{ "uniprot_canonical_ac": "P38249-1", "uniprot_ac": "P38249", "uniprot_id": "EIF3A_YEAST", "mass": { "chemical_mass": 110344.0, "monoisotopic_mass": 110344.0 }, "refseq": { "ac": "NP_009635", "name": "translation initiation factor eIF3 core subunit a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009635" }, "gene_names": [ { "name": "RPG1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P38249", "id": "P38249" }, { "name": "RPG1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009635", "id": "NP_009635" }, { "name": "TIF32", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009635", "id": "NP_009635" }, { "name": "TIF32", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P38249", "id": "P38249" }, { "name": "YBR0734", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P38249", "id": "P38249" } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 3 subunit A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P38249" }, { "name": "Eukaryotic translation initiation factor 3 110 kDa subunit homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38249" }, { "name": "Translation initiation factor eIF3, p110 subunit homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38249" }, { "name": "eIF3 p110", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38249" }, { "name": "eIF3a", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38249" }, { "name": "translation initiation factor eIF3 core subunit a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009635", "id": "NP_009635" } ], "function": [ { "annotation": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249#function" }, { "database": "PubMed", "id": "12651896", "url": "https://glygen.org/publication/PubMed/12651896" }, { "database": "PubMed", "id": "9694884", "url": "https://glygen.org/publication/PubMed/9694884" }, { "database": "UniProtKB", "id": "MF_03000", "url": "https://www.uniprot.org/uniprot/MF_03000#function" }, { "database": "PubMed", "id": "11387228", "url": "https://glygen.org/publication/PubMed/11387228" }, { "database": "PubMed", "id": "18765792", "url": "https://glygen.org/publication/PubMed/18765792" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 692, "end_pos": 701, "sequence_org": "LDLDTIKQVI", "sequence_mut": "AAAAAAAAAA", "comment": "Reduces interaction of eIF-3 with the 40S ribosome.", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" }, { "database": "PubMed", "id": "18765792", "url": "https://glygen.org/publication/PubMed/18765792" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "common_name": "Yeast" } ], "gene": [ { "name": "RPG1", "url": "https://www.uniprot.org/uniprot/P38249", "locus": { "chromosome": "II", "start_pos": 395383, "end_pos": 398277, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YBR079C", "url": "https://www.ensembl.org/id/YBR079C" } ] } } ], "crossref": [ { "id": "852371", "url": "https://www.ncbi.nlm.nih.gov/gene/852371", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P38249", "url": "https://www.ebi.ac.uk/intact/interactors/id:P38249*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027512", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027512", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YBR079C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YBR079C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HQAFQFC", "url": "https://omabrowser.org/oma/group/HQAFQFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "10990at2759", "url": "http://www.orthodb.org/?query=10990at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14005", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14005", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14005:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14005:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3JAP", "url": "https://www.rcsb.org/structure/3JAP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4K51", "url": "https://www.rcsb.org/structure/4K51", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4U1C", "url": "https://www.rcsb.org/structure/4U1C", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4U1D", "url": "https://www.rcsb.org/structure/4U1D", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4U1E", "url": "https://www.rcsb.org/structure/4U1E", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6FYX", "url": "https://www.rcsb.org/structure/6FYX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6FYY", "url": "https://www.rcsb.org/structure/6FYY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6GSM", "url": "https://www.rcsb.org/structure/6GSM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6GSN", "url": "https://www.rcsb.org/structure/6GSN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6ZCE", "url": "https://www.rcsb.org/structure/6ZCE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6ZU9", "url": "https://www.rcsb.org/structure/6ZU9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8CAH", "url": "https://www.rcsb.org/structure/8CAH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8CAS", "url": "https://www.rcsb.org/structure/8CAS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PR_P38249", "url": "http://purl.obolibrary.org/obo/PR_P38249", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_009635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009635", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000283", "url": "https://www.yeastgenome.org/locus/S000000283", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P38249-1", "url": "https://www.uniprot.org/uniprot/P38249-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPPPFRPENAIKRADELISVGEKQAALQSLHDFITARRIRWATPSTVEPVVFKFLEIGVELKKGKLLKDGLHQYKKLIQGSTEGLVSVGAVARKFIDLVESKIASEQTRADELQKQEIDDDLEGGVTPENLLISVYESDQSVAGFNDEAITSWLRFTWESYRAVLDLLRNNALLEITYSGVVKKTMHFCLKYQRKNEFKRLAEMLRQHLDAANYQQSKSGNNLVDLSDADTLQRYLDQRFQQVDVSVKLELWHEAYRSIEDVFHLMKISKRAPKPSTLANYYENLVKVFFVSGDPLLHTTAWKKFYKLYSTNPRATEEEFKTYSSTIFLSAISTQLDEIPSIGYDPHLRMYRLLNLDAKPTRKEMLQSIIEDESIYGKVDEELKELYDIIEVNFDVDTVKQQLENLLVKLSSKTYFSQYIAPLRDVIMRRVFVAASQKFTTVSQSELYKLATLPAPLDLSAWDIEKSLLQAAVEDYVSITIDHESAKVTFAKDPFDIFASTASKEVSEEENTEPEVQEEKEETDEALGPQETEDGEEKEEESDPVIIRNSYIHNKLLELSNVLHDVDSFNNASYMEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKQVIIAEVSKNKSELESRMEYAMKKLDHTERALRKVELPLLQKEVDKLQETDTANYEAMKKKIVDAAKAEYEARMADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIEEAAAKKSTPYSFRAGNREPPSTPSTLPKATVSPDKAKLDMIAQKQREMEEAIEQRLAGRTAGGSSPATPATPATPATPTPSSGPKKMTMAEKLRAKRLAKGGR", "length": 964, "header": "sp|P38249-1|EIF3A_YEAST Isoform 1 of Eukaryotic translation initiation factor 3 subunit A OS=Saccharomyces cerevisiae S288C OX=559292 GN=RPG1 PE=1 SV=1 CANONICAL=P38249-1" }, "isoforms": [ { "isoform_ac": "P38249-1", "url": "", "sequence": { "sequence": "MAPPPFRPENAIKRADELISVGEKQAALQSLHDFITARRIRWATPSTVEPVVFKFLEIGVELKKGKLLKDGLHQYKKLIQGSTEGLVSVGAVARKFIDLVESKIASEQTRADELQKQEIDDDLEGGVTPENLLISVYESDQSVAGFNDEAITSWLRFTWESYRAVLDLLRNNALLEITYSGVVKKTMHFCLKYQRKNEFKRLAEMLRQHLDAANYQQSKSGNNLVDLSDADTLQRYLDQRFQQVDVSVKLELWHEAYRSIEDVFHLMKISKRAPKPSTLANYYENLVKVFFVSGDPLLHTTAWKKFYKLYSTNPRATEEEFKTYSSTIFLSAISTQLDEIPSIGYDPHLRMYRLLNLDAKPTRKEMLQSIIEDESIYGKVDEELKELYDIIEVNFDVDTVKQQLENLLVKLSSKTYFSQYIAPLRDVIMRRVFVAASQKFTTVSQSELYKLATLPAPLDLSAWDIEKSLLQAAVEDYVSITIDHESAKVTFAKDPFDIFASTASKEVSEEENTEPEVQEEKEETDEALGPQETEDGEEKEEESDPVIIRNSYIHNKLLELSNVLHDVDSFNNASYMEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKQVIIAEVSKNKSELESRMEYAMKKLDHTERALRKVELPLLQKEVDKLQETDTANYEAMKKKIVDAAKAEYEARMADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIEEAAAKKSTPYSFRAGNREPPSTPSTLPKATVSPDKAKLDMIAQKQREMEEAIEQRLAGRTAGGSSPATPATPATPATPTPSSGPKKMTMAEKLRAKRLAKGGR", "length": 964, "header": "sp|P38249-1|EIF3A_YEAST Isoform 1 of Eukaryotic translation initiation factor 3 subunit A OS=Saccharomyces cerevisiae S288C OX=559292 GN=RPG1 PE=1 SV=1 CANONICAL=P38249-1" }, "locus": { "chromosome": "II", "start_pos": 398277, "end_pos": 395386, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YBR079C_mRNA", "url": "https://www.ensembl.org/id/YBR079C_mRNA" }, { "database": "Ensembl Peptide", "id": "YBR079C", "url": "https://www.ensembl.org/id/YBR079C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 220, "end_pos": 220, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P38249", "url": "https://www.yeastgenome.org/locus/P38249" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser220" }, { "start_pos": 501, "end_pos": 501, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Ser501" }, { "start_pos": 508, "end_pos": 508, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "P38249", "url": "https://www.yeastgenome.org/locus/P38249" } ], "site_lbl": "Ser508" }, { "start_pos": 513, "end_pos": 513, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ], "site_lbl": "Thr513" }, { "start_pos": 524, "end_pos": 524, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Thr524" }, { "start_pos": 691, "end_pos": 691, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" } ], "site_lbl": "Ser691" }, { "start_pos": 748, "end_pos": 748, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Thr748" }, { "start_pos": 869, "end_pos": 869, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "SGD", "id": "P38249", "url": "https://www.yeastgenome.org/locus/P38249" }, { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Thr869" }, { "start_pos": 882, "end_pos": 882, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" }, { "database": "SGD", "id": "P38249", "url": "https://www.yeastgenome.org/locus/P38249" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser882" }, { "start_pos": 885, "end_pos": 885, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P38249", "url": "https://www.yeastgenome.org/locus/P38249" }, { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser885" }, { "start_pos": 893, "end_pos": 893, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "P38249", "url": "https://www.yeastgenome.org/locus/P38249" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser893" }, { "start_pos": 921, "end_pos": 921, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Thr921" }, { "start_pos": 925, "end_pos": 925, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "SGD", "id": "P38249", "url": "https://www.yeastgenome.org/locus/P38249" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser925" }, { "start_pos": 926, "end_pos": 926, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P38249", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P38249" }, { "database": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" }, { "database": "PubMed", "id": "17330950", "url": 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associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Ribeiro S., Vornlocher H.-P., Hershey J.W.B., Hanachi P.", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "reference": [ { "type": "PubMed", "id": "10358023", "url": "https://glygen.org/publication/PubMed/10358023" } ] }, { "title": "A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met.", "journal": "EMBO J.", "date": "2001", "authors": "Phan L., Nielsen K.H., Hinnebusch A.G., Valasek L., Schoenfeld L.W.", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "reference": [ { "type": "PubMed", "id": "11387228", "url": "https://glygen.org/publication/PubMed/11387228" } ] }, { "title": "The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo.", "journal": "Genes Dev.", "date": "2003", "authors": "Nielsen K.H., Hinnebusch A.G., Valasek L., Mathew A.A., Shin B.-S., Szamecz B.", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "reference": [ { "type": "PubMed", "id": "12651896", "url": "https://glygen.org/publication/PubMed/12651896" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.", "journal": "Mol. 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U.S.A.", "date": "2008", "authors": "Zhou M, Sandercock AM, Fraser CS, Ridlova G, Stephens E, Schenauer MR, Yokoi-Fong T, Barsky D, Leary JA, Hershey JW, Doudna JA, Robinson CV", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "reference": [ { "type": "PubMed", "id": "18599441", "url": "https://glygen.org/publication/PubMed/18599441" } ] }, { "title": "eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA.", "journal": "Genes Dev.", "date": "2008", "authors": "Szamecz B\u00e9la, Rutkai Edit, Cuchalov\u00e1 Lucie, Munzarov\u00e1 Vanda, Herrmannov\u00e1 Anna, Nielsen Klaus H, Burela Laxminarayana, Hinnebusch Alan G, Val\u00e1sek Leos", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "reference": [ { "type": "PubMed", "id": "18765792", "url": 