{ "uniprot_canonical_ac": "P33753-1", "uniprot_ac": "P33753", "uniprot_id": "TRM2_YEAST", "mass": { "chemical_mass": 72852.0, "monoisotopic_mass": 72852.0 }, "refseq": { "ac": "NP_012982", "name": "tRNA (uracil(54)-C(5))-methyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012982" }, "gene_names": [ { "name": "TRM2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P33753", "id": "P33753" }, { "name": "NUC2; NUD1; RNC1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012982", "id": "NP_012982" }, { "name": "NUC2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P33753", "id": "P33753" }, { "name": "NUD1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P33753", "id": "P33753" }, { "name": "RNC1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P33753", "id": "P33753" }, { "name": "TRM2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012982", "id": "NP_012982" } ], "protein_names": [ { "name": "tRNA (uracil(54)-C(5))-methyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P33753" }, { "name": "2.1.1.35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P33753" }, { "name": "Transfer RNA methyltransferase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P33753" }, { "name": "tRNA (uracil(54)-C(5))-methyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012982", "id": "NP_012982" }, { "name": "tRNA(m5U54)-methyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P33753" } ], "function": [ { "annotation": "Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753#function" }, { "database": "PubMed", "id": "10864043", "url": "https://glygen.org/publication/PubMed/10864043" }, { "database": "PubMed", "id": "12003492", "url": "https://glygen.org/publication/PubMed/12003492" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 498, "end_pos": 498, "sequence_org": "G", "sequence_mut": "D", "comment": "Unable to methylate tRNA.", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" }, { "database": "PubMed", "id": "12003492", "url": "https://glygen.org/publication/PubMed/12003492" } ] }, { "start_pos": 591, "end_pos": 591, "sequence_org": "C", "sequence_mut": "A", "comment": "Unable to methylate tRNA.", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" }, { "database": "PubMed", "id": "12003492", "url": "https://glygen.org/publication/PubMed/12003492" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" } ], "common_name": "Yeast" } ], "gene": [ { "name": "TRM2", "url": "https://www.uniprot.org/uniprot/P33753", "locus": { "chromosome": "XI", "start_pos": 551367, "end_pos": 549448, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "YKR056W", "url": "https://www.ensembl.org/id/YKR056W" } ] } } ], "crossref": [ { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "853930", "url": "https://www.ncbi.nlm.nih.gov/gene/853930", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030391", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030391", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YKR056W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YKR056W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYAGDMK", "url": "https://omabrowser.org/oma/group/FYAGDMK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "52228at2759", "url": "http://www.orthodb.org/?query=52228at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11061", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11061", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11061:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11061:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01938", "url": "http://pfam.xfam.org/family/PF01938", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05958", "url": "http://pfam.xfam.org/family/PF05958", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P33753", "url": "http://purl.obolibrary.org/obo/PR_P33753", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_012982