{ "uniprot_canonical_ac": "P42580-1", "uniprot_ac": "P42580", "uniprot_id": "NKX12_MOUSE", "mass": { "chemical_mass": 32013.0, "monoisotopic_mass": 32013.0 }, "refseq": { "ac": "NP_033149", "name": "NK1 transcription factor-related protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149" }, "gene_names": [ { "name": "Nkx1-2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P42580", "id": "P42580" }, { "name": "Nkx-1.1; Nkx-1.2; Sax1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149", "id": "NP_033149" }, { "name": "Nkx1-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149", "id": "NP_033149" }, { "name": "Nkx1.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P42580", "id": "P42580" }, { "name": "Sax1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P42580", "id": "P42580" } ], "protein_names": [ { "name": "NK1 transcription factor-related protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P42580" }, { "name": "Homeobox protein SAX-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P42580" }, { "name": "NK1 transcription factor-related protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149", "id": "NP_033149" }, { "name": "NKX-1.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P42580" }, { "name": "homeobox protein SAX-1; homeobox protein Nkx1.2E427; spinal cord axial homeobox gene 1; NK1 transcription factor related, locus 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149", "id": "NP_033149" } ], "function": [ { "annotation": "In this study use a combination of genomics, CRISPR/Cas9 engineering and TF motif analysis to investigate the transcriptional networks guiding development of the MGE and its descendants. Whereas NKX2-1 is required for initiating MGE characteristics in the VZ. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_033149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149" }, { "database": "PubMed", "id": "30217225", "url": "https://glygen.org/publication/PubMed/30217225" } ] }, { "annotation": "May function in cell specification, particularly in the CNS.", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580#function" } ] }, { "annotation": "Results suggest a role for NK1 homeobox 2 (NKX1-2) in promoting adipogenesis and possibly in regulating the balance between adipocyte and osteoblast differentiation of bone marrow mesenchymal precursor cells.", "evidence": [ { "database": "RefSeq", "id": "NP_033149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149" }, { "database": "PubMed", "id": "31615896", "url": "https://glygen.org/publication/PubMed/31615896" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Nkx1-2", "url": "https://www.uniprot.org/uniprot/P42580", "locus": { "chromosome": "7", "start_pos": 132196607, "end_pos": 132201366, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000048528", "url": "https://www.ensembl.org/id/ENSMUSG00000048528" } ] } } ], "crossref": [ { "id": "ENSMUSG00000048528", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048528", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "20231", "url": "https://www.ncbi.nlm.nih.gov/gene/20231", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:20231", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20231", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "104806", "url": "http://www.informatics.jax.org/marker/MGI:104806", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "IHHKISF", "url": "https://omabrowser.org/oma/group/IHHKISF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "679932at2759", "url": "http://www.orthodb.org/?query=679932at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24340:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24340:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "http://pfam.xfam.org/family/PF00046", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P42580", "url": "http://purl.obolibrary.org/obo/PR_P42580", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_033149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P42580-1", "url": "https://www.uniprot.org/uniprot/P42580-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLAWQDVGAKAAPSHHKISFSVLDILDPQKFTRAALPPVRLAALEAKKSLEEVEAGQDACSGNPIGSQETPDAVGRGIDPGSPVEGSEAEEEEEAEDAGRAHQPERWQGVHEGSPEARAVAVGTEESGAEGLPASPGSPGSPRPRRRRAESSCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAVQAGGGAPQPGTPGAVAGGGGSATGSSPGPPVPGALPYQTFPTYPATNVLFPAASFPLTTAANGSPFTPFLGPSYLTPFYAPHL", "length": 305, "header": "sp|P42580-1|NKX12_MOUSE Isoform 