity", "id": "GO:0010950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010950", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "regulation of G1/S transition of mitotic cell cycle", "id": "GO:2000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000045", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "amine metabolic process", "id": "GO:0009308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009308", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "triglyceride metabolic process", "id": "GO:0006641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006641", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "glycogen metabolic process", "id": "GO:0005977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "response to nutrient levels", "id": "GO:0031667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031667", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "response to food", "id": "GO:0032094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032094", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "multicellular organism growth", "id": "GO:0035264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035264", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "urate metabolic process", "id": "GO:0046415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046415", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "response to carbohydrate", "id": "GO:0009743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009743", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "steroid metabolic process", "id": "GO:0008202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "glucose-6-phosphate transport", "id": "GO:0015760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015760", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "glycogen catabolic process", "id": "GO:0005980", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005980", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "glucose 6-phosphate metabolic process", "id": "GO:0051156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051156", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" }, { "name": "response to resveratrol", "id": "GO:1904638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904638", "evidence": [ { "database": "UniProtKB", "id": "P43428", "url": "https://www.uniprot.org/uniprot/P43428" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWZ2", "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ2" }, { "database": "PubMed", "id": "RU000672", "url": "https://glygen.org/publication/PubMed/RU000672" }, { "database": "PubMed", "id": "PIRSR600269-51", "url": "https://glygen.org/publication/PubMed/PIRSR600269-51" }, { "database": "UniProtKB", "id": "A0A8L2R069", "url": "https://www.uniprot.org/uniprot/A0A8L2R069" } ] } ], "interactions": [], "reactions": [ { "id": "16689", "name": "", "equation": "D-glucose 6-phosphate + H2O = D-glucose + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P43428-1", "Q6AZ83-1", "Q9NQR9-1", "P35575-1", "Q9BUM1-1", "P35576-1", "Q9Z186-1", "Q6NSQ9-1" ], "evidence": [ { "id": "16689", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16689" } ] }, { "id": "R-RNO-71825", "name": "G6PC hydrolyzes G6P to Glc and Pi (liver)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P43428-1" ], "evidence": [ { "id": "R-RNO-71825", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-71825" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35575", "gene_name": "G6PC1", "activity": [ { "ec_number": "3.1.3.9", "activity": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate.", "evidence": [ { "id": "P35575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35575" } ] }, { "ec_number": "3.1.3.9", "activity": "", "evidence": [ { "id": "P35575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35575" } ] } ] }, { "uniprot_ac": "P35576", "gene_name": "G6pc1", "activity": [ { "ec_number": "3.1.3.9", "activity": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate.", "evidence": [ { "id": "P35576", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35576" } ] }, { "ec_number": "3.1.3.9", "activity": "", "evidence": [ { "id": "P35576", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35576" } ] } ] }, { "uniprot_ac": "P43428", "gene_name": "G6pc1", "activity": [ { "ec_number": "1.4.3.-", "activity": "", "evidence": [ { "id": "P43428", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43428" } ] }, { "ec_number": "3.1.3.9", "activity": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate.", "evidence": [ { "id": "P43428", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43428" } ] }, { "ec_number": "3.1.3.9", "activity": "", "evidence": [ { "id": "P43428", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43428" } ] } ] }, { "uniprot_ac": "Q6AZ83", "gene_name": "G6pc3", "activity": [ { "ec_number": "3.1.3.9", "activity": 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"url": "https://www.uniprot.org/uniprot/Q9BUM1" } ] }, { "ec_number": "3.1.3.9", "activity": "", "evidence": [ { "id": "Q9BUM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BUM1" } ] } ] }, { "uniprot_ac": "Q9NQR9", "gene_name": "G6PC2", "activity": [ { "ec_number": "3.1.3.9", "activity": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate.", "evidence": [ { "id": "Q9NQR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQR9" } ] }, { "ec_number": "3.1.3.9", "activity": "", "evidence": [ { "id": "Q9NQR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQR9" } ] } ] }, { "uniprot_ac": "Q9Z186", "gene_name": "G6pc2", "activity": [ { "ec_number": "3.1.3.9", "activity": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate.", "evidence": [ { "id": "Q9Z186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z186" } ] }, { "ec_number": "3.1.3.9", "activity": "", "evidence": [ { "id": "Q9Z186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z186" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", 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