{
    "uniprot_canonical_ac": "P38361-1",
    "uniprot_ac": "P38361",
    "uniprot_id": "PHO89_YEAST",
    "mass": {
        "chemical_mass": 62654.0,
        "monoisotopic_mass": 62654.0
    },
    "refseq": {
        "ac": "NP_009855",
        "name": "Pho89p",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009855"
    },
    "gene_names": [
        {
            "name": "PHO89",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P38361",
            "id": "P38361"
        },
        {
            "name": "ITN1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009855",
            "id": "NP_009855"
        },
        {
            "name": "ITN1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P38361",
            "id": "P38361"
        },
        {
            "name": "PHO89",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009855",
            "id": "NP_009855"
        },
        {
            "name": "YBR2113",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P38361",
            "id": "P38361"
        }
    ],
    "protein_names": [
        {
            "name": "Phosphate permease PHO89",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P38361"
        },
        {
            "name": "Na(+)/Pi cotransporter PHO89",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P38361"
        },
        {
            "name": "Pho89p",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009855",
            "id": "NP_009855"
        }
    ],
    "function": [
        {
            "annotation": "Sodium-phosphate symporter. Active in early growth phase.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P38361",
                    "url": "https://www.uniprot.org/uniprot/P38361#function"
                },
                {
                    "database": "PubMed",
                    "id": "9671031",
                    "url": "https://glygen.org/publication/PubMed/9671031"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0060230",
            "recommended_name": {
                "id": "DOID:0060230",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0060230",
                "name": "basal ganglia calcification",
                "description": "A basal ganglia disease characterized by the presence of abnormal calcium deposits of unknown cause in the brain; has symptom dementia, psychosis, mood swings and loss of acquired motor skills."
            },
            "synonyms": [
                {
                    "id": "DOID:0060230",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0060230",
                    "name": "Fahr disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0014004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014004",
                    "name": "basal ganglia calcification, idiopathic, 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014004",
                    "name": "basal ganglia calcification, idiopathic, 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014004",
                    "name": "basal ganglia calcification, idiopathic, type 4",
                    "description": ""
                },
                {
                    "id": "MONDO:0014004",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014004",
                    "name": "IBGC4",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "basal ganglia calcification, idiopathic, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "IBGC1",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "IBGC2",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "basal ganglia calcification, idiopathic, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "basal ganglia calcification, idiopathic, 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "basal ganglia calcification, idiopathic, type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "idiopathic basal ganglia calcification 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "Fahr disease, familial",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "Fahr disease, familial, formerly",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "basal ganglia calcification, idiopathic, 3",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "basal ganglia calcification, idiopathic, 3, formerly",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "cerebral calcification, nonarteriosclerotic, idiopathic, adult-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "ferrocalcinosis, cerebrovascular",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "striopallidodentate calcinosis, autosomal dominant, adult-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0024538",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0024538",
                    "name": "striopallidodentate calcinosis, bilateral",
                    "description": ""
                },
                {
                    "id": "MONDO:0014204",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014204",
                    "name": "basal ganglia calcification, idiopathic, 5",
                    "description": ""
                },
                {
                    "id": "MONDO:0014204",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014204",
                    "name": "basal ganglia calcification, idiopathic, 5",
                    "description": ""
