{ "uniprot_canonical_ac": "P39945-1", "uniprot_ac": "P39945", "uniprot_id": "AST2_YEAST", "mass": { "chemical_mass": 48371.0, "monoisotopic_mass": 48371.0 }, "refseq": { "ac": "NP_011027", "name": "Ast2p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011027" }, "gene_names": [ { "name": "AST2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P39945", "id": "P39945" }, { "name": "AST2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011027", "id": "NP_011027" } ], "protein_names": [ { "name": "Protein AST2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P39945" }, { "name": "ATPAse stabilizing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P39945" }, { "name": "Ast2p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011027", "id": "NP_011027" } ], "function": [ { "annotation": "Lipid raft-associated protein involved in the targeting of PMA1 from Golgi to the plasma membrane (Probable). May induce clustering of PMA1, which facilitates partition of PMA1 into lipid rafts after leaving the ER its and transport to the cell surface (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945#function" }, { "database": "PubMed", "id": "7822420", "url": "https://glygen.org/publication/PubMed/7822420" }, { "database": "UniProtKB", "id": "P35183", "url": "https://www.uniprot.org/uniprot/P35183#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945" } ], "common_name": "Yeast" } ], "gene": [ { "name": "AST2", "url": "https://www.uniprot.org/uniprot/P39945", "locus": {} } ], "crossref": [ { "id": "cd08247", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08247", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "856838", "url": "https://www.ncbi.nlm.nih.gov/gene/856838", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P39945", "url": "https://www.ebi.ac.uk/intact/interactors/id:P39945*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR011032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YER101C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YER101C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IGREYSG", "url": "https://omabrowser.org/oma/group/IGREYSG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2007886at2759", "url": "http://www.orthodb.org/?query=2007886at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43482", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43482", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43482:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43482:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08240", "url": "http://pfam.xfam.org/family/PF08240", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13602", "url": "http://pfam.xfam.org/family/PF13602", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P39945", "url": "http://purl.obolibrary.org/obo/PR_P39945", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_011027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011027", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000903", "url": "https://www.yeastgenome.org/locus/S000000903", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P39945-1", "url": "https://www.uniprot.org/uniprot/P39945-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEKILENKDPKLEAMTVDHEVSAPKPIPVDEPTLTRVARPLRHVRHIPVKSLVFHSKHGPITFSYENKIKLPISKNKLVVQVNYVGLNPVDMKIRNGYTKPIYGEAGIGREYSGVITHVGDNLTNRWNVGDDVYGIYYHPKLAIGALQSSLLIDPRVDPILMRPKNTLSPEKAAGSLFCLGTALNLLAQLKEKDQLNTESNVLINGGTSSVGMFAIQLLKRYYKVSKKLVVVTSGNGAAVLSEHFPDLKDEIIFINYLSCRGKSSKPLRRMLDTGKVVDYDDFNTLKETEDYTQGKFNVVLDFIGGYDILSHSSSLIHAKGAYITTVGDYVGNYKKDVFDSWDNPSANARKMFGSMLWSYDYSHFYFDPNIKIIPKKNDWIHECGKLLNEGVVDCVVDKVYSWKNFKEAFSYMATQRAQGKLIMKVEGF", "length": 430, "header": "sp|P39945-1|AST2_YEAST Isoform 1 of Protein AST2 OS=Saccharomyces cerevisiae S288C OX=559292 GN=AST2 PE=1 SV=1 CANONICAL=P39945-1" }, "isoforms": [ { "isoform_ac": "P39945-1", "url": "", "sequence": { "sequence": "MAEKILENKDPKLEAMTVDHEVSAPKPIPVDEPTLTRVARPLRHVRHIPVKSLVFHSKHGPITFSYENKIKLPISKNKLVVQVNYVGLNPVDMKIRNGYTKPIYGEAGIGREYSGVITHVGDNLTNRWNVGDDVYGIYYHPKLAIGALQSSLLIDPRVDPILMRPKNTLSPEKAAGSLFCLGTALNLLAQLKEKDQLNTESNVLINGGTSSVGMFAIQLLKRYYKVSKKLVVVTSGNGAAVLSEHFPDLKDEIIFINYLSCRGKSSKPLRRMLDTGKVVDYDDFNTLKETEDYTQGKFNVVLDFIGGYDILSHSSSLIHAKGAYITTVGDYVGNYKKDVFDSWDNPSANARKMFGSMLWSYDYSHFYFDPNIKIIPKKNDWIHECGKLLNEGVVDCVVDKVYSWKNFKEAFSYMATQRAQGKLIMKVEGF", "length": 430, "header": "sp|P39945-1|AST2_YEAST Isoform 1 of Protein AST2 OS=Saccharomyces cerevisiae S288C OX=559292 GN=AST2 PE=1 SV=1 CANONICAL=P39945-1" }, "locus": { "chromosome": "V", "start_pos": 361794, "end_pos": 360505, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YER101C_mRNA", "url": "https://www.ensembl.org/id/YER101C_mRNA" }, { "database": "Ensembl Peptide", "id": "YER101C", "url": "https://www.ensembl.org/id/YER101C" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole.", "journal": "J. Cell Biol.", "date": "1995", "authors": "Chang A., Fink G.R.", "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945" } ], "reference": [ { "type": "PubMed", "id": "7822420", "url": "https://glygen.org/publication/PubMed/7822420" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.", "journal": "Nature", "date": "1997", "authors": "Smith V., Chen E., Guzman E., Chung E., Nakahara K., Botstein D., Davis R.W., Lin D., Wei Y., Duncan M., Berno A., Oh C., Oefner P., Taylor P., Lashkari D., Allen E., Hyman R.W., Araujo R., Komp C., Lew H., Namath A., Roberts D., Mulligan J.T., Sehl P., Schramm S., Hartzell G., Cherry J.M., Dietrich F.S., Aviles E., Brennan T., Carpenter J., Hennessy K.M., Hunicke-Smith S., Kayser A., Mosedale D., Norgren R., Petel F.X., Shogren T., Yelton M.A.", "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945" } ], "reference": [ { "type": "PubMed", "id": "9169868", "url": "https://glygen.org/publication/PubMed/9169868" } ] } ], "pathway": [ { "id": "sce:YER101C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YER101C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "P39945", "url": "https://www.uniprot.org/uniprot/P39945" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }