{
    "uniprot_canonical_ac": "P43425-1",
    "uniprot_ac": "P43425",
    "uniprot_id": "GBG7_RAT",
    "mass": {
        "chemical_mass": 7524.0,
        "monoisotopic_mass": 7524.0
    },
    "refseq": {
        "ac": "NP_077052",
        "name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052"
    },
    "gene_names": [
        {
            "name": "Gng7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P43425",
            "id": "P43425"
        },
        {
            "name": "Gng7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052",
            "id": "NP_077052"
        },
        {
            "name": "Gngt7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P43425",
            "id": "P43425"
        },
        {
            "name": "Hg3b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052",
            "id": "NP_077052"
        }
    ],
    "protein_names": [
        {
            "name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P43425"
        },
        {
            "name": "guanine nucleotide binding protein (G protein), gamma 7 subunit; guanine nucleotide binding protein, gamma 7; heterotrimeric guanine nucleotide-binding protein 3b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052",
            "id": "NP_077052"
        },
        {
            "name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052",
            "id": "NP_077052"
        }
    ],
    "function": [
        {
            "annotation": "GNG7 silencing repressed apoptosis and enhanced the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_077052",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052"
                },
                {
                    "database": "PubMed",
                    "id": "30864685",
                    "url": "https://glygen.org/publication/PubMed/30864685"
                }
            ]
        },
        {
            "annotation": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P43425",
                    "url": "https://www.uniprot.org/uniprot/P43425#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:9970",
            "recommended_name": {
                "id": "DOID:9970",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9970",
                "name": "obesity",
                "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness."
            },
            "synonyms": [
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "inherited obesity",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "genetic obesity",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "genetic obesity (disease)",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "leanness, inherited, autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "monogenic obesity",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "obesity, association with, Autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "obesity, early-onset, susceptibility to, Autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "obesity, late-onset, Autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "obesity, mild, early-onset, Autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "obesity, severe, Autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "obesity, severe, and type II diabetes, Autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MONDO:0019182",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182",
                    "name": "obesity, susceptibility to, Autosomal recessive",
                    "description": ""
                },
                {
                    "id": "MIM:601665",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/601665",
                    "name": "Obesity",
                    "description": "Obesity"
                }
            ],
            "evidence": [
                {
                    "id": "9970",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9970"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P43425",
                    "url": "https://www.uniprot.org/uniprot/P43425"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Gng7",
            "url": "https://www.uniprot.org/uniprot/P43425",
            "locus": {}
        }
    ],
    "crossref": [
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            "id": "cd00068",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00068",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "58979",
            "url": "https://www.ncbi.nlm.nih.gov/gene/58979",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P43425",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P43425*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001770",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001770",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015898",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015898",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036284",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036284",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:58979",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:58979",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "2872810at2759",
            "url": "http://www.orthodb.org/?query=2872810at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13809",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13809",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13809:SF8",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13809:SF8",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00631",
            "url": "http://pfam.xfam.org/family/PF00631",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P43425",
            "url": "http://purl.obolibrary.org/obo/PR_P43425",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-1296041",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1296041",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-202040",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-202040",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-381676",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-381676",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-392170",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-392170",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-392451",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-392451",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-400042",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-400042",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-4086398",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4086398",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-416476",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416476",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-418594",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-418597",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418597",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-420092",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-420092",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-428930",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-428930",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-432040",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-432040",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-456926",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-456926",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-8964616",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8964616",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-997272",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-997272",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_077052",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "61860",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=61860",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P43425",
            "url": "https://www.uniprot.org/uniprot/P43425",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P43425-1",
            "url": "https://www.uniprot.org/uniprot/P43425-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSGTNNVAQARKLVEQLRIEAGIERIKVSKASSELMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL",
        "length": 68,
        "header": "sp|P43425-1|GBG7_RAT Isoform 1 of Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7  OS=Rattus norvegicus OX=10116 GN=Gng7 PE=2 SV=2 CANONICAL=P43425-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P43425-1",
            "url": "",
            "sequence": {
                "sequence": "MSGTNNVAQARKLVEQLRIEAGIERIKVSKASSELMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL",
                "length": 68,
                "header": "sp|P43425-1|GBG7_RAT Isoform 1 of Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7  OS=Rattus norvegicus OX=10116 GN=Gng7 PE=2 SV=2 CANONICAL=P43425-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.",
            "journal": "International journal of molecular medicine",
            "date": "2019",
            "authors": "Lai WS, Ding YL",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_077052",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30864685",
                    "url": "https://glygen.org/publication/PubMed/30864685"
                }
            ]
        },
        {
            "title": "G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum.",
            "journal": "J. Neurosci. Res.",
            "date": "1994",
            "authors": "Watson JB, Coulter PM 2nd, Margulies JE, de Lecea L, Danielson PE, Erlander MG, Sutcliffe JG",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P43425",
                    "url": "https://www.uniprot.org/uniprot/P43425"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7807587",
                    "url": "https://glygen.org/publication/PubMed/7807587"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:58979",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:58979",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-1296041",
            "name": "Activation of G protein gated Potassium channels",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1296041",
            "resource": "Reactome",
            "description": "Activation of G protein gated Potassium channels"
        },
        {
            "id": "R-RNO-202040",
            "name": "G-protein activation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-202040",
            "resource": "Reactome",
            "description": "G-protein activation"
        },
        {
            "id": "R-RNO-381676",
            "name": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-381676",
            "resource": "Reactome",
            "description": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"
        },
        {
            "id": "R-RNO-392170",
            "name": "ADP signalling through P2Y purinoceptor 12",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-392170",
            "resource": "Reactome",
            "description": "ADP signalling through P2Y purinoceptor 12"
        },
        {
            "id": "R-RNO-392451",
            "name": "G beta:gamma signalling through PI3Kgamma",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-392451",
            "resource": "Reactome",
            "description": "G beta:gamma signalling through PI3Kgamma"
        },
        {
            "id": "R-RNO-400042",
            "name": "Adrenaline,noradrenaline inhibits insulin secretion",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-400042",
            "resource": "Reactome",
            "description": "Adrenaline,noradrenaline inhibits insulin secretion"
        },
        {
            "id": "R-RNO-4086398",
            "name": "Ca2+ pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4086398",
            "resource": "Reactome",
            "description": "Ca2+ pathway"
        },
        {
            "id": "R-RNO-416476",
            "name": "G alpha (q) signalling events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416476",
            "resource": "Reactome",
            "description": "G alpha (q) signalling events"
        },
        {
            "id": "R-RNO-418594",
            "name": "G alpha (i) signalling events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418594",
            "resource": "Reactome",
            "description": "G alpha (i) signalling events"
        },
        {
            "id": "R-RNO-418597",
            "name": "G alpha (z) signalling events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-418597",
            "resource": "Reactome",
            "description": "G alpha (z) signalling events"
        },
        {
            "id": "R-RNO-420092",
            "name": "Glucagon-type ligand receptors",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-420092",
            "resource": "Reactome",
            "description": "Glucagon-type ligand receptors"
        },
        {
            "id": "R-RNO-428930",
            "name": "Thromboxane signalling through TP receptor",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-428930",
            "resource": "Reactome",
            "description": "Thromboxane signalling through TP receptor"
        },
        {
            "id": "R-RNO-432040",
            "name": "Vasopressin regulates renal water homeostasis via Aquaporins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-432040",
            "resource": "Reactome",
            "description": "Vasopressin regulates renal water homeostasis via Aquaporins"
        },
        {
            "id": "R-RNO-456926",
            "name": "Thrombin signalling through proteinase activated receptors (PARs)",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-456926",
            "resource": "Reactome",
            "description": "Thrombin signalling through proteinase activated receptors (PARs)"
        },
        {
            "id": "R-RNO-8964616",
            "name": "G beta:gamma signalling through CDC42",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8964616",
            "resource": "Reactome",
            "description": "G beta:gamma signalling through CDC42"
        },
        {
            "id": "R-RNO-997272",
            "name": "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-997272",
            "resource": "Reactome",
            "description": "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O60262-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7",
            "gene_name": "GNG7",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSATNNIAQARKLVEQLRIEAGIERIKVSKAASDLMSYCEQHARNDPLLVGVPASENPFKDKKPCIIL",
                "length": 68
            },
            "evidence": [
                {
                    "id": "45232958",
                    "url": "http://www.informatics.jax.org/homology/45232958",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q61016-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7",
            "gene_name": "Gng7",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSGTNNVAQARKLVEQLRIEAGIERIKVSKASSDLMGYCEQHARNDPLLVGVPASENPFKDKKPCIIL",
                "length": 68
            },
            "evidence": [
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                    "id": "45232958",
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