{ "uniprot_canonical_ac": "P36048-1", "uniprot_ac": "P36048", "uniprot_id": "SN114_YEAST", "mass": { "chemical_mass": 114041.0, "monoisotopic_mass": 114041.0 }, "refseq": { "ac": "NP_012748", "name": "U5 snRNP GTPase SNU114", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012748" }, "gene_names": [ { "name": "SNU114", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P36048", "id": "P36048" }, { "name": "GIN10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012748", "id": "NP_012748" }, { "name": "GIN10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P36048", "id": "P36048" }, { "name": "SNU114", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012748", "id": "NP_012748" }, { "name": "YKL637", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P36048", "id": "P36048" } ], "protein_names": [ { "name": "Pre-mRNA-splicing factor SNU114", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P36048" }, { "name": "114 kDa U5 small nuclear ribonucleoprotein component", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P36048" }, { "name": "Growth inhibitory protein 10", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P36048" }, { "name": "U5 snRNP GTPase SNU114", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012748", "id": "NP_012748" } ], "function": [ { "annotation": "Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048#function" } ] } ], "disease": [ { "disease_id": "DOID:0080196", "recommended_name": { "id": "DOID:0080196", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080196", "name": "mandibulofacial dysostosis, Guion-Almeida type", "description": "A syndrome characterized by progressive microcephaly, micrognathia, microtia, dysplastic ears, preauricular skin tags, speech delay, significant developmental delay, midface and malar hypoplasia." }, "synonyms": [ { "id": "DOID:0080196", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080196", "name": "MFDM syndrome", "description": "" }, { "id": "DOID:0080196", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080196", "name": "mandibulofacial dysostosis with microcephaly", "description": "" }, { "id": "DOID:0080196", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080196", "name": "mandibulofacial dysostosis-microcephaly syndrome", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "mandibulofacial dysostosis-microcephaly syndrome", "description": "Mandibulofacial dysostosis-microcephaly syndrome is a rare genetic multiple malformation disorder characterized by malar and mandibular hypoplasia, microcephaly, ear malformations with associated conductive hearing loss, distinctive facial dysmorphism, developmental delay, and intellectual disability." }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "MFDM syndrome", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "mandibulofacial dysostosis with microcephaly", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "mandibulofacial dysostosis, Guion-Almeida type", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "mandibulofacial dysostosis-microcephaly syndrome", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "Growth and intellectual disability, mandibulofacial dysostosis, microcephaly, and cleft palate", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "Growth and mental retardation, mandibulofacial dysostosis, microcephaly, and cleft palate", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "Growth delay - intellectual disability - mandibulofacial dysostosis - microcephaly - cleft palate", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "Growth delay-intellectual disability-mandibulofacial dysostosis-microcephaly-cleft palate syndrome", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "MFDGA", "description": "" }, { "id": "MONDO:0012516", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012516", "name": "MFDM", "description": "" }, { "id": "MIM:610536", "resource": "MIM", "url": "https://www.omim.org/entry/610536", "name": "Mandibulofacial dysostosis with microcephaly", "description": "Mandibulofacial dysostosis with microcephaly" } ], "evidence": [ { "id": "0080196", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080196" } ] }, { "disease_id": "DOID:10485", "recommended_name": { "id": "DOID:10485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10485", "name": "esophageal atresia", "description": "" }, "synonyms": [ { "id": "DOID:10485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10485", "name": "Congenital atresia of esophagus", "description": "" }, { "id": "DOID:10485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10485", "name": "Congenital imperforate esophagus", "description": "" }, { "id": "DOID:10485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10485", "name": "Imperforate esophagus", "description": "" }, { "id": "DOID:10485", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10485", "name": "Oesophageal atresia", "description": "" } ], "evidence": [ { "id": "10485", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10485" } ] }, { "disease_id": "DOID:10907", "recommended_name": { "id": "DOID:10907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10907", "name": "microcephaly", "description": "A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants." }, "synonyms": [ { "id": "DOID:10907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10907", "name": "Microcephalus", "description": "" }, { "id": "DOID:10907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10907", "name": "microencephaly", "description": "" } ], "evidence": [ { "id": "10907", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10907" } ] }, { "disease_id": "DOID:2043", "recommended_name": { "id": "DOID:2043", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2043", "name": "hepatitis B", "description": "A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, blood transfusions, or fomites like needles or syringes. The infection has_symptom fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain, and jaundice." }, "synonyms": [ { "id": "DOID:2043", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2043", "name": "chronic hepatitis B", "description": "" }, { "id": "DOID:2043", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2043", "name": "hepatitis B infection", "description": "" } ], "evidence": [ { "id": "2043", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2043" } ] }, { "disease_id": "DOID:2908", "recommended_name": { "id": "DOID:2908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2908", "name": "Treacher Collins syndrome", "description": "A syndrome that is characterized by bilateral and symmetric downslanting palpebral fissures, malar hypoplasia, micrognathia, and external ear abnormalities." }, "synonyms": [ { "id": "DOID:2908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2908", "name": "Franceschetti syndrome", "description": "" }, { "id": "DOID:2908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2908", "name": "mandibulofacial dysostosis", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "Treacher Collins syndrome 1", "description": "Any Treacher-Collins syndrome in which the cause of the disease is a mutation in the TCOF1 gene." }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "TCOF1 Treacher-Collins syndrome", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "Treacher Collins syndrome type 1", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "Treacher-Collins syndrome 1", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "Treacher-Collins syndrome caused by mutation in TCOF1", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "TCS1", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "TREACHER COLLINS syndrome 1", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "Treacher Collins syndrome", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "Treacher Collins-Franceschetti syndrome", "description": "" }, { "id": "MONDO:0007944", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007944", "name": "mandibulofacial dysostosis", "description": "" }, { "id": "MIM:154500", "resource": "MIM", "url": "https://www.omim.org/entry/154500", "name": "Treacher Collins syndrome 1", "description": "Treacher Collins syndrome 1" } ], "evidence": [ { "id": "2908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2908" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" } ], "common_name": "Yeast" } ], "gene": [ { "name": "SNU114", "url": "https://www.uniprot.org/uniprot/P36048", "locus": { "chromosome": "XI", "start_pos": 125543, "end_pos": 122517, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "YKL173W", "url": "https://www.ensembl.org/id/YKL173W" } ] } } ], "crossref": [ { "id": "cd01683", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01683", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04090", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04090", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04098", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04098", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04167", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16264", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16264", 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"length": 1008, "header": "sp|P36048-1|SN114_YEAST Isoform 1 of Pre-mRNA-splicing factor SNU114 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SNU114 PE=1 SV=1 CANONICAL=P36048-1" }, "isoforms": [ { "isoform_ac": "P36048-1", "url": "", "sequence": { "sequence": "MEGDDLFDEFGNLIGVDPFDSDEEESVLDEQEQYQTNTFEGSGNNNEIESRQLTSLGSKKELGISLEHPYGKEVEVLMETKNTQSPQTPLVEPVTERTKLQEHTIFTQLKKNIPKTRYNRDYMLSMANIPERIINVGVIGPLHSGKTSLMDLLVIDSHKRIPDMSKNVELGWKPLRYLDNLKQEIDRGLSIKLNGSTLLCTDLESKSRMINFLDAPGHVNFMDETAVALAASDLVLIVIDVVEGVTFVVEQLIKQSIKNNVAMCFVINKLDRLILDLKLPPMDAYLKLNHIIANINSFTKGNVFSPIDNNIIFASTKLGFTFTIKEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRSNFRVNLSQEALQYDPQPFLKHVLQLIFRQQTGLVDAITRCYQPFELFDNKTAHLSIPGKSTPEGTLWAHVLKTVDYGGAEWSLVRIYSGLLKRGDTVRILDTSQSESRQKRQLHDISKTETSNEDEDEDDETPSCEVEEIGLLGGRYVYPVHEAHKGQIVLIKGISSAYIKSATLYSVKSKEDMKQLKFFKPLDYITEAVFKIVLQPLLPRELPKLLDALNKISKYYPGVIIKVEESGEHVILGNGELYMDCLLYDLRASYAKIEIKISDPLTVFSESCSNESFASIPVSNSISRLGEENLPGLSISVAAEPMDSKMIQDLSRNTLGKGQNCLDIDGIMDNPRKLSKILRTEYGWDSLASRNVWSFYNGNVLINDTLPDEISPELLSKYKEQIIQGFYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNIDVMKSQIIPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLLPIVEELMKKRRGSRIYKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTNGLGMCQLYFWHKIWRKVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRRKGISTGGFMSNDGPTLEKYISAELYAQLRENGLVP", "length": 1008, "header": "sp|P36048-1|SN114_YEAST Isoform 1 of Pre-mRNA-splicing factor SNU114 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SNU114 PE=1 SV=1 CANONICAL=P36048-1" }, "locus": { "chromosome": "XI", "start_pos": 125540, "end_pos": 122517, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YKL173W_mRNA", "url": "https://www.ensembl.org/id/YKL173W_mRNA" }, { "database": "Ensembl Peptide", "id": "YKL173W", "url": "https://www.ensembl.org/id/YKL173W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 83, "end_pos": 83, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ], "site_lbl": "Thr83" }, { "start_pos": 85, "end_pos": 85, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" }, { "database": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "P36048", "url": "https://www.yeastgenome.org/locus/P36048" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser85" }, { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "P36048", "url": "https://www.yeastgenome.org/locus/P36048" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Thr88" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.", "journal": "EMBO J.", "date": "1999", "authors": "Mann M., Luehrmann R., Neubauer G., Fabrizio P., Gottschalk A., Banroques J.", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" } ], "reference": [ { "type": "PubMed", "id": "10449419", "url": "https://glygen.org/publication/PubMed/10449419" } ] }, { "title": "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.", "journal": "Mol. Cell. Biol.", "date": "2002", "authors": "Ohi MD, Link AJ, Ren L, Jennings JL, McDonald WH, Gould KL", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" } ], "reference": [ { "type": "PubMed", "id": "11884590", "url": "https://glygen.org/publication/PubMed/11884590" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Assigning function to yeast proteins by integration of technologies.", "journal": "Mol. Cell", "date": "2003", "authors": "Anderson S., Yates J.R. III, Baker D., Fields S., Bradley P., Fox B., Hazbun T.R., Davis T.N., Chiu C.-H., Malmstroem L., Aranda J.D., Graczyk B.J., McDonald W.H., Muller E.G.D., Riffle M., Snydsman B.E., Sundin B.A.", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" } ], "reference": [ { "type": "PubMed", "id": "14690591", "url": "https://glygen.org/publication/PubMed/14690591" } ] }, { "title": "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.", "journal": "Molecular & cellular proteomics : MCP", "date": "2005-03", "authors": "Gruhler Albrecht, Olsen Jesper V, Mohammed Shabaz, Mortensen Peter, Faergeman Nils J, Mann Matthias, Jensen Ole N", "evidence": [ { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" } ], "reference": [ { "type": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" }, { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008-07", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" }, { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy.", "journal": "Nat. Struct. Mol. Biol.", "date": "2008", "authors": "Sander B., Stark H., Golas M.M., Luhrmann R., Wolf E., Kastner B., Fabrizio P., Hacker I., Karagoz E.", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" } ], "reference": [ { "type": "PubMed", "id": "18953335", "url": "https://glygen.org/publication/PubMed/18953335" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "P36048", "url": "https://www.uniprot.org/uniprot/P36048" }, { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast.", "journal": "Proteomics", "date": "2009-10", "authors": "Gnad Florian, de Godoy Lyris M F, Cox J\u00fcrgen, Neuhauser Nadin, Ren Shubin, Olsen Jesper V, Mann Matthias", "evidence": [ { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" } ], "reference": [ { "type": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" } ] }, { "title": "Global analysis of the yeast osmotic stress response by quantitative proteomics.", "journal": "Molecular bioSystems", "date": "2009-11", "authors": "Soufi Boumediene, Kelstrup Christian D, Stoehr Gabriele, Fr\u00f6hlich Florian, Walther Tobias C, Olsen Jesper V", "evidence": [ { "database": "iPTMnet", "id": "P36048", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P36048" } ], "reference": [ { "type": "PubMed", "id": "19823750", "url": 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