{ "uniprot_canonical_ac": "P40088-1", "uniprot_ac": "P40088", "uniprot_id": "FTR1_YEAST", "mass": { "chemical_mass": 45722.0, "monoisotopic_mass": 45722.0 }, "refseq": { "ac": "NP_011072", "name": "high-affinity iron permease FTR1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011072" }, "gene_names": [ { "name": "FTR1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P40088", "id": "P40088" }, { "name": "FTR1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011072", "id": "NP_011072" } ], "protein_names": [ { "name": "Plasma membrane iron permease", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P40088" }, { "name": "high-affinity iron permease FTR1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011072", "id": "NP_011072" } ], "function": [ { "annotation": "Permease for high affinity iron uptake.", "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "common_name": "Yeast" } ], "gene": [ { "name": "FTR1", "url": "https://www.uniprot.org/uniprot/P40088", "locus": {} } ], "crossref": [ { "id": "856888", "url": "https://www.ncbi.nlm.nih.gov/gene/856888", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P40088", "url": "https://www.ebi.ac.uk/intact/interactors/id:P40088*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR004923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YER145C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YER145C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SVWHLDC", "url": "https://omabrowser.org/oma/group/SVWHLDC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1386471at2759", "url": "http://www.orthodb.org/?query=1386471at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31632", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31632", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31632:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31632:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03239", "url": "http://pfam.xfam.org/family/PF03239", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P40088", "url": "http://purl.obolibrary.org/obo/PR_P40088", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_011072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011072", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000947", "url": "https://www.yeastgenome.org/locus/S000000947", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P40088-1", "url": "https://www.uniprot.org/uniprot/P40088-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPNKVFNVAVFFVVFRECLEAVIVISVLLSFLKQAIGEHDRALYRKLRIQVWVGVLLGFIICLAIGAGFIGAYYSLQKDIFGSAEDLWEGIFCMIATIMISMMGIPMLRMNKMQSKWRVKIARSLVEIPHRKRDYFKIGFLSRRYAMFLLPFITVLREGLEAVVFVAGAGITTQGSHASAYPLPVVVGLICGGLVGYLLYYGASKSSLQIFLILSTSILYLISAGLFSRGAWYFENYRFNLASGGDASEGGDGNGSYNIRKAVYHVNCCNPELDNGWDIFNALLGWQNTGYLSSMLCYNIYWLVLIIVLSLMIFEERRGHLPFTKNLQLKHLNPGYWIKNKKKQELTEEQKRQLFAKMENINFNEDGEINVQENYELPEQTTSHSSSQNVATDKEVLHVKADSL", "length": 404, "header": "sp|P40088-1|FTR1_YEAST Isoform 1 of Plasma membrane iron permease OS=Saccharomyces cerevisiae S288C OX=559292 GN=FTR1 PE=1 SV=1 CANONICAL=P40088-1" }, "isoforms": [ { "isoform_ac": "P40088-1", "url": "", "sequence": { "sequence": "MPNKVFNVAVFFVVFRECLEAVIVISVLLSFLKQAIGEHDRALYRKLRIQVWVGVLLGFIICLAIGAGFIGAYYSLQKDIFGSAEDLWEGIFCMIATIMISMMGIPMLRMNKMQSKWRVKIARSLVEIPHRKRDYFKIGFLSRRYAMFLLPFITVLREGLEAVVFVAGAGITTQGSHASAYPLPVVVGLICGGLVGYLLYYGASKSSLQIFLILSTSILYLISAGLFSRGAWYFENYRFNLASGGDASEGGDGNGSYNIRKAVYHVNCCNPELDNGWDIFNALLGWQNTGYLSSMLCYNIYWLVLIIVLSLMIFEERRGHLPFTKNLQLKHLNPGYWIKNKKKQELTEEQKRQLFAKMENINFNEDGEINVQENYELPEQTTSHSSSQNVATDKEVLHVKADSL", "length": 404, "header": "sp|P40088-1|FTR1_YEAST Isoform 1 of Plasma membrane iron permease OS=Saccharomyces cerevisiae S288C OX=559292 GN=FTR1 PE=1 SV=1 CANONICAL=P40088-1" }, "locus": { "chromosome": "V", "start_pos": 461740, "end_pos": 460529, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YER145C_mRNA", "url": "https://www.ensembl.org/id/YER145C_mRNA" }, { "database": "Ensembl Peptide", "id": "YER145C", "url": "https://www.ensembl.org/id/YER145C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 403, "end_pos": 403, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P40088", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40088" }, { "database": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "P40088", "url": "https://www.yeastgenome.org/locus/P40088" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser403" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.", "journal": "Molecular & cellular proteomics : MCP", "date": "2005-03", "authors": "Gruhler Albrecht, Olsen Jesper V, Mohammed Shabaz, Mortensen Peter, Faergeman Nils J, Mann Matthias, Jensen Ole N", "evidence": [ { "database": "iPTMnet", "id": "P40088", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40088" } ], "reference": [ { "type": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "iPTMnet", "id": "P40088", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40088" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast.", "journal": "Proteomics", "date": "2009-10", "authors": "Gnad Florian, de Godoy Lyris M F, Cox J\u00fcrgen, Neuhauser Nadin, Ren Shubin, Olsen Jesper V, Mann Matthias", "evidence": [ { "database": "iPTMnet", "id": "P40088", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40088" } ], "reference": [ { "type": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" } ] }, { "title": "Global analysis of the yeast osmotic stress response by quantitative proteomics.", "journal": "Molecular bioSystems", "date": "2009-11", "authors": "Soufi Boumediene, Kelstrup Christian D, Stoehr Gabriele, Fr\u00f6hlich Florian, Walther Tobias C, Olsen Jesper V", "evidence": [ { "database": "iPTMnet", "id": "P40088", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40088" } ], "reference": [ { "type": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", "evidence": [ { "database": "iPTMnet", "id": "P40088", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40088" } ], "reference": [ { "type": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "A permease-oxidase complex involved in high-affinity iron uptake in yeast.", "journal": "Science", "date": "1996", "authors": "Klausner R.D., Yuan D.S., Stearman R., Dancis A., Yamaguchi-Iwai Y.", "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "reference": [ { "type": "PubMed", "id": "8599111", "url": "https://glygen.org/publication/PubMed/8599111" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.", "journal": "Nature", "date": "1997", "authors": "Smith V., Chen E., Guzman E., Chung E., Nakahara K., Botstein D., Davis R.W., Lin D., Wei Y., Duncan M., Berno A., Oh C., Oefner P., Taylor P., Lashkari D., Allen E., Hyman R.W., Araujo R., Komp C., Lew H., Namath A., Roberts D., Mulligan J.T., Sehl P., Schramm S., Hartzell G., Cherry J.M., Dietrich F.S., Aviles E., Brennan T., Carpenter J., Hennessy K.M., Hunicke-Smith S., Kayser A., Mosedale D., Norgren R., Petel F.X., Shogren T., Yelton M.A.", "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "reference": [ { "type": "PubMed", "id": "9169868", "url": "https://glygen.org/publication/PubMed/9169868" } ] } ], "pathway": [ { "id": "sce:YER145C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YER145C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "iron ion transmembrane transport", "id": "GO:0034755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034755", "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "pmid": "" }, { "name": "iron ion import across cell outer membrane", "id": "GO:0098706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098706", "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "pmid": "" }, { "name": "arsenate ion transmembrane transport", "id": "GO:1901684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901684", "evidence": [ { "database": "UniProtKB", "id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "pmid": "" } ] }, { "name": "Cellular Component", 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"id": "P40088", "url": "https://www.uniprot.org/uniprot/P40088" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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