{ "uniprot_canonical_ac": "P37136-1", "uniprot_ac": "P37136", "uniprot_id": "ACES_RAT", "mass": { "chemical_mass": 68196.0, "monoisotopic_mass": 68196.0 }, "refseq": { "ac": "NP_742006", "name": "acetylcholinesterase precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006" }, "gene_names": [ { "name": "Ache", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P37136", "id": "P37136" }, { "name": "Ache", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006", "id": "NP_742006" } ], "protein_names": [ { "name": "Acetylcholinesterase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P37136" }, { "name": "3.1.1.7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P37136" }, { "name": "AChE", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P37136" }, { "name": "acetylcholinesterase precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006", "id": "NP_742006" }, { "name": "glycolipid-anchored form of acetylcholinesterase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006", "id": "NP_742006" } ], "function": [ { "annotation": "Paraquat-induced death of hippocampal neurons was partially mediated by AChE variants inducing and cholinergic and gultamatergic transmission disruption.", "evidence": [ { "database": "RefSeq", "id": "NP_742006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006" }, { "database": "PubMed", "id": "28916328", "url": "https://glygen.org/publication/PubMed/28916328" } ] }, { "annotation": "Quercetin improves memory and anxiogenic-like behavior in diabetic rats by preventing the increase in Ache activity seen in streptozocin induced diabetes.", "evidence": [ { "database": "RefSeq", "id": "NP_742006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006" }, { "database": "PubMed", "id": "27694000", "url": "https://glygen.org/publication/PubMed/27694000" } ] }, { "annotation": "Sepsis decreased AChE activity by reducing its expression at the neuromuscular junction.", "evidence": [ { "database": "RefSeq", "id": "NP_742006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006" }, { "database": "PubMed", "id": "28849127", "url": "https://glygen.org/publication/PubMed/28849127" } ] }, { "annotation": "Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136#function" } ] } ], "disease": [ { "disease_id": "DOID:10487", "recommended_name": { "id": "DOID:10487", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10487", "name": "Hirschsprung's disease", "description": "A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel." }, "synonyms": [ { "id": "DOID:10487", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10487", "name": "Hirschsprung disease", "description": "" }, { "id": "DOID:10487", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10487", "name": "aganglionic megacolon", "description": "" }, { "id": "DOID:10487", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10487", "name": "congenital megacolon", "description": "" }, { "id": "DOID:10487", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10487", "name": "macrocolon", "description": "" }, { "id": "DOID:10487", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10487", "name": "pelvirectal achalasia", "description": "" }, { "id": "DOID:10487", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10487", "name": "total intestinal aganglionosis", "description": "" }, { "id": "MONDO:0010834", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010834", "name": "Hirschsprung disease, susceptibility to, 5", "description": "" }, { "id": "MONDO:0010834", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010834", "name": "HSCR5", "description": "" }, { "id": "MONDO:0010834", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010834", "name": "Hirschsprung disease, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012042", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012042", "name": "Hirschsprung disease, susceptibility to, 8", "description": "" }, { "id": "MONDO:0012042", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012042", "name": "HSCR8", "description": "" }, { "id": "MONDO:0012042", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012042", "name": "Hirschsprung disease, susceptibility to, 8", "description": "" }, { "id": "MONDO:0012710", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012710", "name": "Hirschsprung disease, susceptibility to, 9", "description": "" }, { "id": "MONDO:0012710", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012710", "name": "HSCR9", "description": "" }, { "id": "MONDO:0012710", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012710", "name": "Hirschsprung disease, susceptibility to, 9", "description": "" }, { "id": "MONDO:0011742", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011742", "name": "Hirschsprung disease, susceptibility to, 7", "description": "" }, { "id": "MONDO:0011742", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011742", "name": "HSCR7", "description": "" }, { "id": "MONDO:0011742", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011742", "name": "Hirschsprung disease, susceptibility to, 7", "description": "" }, { "id": "MONDO:0011741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011741", "name": "Hirschsprung disease, susceptibility to, 6", "description": "" }, { "id": "MONDO:0011741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011741", "name": "HSCR6", "description": "" }, { "id": "MONDO:0011741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011741", "name": "Hirschsprung disease, susceptibility to, 6", "description": "" } ], "evidence": [ { "id": "10487", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10487" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:12858", "recommended_name": { "id": "DOID:12858", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12858", "name": "Huntington's disease", "description": "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities." }, "synonyms": [ { "id": "DOID:12858", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12858", "name": "HD", "description": "" }, { "id": "DOID:12858", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12858", "name": "Huntington disease", "description": "" }, { "id": "DOID:12858", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12858", "name": "Huntington's chorea", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington disease", "description": "Huntington disease (HD) is a rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia." }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "HD", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington chorea", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington disease", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington's chorea", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington's disease", "description": "" }, { "id": "MIM:143100", "resource": "MIM", "url": "https://www.omim.org/entry/143100", "name": "Huntington disease", "description": "Huntington disease" } ], "evidence": [ { "id": "12858", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12858" } ] }, { "disease_id": "DOID:14330", "recommended_name": { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions." }, "synonyms": [ { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "Parkinson disease", "description": "" }, { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "paralysis agitans", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "A Parkinson disease that begins after around the age of 50." }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "LOPD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PARK", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, age of onset, modifier, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "autosomal dominant late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson's disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "" }, { "id": "MIM:168600", "resource": "MIM", "url": "https://www.omim.org/entry/168600", "name": "Parkinson disease", "description": "Parkinson disease" } ], "evidence": [ { "id": "14330", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "evidence": [ { "id": "1826", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] }, { "disease_id": "DOID:2297", "recommended_name": { "id": "DOID:2297", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2297", "name": "leptospirosis", "description": "A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly." }, "synonyms": [ { "id": "DOID:2297", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2297", "name": "Fort Bragg fever", "description": "" }, { "id": "DOID:2297", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2297", "name": "Leptospirosis icterohaemorrhagica", "description": "" }, { "id": "DOID:2297", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2297", "name": "Rat Catcher's Yellows", "description": "" }, { "id": "DOID:2297", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2297", "name": "Weil's disease", "description": "" }, { "id": "DOID:2297", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2297", "name": "nanukayami fever", "description": "" }, { "id": "DOID:2297", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2297", "name": "spirochetal jaundice", "description": "" } ], "evidence": [ { "id": "2297", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2297" } ] }, { "disease_id": "DOID:2377", "recommended_name": { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "multiple sclerosis", "description": "A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring." }, "synonyms": [ { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "Generalized multiple sclerosis", "description": "" }, { "id": "DOID:2377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2377", "name": "insular sclerosis", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "multiple sclerosis, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "MS3", "description": "" }, { "id": "MONDO:0012957", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012957", "name": "multiple sclerosis, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "multiple sclerosis, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "MS2", "description": "" }, { "id": "MONDO:0012956", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012956", "name": "multiple sclerosis, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "multiple sclerosis, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "MS4", "description": "" }, { "id": "MONDO:0012958", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012958", "name": "multiple sclerosis, susceptibility to, 4", "description": "" }, { "id": "MIM:612595", "resource": "MIM", "url": "https://www.omim.org/entry/612595", "name": "Multiple sclerosis 3", "description": "Multiple sclerosis 3" } ], "evidence": [ { "id": "2377", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2377" } ] }, { "disease_id": "DOID:437", "recommended_name": { "id": "DOID:437", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:437", "name": "myasthenia gravis", "description": "An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath." }, "synonyms": [ { "id": "MONDO:0009688", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009688", "name": "myasthenia gravis", "description": "Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles." }, { "id": "MONDO:0009688", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009688", "name": "acquired myasthenia", "description": "" }, { "id": "MONDO:0009688", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009688", "name": "autoimmune myasthenia gravis", "description": "" }, { "id": "MONDO:0009688", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009688", "name": "myasthenia gravis", "description": "" }, { "id": "MONDO:0009688", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009688", "name": "MG", "description": "" } ], "evidence": [ { "id": "437", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:437" } ] }, { "disease_id": "DOID:6088", "recommended_name": { "id": "DOID:6088", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6088", "name": "acute stress disorder", "description": "An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD." }, "synonyms": [ { "id": "DOID:6088", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6088", "name": "traumatic stress disorder", "description": "" } ], "evidence": [ { "id": "6088", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6088" } ] }, { "disease_id": "DOID:9470", "recommended_name": { "id": "DOID:9470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9470", "name": "bacterial meningitis", "description": "A meningitis that has_material_basis_in a bacterial infection." }, "synonyms": [], "evidence": [ { "id": "9470", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9470" } ] }, { "disease_id": "DOID:9744", "recommended_name": { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production." }, "synonyms": [ { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "IDDM", "description": "" }, { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "type I diabetes mellitus", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type 1 diabetes mellitus", "description": "A chronic condition characterized by minimal or absent production of insulin by the pancreas." }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "IDDM", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "diabetes mellitis type 1", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "diabetes mellitis type I", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "immune mediated diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "juvenile diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type 1 diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type I diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type I diabetes mellitus", "description": "" }, { "id": "MIM:222100", "resource": "MIM", "url": "https://www.omim.org/entry/222100", "name": "Type 1 diabetes mellitus", "description": "Type 1 diabetes mellitus" } ], "evidence": [ { "id": "9744", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "common_name": "Rat" } ], "gene": [ { "name": "Ache", "url": "https://www.uniprot.org/uniprot/P37136", "locus": { "chromosome": "12", "start_pos": 19407360, "end_pos": 19413651, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000050841", "url": "https://www.ensembl.org/id/ENSRNOG00000050841" } ] } } ], "crossref": [ { "id": "ENSRNOG00000050841", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000050841", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.1.1.7", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.1.7&UniProtAcc=P37136", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd00312", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00312", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3199", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3199", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "83817", "url": "https://www.ncbi.nlm.nih.gov/gene/83817", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:83817", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:83817", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CDHLVAP", "url": "https://omabrowser.org/oma/group/CDHLVAP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4386at2759", "url": "http://www.orthodb.org/?query=4386at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43918", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43918", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43918:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43918:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00135", "url": "http://pfam.xfam.org/family/PF00135", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08674", "url": "http://pfam.xfam.org/family/PF08674", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P37136", "url": "http://purl.obolibrary.org/obo/PR_P37136", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_742006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "69313", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=69313", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "17561", "url": "https://www.rhea-db.org/rhea/17561", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "M0R4A5", "url": "https://www.uniprot.org/uniprot/M0R4A5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0R4A5-1", "url": "https://www.uniprot.org/uniprot/M0R4A5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P37136-1", "url": "https://www.uniprot.org/uniprot/P37136-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P37136-2", "url": "https://www.uniprot.org/uniprot/P37136-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P37136-3", "url": "https://www.uniprot.org/uniprot/P37136-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q505J2", "url": "https://www.uniprot.org/uniprot/Q505J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q505J2-1", "url": "https://www.uniprot.org/uniprot/Q505J2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQERCSDL", "length": 614, "header": "sp|P37136-1|ACES_RAT Isoform 1 of Acetylcholinesterase OS=Rattus norvegicus OX=10116 GN=Ache PE=1 SV=1 CANONICAL=P37136-1" }, "isoforms": [ { "isoform_ac": "M0R4A5-1", "url": "", "sequence": { "sequence": "MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSRDAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMKYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATATEVPCTCPSPAHGEAAPRPGPALSLSLLFFLFLLHSGLRRL", "length": 616, "header": "tr|M0R4A5-1|ACES_RAT Computationally mapped isoform of Acetylcholinesterase OS=Rattus norvegicus OX=10116 GN=Ache PE=1 SV=3 CANONICAL=P37136-1" }, "locus": { "chromosome": "12", "start_pos": 19412011, "end_pos": 19408256, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000075504.3", "url": "https://www.ensembl.org/id/ENSRNOT00000075504.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000064185.3", "url": "https://www.ensembl.org/id/ENSRNOP00000064185.3" } ] } }, { "isoform_ac": "P37136-1", "url": "", "sequence": { "sequence": "MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQERCSDL", "length": 614, "header": "sp|P37136-1|ACES_RAT Isoform 1 of Acetylcholinesterase OS=Rattus norvegicus OX=10116 GN=Ache PE=1 SV=1 CANONICAL=P37136-1" }, "locus": {} }, { "isoform_ac": "P37136-2", "url": "", "sequence": { "sequence": "MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATATEVPCTCPSPAHGEAAPRPGPALSLSLLFFLFLLHSGLRWL", "length": 616, "header": "sp|P37136-2|ACES_RAT Isoform 2 of Acetylcholinesterase OS=Rattus norvegicus OX=10116 GN=Ache PE=1 SV=1 CANONICAL=P37136-1" }, "locus": {} }, { "isoform_ac": "P37136-3", "url": "", "sequence": { "sequence": "MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATGRRGVGKQGMHKAARVGRTGERKGGKHRM", "length": 603, "header": "sp|P37136-3|ACES_RAT Isoform 3 of Acetylcholinesterase OS=Rattus norvegicus OX=10116 GN=Ache PE=1 SV=1 CANONICAL=P37136-1" }, "locus": {} }, { "isoform_ac": "Q505J2-1", "url": "", "sequence": { "sequence": "MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSRDAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMKYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQERCSDL", "length": 614, "header": "tr|Q505J2-1|ACES_RAT Computationally mapped isoform of Acetylcholinesterase OS=Rattus norvegicus OX=10116 GN=Ache PE=1 SV=1 CANONICAL=P37136-1" }, "locus": { "chromosome": "12", "start_pos": 19412011, "end_pos": 19407583, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000089392.2", "url": "https://www.ensembl.org/id/ENSRNOT00000089392.