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012982", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000001764", "url": "https://www.yeastgenome.org/locus/S000001764", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P33753-1", "url": "https://www.uniprot.org/uniprot/P33753-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYEQFEFSFFFFENSDNKVKYKAHLISSIKRWSIITCMRCFWTVQKSIFKARFFACRNFVKKHNYKLISTMTGSTEMVPPTMKHTVDNKRLSSPLTDSGNRRTKKPKLRKYKAKKVETTSPMGVLEFEVNDLLKSQNLSREQVLNDVTSILNDKSSTDGPIVLQYHREVKNVKVLEITSNGNGLALIDNPVETEKKQVVIIPFGLPGDVVNIKVFKTHPYYVESDLLDVVEKSPMRRDDLIRDKYFGKSSGSQLEFLTYDDQLELKRKTIMNAYKFFAPRLVAEKLLPPFDTTVASPLQFGYRTKITPHFDMPKRKQKELSVRPPLGFGQKGRPQWRKDTLDIGGHGSILDIDECVLATEVLNKGLTNERRKFEQEFKNYKKGATILLRENTTILDPSKPTLEQLTEEASRDENGDISYVEVEDKKNNVRLAKTCVTNPRQIVTEYVDGYTFNFSAGEFFQNNNSILPIVTKYVRDNLQAPAKGDDNKTKFLVDAYCGSGLFSICSSKGVDKVIGVEISADSVSFAEKNAKANGVENCRFIVGKAEKLFESIDTPSENTSVILDPPRKGCDELFLKQLAAYNPAKIIYISCNVHSQARDVEYFLKETENGSAHQIESIRGFDFFPQTHHVESVCIMKRI", "length": 639, "header": "sp|P33753-1|TRM2_YEAST Isoform 1 of tRNA (uracil(54)-C(5))-methyltransferase OS=Saccharomyces cerevisiae S288C OX=559292 GN=TRM2 PE=1 SV=2 CANONICAL=P33753-1" }, "isoforms": [ { "isoform_ac": "P33753-1", "url": "", "sequence": { "sequence": "MYEQFEFSFFFFENSDNKVKYKAHLISSIKRWSIITCMRCFWTVQKSIFKARFFACRNFVKKHNYKLISTMTGSTEMVPPTMKHTVDNKRLSSPLTDSGNRRTKKPKLRKYKAKKVETTSPMGVLEFEVNDLLKSQNLSREQVLNDVTSILNDKSSTDGPIVLQYHREVKNVKVLEITSNGNGLALIDNPVETEKKQVVIIPFGLPGDVVNIKVFKTHPYYVESDLLDVVEKSPMRRDDLIRDKYFGKSSGSQLEFLTYDDQLELKRKTIMNAYKFFAPRLVAEKLLPPFDTTVASPLQFGYRTKITPHFDMPKRKQKELSVRPPLGFGQKGRPQWRKDTLDIGGHGSILDIDECVLATEVLNKGLTNERRKFEQEFKNYKKGATILLRENTTILDPSKPTLEQLTEEASRDENGDISYVEVEDKKNNVRLAKTCVTNPRQIVTEYVDGYTFNFSAGEFFQNNNSILPIVTKYVRDNLQAPAKGDDNKTKFLVDAYCGSGLFSICSSKGVDKVIGVEISADSVSFAEKNAKANGVENCRFIVGKAEKLFESIDTPSENTSVILDPPRKGCDELFLKQLAAYNPAKIIYISCNVHSQARDVEYFLKETENGSAHQIESIRGFDFFPQTHHVESVCIMKRI", "length": 639, "header": "sp|P33753-1|TRM2_YEAST Isoform 1 of tRNA (uracil(54)-C(5))-methyltransferase OS=Saccharomyces cerevisiae S288C OX=559292 GN=TRM2 PE=1 SV=2 CANONICAL=P33753-1" }, "locus": { "chromosome": "XI", "start_pos": 551364, "end_pos": 549448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YKR056W_mRNA", "url": "https://www.ensembl.org/id/YKR056W_mRNA" }, { "database": "Ensembl Peptide", "id": "YKR056W", "url": "https://www.ensembl.org/id/YKR056W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 92, "end_pos": 92, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "P33753", "url": "https://www.yeastgenome.org/locus/P33753" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser92" }, { "start_pos": 93, "end_pos": 93, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" }, { "database": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "P33753", "url": "https://www.yeastgenome.org/locus/P33753" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser93" }, { "start_pos": 96, "end_pos": 96, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" }, { "database": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" }, { "database": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "P33753", "url": "https://www.yeastgenome.org/locus/P33753" } ], "site_lbl": "Thr96" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Identification of the TRM2 gene encoding the tRNA(m5U54)methyltransferase of Saccharomyces cerevisiae.", "journal": "RNA", "date": "2000", "authors": "Bystroem A.S., Johansson J.O.M., Nordlund M.E., Von Pawel-Rammingen U.", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" } ], "reference": [ { "type": "PubMed", "id": "10864043", "url": "https://glygen.org/publication/PubMed/10864043" } ] }, { "title": "Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation.", "journal": "RNA", "date": "2002", "authors": "Johansson Marcus J O, Bystr\u00f6m Anders S", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" } ], "reference": [ { "type": "PubMed", "id": "12003492", "url": "https://glygen.org/publication/PubMed/12003492" } ] }, { "title": "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.", "journal": "Genome Biol.", "date": "2003", "authors": "Zhang Z., Philippsen P., Stuart L., Dietrich F.S., Brachat S., Gaffney T.D., Gates K., Lerch A., Voegeli S.", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" } ], "reference": [ { "type": "PubMed", "id": "12844361", "url": "https://glygen.org/publication/PubMed/12844361" } ] }, { "title": "Yeast RNC1 encodes a chimeric protein, RhoNUC, with a human rho motif and deoxyribonuclease activity.", "journal": "Nucleic Acids Res.", "date": "1992", "authors": "Perkins E.L., Resnick M.A., Chow T.Y.-K.", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" } ], "reference": [ { "type": "PubMed", "id": "1408836", "url": "https://glygen.org/publication/PubMed/1408836" } ] }, { "title": "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Chi An, Huttenhower Curtis, Geer Lewis Y, Coon Joshua J, Syka John E P, Bai Dina L, Shabanowitz Jeffrey, Burke Daniel J, Troyanskaya Olga G, Hunt Donald F", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" }, { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" }, { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Mol. Cell. Proteomics", "date": "2008", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" }, { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.", "journal": "Genes & development", "date": "2009-08-15", "authors": "Huber Alexandre, Bodenmiller Bernd, Uotila Aino, Stahl Michael, Wanka Stefanie, Gerrits Bertran, Aebersold Ruedi, Loewith Robbie", "evidence": [ { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "P33753", "url": "https://www.uniprot.org/uniprot/P33753" }, { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast.", "journal": "Proteomics", "date": "2009-10", "authors": "Gnad Florian, de Godoy Lyris M F, Cox J\u00fcrgen, Neuhauser Nadin, Ren Shubin, Olsen Jesper V, Mann Matthias", "evidence": [ { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" } ] }, { "title": "Global analysis of the yeast osmotic stress response by quantitative proteomics.", "journal": "Molecular bioSystems", "date": "2009-11", "authors": "Soufi Boumediene, Kelstrup Christian D, Stoehr Gabriele, Fr\u00f6hlich Florian, Walther Tobias C, Olsen Jesper V", "evidence": [ { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" } ] }, { "title": "The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates.", "journal": "Molecular biology of the cell", "date": "2010-10-01", "authors": "Soulard Alexandre, Cremonesi Alessio, Moes Suzette, Sch\u00fctz Fr\u00e9d\u00e9ric, Jen\u00f6 Paul, Hall Michael N", "evidence": [ { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" } ] }, { "title": "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.", "journal": "BMC genomics", "date": "2010-12-02", "authors": "Helbig Andreas O, Rosati Sara, Pijnappel Pim W W M, van Breukelen Bas, Timmers Marc H T H, Mohammed Shabaz, Slijper Monique, Heck Albert J R", "evidence": [ { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ] }, { "title": "Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.", "journal": "Science signaling", "date": "2010-12-21", "authors": "Bodenmiller Bernd, Wanka Stefanie, Kraft Claudine, Urban J\u00f6rg, Campbell David, Pedrioli Patrick G, Gerrits Bertran, Picotti Paola, Lam Henry, Vitek Olga, Brusniak Mi-Youn, Roschitzki Bernd, Zhang Chao, Shokat Kevan M, Schlapbach Ralph, Colman-Lerner Alejandro, Nolan Garry P, Nesvizhskii Alexey I, Peter Matthias, Loewith Robbie, von Mering Christian, Aebersold Ruedi", "evidence": [ { "database": "iPTMnet", "id": "P33753", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33753" } ], "reference": [ { "type": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", 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