{ "uniprot_canonical_ac": "P40807-1", "uniprot_ac": "P40807", "uniprot_id": "DCOR1_DROME", "mass": { "chemical_mass": 44195.0, "monoisotopic_mass": 44195.0 }, "refseq": { "ac": "NP_477052", "name": "ornithine decarboxylase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477052" }, "gene_names": [ { "name": "Odc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P40807", "id": "P40807" }, { "name": "CG8721; Dmel\\CG8721; dodc1; Odc-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477052", "id": "NP_477052" }, { "name": "CG8721", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P40807", "id": "P40807" }, { "name": "Odc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477052", "id": "NP_477052" } ], "protein_names": [ { "name": "Ornithine decarboxylase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P40807" }, { "name": "4.1.1.17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P40807" }, { "name": "CG8721-PA; Odc1-PA; ornithine decarboxylase-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477052", "id": "NP_477052" }, { "name": "ODC", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P40807" }, { "name": "ornithine decarboxylase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477052", "id": "NP_477052" } ], "function": [ { "annotation": "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807#function" }, { "database": "UniProtKB", "id": "P11926", "url": "https://www.uniprot.org/uniprot/P11926#function" } ] } ], "disease": [ { "disease_id": "DOID:11339", "recommended_name": { "id": "DOID:11339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11339", "name": "pneumocystosis", "description": "An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever." }, "synonyms": [ { "id": "DOID:11339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11339", "name": "Pneumocystis carinii pneumonia", "description": "" }, { "id": "DOID:11339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11339", "name": "Pneumocystis jirovecii pneumonia", "description": "" }, { "id": "DOID:11339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11339", "name": "Pneumocystis pneumonia", "description": "" }, { "id": "DOID:11339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11339", "name": "Pneumocystosis pneumonia", "description": "" }, { "id": "DOID:11339", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11339", "name": "pulmonary pneumocystosis", "description": "" } ], "evidence": [ { "id": "11339", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11339" } ] }, { "disease_id": "DOID:3748", "recommended_name": { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "esophagus squamous cell carcinoma", "description": "An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus." }, "synonyms": [ { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "SCC of esophagus", "description": "" }, { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "SCC of oesophagus", "description": "" }, { "id": "DOID:3748", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3748", "name": "oesophagus squamous cell carcinoma", "description": "" } ], "evidence": [ { "id": "3748", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3748" } ] }, { "disease_id": "DOID:5082", "recommended_name": { "id": "DOID:5082", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5082", "name": "liver cirrhosis", "description": "" }, "synonyms": [ { "id": "DOID:5082", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5082", "name": "Cirrhosis", "description": "" }, { "id": "DOID:5082", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5082", "name": "cirrhosis of liver", "description": "" }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "cirrhosis of liver", "description": "A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy." }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "cirrhosis", "description": "" }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "cirrhosis of liver", "description": "" }, { "id": "MONDO:0005155", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005155", "name": "liver cirrhosis", "description": "" } ], "evidence": [ { "id": "5082", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5082" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Odc1", "url": "https://www.uniprot.org/uniprot/P40807", "locus": { "chromosome": "2R", "start_pos": 8006672, "end_pos": 8004824, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0013307", "url": "https://www.ensembl.org/id/FBgn0013307" } ] } } ], "crossref": [ { "id": "FBgn0013307", "url": "https://bgee.org/?page=gene&gene_id=FBgn0013307", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00622", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00622", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0013307", "url": "https://flybase.org/reports/FBgn0013307", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "35766", "url": "https://www.ncbi.nlm.nih.gov/gene/35766", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P40807", "url": "https://www.ebi.ac.uk/intact/interactors/id:P40807*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022644", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG8721", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8721", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YCRSMAS", "url": "https://omabrowser.org/oma/group/YCRSMAS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "48358at2759", "url": "http://www.orthodb.org/?query=48358at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11482", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11482", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11482:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11482:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00278", "url": "http://pfam.xfam.org/family/PF00278", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02784", "url": "http://pfam.xfam.org/family/PF02784", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P40807", "url": "http://purl.obolibrary.org/obo/PR_P40807", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-350562", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-350562", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-351143", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-351143", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_477052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477052", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "22964", "url": "https://www.rhea-db.org/rhea/22964", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P40807-1", "url": "https://www.uniprot.org/uniprot/P40807-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAATPEIQFYERELNIRRVIEECDLQRLDQALNICDLSSVERKLRLWQKLLPRIKPFYAVKCNDDPMVVRLLAQLGAGFDCASKNEVKLVLGFDVSPERIIFANPCRPVSHLEYAKEHQVSNGTVDNEFEVYKLHTHYPNSNLIVRFKSEAKEAQCPLGDKFGCDADVDAAALMLLAKSLELKVTGTSFHVGSGCSELQAYDRAIKKAKNLFKFGALLGYDMDFLDIGGGFPGSDDVKFEKIAESVNTSVQRHFPDERVHIIAEPGRFFVAAACTLVCKIHAKREIRNEAGKLDTVMYYLNDGVYGSFNCILYDHQVVIAEHYLDNAESLPHLKSLIWGPSCDALDKISEDLHLPNLNRGDLLGFRNMGAYTMPIASAFNGFEVPKTLYFQAI", "length": 394, "header": "sp|P40807-1|DCOR1_DROME Isoform 1 of Ornithine decarboxylase 1 OS=Drosophila melanogaster OX=7227 GN=Odc1 PE=2 SV=3 CANONICAL=P40807-1" }, "isoforms": [ { "isoform_ac": "P40807-1", "url": "", "sequence": { "sequence": "MAAATPEIQFYERELNIRRVIEECDLQRLDQALNICDLSSVERKLRLWQKLLPRIKPFYAVKCNDDPMVVRLLAQLGAGFDCASKNEVKLVLGFDVSPERIIFANPCRPVSHLEYAKEHQVSNGTVDNEFEVYKLHTHYPNSNLIVRFKSEAKEAQCPLGDKFGCDADVDAAALMLLAKSLELKVTGTSFHVGSGCSELQAYDRAIKKAKNLFKFGALLGYDMDFLDIGGGFPGSDDVKFEKIAESVNTSVQRHFPDERVHIIAEPGRFFVAAACTLVCKIHAKREIRNEAGKLDTVMYYLNDGVYGSFNCILYDHQVVIAEHYLDNAESLPHLKSLIWGPSCDALDKISEDLHLPNLNRGDLLGFRNMGAYTMPIASAFNGFEVPKTLYFQAI", "length": 394, "header": "sp|P40807-1|DCOR1_DROME Isoform 1 of Ornithine decarboxylase 1 OS=Drosophila melanogaster OX=7227 GN=Odc1 PE=2 SV=3 CANONICAL=P40807-1" }, "locus": { "chromosome": "2R", "start_pos": 8006628, "end_pos": 8004851, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0088863", "url": "https://www.ensembl.org/id/FBtr0088863" }, { "database": "Ensembl Peptide", "id": "FBpp0087939", "url": "https://www.ensembl.org/id/FBpp0087939" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Isolation and characterization of the Drosophila ornithine decarboxylase locus: evidence for the presence of two transcribed ODC genes in the Drosophila genome.", "journal": "DNA Cell Biol.", "date": "1993", "authors": "Rom E., Kahana C.", "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807" } ], "reference": [ { "type": "PubMed", "id": "8329117", "url": "https://glygen.org/publication/PubMed/8329117" } ] } ], "pathway": [ { "id": "dme:Dmel_CG8721", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8721", "resource": "KEGG Pathway" }, { "id": "R-DME-350562", "name": "Regulation of ornithine decarboxylase (ODC)", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-350562", "resource": "Reactome", "description": "Regulation of ornithine decarboxylase (ODC)" }, { "id": "R-DME-351143", "name": "Agmatine biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-351143", "resource": "Reactome", "description": "Agmatine biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "P00860-1", "protein_name": "Ornithine decarboxylase", "gene_name": "Odc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSFTKDEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPAERVIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCVFDMATEVGFSMHLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQPGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRPMWQLMKQIQSHGFPPEVEEQDDGTLPMSCAQESGMDRHPAACASARINV", "length": 461 }, "evidence": [ { "id": "P40807", "url": "https://omabrowser.org/oma/group/P40807/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P09057-1", "protein_name": "Ornithine decarboxylase", "gene_name": "Odc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSFTKEEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDVLKKHLRWLKALPRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPPERIIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCVFDMGTEVGFSMYLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQTGSDDEDESNEQTLMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCSLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRSMWQLMKQIQSHGFPPEVEEQDVGTLPMSCAQESGMDRHPAACASASINV", "length": 461 }, "evidence": [ { "id": "P40807", "url": "https://omabrowser.org/oma/group/P40807/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P11926-1", "protein_name": "Ornithine decarboxylase", "gene_name": "ODC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV", "length": 461 }, "evidence": [ { "id": "P40807", "url": "https://omabrowser.org/oma/group/P40807/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ornithine decarboxylase