{ "uniprot_canonical_ac": "P38688-1", "uniprot_ac": "P38688", "uniprot_id": "SRP72_YEAST", "mass": { "chemical_mass": 73541.0, "monoisotopic_mass": 73541.0 }, "refseq": { "ac": "NP_015114", "name": "signal recognition particle subunit SRP72", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015114" }, "gene_names": [ { "name": "SRP72", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P38688", "id": "P38688" }, { "name": "SRP72", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015114", "id": "NP_015114" } ], "protein_names": [ { "name": "Signal recognition particle subunit SRP72", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P38688" }, { "name": "Signal recognition particle 72 kDa protein homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38688" }, { "name": "signal recognition particle subunit SRP72", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015114", "id": "NP_015114" } ], "function": [ { "annotation": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:7925282, PubMed:10921896). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:10921896, PubMed:7925282). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds signal recognition particle RNA (7SL RNA) in presence of SRP68 (By similarity). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (PubMed:10921896).", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688#function" }, { "database": "PubMed", "id": "7925282", "url": "https://glygen.org/publication/PubMed/7925282" }, { "database": "PubMed", "id": "10921896", "url": "https://glygen.org/publication/PubMed/10921896" }, { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "common_name": "Yeast" } ], "gene": [ { "name": "SRP72", "url": "https://www.uniprot.org/uniprot/P38688", "locus": {} } ], "crossref": [ { "id": "855891", "url": "https://www.ncbi.nlm.nih.gov/gene/855891", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P38688", "url": "https://www.ebi.ac.uk/intact/interactors/id:P38688*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YPL210C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YPL210C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ELACNER", "url": "https://omabrowser.org/oma/group/ELACNER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "91080at2759", "url": "http://www.orthodb.org/?query=91080at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14094", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14094", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14094:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14094:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08492", "url": "http://pfam.xfam.org/family/PF08492", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P38688", "url": "http://purl.obolibrary.org/obo/PR_P38688", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_015114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015114", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000006131", "url": "https://www.yeastgenome.org/locus/S000006131", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P38688-1", "url": "https://www.uniprot.org/uniprot/P38688-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKDNLTNLLSQLNIQLSQDEHSQVEQTCVKLLDSGCENPADVFRRCLVAVIQQDKYQKALHYLKKFKHIDDKYGRKFALEKLYIFYKLNMPDEFNTLYTAIITDDLDTVLKKDIESLRGILHVRAQYCYKNGLYQEAFKIYQHLASHNEKDQDSQIELSCNERVPLSVATELMNRSPLVTPMDESSYDLLFNESFIMASVGKYDKAIELLEKALQGATNEGYQNDINTIKLQLSFVLQMVGKTAQSKEILKGLLQELKADSPFSLICQNNLNAFVDFSKYNTNFNLLLRELNVEKLNTFNLQTFTHEQWSNIQRNVLFLRLFNNVKIHSQESLLSRTFDKYSKLVDNVTLESYKTQAKKLYHHTTKTILSGTDGSTIGILLLTIQLLIIEKEWENAIRIGELFLNESWKSSFEKFNDSQAIVCYILFELYKIKGRNNSKSVLLKKLGSVRVQLSGKIQENIPFWKHVGFELLSMGNAKESKALLREISNFSKGDADVLVDRVVSSDSLDIAQGIDLVRDIDIDKLIQLGVKPLESSAKRSKNTAVSKVQKRKVLELKKKRKIKRLEKFLQGRDTSKLPDPERWLPLRDRSTYRPKKKQQGAKQTQGGAMNKKSEQALDISKKGKPTVNKKPKNKKKGRK", "length": 640, "header": "sp|P38688-1|SRP72_YEAST Isoform 1 of Signal recognition particle subunit SRP72 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SRP72 PE=1 SV=2 CANONICAL=P38688-1" }, "isoforms": [ { "isoform_ac": "P38688-1", "url": "", "sequence": { "sequence": "MAKDNLTNLLSQLNIQLSQDEHSQVEQTCVKLLDSGCENPADVFRRCLVAVIQQDKYQKALHYLKKFKHIDDKYGRKFALEKLYIFYKLNMPDEFNTLYTAIITDDLDTVLKKDIESLRGILHVRAQYCYKNGLYQEAFKIYQHLASHNEKDQDSQIELSCNERVPLSVATELMNRSPLVTPMDESSYDLLFNESFIMASVGKYDKAIELLEKALQGATNEGYQNDINTIKLQLSFVLQMVGKTAQSKEILKGLLQELKADSPFSLICQNNLNAFVDFSKYNTNFNLLLRELNVEKLNTFNLQTFTHEQWSNIQRNVLFLRLFNNVKIHSQESLLSRTFDKYSKLVDNVTLESYKTQAKKLYHHTTKTILSGTDGSTIGILLLTIQLLIIEKEWENAIRIGELFLNESWKSSFEKFNDSQAIVCYILFELYKIKGRNNSKSVLLKKLGSVRVQLSGKIQENIPFWKHVGFELLSMGNAKESKALLREISNFSKGDADVLVDRVVSSDSLDIAQGIDLVRDIDIDKLIQLGVKPLESSAKRSKNTAVSKVQKRKVLELKKKRKIKRLEKFLQGRDTSKLPDPERWLPLRDRSTYRPKKKQQGAKQTQGGAMNKKSEQALDISKKGKPTVNKKPKNKKKGRK", "length": 