{ "uniprot_canonical_ac": "P40310-1", "uniprot_ac": "P40310", "uniprot_id": "TOK1_YEAST", "mass": { "chemical_mass": 77408.0, "monoisotopic_mass": 77408.0 }, "refseq": { "ac": "NP_012442", "name": "Tok1p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012442" }, "gene_names": [ { "name": "TOK1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P40310", "id": "P40310" }, { "name": "DUK1; YKC1; YPK1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012442", "id": "NP_012442" }, { "name": "DUK1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P40310", "id": "P40310" }, { "name": "J0911", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P40310", "id": "P40310" }, { "name": "TOK1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012442", "id": "NP_012442" } ], "protein_names": [ { "name": "Outward-rectifier potassium channel TOK1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P40310" }, { "name": "Tok1p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012442", "id": "NP_012442" }, { "name": "Two-domain outward rectifier K(+) channel YORK", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P40310" } ], "function": [ { "annotation": "Outwardly rectifying potassium channel.", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310#function" }, { "database": "PubMed", "id": "7651518", "url": "https://glygen.org/publication/PubMed/7651518" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] } ], "disease": [ { "disease_id": "DOID:14557", "recommended_name": { "id": "DOID:14557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14557", "name": "primary pulmonary hypertension", "description": "A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling." }, "synonyms": [ { "id": "DOID:14557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14557", "name": "Idiopathic pulmonary arterial hypertension", "description": "" }, { "id": "MONDO:0009935", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009935", "name": "pulmonary hypertension, primary, autosomal recessive", "description": "" }, { "id": "MONDO:0009935", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009935", "name": "pulmonary hypertension, primary, autosomal recessive", "description": "" }, { "id": "MONDO:0014136", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014136", "name": "pulmonary hypertension, primary, 4", "description": "Any primary pulmonary hypertension in which the cause of the disease is a mutation in the KCNK3 gene." }, { "id": "MONDO:0014136", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014136", "name": "KCNK3 primary pulmonary hypertension", "description": "" }, { "id": "MONDO:0014136", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014136", "name": "primary pulmonary hypertension caused by mutation in KCNK3", "description": "" }, { "id": "MONDO:0014136", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014136", "name": "pulmonary hypertension, primary, 4", "description": "" }, { "id": "MONDO:0014136", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014136", "name": "pulmonary hypertension, primary, type 4", "description": "" }, { "id": "MONDO:0014136", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014136", "name": "PPH4", "description": "" }, { "id": "MONDO:0014135", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014135", "name": "pulmonary hypertension, primary, 3", "description": "Any primary pulmonary hypertension in which the cause of the disease is a mutation in the CAV1 gene." }, { "id": "MONDO:0014135", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014135", "name": "CAV1 primary pulmonary hypertension", "description": "" }, { "id": "MONDO:0014135", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014135", "name": "primary pulmonary hypertension caused by mutation in CAV1", "description": "" }, { "id": "MONDO:0014135", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014135", "name": "pulmonary hypertension, primary, 3", "description": "" }, { "id": "MONDO:0014135", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014135", "name": "pulmonary hypertension, primary, type 3", "description": "" }, { "id": "MONDO:0014135", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014135", "name": "PPH3", "description": "" }, { "id": "MONDO:0014134", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014134", "name": "pulmonary hypertension, primary, 2", "description": "Any primary pulmonary hypertension in which the cause of the disease is a mutation in the SMAD9 gene." }, { "id": "MONDO:0014134", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014134", "name": "SMAD9 primary pulmonary hypertension", "description": "" }, { "id": "MONDO:0014134", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014134", "name": "primary pulmonary hypertension caused by mutation in SMAD9", "description": "" }, { "id": "MONDO:0014134", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014134", "name": "pulmonary hypertension, primary, 2", "description": "" }, { "id": "MONDO:0014134", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014134", "name": "pulmonary hypertension, primary, type 2", "description": "" }, { "id": "MONDO:0014134", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014134", "name": "PPH2", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "pulmonary