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"MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTEAAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQDEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVAQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYIKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRVKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERKITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGEDPLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRETRDDERPHRRDEDRLRRLGGDDEERESSLRPDDDRIPRRGLDDDRGPRRGPDEDRFSRRGTDDDRPSWRNADDDRPPRRIGDDDRGSWRHTDDDRPPRRGLDDDRPPRRGLDDERGSWRTAEEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGMDDDRGPRRGLDDDRGPWRNAAEDRISRRGADDDRGPWRNMDDDRVPRRGDDARPGPWRPFVKPGGWREKEKAREESWGPPRESRPPEEREWDRDKEKDRDNQDREENDKDLERDRDRERDGDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRDRDDRRDLRDLRDRRDLRDDRDRRGPPLRSEREEASSWRRTDDRKDDRTEERDPPRRVPPPTLSRERERERDREGEKEKASWRAEKDRESLRRTKNETDEDGWTTVRR", "length": 1354 }, "evidence": [ { "id": "P38249", "url": "https://omabrowser.org/oma/group/P38249/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VN25-1", "protein_name": "Eukaryotic translation initiation factor 3 subunit A", "gene_name": "eIF3a", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MARYTQRPENALKRANEFIEVGKPLRALDTLQEVFRNKRWNYAYSETVIEPLMFKYLYLCVELKKSHIAKEGLFQYRNMFQLVNVNSLENVIRGYLKMAEEHTEAAQAQSSAAVAVLELDDLDNIATPESILMSAVCGEDAQDRSDRTILLPWVKFLWESYCQCLELLRVNTHCEALYHDIARMAFQFCLKYNRKSEFRRLCDKLRKHLEDICKSSNQTTGVSINKVETQQLCLDTRLYLLDSAIQMELWQEAYKAIEDIHGLMALSKKTPVPKTMANYYQKLAMVFSKAGNQLFHAAALLKLFQLTRELKKNLTKDDLQRMAAHVLLATLSIPLPSAHPEFDRFIEADKSPLEKAQKLAVLLGLPQPPTRVSLIREVVRLNVPQLVSEDFRNLYNWLEVDFNPLNLCKRIQSIVDFIENGPENALLTPYIQSLKDVTIMRLIRQISQVYESIKFQRLLQLASFCNIFELEKLLVESVRHNDMQIRIDHQKNSIYFGTDLTESQREYRPDGPALQSMPSEQIRSQLVNMSTVLTRAVSIVYPNRERDQRAKLRNQMVNHYHEIKDREHQRILQRQKIIEDRKEYIEKQNNAREEEEARRQEEESRKAKLAEQKRLEQEQEERERKRHQNEIQAIREKSLKEKVQQISQTAHGKKMLSKLDEEGIKKLDAEQIAKRESEELQREAKELQSKLKSQEKKIDYFERAKRLEEIPLFEKYLAEKQVKDKEFWEATEKTRIENAIAERKDAVAQQERLKRMYPDRDEFLEALKKERASLYVEKLKKFEAALEAERKKRLADRIIRRREERRQAFLREKEEERLRKEEEIRLAQAAEERAAAEARRLEREAEDEKRRAQYEKQRAKEEEAERKIKEDRDRLSRELASERERTEKDRDTWRPRGGDRPSASNGGSSEWRRAAPAASERNDRGGERIERGGERIERGGERLERGGERIERGGDRDRKDNEGADSSWRVRREPDSQRAAAPKDSGAPQSRDDKWRRGGERDRDFRIDGARRDRDDGPRRDRDDGPRRDRDDERGGFRRADGARRTDEPQRETGGNWRDAPRHADRETRRPAERRDRDVRETRGDQRGSAPKEAASGGVGGNWRTAPATREEKPAAKRDQAQEKENKAGDDGEWTSVKRR", "length": 1140 }, "evidence": [ { "id": "P38249", "url": "https://omabrowser.org/oma/group/P38249/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "translation reinitiation", "id": "GO:0002188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002188", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "formation of cytoplasmic translation initiation complex", "id": "GO:0001732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001732", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "eukaryotic 43S preinitiation complex", "id": "GO:0016282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016282", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "eukaryotic 48S preinitiation complex", "id": "GO:0033290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033290", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "multi-eIF complex", "id": "GO:0043614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043614", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 3 complex, eIF3e", "id": "GO:0071540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071540", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 3 complex, eIF3m", "id": "GO:0071541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071541", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 3 complex", "id": "GO:0005852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005852", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" }, { "name": "incipient cellular bud site", "id": "GO:0000131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000131", "evidence": [ { "database": "UniProtKB", "id": "P38249", "url": "https://www.uniprot.org/uniprot/P38249" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 18 }, { "field": "total_sites", "count": 18 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 22 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }