{
    "uniprot_canonical_ac": "P34064-1",
    "uniprot_ac": "P34064",
    "uniprot_id": "PSA5_RAT",
    "mass": {
        "chemical_mass": 26391.0,
        "monoisotopic_mass": 26391.0
    },
    "refseq": {
        "ac": "NP_058978",
        "name": "proteasome subunit alpha type-5",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058978"
    },
    "gene_names": [
        {
            "name": "Psma5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P34064",
            "id": "P34064"
        },
        {
            "name": "Psma5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058978",
            "id": "NP_058978"
        }
    ],
    "protein_names": [
        {
            "name": "Proteasome subunit alpha type-5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P34064"
        },
        {
            "name": "Macropain zeta chain",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P34064"
        },
        {
            "name": "Multicatalytic endopeptidase complex zeta chain",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P34064"
        },
        {
            "name": "Proteasome zeta chain",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P34064"
        },
        {
            "name": "macropain zeta chain; proteasome zeta chain; multicatalytic endopeptidase complex zeta chain; proteasome alpha 5 subunit; proteasome (prosome, macropain) subunit, alpha type 5; proteasome subunit alpha 5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058978",
            "id": "NP_058978"
        },
        {
            "name": "proteasome subunit alpha type-5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058978",
            "id": "NP_058978"
        }
    ],
    "function": [
        {
            "annotation": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P34064",
                    "url": "https://www.uniprot.org/uniprot/P34064#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "P28066",
                    "url": "https://www.uniprot.org/uniprot/P28066#function"
                }
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        }
    ],
    "disease": [
        {
            "disease_id": "DOID:1289",
            "recommended_name": {
                "id": "DOID:1289",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1289",
                "name": "neurodegenerative disease",
                "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons."
            },
            "synonyms": [
                {
                    "id": "DOID:1289",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1289",
                    "name": "degenerative disease",
                    "description": ""
                }
            ],
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                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
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                    "url": "https://www.uniprot.org/uniprot/P34064"
                }
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            "common_name": "Rat"
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                        "id": "ENSRNOT00000111330.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000111330.1"
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                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000097948.1",
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            "isoform_ac": "Q6P9V6-1",
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                "sequence": "MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI",
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                "header": "tr|Q6P9V6-1|Q6P9V6_RAT Computationally mapped isoform of Proteasome subunit alpha type  OS=Rattus norvegicus OX=10116 GN=Psma5 PE=1 SV=1 CANONICAL=P34064-1"
            },
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                "chromosome": "2",
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                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000026928.8",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000026928.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000026928.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000026928.5"
                    }
                ]
            }
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        {
            "glytoucan_ac": "",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
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            "site_seq": "S",
            "relation": "attached",
            "comment": "O-linked (GlcNAc) serine O-GlcNAcylation",
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            "start_aa": "Ser",
            "end_pos": 198,
            "end_aa": "Ser",
            "residue": "Ser",
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                {
                    "id": "P34064",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P34064#ptm_processing"
                }
            ]
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        {
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            "end_pos": 16,
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            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
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                    "database": "UniProtKB",
                    "id": "P34064",
                    "url": "https://www.uniprot.org/uniprot/P34064"
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                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "P34064",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P34064"
                }
            ],
            "site_lbl": "Ser16"
        },
        {
            "start_pos": 55,
            "end_pos": 55,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P34064",
                    "url": "https://www.uniprot.org/uniprot/P34064"
                }
            ],
            "site_lbl": "Thr55"
        },
        {
            "start_pos": 56,
            "end_pos": 56,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P34064",
                    "url": "https://www.uniprot.org/uniprot/P34064"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "P34064",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P34064"
                }
            ],
            "site_lbl": "Ser56"
        },
        {
            "start_pos": 63,
            "end_pos": 63,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
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                    "database": "UniProtKB",
                    "id": "P34064",
                    "url": "https://www.uniprot.org/uniprot/P34064"
                }
            ],
            "site_lbl": "Ser63"
        }
    ],
    "glycation": [],
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        "glycoprotein",
        "glycoprotein_predicted"
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        {
            "title": "Molecular cloning of cDNAs for rat proteasomes: deduced primary structures of four other subunits.",
            "journal": "J. Biochem.",
            "date": "1992",
            "authors": "Tanaka K., Tamura T., Ishida N., Ichihara A., Shimbara N., Bey F., Scherrer K., Aki M.",
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                {
                    "database": "UniProtKB",
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                    "url": "https://www.uniprot.org/uniprot/P34064"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "1491007",
                    "url": "https://glygen.org/publication/PubMed/1491007"
                }
            ]
        },
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nature communications",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
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                    "url": "https://www.uniprot.org/uniprot/P34064"
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                {
                    "database": "UniProtKB",
                    "id": "Q6P9V6",
                    "url": "https://www.uniprot.org/uniprot/Q6P9V6"
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                {
                    "database": "iPTMnet",
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                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P34064"
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                    "type": "PubMed",
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                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
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