{
    "uniprot_canonical_ac": "P33748-1",
    "uniprot_ac": "P33748",
    "uniprot_id": "MSN2_YEAST",
    "mass": {
        "chemical_mass": 77861.0,
        "monoisotopic_mass": 77861.0
    },
    "refseq": {
        "ac": "NP_013751",
        "name": "stress-responsive transcriptional activator MSN2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013751"
    },
    "gene_names": [
        {
            "name": "MSN2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P33748",
            "id": "P33748"
        },
        {
            "name": "MSN2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013751",
            "id": "NP_013751"
        },
        {
            "name": "YM9532.02C",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P33748",
            "id": "P33748"
        }
    ],
    "protein_names": [
        {
            "name": "Zinc finger protein MSN2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P33748"
        },
        {
            "name": "Multicopy suppressor of SNF1 protein 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P33748"
        },
        {
            "name": "stress-responsive transcriptional activator MSN2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013751",
            "id": "NP_013751"
        }
    ],
    "function": [
        {
            "annotation": "Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes. May be regulated via WHI2-PSR1 complex phosphatase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P33748",
                    "url": "https://www.uniprot.org/uniprot/P33748#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P33748",
                    "url": "https://www.uniprot.org/uniprot/P33748"
                }
            ],
            "common_name": "Yeast"
        }
    ],
    "gene": [
        {
            "name": "MSN2",
            "url": "https://www.uniprot.org/uniprot/P33748",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "855053",
            "url": "https://www.ncbi.nlm.nih.gov/gene/855053",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "P33748",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:P33748*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR013087",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036236",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "sce:YMR037C",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YMR037C",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "AIDINEM",
            "url": "https://omabrowser.org/oma/group/AIDINEM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1912438at2759",
            "url": "http://www.orthodb.org/?query=1912438at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR40626",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR40626",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR40626:SF11",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR40626:SF11",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00096",
            "url": "http://pfam.xfam.org/family/PF00096",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P33748",
            "url": "http://purl.obolibrary.org/obo/PR_P33748",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_013751",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013751",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S000004640",
            "url": "https://www.yeastgenome.org/locus/S000004640",
            "database": "SGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "P33748",
            "url": "https://www.uniprot.org/uniprot/P33748",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P33748-1",
            "url": "https://www.uniprot.org/uniprot/P33748-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTVDHDFNSEDILFPIESMSSIQYVENNNPNNINNDVIPYSLDIKNTVLDSADLNDIQNQETSLNLGLPPLSFDSPLPVTETIPSTTDNSLHLKADSNKNRDARTIENDSEIKSTNNASGSGANQYTTLTSPYPMNDILYNMNNPLQSPSPSSVPQNPTINPPINTASNETNLSPQTSNGNETLISPRAQQHTSIKDNRLSLPNGANSNLFIDTNPNNLNEKLRNQLNSDTNSYSNSISNSNSNSTGNLNSSYFNSLNIDSMLDDYVSSDLLLNDDDDDTNLSRRRFSDVITNQFPSMTNSRNSISHSLDLWNHPKINPSNRNTNLNITTNSTSSSNASPNTTTMNANADSNIAGNPKNNDATIDNELTQILNEYNMNFNDNLGTSTSGKNKSACPSSFDANAMTKINPSQQLQQQLNRVQHKQLTSSHNNSSTNMKSFNSDLYSRRQRASLPIIDDSLSYDLVNKQDEDPKNDMLPNSNLSSSQQFIKPSMILSDNASVIAKVATTGLSNDMPFLTEEGEQNANSTPNFDLSITQMNMAPLSPASSSSTSLATNHFYHHFPQQGHHTMNSKIGSSLRRRKSAVPLMGTVPLTNQQNNISSSSVNSTGNGAGVTKERRPSYRRKSMTPSRRSSVVIESTKELEEKPFHCHICPKSFKRSEHLKRHVRSVHSNERPFACHICDKKFSRSDNLSQHIKTHKKHGDI",
        "length": 704,
        "header": "sp|P33748-1|MSN2_YEAST Isoform 1 of Zinc finger protein MSN2  OS=Saccharomyces cerevisiae S288C OX=559292 GN=MSN2 PE=1 SV=1 CANONICAL=P33748-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P33748-1",
            "url": "",
            "sequence": {
                "sequence": "MTVDHDFNSEDILFPIESMSSIQYVENNNPNNINNDVIPYSLDIKNTVLDSADLNDIQNQETSLNLGLPPLSFDSPLPVTETIPSTTDNSLHLKADSNKNRDARTIENDSEIKSTNNASGSGANQYTTLTSPYPMNDILYNMNNPLQSPSPSSVPQNPTINPPINTASNETNLSPQTSNGNETLISPRAQQHTSIKDNRLSLPNGANSNLFIDTNPNNLNEKLRNQLNSDTNSYSNSISNSNSNSTGNLNSSYFNSLNIDSMLDDYVSSDLLLNDDDDDTNLSRRRFSDVITNQFPSMTNSRNSISHSLDLWNHPKINPSNRNTNLNITTNSTSSSNASPNTTTMNANADSNIAGNPKNNDATIDNELTQILNEYNMNFNDNLGTSTSGKNKSACPSSFDANAMTKINPSQQLQQQLNRVQHKQLTSSHNNSSTNMKSFNSDLYSRRQRASLPIIDDSLSYDLVNKQDEDPKNDMLPNSNLSSSQQFIKPSMILSDNASVIAKVATTGLSNDMPFLTEEGEQNANSTPNFDLSITQMNMAPLSPASSSSTSLATNHFYHHFPQQGHHTMNSKIGSSLRRRKSAVPLMGTVPLTNQQNNISSSSVNSTGNGAGVTKERRPSYRRKSMTPSRRSSVVIESTKELEEKPFHCHICPKSFKRSEHLKRHVRSVHSNERPFACHICDKKFSRSDNLSQHIKTHKKHGDI",
                "length": 704,
                "header": "sp|P33748-1|MSN2_YEAST Isoform 1 of Zinc finger protein MSN2  OS=Saccharomyces cerevisiae S288C OX=559292 GN=MSN2 PE=1 SV=1 CANONICAL=P33748-1"
            },
            "locus": {
                "chromosome": "XIII",
                "start_pos": 346517,
                "end_pos": 344406,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "YMR037C_mRNA",
                        "url": "https://www.ensembl.org/id/YMR037C_mRNA"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "YMR037C",
                        "url": "https://www.ensembl.org/id/YMR037C"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 194,
            "end_pos": 194,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "PubMed",
                    "id": "28330760",
                    "url": "https://glygen.org/publication/PubMed/28330760"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser194"
        },
        {
            "start_pos": 201,
            "end_pos": 201,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "19795423",
                    "url": "https://glygen.org/publication/PubMed/19795423"
                },
                {
                    "database": "PubMed",
                    "id": "19823750",
                    "url": "https://glygen.org/publication/PubMed/19823750"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser201"
        },
        {
            "start_pos": 288,
            "end_pos": 288,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P33748",
                    "url": "https://www.uniprot.org/uniprot/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser288"
        },
        {
            "start_pos": 304,
            "end_pos": 304,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P33748",
                    "url": "https://www.uniprot.org/uniprot/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                },
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "19684113",
                    "url": "https://glygen.org/publication/PubMed/19684113"
                },
                {
                    "database": "PubMed",
                    "id": "21177495",
                    "url": "https://glygen.org/publication/PubMed/21177495"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                }
            ],
            "site_lbl": "Ser304"
        },
        {
            "start_pos": 306,
            "end_pos": 306,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "21177495",
                    "url": "https://glygen.org/publication/PubMed/21177495"
                }
            ],
            "site_lbl": "Ser306"
        },
        {
            "start_pos": 308,
            "end_pos": 308,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "17330950",
                    "url": "https://glygen.org/publication/PubMed/17330950"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "PubMed",
                    "id": "21177495",
                    "url": "https://glygen.org/publication/PubMed/21177495"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                }
            ],
            "site_lbl": "Ser308"
        },
        {
            "start_pos": 427,
            "end_pos": 427,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                },
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser427"
        },
        {
            "start_pos": 428,
            "end_pos": 428,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                },
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser428"
        },
        {
            "start_pos": 432,
            "end_pos": 432,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "19795423",
                    "url": "https://glygen.org/publication/PubMed/19795423"
                },
                {
                    "database": "PubMed",
                    "id": "19823750",
                    "url": "https://glygen.org/publication/PubMed/19823750"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "23749301",
                    "url": "https://glygen.org/publication/PubMed/23749301"
                }
            ],
            "site_lbl": "Ser432"
        },
        {
            "start_pos": 451,
            "end_pos": 451,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P33748",
                    "url": "https://www.uniprot.org/uniprot/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "18407956",
                    "url": "https://glygen.org/publication/PubMed/18407956"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "17563356",
                    "url": "https://glygen.org/publication/PubMed/17563356"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                }
            ],
            "site_lbl": "Ser451"
        },
        {
            "start_pos": 582,
            "end_pos": 582,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P33748",
                    "url": "https://www.uniprot.org/uniprot/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "19779198",
                    "url": "https://glygen.org/publication/PubMed/19779198"
                },
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "16281053",
                    "url": "https://glygen.org/publication/PubMed/16281053"
                },
                {
                    "database": "PubMed",
                    "id": "24981510",
                    "url": "https://glygen.org/publication/PubMed/24981510"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                }
            ],
            "site_lbl": "Ser582"
        },
        {
            "start_pos": 620,
            "end_pos": 620,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "11875433",
                    "url": "https://glygen.org/publication/PubMed/11875433"
                },
                {
                    "database": "PubMed",
                    "id": "18375619",
                    "url": "https://glygen.org/publication/PubMed/18375619"
                },
                {
                    "database": "PubMed",
                    "id": "24981510",
                    "url": "https://glygen.org/publication/PubMed/24981510"
                },
                {
                    "database": "SGD",
                    "id": "P33748",
                    "url": "https://www.yeastgenome.org/locus/P33748"
                }
            ],
            "site_lbl": "Ser620"
        },
        {
            "start_pos": 625,
            "end_pos": 625,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P33748",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33748"
                },
                {
                    "database": "PubMed",
                    "id": "17287358",
                    "url": "https://glygen.org/publication/PubMed/17287358"
                },
                {
                    "database": "PubMed",
                    "id": "19684113",
                    "url": "https://glygen.org/publication/PubMed/19684113"
                },
                {
                    "database": "PubMed",
                    "id": "21177495",
                    "url": "https://glygen.org/publication/PubMed/21177495"
                },
                {
                    "database": "PubMed",
                    "id": "24981510",
                    "url": "https://glygen.org/publication/PubMed/24981510"
                }
            ],
            "site_lbl": "Ser625"
        },
        {
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