{ "uniprot_canonical_ac": "P38074-1", "uniprot_ac": "P38074", "uniprot_id": "HMT1_YEAST", "mass": { "chemical_mass": 39786.0, "monoisotopic_mass": 39786.0 }, "refseq": { "ac": "NP_009590", "name": "protein-arginine omega-N methyltransferase HMT1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009590" }, "gene_names": [ { "name": "HMT1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P38074", "id": "P38074" }, { "name": "HCP1; ODP1; RMT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009590", "id": "NP_009590" }, { "name": "HMT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009590", "id": "NP_009590" }, { "name": "ODP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P38074", "id": "P38074" }, { "name": "RMT1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P38074", "id": "P38074" }, { "name": "YBR0320", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P38074", "id": "P38074" } ], "protein_names": [ { "name": "Protein arginine N-methyltransferase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P38074" }, { "name": "2.1.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38074" }, { "name": "Major type I protein arginine N-methyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38074" }, { "name": "Type I PRMT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38074" }, { "name": "hnRNP arginine N-methyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P38074" }, { "name": "protein-arginine omega-N methyltransferase HMT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009590", "id": "NP_009590" } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in a variety of RNA-binding proteins such as heterogeneous nuclear ribonucleoproteins (hnRNPs) and small nuclear ribonucleoproteins (snRNPs) (PubMed:8668183, PubMed:8647869). Methylates NAB2, NPL3, HRP1 and YRA1, shuttling hnRNPs involved in mRNA processing and export, facilitating their export out of the nucleus (PubMed:8668183, PubMed:9499403, PubMed:10652296, PubMed:11779864, PubMed:15314027). Methylation of NPL3 weakens its interaction with THO2, a component of the TREX (transcription/export) complex important for transcriptional elongation and recruitment of mRNA export factors (PubMed:15314027, PubMed:20053728). Methylates the hnRNP HRB1, but does not influence its subcellular location (PubMed:9499403). Methylates the nucleolar proteins GAR1, NOP1 and NSR1 (PubMed:12756332). Methylates the snRNP SNP1 and modulates the cotranscriptional recruitment of splicing factors (PubMed:20823272). Dimethylates free histone H4 (HHF1/HHF2) at 'Arg-4' (H4R3me2a) and plays a role in preservation and establishment of silent chromatin domains (PubMed:12097318, PubMed:17158743). Mono- and dimethylates ribosomal protein S2 (RPS2) at 'Arg-11' (PubMed:20035717). Methylates the catalytic subunit of the SWI/SNF chromatin-remodeling complex SNF2 (PubMed:22997150).", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074#function" }, { "database": "PubMed", "id": "11101900", "url": "https://glygen.org/publication/PubMed/11101900" }, { "database": "PubMed", "id": "22997150", "url": "https://glygen.org/publication/PubMed/22997150" }, { "database": "PubMed", "id": "8647869", "url": "https://glygen.org/publication/PubMed/8647869" }, { "database": "PubMed", "id": "15314027", "url": "https://glygen.org/publication/PubMed/15314027" }, { "database": "PubMed", "id": "9499403", "url": "https://glygen.org/publication/PubMed/9499403" }, { "database": "PubMed", "id": "20035717", "url": "https://glygen.org/publication/PubMed/20035717" }, { "database": "PubMed", "id": "20823272", "url": "https://glygen.org/publication/PubMed/20823272" }, { "database": "PubMed", "id": "12097318", "url": "https://glygen.org/publication/PubMed/12097318" }, { "database": "PubMed", "id": "11779864", "url": "https://glygen.org/publication/PubMed/11779864" }, { "database": "PubMed", "id": "20053728", "url": "https://glygen.org/publication/PubMed/20053728" }, { "database": "PubMed", "id": "12756332", "url": "https://glygen.org/publication/PubMed/12756332" }, { "database": "PubMed", "id": "8668183", "url": "https://glygen.org/publication/PubMed/8668183" }, { "database": "PubMed", "id": "17158743", "url": "https://glygen.org/publication/PubMed/17158743" }, { "database": "PubMed", "id": "10652296", "url": "https://glygen.org/publication/PubMed/10652296" } ] } ], "disease": [ { "disease_id": "DOID:2841", "recommended_name": { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "asthma", "description": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing." }, "synonyms": [ { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "Exercise induced asthma", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "bronchial hyperreactivity", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma with acute exacerbation", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "chronic obstructive asthma with status asthmaticus", "description": "" }, { "id": "DOID:2841", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2841", "name": "exercise-induced asthma", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "inherited susceptibility to asthma", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, nocturnal, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, bronchial", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, diminished response to Antileukotriene treatment 1N", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, protection against", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma, susceptibility to", "description": "" }, { "id": "MONDO:0010940", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010940", "name": "asthma-related traits, susceptibility to", "description": "" }, { "id": "MIM:600807", "resource": "MIM", "url": "https://www.omim.org/entry/600807", "name": "Asthma", "description": "Asthma" } ], "evidence": [ { "id": "2841", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2841" } ] }, { "disease_id": "DOID:674", "recommended_name": { "id": "DOID:674", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:674", "name": "cleft palate", "description": "An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate." }, "synonyms": [ { "id": "DOID:674", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:674", "name": "Palatoschisis", "description": "" } ], "evidence": [ { "id": "674", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:674" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 18, "end_pos": 18, "sequence_org": "E", "sequence_mut": "V", "comment": "Cold-sensitive; reduces catalytic activity more than 20-fold at 14 degrees Celsius.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" }, { "database": "PubMed", "id": "10652296", "url": "https://glygen.org/publication/PubMed/10652296" } ] }, { "start_pos": 68, "end_pos": 68, "sequence_org": "G", "sequence_mut": "A", "comment": "Reduces catalytic activity between 5- to 25-fold.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" }, { "database": "PubMed", "id": "10652296", "url": "https://glygen.org/publication/PubMed/10652296" } ] }, { "start_pos": 68, "end_pos": 68, "sequence_org": "G", "sequence_mut": "R", "comment": "Abolishes catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" }, { "database": "PubMed", "id": "10652296", "url": "https://glygen.org/publication/PubMed/10652296" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "common_name": "Yeast" } ], "gene": [ { "name": "HMT1", "url": "https://www.uniprot.org/uniprot/P38074", "locus": { "chromosome": "II", "start_pos": 304930, "end_pos": 305976, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YBR034C", "url": "https://www.ensembl.org/id/YBR034C" } ] } } ], "crossref": [ { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "852322", "url": "https://www.ncbi.nlm.nih.gov/gene/852322", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P38074", "url": "https://www.ebi.ac.uk/intact/interactors/id:P38074*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR025799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YBR034C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YBR034C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RNDFVHA", "url": "https://omabrowser.org/oma/group/RNDFVHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "197898at2759", "url": "http://www.orthodb.org/?query=197898at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11006:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11006:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1G6Q", "url": "https://www.rcsb.org/structure/1G6Q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF06325", "url": "http://pfam.xfam.org/family/PF06325", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P38074", "url": "http://purl.obolibrary.org/obo/PR_P38074", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_009590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009590", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000238", "url": "https://www.yeastgenome.org/locus/S000000238", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P38074-1", "url": "https://www.uniprot.org/uniprot/P38074-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRKNEGSYLMH", "length": 348, "header": "sp|P38074-1|HMT1_YEAST Isoform 1 of Protein arginine N-methyltransferase 1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=HMT1 PE=1 SV=1 CANONICAL=P38074-1" }, "isoforms": [ { "isoform_ac": "P38074-1", "url": "", "sequence": { "sequence": "MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRKNEGSYLMH", "length": 348, "header": "sp|P38074-1|HMT1_YEAST Isoform 1 of Protein arginine N-methyltransferase 1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=HMT1 PE=1 SV=1 CANONICAL=P38074-1" }, "locus": { "chromosome": "II", "start_pos": 305976, "end_pos": 304933, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YBR034C_mRNA", "url": "https://www.ensembl.org/id/YBR034C_mRNA" }, { "database": "Ensembl Peptide", "id": "YBR034C", "url": "https://www.ensembl.org/id/YBR034C" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Analysis of the yeast arginine methyltransferase Hmt1p/Rmt1p and its in vivo function. Cofactor binding and substrate interactions.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "McBride A E, Weiss V H, Kim H K, Hogle J M, Silver P A", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "10652296", "url": "https://glygen.org/publication/PubMed/10652296" } ] }, { "title": "The structure and oligomerization of the yeast arginine methyltransferase, Hmt1.", "journal": "Nat. Struct. Biol.", "date": "2000", "authors": "Filman D.J., Hogle J.M., McBride A.E., Silver P.A., Soriano M.A., Weiss V.H.