640, "header": "sp|P38688-1|SRP72_YEAST Isoform 1 of Signal recognition particle subunit SRP72 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SRP72 PE=1 SV=2 CANONICAL=P38688-1" }, "locus": { "chromosome": "XVI", "start_pos": 156212, "end_pos": 154293, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YPL210C_mRNA", "url": "https://www.ensembl.org/id/YPL210C_mRNA" }, { "database": "Ensembl Peptide", "id": "YPL210C", "url": "https://www.ensembl.org/id/YPL210C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 508, "end_pos": 508, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38688", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38688" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P38688", "url": "https://www.yeastgenome.org/locus/P38688" } ], "site_lbl": "Ser508" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Elongation arrest is a physiologically important function of signal recognition particle.", "journal": "EMBO J.", "date": "2000", "authors": "Brown J.D., Ciufo L.F., Mason N.", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "reference": [ { "type": "PubMed", "id": "10921896", "url": "https://glygen.org/publication/PubMed/10921896" } ] }, { "title": "Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.", "journal": "J. Cell Biol.", "date": "2001", "authors": "Simos G., Grosshans H., Hurt E.C., Deinert K.", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "reference": [ { "type": "PubMed", "id": "11352936", "url": "https://glygen.org/publication/PubMed/11352936" } ] }, { "title": "Sequencing and comparison of yeast species to identify genes and regulatory elements.", "journal": "Nature", "date": "2003", "authors": "Birren B.W., Lander E.S., Kellis M., Patterson N., Endrizzi M.", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "reference": [ { "type": "PubMed", "id": "12748633", "url": "https://glygen.org/publication/PubMed/12748633" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" }, { "database": "iPTMnet", "id": "P38688", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38688" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression.", "journal": "EMBO J.", "date": "1994", "authors": "Brown J D, Hann B C, Medzihradszky K F, Niwa M, Burlingame A L, Walter P", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "reference": [ { "type": "PubMed", "id": "7925282", "url": "https://glygen.org/publication/PubMed/7925282" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Davis K., Duesterhoeft A., Hillier L.W., Mewes H.-W., Pearson D., Schaefer M., Scharfe M., Wambutt R., Wang Y., Wedler H., Hall J., Bowman S., Chung E., Benes V., Botstein D., Brueckner M., Davis R.W., Lin A., Lin D., Duncan M., Barrell B.G., Rieger M., Ahmed A., Schroeder M., Oefner P., Delius H., Kleine K., Floeth M., Bussey H., Voss H., Lashkari D., Allen E., Dubois E., Hyman R.W., Aparicio A., Araujo R., Kalman S., Komp C., Kurdi O., Lew H., Namath A., Roberts D., Friesen J.D., Louis E.J., Johnston M., Pohl T.M., Schramm S., Cherry J.M., Badcock K., Churcher C.M., DiPaolo T., Dietrich F.S., Goffeau A., Hani J., Messenguy F., Mueller-Auer S., Rajandream M.A., Scherens B., Vissers S., Walsh S.V., Zollner A., Fortin N., Purnelle B., Sdicu A.-M., Storms R.K., Urrestarazu L.A., Vierendeels F., Vo D.H., Zhong W.-W., Albermann K., Carpenter J., Coster F., Fritz C., Hebling U., Heumann K., Hilbert H., Hunicke-Smith S., Marathe R., Mirtipati S., Moestl D., Nentwich U., Petel F.X., Rechmann S., Riles L., Tettelin H., Ushinsky S., Wedler E., Winnett E.", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "reference": [ { "type": "PubMed", "id": "9169875", "url": "https://glygen.org/publication/PubMed/9169875" } ] } ], "pathway": [ { "id": "sce:YPL210C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YPL210C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "signal recognition particle, endoplasmic reticulum targeting", "id": "GO:0005786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005786", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "SRP-dependent cotranslational protein targeting to membrane", "id": "GO:0006614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006614", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "pmid": "" }, { "name": "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "id": "GO:0006617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006617", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "7S RNA binding", "id": "GO:0008312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008312", "evidence": [ { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 9 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }