{
    "uniprot_canonical_ac": "P40013-1",
    "uniprot_ac": "P40013",
    "uniprot_id": "BIM1_YEAST",
    "mass": {
        "chemical_mass": 38362.0,
        "monoisotopic_mass": 38362.0
    },
    "refseq": {
        "ac": "NP_010932",
        "name": "microtubule-binding protein BIM1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010932"
    },
    "gene_names": [
        {
            "name": "BIM1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P40013",
            "id": "P40013"
        },
        {
            "name": "BIM1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010932",
            "id": "NP_010932"
        },
        {
            "name": "YEB1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010932",
            "id": "NP_010932"
        }
    ],
    "protein_names": [
        {
            "name": "Protein BIM1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P40013"
        },
        {
            "name": "microtubule-binding protein BIM1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010932",
            "id": "NP_010932"
        }
    ],
    "function": [
        {
            "annotation": "Binds microtubules.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P40013",
                    "url": "https://www.uniprot.org/uniprot/P40013#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0112243",
            "recommended_name": {
                "id": "DOID:0112243",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112243",
                "name": "congenital symmetric circumferential skin creases 2",
                "description": "A multiple benign circumferential skin creases on limbs characterized by folding of excess skin, which leads to ringed creases, primarily of the limbs, intellectual disability, cleft palate, and dysmorphic features that has_material_basis_in heterozygous mutation in the MAPRE2 gene on chromosome 18q12.1-q12.2."
            },
            "synonyms": [
                {
                    "id": "DOID:0112243",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112243",
                    "name": "CSCSC2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014755",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014755",
                    "name": "skin creases, congenital symmetric circumferential, 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014755",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014755",
                    "name": "CSCSC2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014755",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014755",
                    "name": "MAPRE2 multiple benign circumferential skin creases on limbs",
                    "description": ""
                },
                {
                    "id": "MONDO:0014755",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014755",
                    "name": "multiple benign circumferential skin creases on limbs caused by mutation in MAPRE2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014755",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014755",
                    "name": "skin creases, congenital symmetric circumferential, 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014755",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014755",
                    "name": "skin creases, congenital symmetric circumferential, 2; CSCSC2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014755",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014755",
                    "name": "skin creases, congenital symmetric circumferential, type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014755",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014755",
                    "name": "symmetric circumferential skin creases, congenital, 2",
                    "description": ""
                },
                {
                    "id": "MIM:616734",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/616734",
                    "name": "Skin creases, congenital symmetric circumferential, 2",
                    "description": "Skin creases, congenital symmetric circumferential, 2"
                }
            ],
            "evidence": [
                {
                    "id": "0112243",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112243"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P40013",
                    "url": "https://www.uniprot.org/uniprot/P40013"
                }
            ],
            "common_name": "Yeast"
        }
    ],
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        {
            "name": "BIM1",
            "url": "https://www.uniprot.org/uniprot/P40013",
            "locus": {
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                "start_pos": 189311,
                "end_pos": 188277,
                "strand": "-",
                "evidence": [
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                        "id": "YER016W",
                        "url": "https://www.ensembl.org/id/YER016W"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "856736",
            "url": "https://www.ncbi.nlm.nih.gov/gene/856736",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P40013",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P40013*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001715",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR004953",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004953",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027328",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027328",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036133",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036133",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036872",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YER016W",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YER016W",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "CQIYDSI",
            "url": "https://omabrowser.org/oma/group/CQIYDSI/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "11676at2759",
            "url": "http://www.orthodb.org/?query=11676at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10623",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10623",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10623:SF6",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10623:SF6",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2QJX",
            "url": "https://www.rcsb.org/structure/2QJX",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "4E61",
            "url": "https://www.rcsb.org/structure/4E61",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "6FC6",
            "url": "https://www.rcsb.org/structure/6FC6",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF03271",
            "url": "http://pfam.xfam.org/family/PF03271",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P40013",
            "url": "http://purl.obolibrary.org/obo/PR_P40013",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_010932",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010932",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000000818",
            "url": "https://www.yeastgenome.org/locus/S000000818",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P40013",