activity", "id": "GO:0004586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004586", "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "putrescine biosynthetic process from ornithine", "id": "GO:0033387", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033387", "evidence": [ { "database": "UniProtKB", "id": "P40807", "url": "https://www.uniprot.org/uniprot/P40807" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22964", "name": "", "equation": "H(+) + L-ornithine = CO2 + putrescine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P09057-1", "P11926-1", "P00860-1", "P08432-1", "Q54UF3-1", "P40808-1", "P40807-1" ], "evidence": [ { "id": "22964", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22964" } ] }, { "id": "R-DME-350598", "name": "Arginine<=>Agmatine+CO2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29468" ], "output_participant_list": [ "R-ALL-113528", "R-ALL-351164" ], "enzyme_list": [ "P40808-1", "P40807-1" ], "evidence": [ { "id": "R-DME-350598", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-350598" } ] }, { "id": "R-DME-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40808-1", "P40807-1" ], "evidence": [ { "id": "R-DME-350600", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-350600" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113528", "participant_name": "CO2 [cytosol]", "crossref": [ { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-29468", "participant_name": "L-Arg [cytosol]", "crossref": [ { "id": "C00062", "database": "COMPOUND", "url": "" }, { "id": "32682", "database": "ChEBI", "url": "" }, { "id": "HMDB0062762", "database": "HMDB Metabolite", "url": "" }, { "id": "000001532525", "database": "ZINC", "url": "" }, { "id": "32682", "database": "ChEBI", "url": "" }, { "id": "000001532525", "database": "ZINC", "url": "" }, { "id": "HMDB0062762", "database": "HMDB Metabolite", "url": "" }, { "id": "C00062", "database": "COMPOUND", "url": "" }, { "id": "32682", "database": "ChEBI", "url": "" }, { "id": "000001532525", "database": "ZINC", "url": "" }, { "id": "HMDB0062762", "database": "HMDB Metabolite", "url": "" }, { "id": "C00062", "database": "COMPOUND", "url": "" }, { "id": "HMDB0062762", "database": "HMDB Metabolite", "url": "" }, { "id": "C00062", "database": "COMPOUND", "url": "" }, { "id": "000001532525", "database": "ZINC", "url": "" }, { "id": "32682", "database": "ChEBI", "url": "" }, { "id": "C00062", "database": "COMPOUND", "url": "" }, { "id": "32682", "database": "ChEBI", "url": "" }, { "id": "HMDB0062762", "database": "HMDB Metabolite", "url": "" }, { "id": "000001532525", "database": "ZINC", "url": "" }, { "id": "HMDB0062762", "database": "HMDB Metabolite", "url": "" }, { "id": "C00062", "database": "COMPOUND", "url": "" }, { "id": "000001532525", "database": "ZINC", "url": "" }, { "id": "32682", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-351164", "participant_name": "AGM [cytosol]", "crossref": [ { "id": "000001532560", "database": "ZINC", "url": "" }, { "id": "58145", "database": "ChEBI", "url": "" }, { "id": "58145", "database": "ChEBI", "url": "" }, { "id": "000001532560", "database": "ZINC", "url": "" }, { "id": "58145", "database": "ChEBI", "url": "" }, { "id": "000001532560", "database": "ZINC", "url": "" }, { "id": "000001532560", "database": "ZINC", "url": "" }, { "id": "58145", "database": "ChEBI", "url": "" }, { "id": "000001532560", "database": "ZINC", "url": "" }, { "id": "58145", "database": "ChEBI", "url": "" }, { "id": "58145", "database": "ChEBI", "url": "" }, { "id": "000001532560", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P00860", "gene_name": "Odc1", "activity": [ { "ec_number": "4.1.1.17", "activity": "H(+) + L-ornithine = CO2 + putrescine.", "evidence": [ { "id": "P00860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00860" } ] }, { "ec_number": "4.1.1.17", "activity": "", "evidence": [ { "id": "P00860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00860" } ] } ] }, { "uniprot_ac": "P08432", "gene_name": "SPE1", "activity": [ { "ec_number": "4.1.1.17", "activity": "H(+) + L-ornithine = CO2 + putrescine.", "evidence": [ { "id": "P08432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08432" } ] }, { "ec_number": "4.1.1.17", "activity": "", "evidence": [ { "id": "P08432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08432" } ] } ] }, { "uniprot_ac": "P09057", "gene_name": "Odc1", "activity": [ { "ec_number": "4.1.1.17", "activity": "H(+) + L-ornithine = CO2 + putrescine.", "evidence": [ { "id": "P09057", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09057" } ] }, { "ec_number": "4.1.1.17", "activity": "", "evidence": [ { "id": "P09057", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09057" } ] } ] }, { "uniprot_ac": "P11926", "gene_name": "ODC1", "activity": [ { "ec_number": "4.1.1.17", "activity": "H(+) + L-ornithine = CO2 + putrescine.", "evidence": [ { "id": "P11926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11926" } ] }, { "ec_number": "4.1.1.17", "activity": "", "evidence": [ { "id": "P11926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11926" } ] } ] }, { "uniprot_ac": "P40807", "gene_name": "Odc1", "activity": [ { "ec_number": "4.1.1.17", "activity": "H(+) + L-ornithine = CO2 + putrescine.", "evidence": [ { "id": "P40807", "database": "UniProtKB", 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