{ "uniprot_canonical_ac": "P39736-1", "uniprot_ac": "P39736", "uniprot_id": "BX42_DROME", "mass": { "chemical_mass": 61157.0, "monoisotopic_mass": 61157.0 }, "refseq": { "ac": "NP_001259370", "name": "Bx42, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259370" }, "gene_names": [ { "name": "Bx42", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P39736", "id": "P39736" }, { "name": "BX42", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P39736", "id": "P39736" }, { "name": "Bx-42; bx42; BX42; CG8264; Dmel\\CG8264; Skip; SKIP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259370", "id": "NP_001259370" }, { "name": "Bx42", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259370", "id": "NP_001259370" }, { "name": "CG8264", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P39736", "id": "P39736" }, { "name": "Dmel\\CG8264", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P39736", "id": "P39736" }, { "name": "Dmel_CG8264", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P39736", "id": "P39736" }, { "name": "SKIP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P39736", "id": "P39736" }, { "name": "Skip", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P39736", "id": "P39736" }, { "name": "bx42", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P39736", "id": "P39736" } ], "protein_names": [ { "name": "Puff-specific protein Bx42", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P39736" }, { "name": "Bx42, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259370", "id": "NP_001259370" }, { "name": "CG8264-PB; Bx42-PB; Ski-interacting protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259370", "id": "NP_001259370" } ], "function": [ { "annotation": "May play a role in chromatin structure and function.", "evidence": [ { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736#function" } ] } ], "disease": [ { "disease_id": "DOID:11446", "recommended_name": { "id": "DOID:11446", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11446", "name": "sciatic neuropathy", "description": "" }, "synonyms": [], "evidence": [ { "id": "11446", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:11446" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "evidence": [ { "id": "1612", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "evidence": [ { "id": "1793", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:3459", "recommended_name": { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "breast carcinoma", "description": "A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "Mammary carcinoma", "description": "" }, { "id": "DOID:3459", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3459", "name": "carcinoma of breast", "description": "" } ], "evidence": [ { "id": "3459", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3459" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Bx42", "url": "https://www.uniprot.org/uniprot/P39736", "locus": { "chromosome": "X", "start_pos": 9103870, "end_pos": 9106604, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0004856", "url": "https://www.ensembl.org/id/FBgn0004856" } ] } } ], "crossref": [ { "id": "FBgn0004856", "url": "https://bgee.org/?page=gene&gene_id=FBgn0004856", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0004856", "url": "https://flybase.org/reports/FBgn0004856", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "31840", "url": "https://www.ncbi.nlm.nih.gov/gene/31840", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P39736", "url": "https://www.ebi.ac.uk/intact/interactors/id:P39736*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR004015", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004015", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017862", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017862", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG8264", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8264", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YGQRRGW", "url": "https://omabrowser.org/oma/group/YGQRRGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5490078at2759", "url": "http://www.orthodb.org/?query=5490078at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12096", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12096", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12096:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12096:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02731", "url": "http://pfam.xfam.org/family/PF02731", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P39736", "url": "http://purl.obolibrary.org/obo/PR_P39736", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-2173795", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2173795", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-350054", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-350054", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72163", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001259370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259370", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9PGQ6-1", "url": "https://www.uniprot.org/uniprot/M9PGQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P39736-1", "url": "https://www.uniprot.org/uniprot/P39736-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLSSLLPTPTNAIWDREDERRLVARGAPKIGALVSAKIAAPPYGQRKDWVPHTDADFGDGGAFPEIHVAQYPLGLGAPGNVGKKSDALAVRLDDKGKVKYDAIARQGHGKDKIVYSSISQLLPAEVLAEDADELQRPDEETVMETTEETRLALEKLTNQKITSALPVRHAQKAGPAQYIRYTPSQQGDTFNSGAKQRVIRMVEAQLDPMEPPKFRINKKIPRGPPSPPAPVLHSPSRKVTVKEQKEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQQVHINEKFAKMAEALYIADRKAREAVEARSQLEKKLAQKEKEKKEDMLRMMAQRAREERAGLRNPEAAEPSGSGATGSEVRERNDLRAERQRERQRDRNLQRAAPEKRSKLQKERERDISEQIALGLPAKSAGNGETLFDQRLFNTTKGMDSGYGDDEAYNVYDKPWRDSNTLGAHIYRPSKQADSDNYGGDLDAIVNTKRFVPDKQFSGASKEAAAGQRSGPVEFEKEEDPFGLDQFLNMAKKAPKRAEEKNNERSSHSDRKRSKRD", "length": 