            "url": "https://www.uniprot.org/uniprot/P40013",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P40013-1",
            "url": "https://www.uniprot.org/uniprot/P40013-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSAGIGESRTELLTWLNGLLNLNYKKIEECGTGAAYCQIMDSIYGDLPMNRVKFNATAEYEFQTNYKILQSCFSRHGIEKTVYVDKLIRCKFQDNLEFLQWLKKHWIRHKDESVYDPDARRKYRPIITNNSATKPRTVSNPTTAKRSSSTGTGSAMSGGLATRHSSLGINGSRKTSVTQGQLVAIQAELTKSQETIGSLNEEIEQYKGTVSTLEIEREFYFNKLRDIEILVHTTQDLINEGVYKFNDETITGHGNGNGGALLRFVKKVESILYATAEGFEMNDGEDELNDKNLGEHGTVPNQGGYANSNGEVNGNEGSNHDVIMQNDEGEVGVSNNLIIDEETF",
        "length": 344,
        "header": "sp|P40013-1|BIM1_YEAST Isoform 1 of Protein BIM1  OS=Saccharomyces cerevisiae S288C OX=559292 GN=BIM1 PE=1 SV=1 CANONICAL=P40013-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P40013-1",
            "url": "",
            "sequence": {
                "sequence": "MSAGIGESRTELLTWLNGLLNLNYKKIEECGTGAAYCQIMDSIYGDLPMNRVKFNATAEYEFQTNYKILQSCFSRHGIEKTVYVDKLIRCKFQDNLEFLQWLKKHWIRHKDESVYDPDARRKYRPIITNNSATKPRTVSNPTTAKRSSSTGTGSAMSGGLATRHSSLGINGSRKTSVTQGQLVAIQAELTKSQETIGSLNEEIEQYKGTVSTLEIEREFYFNKLRDIEILVHTTQDLINEGVYKFNDETITGHGNGNGGALLRFVKKVESILYATAEGFEMNDGEDELNDKNLGEHGTVPNQGGYANSNGEVNGNEGSNHDVIMQNDEGEVGVSNNLIIDEETF",
                "length": 344,
                "header": "sp|P40013-1|BIM1_YEAST Isoform 1 of Protein BIM1  OS=Saccharomyces cerevisiae S288C OX=559292 GN=BIM1 PE=1 SV=1 CANONICAL=P40013-1"
            },
            "locus": {
                "chromosome": "V",
                "start_pos": 189308,
                "end_pos": 188277,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YER016W_mRNA",
                        "url": "https://www.ensembl.org/id/YER016W_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YER016W",
                        "url": "https://www.ensembl.org/id/YER016W"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 139,
            "end_pos": 139,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "19795423",
                    "url": "https://glygen.org/publication/PubMed/19795423"
                },
                {
                    "database": "PubMed",
                    "id": "19823750",
                    "url": "https://glygen.org/publication/PubMed/19823750"
                },
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser139"
        },
        {
            "start_pos": 147,
            "end_pos": 147,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                },
                {
                    "database": "PubMed",
                    "id": "20702584",
                    "url": "https://glygen.org/publication/PubMed/20702584"
                },
                {
                    "database": "PubMed",
                    "id": "21126336",
                    "url": "https://glygen.org/publication/PubMed/21126336"
                },
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                }
            ],
            "site_lbl": "Ser147"
        },
        {
            "start_pos": 148,
            "end_pos": 148,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                },
                {
                    "database": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                },
                {
                    "database": "PubMed",
                    "id": "20702584",
                    "url": "https://glygen.org/publication/PubMed/20702584"
                },
                {
                    "database": "PubMed",
                    "id": "21177495",
                    "url": "https://glygen.org/publication/PubMed/21177495"
                },
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser148"
        },
        {
            "start_pos": 149,
            "end_pos": 149,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "PubMed",
                    "id": "20702584",
                    "url": "https://glygen.org/publication/PubMed/20702584"
                },
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser149"
        },
        {
            "start_pos": 150,
            "end_pos": 150,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                },
                {
                    "database": "PubMed",
                    "id": "20702584",
                    "url": "https://glygen.org/publication/PubMed/20702584"
                },
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                }
            ],
            "site_lbl": "Thr150"
        },
        {
            "start_pos": 152,
            "end_pos": 152,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "PubMed",
                    "id": "20702584",
                    "url": "https://glygen.org/publication/PubMed/20702584"
                },
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                }
            ],
            "site_lbl": "Thr152"
        },
        {
            "start_pos": 154,
            "end_pos": 154,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "20702584",
                    "url": "https://glygen.org/publication/PubMed/20702584"
                },
                {
                    "database": "PubMed",
                    "id": "21177495",
                    "url": "https://glygen.org/publication/PubMed/21177495"
                },
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                }
            ],
            "site_lbl": "Ser154"
        },
        {
            "start_pos": 157,
            "end_pos": 157,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P40013",
                    "url": "https://www.uniprot.org/uniprot/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "17287358",
                    "url": "https://glygen.org/publication/PubMed/17287358"
                },
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                }
            ],
            "site_lbl": "Ser157"
        },
        {
            "start_pos": 162,
            "end_pos": 162,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                },
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Thr162"
        },
        {
            "start_pos": 165,
            "end_pos": 165,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P40013",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "17287358",
                    "url": "https://glygen.org/publication/PubMed/17287358"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "SGD",
                    "id": "P40013",
                    "url": "https://www.yeastgenome.org/locus/P40013"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
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                    {
                        "name": "nuclear migration along microtubule",
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                                "id": "P40013",
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                        "pmid": ""
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                "name": "Cellular Component",
                "total": 6,
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                        "name": "spindle pole",
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                        "pmid": ""
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