                },
                {
                    "id": "MONDO:0014204",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014204",
                    "name": "basal ganglia calcification, idiopathic, type 5",
                    "description": ""
                },
                {
                    "id": "MONDO:0014204",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014204",
                    "name": "IBGC5",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "basal ganglia calcification, idiopathic, childhood-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "basal ganglia calcification, idiopathic, childhood-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "IBGC childhood onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "IBGC, childhood-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "bilateral striopallidodentate calcinosis childhood-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "cerebral calcification nonarteriosclerotic idiopathic childhood-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "cerebral calcification, nonarteriosclerotic, idiopathic, childhood-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "idiopathic basal ganglia calcification childhood-onset",
                    "description": ""
                },
                {
                    "id": "MONDO:0007247",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007247",
                    "name": "striopallidodentate calcinosis, bilateral, childhood-onset",
                    "description": ""
                },
                {
                    "id": "MIM:615007",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615007",
                    "name": "Basal ganglia calcification, idiopathic, 4",
                    "description": "Basal ganglia calcification, idiopathic, 4"
                },
                {
                    "id": "MIM:213600",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/213600",
                    "name": "Basal ganglia calcification, idiopathic, 1",
                    "description": "Basal ganglia calcification, idiopathic, 1"
                },
                {
                    "id": "MIM:615483",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615483",
                    "name": "Basal ganglia calcification, idiopathic, 5",
                    "description": "Basal ganglia calcification, idiopathic, 5"
                }
            ],
            "evidence": [
                {
                    "id": "0060230",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060230"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P38361",
                    "url": "https://www.uniprot.org/uniprot/P38361"
                }
            ],
            "common_name": "Yeast"
        }
    ],
    "gene": [
        {
            "name": "PHO89",
            "url": "https://www.uniprot.org/uniprot/P38361",
            "locus": {
                "chromosome": "II",
                "start_pos": 796798,
                "end_pos": 798522,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "YBR296C",
                        "url": "https://www.ensembl.org/id/YBR296C"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "852599",
            "url": "https://www.ncbi.nlm.nih.gov/gene/852599",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P38361",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P38361*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001204",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001204",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YBR296C",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YBR296C",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "ATIYAIW",
            "url": "https://omabrowser.org/oma/group/ATIYAIW/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5488632at2759",
            "url": "http://www.orthodb.org/?query=5488632at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11101",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11101",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11101:SF80",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11101:SF80",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01384",
            "url": "http://pfam.xfam.org/family/PF01384",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P38361",
            "url": "http://purl.obolibrary.org/obo/PR_P38361",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_009855",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009855",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000000500",
            "url": "https://www.yeastgenome.org/locus/S000000500",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P38361",
            "url": "https://www.uniprot.org/uniprot/P38361",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P38361-1",
            "url": "https://www.uniprot.org/uniprot/P38361-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MALHQFDYIFAIAMLFAFLDAFNIGANDVANSFASSISSRSLKYWQAMVLAGLCEFLGAVLAGARVSGTIKNNIIDSSIFTNDPAVLMLTMTSALIGSSCWLTFATAIGMPVSTTHSIVGGTIGAGIAAGGANGVVWGWSGVSQIIASWFIAPILAGAIAAIVFSISRFSVLEVKSLERSIKNALLLVGVLVFATFSILTMLIVWKGSPNLHLDDLSETETAVSIVLTGAIASIVYFIFFYPFYRRKVLDQDWTLKLIDIFRGPSFYFKSTDDIPPMPEGHQLTIDYYEGRRNLGTTVSVEDEENKAASNSNDSVKNKEDIQEVDLVRTETEPETKLSTKQYWWSLLKQGPKKWPLLFWLVISHGWTQDVIHAQVNDRDMLSGDLKGMYERSKFYDNRVEYIYSVLQAITAATMSFAHGANDVANATGPLSAVYVIWKTNTIGAKSEVPVWVLAYGGVALVIGCWTYGYNIIKNLGNKMILQSPSRGFSIELAVAITTVMATQLGIPTSTTQIAVGGIVAVGLCNKDLKSVNWRMVAWCYSGWFLTLPIAGLIAGIINGIILNAPRFGVEYQMT",
        "length": 574,
        "header": "sp|P38361-1|PHO89_YEAST Isoform 1 of Phosphate permease PHO89  OS=Saccharomyces cerevisiae S288C OX=559292 GN=PHO89 PE=1 SV=1 CANONICAL=P38361-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P38361-1",
            "url": "",
            "sequence": {
                "sequence": "MALHQFDYIFAIAMLFAFLDAFNIGANDVANSFASSISSRSLKYWQAMVLAGLCEFLGAVLAGARVSGTIKNNIIDSSIFTNDPAVLMLTMTSALIGSSCWLTFATAIGMPVSTTHSIVGGTIGAGIAAGGANGVVWGWSGVSQIIASWFIAPILAGAIAAIVFSISRFSVLEVKSLERSIKNALLLVGVLVFATFSILTMLIVWKGSPNLHLDDLSETETAVSIVLTGAIASIVYFIFFYPFYRRKVLDQDWTLKLIDIFRGPSFYFKSTDDIPPMPEGHQLTIDYYEGRRNLGTTVSVEDEENKAASNSNDSVKNKEDIQEVDLVRTETEPETKLSTKQYWWSLLKQGPKKWPLLFWLVISHGWTQDVIHAQVNDRDMLSGDLKGMYERSKFYDNRVEYIYSVLQAITAATMSFAHGANDVANATGPLSAVYVIWKTNTIGAKSEVPVWVLAYGGVALVIGCWTYGYNIIKNLGNKMILQSPSRGFSIELAVAITTVMATQLGIPTSTTQIAVGGIVAVGLCNKDLKSVNWRMVAWCYSGWFLTLPIAGLIAGIINGIILNAPRFGVEYQMT",
                "length": 574,
                "header": "sp|P38361-1|PHO89_YEAST Isoform 1 of Phosphate permease PHO89  OS=Saccharomyces cerevisiae S288C OX=559292 GN=PHO89 PE=1 SV=1 CANONICAL=P38361-1"
            },
            "locus": {
                "chromosome": "II",
                "start_pos": 798522,
                "end_pos": 796801,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YBR296C_mRNA",
                        "url": "https://www.ensembl.org/id/YBR296C_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YBR296C",
                        "url": "https://www.ensembl.org/id/YBR296C"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 331,
            "end_pos": 331,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P38361",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38361"
                },
                {
                    "database": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "SGD",
                    "id": "P38361",
                    "url": "https://www.yeastgenome.org/locus/P38361"
                }
            ],
            "site_lbl": "Thr331"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.",
            "journal": "J. Proteome Res.",
            "date": "2007",
            "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P38361",
                    "url": "https://www.uniprot.org/uniprot/P38361"
                },
                {
                    "database": "iPTMnet",
                    "id": "P38361",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38361"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                }
            ]
        },
        {
            "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.",
            "journal": "Science",
            "date": "2009",
            "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P38361",
                    "url": "https://www.uniprot.org/uniprot/P38361"
                },
                {
                    "database": "iPTMnet",
                    "id": "P38361",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38361"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                }
            ]
        },
        {
            "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.",
            "journal": "G3 (Bethesda)",
            "date": "2014",
            "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P38361",
                    "url": "https://www.uniprot.org/uniprot/P38361"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24374639",
                    "url": "https://glygen.org/publication/PubMed/24374639"
                }
            ]
        },
        {
            "title": "Complete DNA sequence of yeast chromosome II.",
            "journal": "EMBO J.",
            "date": "1994",
            "authors": "Gassenhuber J., Mewes H.-W., Obermaier B., Stucka R., Rose M., Wagner G., Boles E., Brueckner M., Jacquet M., Rieger M., Mueller S., Molemans F., Zagulski M., Brandt T., Christiansen C., Barthe C., Feldmann H., Kleine K., Cziepluch C., Fiers W., Mallet L., Jauniaux J.-C., Dubois E., Andre B., Li Z.Y., Koetter P., Hein C., Entian K.-D., Slonimski P.P., Vetter I., Nasr F., Louis E.J., Delaveau T., Hollenberg C.P., Contreras R., Domdey H., Pohl T.M., Brendel M., Becam A.-M., Bussereau F., Crouzet M., Doignon F., Dujon B., El Bakkoury M., Feuermann M., Glansdorff N., Goffeau A., Grivell L.A., Herbert C.J., Jacq C., Mannhaupt G., Messenguy F., Miosga T., Perea J., Pierard A., Potier S., Proft M., Schaaff-Gerstenschlaeger I., Scherens B., Souciet J.-L., Steensma H.Y., Vissers S., Zimmermann F.K., Aljinovic G., Duesterhus S., Jonniaux J.-L., Kirchrath L., Purnelle B., Ramezani Rad M., Skala J., Urrestarazu L.A., Vierendeels F., de Wergifosse P., Aigle M., Baclet M.C., Baur A., Biteau N., Demolis N., Fobo G.M., Fritz C., Holmstroem K., Kallesoee T., Kiesau P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Maat M.J., Piravandi E., Pohl F.M., Schwarzlose C., Smits P.H.M., Van Dyck L., Vassarotti A., Wolfe K.H., de Haan M., van der Aart Q.J.M.",
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