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "11101900", "url": "https://glygen.org/publication/PubMed/11101900" } ] }, { "title": "Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Green Deanna M, Marfatia Kavita A, Crafton Emily B, Zhang Xing, Cheng Xiaodong, Corbett Anita H", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "11779864", "url": "https://glygen.org/publication/PubMed/11779864" } ] }, { "title": "Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Lacoste Nicolas, Utley Rhea T, Hunter Joanna M, Poirier Guy G, C\u00f4te Jacques", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "12097318", "url": "https://glygen.org/publication/PubMed/12097318" } ] }, { "title": "In vivo analysis of nucleolar proteins modified by the yeast arginine methyltransferase Hmt1/Rmt1p.", "journal": "RNA", "date": "2003", "authors": "Xu Chong, Henry Pamela A, Setya Amit, Henry Michael F", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "12756332", "url": "https://glygen.org/publication/PubMed/12756332" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Arginine methyltransferase affects interactions and recruitment of mRNA processing and export factors.", "journal": "Genes Dev.", "date": "2004", "authors": "McBride A.E., Silver P.A., Yu M.C., Bachand F., Casolari J.M., Komili S.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "15314027", "url": "https://glygen.org/publication/PubMed/15314027" } ] }, { "title": "The role of protein arginine methylation in the formation of silent chromatin.", "journal": "Genes Dev.", "date": "2006", "authors": "Silver P.A., Sinclair D.A., Lamming D.W., Yu M.C., Eskin J.A.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "17158743", "url": "https://glygen.org/publication/PubMed/17158743" } ] }, { "title": "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.", "journal": "Genome Res.", "date": "2007", "authors": "Hu Y., LaBaer J., Moreira D., Raphael J., Rolfs A., Zuo D., Richardson A., Simpson A.J.G., Zhu C., Harlow E., Camargo A.A., Jepson D., Kelley F., McCarron S., Taycher E., Kolodner R.D., Kane M.F., Williamson J., Berger M.F., Bulyk M.L., Bhullar B., Mohr S., Marsischky G., Murthy T.V.S.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "17322287", "url": "https://glygen.org/publication/PubMed/17322287" } ] }, { "title": "Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2010", "authors": "Lipson Rebecca S, Webb Kristofor J, Clarke Steven G", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "20035717", "url": "https://glygen.org/publication/PubMed/20035717" } ] }, { "title": "Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p.", "journal": "Nucleic Acids Res.", "date": "2010", "authors": "Wong G.W., Qiu H., Jin D.Y., Hinnebusch A.G., Wong C.M., Kong K.Y., Tang H.M.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "20053728", "url": "https://glygen.org/publication/PubMed/20053728" } ] }, { "title": "Protein arginine methylation facilitates cotranscriptional recruitment of pre-mRNA splicing factors.", "journal": "Mol. Cell. Biol.", "date": "2010", "authors": "Cote J., Chen Y.C., Goulet I., Yu M.C., Jackson C.A., Milliman E.J., Vollbracht J.A.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "20823272", "url": "https://glygen.org/publication/PubMed/20823272" } ] }, { "title": "Proteomic analysis of interactors for yeast protein arginine methyltransferase Hmt1 reveals novel substrate and insights into additional biological roles.", "journal": "Proteomics", "date": "2012", "authors": "Li J., Qu J., Yadav N., Chen Y.C., Min S., Yu M.C., Jackson C.A., Milliman E.J.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "22997150", "url": "https://glygen.org/publication/PubMed/22997150" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Complete DNA sequence of yeast chromosome II.", "journal": "EMBO J.", "date": "1994", "authors": "Gassenhuber J., Mewes H.-W., Obermaier B., Stucka R., Rose M., Wagner G., Boles E., Brueckner M., Jacquet M., Rieger M., Mueller S., Molemans F., Zagulski M., Brandt T., Christiansen C., Barthe C., Feldmann H., Kleine K., Cziepluch C., Fiers W., Mallet L., Jauniaux J.-C., Dubois E., Andre B., Li Z.Y., Koetter P., Hein C., Entian K.-D., Slonimski P.P., Vetter I., Nasr F., Louis E.J., Delaveau T., Hollenberg C.P., Contreras R., Domdey H., Pohl T.M., Brendel M., Becam A.-M., Bussereau F., Crouzet M., Doignon F., Dujon B., El Bakkoury M., Feuermann M., Glansdorff N., Goffeau A., Grivell L.A., Herbert C.J., Jacq C., Mannhaupt G., Messenguy F., Miosga T., Perea J., Pierard A., Potier S., Proft M., Schaaff-Gerstenschlaeger I., Scherens B., Souciet J.-L., Steensma H.Y., Vissers S., Zimmermann F.K., Aljinovic G., Duesterhus S., Jonniaux J.-L., Kirchrath L., Purnelle B., Ramezani Rad M., Skala J., Urrestarazu L.A., Vierendeels F., de Wergifosse P., Aigle M., Baclet M.C., Baur A., Biteau N., Demolis N., Fobo G.M., Fritz C., Holmstroem K., Kallesoee T., Kiesau P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Maat M.J., Piravandi E., Pohl F.M., Schwarzlose C., Smits P.H.M., Van Dyck L., Vassarotti A., Wolfe K.H., de Haan M., van der Aart Q.J.M.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "7813418", "url": "https://glygen.org/publication/PubMed/7813418" } ] }, { "title": "Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase.", "journal": "J. Bacteriol.", "date": "1995", "authors": "Karst F., Guilloton M., Marcireau C., Loubbardi A.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "7896706", "url": "https://glygen.org/publication/PubMed/7896706" } ] }, { "title": "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene.", "journal": "Yeast", "date": "1994", "authors": "Maat C., Grivell L.A., Smits P.H.M., de Haan M.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "8091864", "url": "https://glygen.org/publication/PubMed/8091864" } ] }, { "title": "The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae.", "journal": "J. Biol. Chem.", "date": "1996", "authors": "Clarke S., Gary J.D., Lin W.-J., Yang M.C., Herschmann H.R.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "8647869", "url": "https://glygen.org/publication/PubMed/8647869" } ] }, { "title": "A novel methyltransferase (Hmt1p) modifies poly(A)+-RNA-binding proteins.", "journal": "Mol. Cell. Biol.", "date": "1996", "authors": "Henry M.F., Silver P.A.", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "8668183", "url": "https://glygen.org/publication/PubMed/8668183" } ] }, { "title": "Arginine methylation facilitates the nuclear export of hnRNP proteins.", "journal": "Genes Dev.", "date": "1998", "authors": "Shen E C, Henry M F, Weiss V H, Valentini S R, Silver P A, Lee M S", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "reference": [ { "type": "PubMed", "id": "9499403", "url": "https://glygen.org/publication/PubMed/9499403" } ] } ], "pathway": [ { "id": "sce:YBR034C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YBR034C", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6PAK3-1", "protein_name": "Protein arginine N-methyltransferase 8", "gene_name": "Prmt8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAVESTEVSSAPPQPPQPVIPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNVITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR", "length": 394 }, "evidence": [ { "id": "P38074", "url": "https://omabrowser.org/oma/group/P38074/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NR22-1", "protein_name": "Protein arginine N-methyltransferase 8", "gene_name": "PRMT8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR", "length": 394 }, "evidence": [ { "id": "P38074", "url": "https://omabrowser.org/oma/group/P38074/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of termination of DNA-templated transcription", "id": "GO:0060567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060567", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" }, { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" }, { "name": "peptidyl-arginine methylation", "id": "GO:0018216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018216", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" }, { "name": "positive regulation of transcription elongation by RNA polymerase II", "id": "GO:0032968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032968", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" }, { "name": "folic acid biosynthetic process", "id": "GO:0046656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046656", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" }, { "name": "protein-arginine omega-N asymmetric methyltransferase activity", "id": "GO:0035242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035242", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" }, { "name": "protein-arginine omega-N monomethyltransferase activity", "id": "GO:0035241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035241", "evidence": [ { "database": "UniProtKB", "id": "P38074", "url": "https://www.uniprot.org/uniprot/P38074" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-SCE-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-77087" ], "output_participant_list": [ "R-ALL-77502", "R-SCE-4754240" ], "enzyme_list": [ "P38074-1" ], "evidence": [ { "id": "R-SCE-5205798", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-5205798" } ] }, { "id": "R-SCE-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P38074-1" ], "evidence": [ { "id": "R-SCE-5205867", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-5205867" } ] }, { "id": "R-SCE-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-SCE-5229015" ], "enzyme_list": [ "P38074-1" ], "evidence": [ { "id": "R-SCE-5661126", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-5661126" } ] }, { "id": "R-SCE-8879123", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-SCE-72347" ], "output_participant_list": [ "R-ALL-71285", "R-SCE-8879138" ], "enzyme_list": [ "P38074-1" ], "evidence": [ { "id": "R-SCE-8879123", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-8879123" } ] }, { "id": "R-SCE-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08649-1", "Q03330-1", "P24783-1", "P38074-1" ], "evidence": [ { "id": "R-SCE-9023860", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-9023860" } ] }, { "id": "R-SCE-9023861", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. 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