hypertension, primary, 1", "description": "Any primary pulmonary hypertension in which the cause of the disease is a mutation in the BMPR2 gene." }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "BMPR2 primary pulmonary hypertension", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "primary pulmonary hypertension caused by mutation in BMPR2", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "pulmonary hypertension, familial primary, 1, with or without HHT", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "pulmonary hypertension, primary, 1", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "pulmonary hypertension, primary, fenfluramine or dexfenfluramine-associated", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "PHT", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "PPH1", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "Pph1 with Hht", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "pulmonary arterial hypertension", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "pulmonary hypertension, primary, Dexfenfluramine-associated", "description": "" }, { "id": "MONDO:0024533", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024533", "name": "pulmonary hypertension, primary, Fenfluramine-associated", "description": "" }, { "id": "MIM:265400", "resource": "MIM", "url": "https://www.omim.org/entry/265400", "name": "Pulmonary hypertension, primary, 5", "description": "Pulmonary hypertension, primary, 5" }, { "id": "MIM:615344", "resource": "MIM", "url": "https://www.omim.org/entry/615344", "name": "Pulmonary hypertension, primary, 4", "description": "Pulmonary hypertension, primary, 4" }, { "id": "MIM:615343", "resource": "MIM", "url": "https://www.omim.org/entry/615343", "name": "Pulmonary hypertension, primary, 3", "description": "Pulmonary hypertension, primary, 3" }, { "id": "MIM:615342", "resource": "MIM", "url": "https://www.omim.org/entry/615342", "name": "Pulmonary hypertension, primary, 2", "description": "Pulmonary hypertension, primary, 2" }, { "id": "MIM:178600", "resource": "MIM", "url": "https://www.omim.org/entry/178600", "name": "Pulmonary hypertension, primary, 1", "description": "Pulmonary hypertension, primary, 1" } ], "evidence": [ { "id": "14557", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:14557" } ] }, { "disease_id": "DOID:1824", "recommended_name": { "id": "DOID:1824", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1824", "name": "status epilepticus", "description": "" }, "synonyms": [ { "id": "DOID:1824", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1824", "name": "Grand mal status", "description": "" } ], "evidence": [ { "id": "1824", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1824" } ] }, { "disease_id": "DOID:224", "recommended_name": { "id": "DOID:224", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:224", "name": "transient cerebral ischemia", "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death." }, "synonyms": [ { "id": "DOID:224", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:224", "name": "TIA", "description": "" }, { "id": "DOID:224", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:224", "name": "TIA - Transient ischaemic attack", "description": "" }, { "id": "DOID:224", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:224", "name": "Transient cerebral ischaemia", "description": "" }, { "id": "DOID:224", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:224", "name": "Transient ischemic attacks", "description": "" }, { "id": "DOID:224", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:224", "name": "transient ischemic attack", "description": "" } ], "evidence": [ { "id": "224", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:224" } ] }, { "disease_id": "DOID:2316", "recommended_name": { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "brain ischemia", "description": "An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand." }, "synonyms": [ { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischaemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "Ischemic encephalopathy", "description": "" }, { "id": "DOID:2316", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2316", "name": "cerebral ischemia", "description": "" } ], "evidence": [ { "id": "2316", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2316" } ] }, { "disease_id": "DOID:3454", "recommended_name": { "id": "DOID:3454", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3454", "name": "brain infarction", "description": "A cerebrovascular disease that is characterized by tissue necrosis located_in the brain, resulting from inadequate blood flow through the brain." }, "synonyms": [], "evidence": [ { "id": "3454", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3454" } ] }, { "disease_id": "DOID:5453", "recommended_name": { "id": "DOID:5453", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5453", "name": "pulmonary venoocclusive disease", "description": "A pulmonary hypertension that is characterized by pulmonary venous constriction or occlusion, resulting in pulmonary hypertension." }, "synonyms": [ { "id": "DOID:5453", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5453", "name": "pulmonary veno-occlusive disease", "description": "" }, { "id": "MONDO:0020713", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020713", "name": "pulmonary venoocclusive disease 1", "description": "" }, { "id": "MONDO:0020713", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020713", "name": "PVOD1", "description": "" }, { "id": "MONDO:0020713", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020713", "name": "pulmonary venoocclusive disease 1, autosomal dominant", "description": "" }, { "id": "MIM:265450", "resource": "MIM", "url": "https://www.omim.org/entry/265450", "name": "Pulmonary venoocclusive disease 1, autosomal dominant", "description": "Pulmonary venoocclusive disease 1, autosomal dominant" } ], "evidence": [ { "id": "5453", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5453" } ] }, { "disease_id": "DOID:5844", "recommended_name": { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." }, "synonyms": [ { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "Myocardial infarct", "description": "" }, { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "heart attack", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "Mci2", "description": "" } ], "evidence": [ { "id": "5844", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ] }, { "disease_id": "DOID:6000", "recommended_name": { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." }, "synonyms": [ { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "CHF", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Cardiac Failure Congestive", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Congestive heart disease", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Weak heart", "description": "" } ], "evidence": [ { "id": "6000", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ] }, { "disease_id": "DOID:6432", "recommended_name": { "id": "DOID:6432", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6432", "name": "pulmonary hypertension", "description": "A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries." }, "synonyms": [], "evidence": [ { "id": "6432", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6432" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "common_name": "Yeast" } ], "gene": [ { "name": "TOK1", "url": "https://www.uniprot.org/uniprot/P40310", "locus": { "chromosome": "X", "start_pos": 254737, "end_pos": 256812, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YJL093C", "url": "https://www.ensembl.org/id/YJL093C" } ] } } ], "crossref": [ { "id": "853352", "url": "https://www.ncbi.nlm.nih.gov/gene/853352", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P40310", "url": "https://www.ebi.ac.uk/intact/interactors/id:P40310*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YJL093C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YJL093C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RVFFVSW", "url": "https://omabrowser.org/oma/group/RVFFVSW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5010334at2759", "url": "http://www.orthodb.org/?query=5010334at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11003:SF342", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11003:SF342", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07885", "url": "http://pfam.xfam.org/family/PF07885", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P40310", "url": "http://purl.obolibrary.org/obo/PR_P40310", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_012442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000003629", "url": "https://www.yeastgenome.org/locus/S000003629", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P40310-1", "url": "https://www.uniprot.org/uniprot/P40310-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRFMNSFAKQTLGYGNMATVEQESSAQAVDSHSNNTPKQAKGVLAEELKDALRFRDERVSIINAEPSSTLFVFWFVVSCYFPVITACLGPVANTISIACVVEKWRSLKNNSVVTNPRSNDTDVLMNQVKTVFDPPGIFAVNIISLVLGFTSNIILMLHFSKKLTYLKSQLINITGWTIAGGMLLVDVIVCSLNDMPSIYSKTIGFWFACISSGLYLVCTIILTIHFIGYKLGKYPPTFNLLPNERSIMAYTVLLSLWLIWGAGMFSGLLHITYGNALYFCTVSLLTVGLGDILPKSVGAKIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGPIFFFHRVEKGRSKSWKHYMDSSKNLSEREAFDLMKCIRQTASRKQHWFSLSVTIAIFMAFWLLGALVFKFAENWSYFNCIYFCFLCLLTIGYGDYAPRTGAGRAFFVIWALGAVPLMGAILSTVGDLLFDISTSLDIKIGESFNNKVKSIVFNGRQRALSFMVNTGEIFEESDTADGDLEENTTSSQSSQISEFNDNNSEENDSGVTSPPASLQESFSSLSKASSPEGILPLEYVSSAEYALQDSGTCNLRNLQELLKAVKKLHRICLADKDYTLSFSDWSYIHKLHLRNITDIEEYTRGPEFWISPDTPLKFPLNEPHFAFMMLFKNIEELVGNLVEDEELYKVISKRKFLGEHRKTL", "length": 691, "header": "sp|P40310-1|TOK1_YEAST Isoform 1 of Outward-rectifier potassium channel TOK1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=TOK1 PE=1 SV=1 CANONICAL=P40310-1" }, "isoforms": [ { "isoform_ac": "P40310-1", "url": "", "sequence": { "sequence": "MTRFMNSFAKQTLGYGNMATVEQESSAQAVDSHSNNTPKQAKGVLAEELKDALRFRDERVSIINAEPSSTLFVFWFVVSCYFPVITACLGPVANTISIACVVEKWRSLKNNSVVTNPRSNDTDVLMNQVKTVFDPPGIFAVNIISLVLGFTSNIILMLHFSKKLTYLKSQLINITGWTIAGGMLLVDVIVCSLNDMPSIYSKTIGFWFACISSGLYLVCTIILTIHFIGYKLGKYPPTFNLLPNERSIMAYTVLLSLWLIWGAGMFSGLLHITYGNALYFCTVSLLTVGLGDILPKSVGAKIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGPIFFFHRVEKGRSKSWKHYMDSSKNLSEREAFDLMKCIRQTASRKQHWFSLSVTIAIFMAFWLLGALVFKFAENWSYFNCIYFCFLCLLTIGYGDYAPRTGAGRAFFVIWALGAVPLMGAILSTVGDLLFDISTSLDIKIGESFNNKVKSIVFNGRQRALSFMVNTGEIFEESDTADGDLEENTTSSQSSQISEFNDNNSEENDSGVTSPPASLQESFSSLSKASSPEGILPLEYVSSAEYALQDSGTCNLRNLQELLKAVKKLHRICLADKDYTLSFSDWSYIHKLHLRNITDIEEYTRGPEFWISPDTPLKFPLNEPHFAFMMLFKNIEELVGNLVEDEELYKVISKRKFLGEHRKTL", "length": 