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073951.2", "url": "https://www.ensembl.org/id/ENSRNOP00000073951.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 296, "start_aa": "Asn", "end_pos": 296, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn296", "evidence": [ { "id": "P37136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37136#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 381, "start_aa": "Asn", "end_pos": 381, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn381", "evidence": [ { "id": "P37136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37136#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 495, "start_aa": "Asn", "end_pos": 495, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn495", "evidence": [ { "id": "P37136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37136#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Neuroprotective effects of quercetin on memory and anxiogenic-like behavior in diabetic rats: Role of ectonucleotidases and acetylcholinesterase activities.", "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie", "date": "2016", "authors": "Maciel RM, Carvalho FB, Olabiyi AA, Schmatz R, Gutierres JM, Stefanello N, Zanini D, Rosa MM, Andrade CM, Rubin MA, Schetinger MR, Morsch VM, Danesi CC, Lopes STA", "evidence": [ { "database": "RefSeq", "id": "NP_742006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006" } ], "reference": [ { "type": "PubMed", "id": "27694000", "url": "https://glygen.org/publication/PubMed/27694000" } ] }, { "title": "Sepsis decreases the activity of acetylcholinesterase by reducing its expression at the neuromuscular junction.", "journal": "Molecular medicine reports", "date": "2017", "authors": "Wu J, Jin T, Wang H, Li ST", "evidence": [ { "database": "RefSeq", "id": "NP_742006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006" } ], "reference": [ { "type": "PubMed", "id": "28849127", "url": "https://glygen.org/publication/PubMed/28849127" } ] }, { "title": "Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption.", "journal": "Toxicology", "date": "2017", "authors": "Del Pino J, Moyano P, Diaz GG, Anadon MJ, Diaz MJ, Garcia JM, Lobo M, Pelayo A, Sola E, Frejo MT", "evidence": [ { "database": "RefSeq", "id": "NP_742006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006" } ], "reference": [ { "type": "PubMed", "id": "28916328", "url": "https://glygen.org/publication/PubMed/28916328" } ] }, { "title": "Cloning and expression of a rat acetylcholinesterase subunit: generation of multiple molecular forms and complementarity with a Torpedo collagenic subunit.", "journal": "J. Neurochem.", "date": "1993", "authors": "Bon S., Massoulie J., Legay C., Vernier P., Coussen F.", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "reference": [ { "type": "PubMed", "id": "8417155", "url": "https://glygen.org/publication/PubMed/8417155" } ] }, { "title": "Expression of a cDNA encoding the glycolipid-anchored form of rat acetylcholinesterase.", "journal": "FEBS Lett.", "date": "1993", "authors": "Bon S., Massoulie J., Legay C.", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "reference": [ { "type": "PubMed", "id": "8417973", "url": "https://glygen.org/publication/PubMed/8417973" } ] } ], "pathway": [ { "id": "rno:83817", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:83817", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P21836-1", "protein_name": "Acetylcholinesterase", "gene_name": "Ache", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPPWYPLHTPSLAFPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQERCSDL", "length": 614 }, "evidence": [ { "id": "45224041", "url": "http://www.informatics.jax.org/homology/45224041", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P22303-1", "protein_name": "Acetylcholinesterase", "gene_name": "ACHE", "tax_id": 9606, "organism": "Homo sapiens", 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"https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "response to cadmium ion", "id": "GO:0046686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046686", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "positive regulation of dendrite morphogenesis", "id": "GO:0050775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050775", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "positive regulation of axonogenesis", "id": "GO:0050772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050772", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "acetylcholine metabolic process", "id": "GO:0008291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008291", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 11, "go_terms": [ { "name": "choline binding", "id": "GO:0033265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033265", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "acetylcholine binding", "id": "GO:0042166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042166", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "laminin binding", "id": "GO:0043236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043236", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "protein self-association", "id": "GO:0043621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043621", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "acetylcholinesterase activity", "id": "GO:0003990", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003990", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "cholinesterase activity", "id": "GO:0004104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004104", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "serine hydrolase activity", "id": "GO:0017171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017171", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 19, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P37136", "url": "https://www.uniprot.org/uniprot/P37136" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": 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