547, "header": "sp|P39736-1|BX42_DROME Isoform 1 of Puff-specific protein Bx42 OS=Drosophila melanogaster OX=7227 GN=Bx42 PE=1 SV=1 CANONICAL=P39736-1" }, "isoforms": [ { "isoform_ac": "M9PGQ6-1", "url": "", "sequence": { "sequence": "MSLSSLLPTPTNAIWDREDERRLVARGAPKIGALVSAKIAAPPYGQRKDWVPHTDADFGDGGAFPEIHVAQYPLGLGAPGNVGKKSDALAVRLDDKGKVKYDAIARQGHGKDKIVYSSISQLLPAEVLAEDADELQRPDEETVMETTEETRLALEKLTNQKITSALPVRHAQKAGPAQYIRYTPSQQGDTFNSGAKQRVIRMVEAQLDPMEPPKFRINKKIPRGPPSPPAPVLHSPSRKVTVKEQKEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQQVHINEKFAKMAEALYIADRKAREAVEARSQLEKKLAQKEKEKKEDMLRMMAQRAREERAGLRNPEAAEPSGSGATGSEVRERNDLRAERQRERQRDRNLQRAAPEKRSKLQKERERDISEQIALGLPAKSAGNGETLFDQRLFNTTKGMDSGYGDDEAYNVYDKPWRDSNTLGAHIYRPSKQADSDNYGGDLDAIVNTKRFVPDKQFSGASKEAAAGQRSGPVEFEKEEDPFGLDQFLNMAKKAPKRAEEKNNERSSHSDRKRSKRD", "length": 547, "header": "tr|M9PGQ6-1|BX42_DROME Computationally mapped isoform of Puff-specific protein Bx42 OS=Drosophila melanogaster OX=7227 GN=Bx42 PE=1 SV=1 CANONICAL=P39736-1" }, "locus": { "chromosome": "X", "start_pos": 9106447, "end_pos": 9104475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0071350", "url": "https://www.ensembl.org/id/FBtr0071350" }, { "database": "Ensembl Peptide", "id": "FBpp0071285", "url": "https://www.ensembl.org/id/FBpp0071285" } ] } }, { "isoform_ac": "P39736-1", "url": "", "sequence": { "sequence": "MSLSSLLPTPTNAIWDREDERRLVARGAPKIGALVSAKIAAPPYGQRKDWVPHTDADFGDGGAFPEIHVAQYPLGLGAPGNVGKKSDALAVRLDDKGKVKYDAIARQGHGKDKIVYSSISQLLPAEVLAEDADELQRPDEETVMETTEETRLALEKLTNQKITSALPVRHAQKAGPAQYIRYTPSQQGDTFNSGAKQRVIRMVEAQLDPMEPPKFRINKKIPRGPPSPPAPVLHSPSRKVTVKEQKEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQQVHINEKFAKMAEALYIADRKAREAVEARSQLEKKLAQKEKEKKEDMLRMMAQRAREERAGLRNPEAAEPSGSGATGSEVRERNDLRAERQRERQRDRNLQRAAPEKRSKLQKERERDISEQIALGLPAKSAGNGETLFDQRLFNTTKGMDSGYGDDEAYNVYDKPWRDSNTLGAHIYRPSKQADSDNYGGDLDAIVNTKRFVPDKQFSGASKEAAAGQRSGPVEFEKEEDPFGLDQFLNMAKKAPKRAEEKNNERSSHSDRKRSKRD", "length": 547, "header": "sp|P39736-1|BX42_DROME Isoform 1 of Puff-specific protein Bx42 OS=Drosophila melanogaster OX=7227 GN=Bx42 PE=1 SV=1 CANONICAL=P39736-1" }, "locus": { "chromosome": "X", "start_pos": 9106447, "end_pos": 9104475, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0071350", "url": "https://www.ensembl.org/id/FBtr0071350" }, { "database": "Ensembl Peptide", "id": "FBpp0071285", "url": "https://www.ensembl.org/id/FBpp0071285" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "P39736", "url": "http://phospho.elm.eu.org/byAccession/P39736.html" }, { "database": "iPTMnet", "id": "P39736", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P39736" } ], "site_lbl": "Ser227" }, { "start_pos": 235, "end_pos": 235, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "P39736", "url": "http://phospho.elm.eu.org/byAccession/P39736.html" }, { "database": "iPTMnet", "id": "P39736", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P39736" } ], "site_lbl": "Ser235" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6" }, { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6" }, { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "The Drosophila nuclear protein Bx42, which is found in many puffs on polytene chromosomes, is highly charged.", "journal": "Chromosoma", "date": "1992", "authors": "Mann S., Saumweber H., Wieland C., von Besser H.", "evidence": [ { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" } ], "reference": [ { "type": "PubMed", "id": "1424996", "url": "https://glygen.org/publication/PubMed/1424996" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "M9PGQ6", "url": "https://www.uniprot.org/uniprot/M9PGQ6" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] }, { "title": "Phosphoproteome analysis of Drosophila melanogaster embryos.", "journal": "Journal of proteome research", "date": "2008", "authors": "Zhai B, Villen J, Beausoleil SA, Mintseris J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" }, { "database": "iPTMnet", "id": "P39736", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P39736" } ], "reference": [ { "type": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" } ] } ], "pathway": [ { "id": "dme:Dmel_CG8264", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8264", "resource": "KEGG Pathway" }, { "id": "R-DME-2173795", "name": "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-2173795", "resource": "Reactome", "description": "Downregulation of SMAD2/3:SMAD4 transcriptional activity" }, { "id": "R-DME-350054", "name": "Notch-HLH transcription pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-350054", "resource": "Reactome", "description": "Notch-HLH transcription pathway" }, { "id": "R-DME-72163", "name": "mRNA Splicing - Major Pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE", "length": 536 }, "evidence": [ { "id": "P39736", "url": "https://omabrowser.org/oma/group/P39736/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "P39736", "url": "https://www.uniprot.org/uniprot/P39736" } 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