691, "header": "sp|P40310-1|TOK1_YEAST Isoform 1 of Outward-rectifier potassium channel TOK1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=TOK1 PE=1 SV=1 CANONICAL=P40310-1" }, "locus": { "chromosome": "X", "start_pos": 256812, "end_pos": 254740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YJL093C_mRNA", "url": "https://www.ensembl.org/id/YJL093C_mRNA" }, { "database": "Ensembl Peptide", "id": "YJL093C", "url": "https://www.ensembl.org/id/YJL093C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 119, "end_pos": 119, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "iPTMnet", "id": "P40310", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40310" }, { "database": "SGD", "id": "P40310", "url": "https://www.yeastgenome.org/locus/P40310" } ], "site_lbl": "Ser119" } ], "glycation": [], "keywords": [], "publication": [ { "title": "A global topology map of the Saccharomyces cerevisiae membrane proteome.", "journal": "Proc. 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U.S.A.", "date": "2006", "authors": "Kim H., von Heijne G., Melen K., Oesterberg M.", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "reference": [ { "type": "PubMed", "id": "16847258", "url": "https://glygen.org/publication/PubMed/16847258" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008-07", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" }, { "database": "iPTMnet", "id": "P40310", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40310" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Plasma-membrane hyperpolarization diminishes the cation efflux via Nha1 antiporter and Ena ATPase under potassium-limiting conditions.", "journal": "FEMS Yeast Res.", "date": "2012", "authors": "Sychrova H., Zahradka J.", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "reference": [ { "type": "PubMed", "id": "22329368", "url": "https://glygen.org/publication/PubMed/22329368" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.", "journal": "Nature", "date": "1995", "authors": "Kaczmarek L.K., Goldstein S.A.N., Joiner W.J., Ketchum K.A., Sellers A.J.", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "reference": [ { "type": "PubMed", "id": "7651518", "url": "https://glygen.org/publication/PubMed/7651518" } ] }, { "title": "Sequence and function analysis of a 9.46 kb fragment of Saccharomyces cerevisiae chromosome X.", "journal": "Yeast", "date": "1994", "authors": "Miosga T., Zimmermann F.K., Witzel A.", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "reference": [ { "type": "PubMed", "id": "7985424", "url": "https://glygen.org/publication/PubMed/7985424" } ] }, { "title": "A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties.", "journal": "J. Biol. Chem.", "date": "1996", "authors": "Lazdunski M., Fink M., Barhanin J., Lesage F., Duprat F., Guillemare E., Romey G.", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "reference": [ { "type": "PubMed", "id": "8626760", "url": "https://glygen.org/publication/PubMed/8626760" } ] }, { "title": "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.", "journal": "EMBO J.", "date": "1996", "authors": "Mewes H.-W., Obermaier B., Wambutt R., Wedler H., Pujol A., Galibert F., Rose M., Boles E., Durand P., Portetelle D., Zagulski M., Kleine K., Manus V., Rossau R., Cziepluch C., Jauniaux J.-C., Soriano N., Chuat J.-C., Koetter P., Entian K.-D., Kordes E., Louis E.J., Hollenberg C.P., Vandenbol M., Domdey H., Pohl T.M., Scarcez T., Goffeau A., Grivell L.A., Herbert C.J., Hilger F., Jacq C., Miosga T., Perea J., Schaaff-Gerstenschlaeger I., Zollner A., Alexandraki D., Huang M.-E., Kirchrath L., Purnelle B., Ramezani Rad M., Tzermia M., Baur A., Chalwatzis N., Coster F., Gatius M., Hennemann A., Heumann K., Karpfinger-Hartl L., Katsoulou C., Liebl S., Rasmussen S.W., Smits P.H.M., To Van D., Van Broekhoven A., de Haan M., von Wettstein D.", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "reference": [ { "type": "PubMed", "id": "8641269", "url": "https://glygen.org/publication/PubMed/8641269" } ] }, { "title": "The S. cerevisiae outwardly-rectifying potassium channel (DUK1) identifies a new family of channels with duplicated pore domains.", "journal": "Recept. Channels", "date": "1996", "authors": "North R.A., Shafaatian R., Guy H.R., Reid J.D., Bertl A., Lukas W., Scheurmann-Kettner C.", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "reference": [ { "type": "PubMed", "id": "8723646", "url": "https://glygen.org/publication/PubMed/8723646" } ] } ], "pathway": [ { "id": "sce:YJL093C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YJL093C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "outward rectifier potassium channel activity", "id": "GO:0015271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015271", "evidence": [ { "database": "UniProtKB", "id": "P40310", "url": "https://www.uniprot.org/uniprot/P40310" } ], "pmid": "" }, { "name": "potassium ion leak channel activity", "id": "GO:0022841", "url": 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