1 of NK1 transcription factor-related protein 2 OS=Mus musculus OX=10090 GN=Nkx1-2 PE=1 SV=1 CANONICAL=P42580-1" }, "isoforms": [ { "isoform_ac": "P42580-1", "url": "", "sequence": { "sequence": "MLAWQDVGAKAAPSHHKISFSVLDILDPQKFTRAALPPVRLAALEAKKSLEEVEAGQDACSGNPIGSQETPDAVGRGIDPGSPVEGSEAEEEEEAEDAGRAHQPERWQGVHEGSPEARAVAVGTEESGAEGLPASPGSPGSPRPRRRRAESSCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAVQAGGGAPQPGTPGAVAGGGGSATGSSPGPPVPGALPYQTFPTYPATNVLFPAASFPLTTAANGSPFTPFLGPSYLTPFYAPHL", "length": 305, "header": "sp|P42580-1|NKX12_MOUSE Isoform 1 of NK1 transcription factor-related protein 2 OS=Mus musculus OX=10090 GN=Nkx1-2 PE=1 SV=1 CANONICAL=P42580-1" }, "locus": { "chromosome": "7", "start_pos": 132201255, "end_pos": 132198845, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000054562", "url": "https://www.ensembl.org/id/ENSMUST00000054562" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000052778", "url": "https://www.ensembl.org/id/ENSMUSP00000052778" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2000", "authors": "Rovescalli AC, Cinquanta M, Ferrante J, Kozak CA, Nirenberg M", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "reference": [ { "type": "PubMed", "id": "10681422", "url": "https://glygen.org/publication/PubMed/10681422" } ] }, { "title": "Genomic analysis of transcriptional networks directing progression of cell states during MGE development.", "journal": "Neural development", "date": "2018", "authors": "Sandberg M, Taher L, Hu J, Black BL, Nord AS, Rubenstein JLR", "evidence": [ { "database": "RefSeq", "id": "NP_033149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149" } ], "reference": [ { "type": "PubMed", "id": "30217225", "url": "https://glygen.org/publication/PubMed/30217225" } ] }, { "title": "The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation.", "journal": "The Journal of biological chemistry", "date": "2019", "authors": "Chen N, Schill RL, O'Donnell M, Xu K, Bagchi DP, MacDougald OA, Koenig RJ, Xu B", "evidence": [ { "database": "RefSeq", "id": "NP_033149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033149" } ], "reference": [ { "type": "PubMed", "id": "31615896", "url": "https://glygen.org/publication/PubMed/31615896" } ] }, { "title": "Expression of the novel murine homeobox gene Sax-1 in the developing nervous system.", "journal": "Mech. Dev.", "date": "1995", "authors": "Gruss P., Gruenbaum Y., Schubert F.R., Fainsod A.", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "reference": [ { "type": "PubMed", "id": "7669696", "url": "https://glygen.org/publication/PubMed/7669696" } ] }, { "title": "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "reference": [ { "type": "PubMed", "id": "9748262", "url": "https://glygen.org/publication/PubMed/9748262" } ] } ], "pathway": [ { "id": "mmu:20231", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:20231", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z9E2-1", "protein_name": "NK1 homeobox 2", "gene_name": "Nkx1-2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLAWQDGGAKAAPSHHKISFSVLDILDPQKFTRAALPPVRLAALEAKKSLVEVEAGEDACSGNPIGSQETPDAVGGGTDPASPVEGSEAEEEEEAEDAGRAQRPERWQGAHAGSLEAGAVAVGTEESGADGLPASPGSPGSPRPRRRRAESSCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAVQAGGSAPQPGTPNAVTGGGGSATGSSPGPPVPGALPFQTFPTYPATNVLFPAASFPLTTTATGSPFTPFLGPPYLTPFYAPHL", "length": 305 }, "evidence": [ { "id": "45226179", "url": "http://www.informatics.jax.org/homology/45226179", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UD57-1", "protein_name": "NK1 transcription factor-related protein 2", "gene_name": "NKX1-2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLAWQDGGAKAAPSHHKISFSVLDILDPQKFTRAALPAVRPAPREARKSLAEVEAGKDASSRDPVRQLETPDAAGPGAGQASPLEGSEAEEEEDAEDPRRPRLRERAARLLPGLARSPDAPAGALASGEPCEDGGGGPVRSPPGSPGSPRPRRRRLEPNCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAAQVGGGAPQPGAAGGGGGGGSGGSPGPPGTGALHFQTFPSYSAANVLFPSAASFPLTAAAPGSPFAPFLGPSYLTPFYAPRL", "length": 310 }, "evidence": [ { "id": "45226179", "url": "http://www.informatics.jax.org/homology/45226179", "database": "MGI" }, { "id": "P42580", "url": "https://omabrowser.org/oma/group/P42580/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated by HIPK2 in vitro.", "evidence": [ { "database": "UniProtKB", "id": "P42580", "url": "https://www.uniprot.org/uniprot/P42580" }, { "database": "PubMed", "id": "9748262", "url": "https://glygen.org/publication/PubMed/9748262" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }