{ "uniprot_canonical_ac": "P33450-1", "uniprot_ac": "P33450", "uniprot_id": "FAT_DROME", "mass": { "chemical_mass": 564791.0, "monoisotopic_mass": 564791.0 }, "refseq": { "ac": "NP_477497", "name": "fat", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477497" }, "gene_names": [ { "name": "ft", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P33450", "id": "P33450" }, { "name": "79/18; CG3352; CT11259; Dm Fat; Dmel\\CG3352; Fat; Ft; FT; l(2)24Da; l(2)79/18; l(2)fat; l(2)fd; l(2)ft; l(2)gd-1; l(2)gd-l; l(2)gd2; l(2)k07918", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477497", "id": "NP_477497" }, { "name": "CG3352", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P33450", "id": "P33450" }, { "name": "ft", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477497", "id": "NP_477497" } ], "protein_names": [ { "name": "Cadherin-related tumor suppressor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P33450" }, { "name": "CG3352-PA; ft-PA; giant discs 2; floppy-discs; giant-discs-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477497", "id": "NP_477497" }, { "name": "Protein fat", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P33450" }, { "name": "fat", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477497", "id": "NP_477497" } ], "function": [ { "annotation": "Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells (PubMed:11893338). This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor (PubMed:15548581). Also required for planar cell polarity of wing hairs (PubMed:12540853, PubMed:15240556). Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface (PubMed:15240556). Involved in regulation of eye imaginal disk size (PubMed:23667559). Upstream component of the Hippo pathway where it is likely to act as a cell surface receptor involved in regulation of tissue size and is required for the localization and stability of ex (PubMed:16996265). Probably acts as a cell surface receptor for ds (PubMed:20434335).", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450#function" }, { "database": "PubMed", "id": "20434335", "url": "https://glygen.org/publication/PubMed/20434335" }, { "database": "PubMed", "id": "15240556", "url": "https://glygen.org/publication/PubMed/15240556" }, { "database": "PubMed", "id": "15548581", "url": "https://glygen.org/publication/PubMed/15548581" }, { "database": "PubMed", "id": "12540853", "url": "https://glygen.org/publication/PubMed/12540853" }, { "database": "PubMed", "id": "11893338", "url": "https://glygen.org/publication/PubMed/11893338" }, { "database": "PubMed", "id": "23667559", "url": "https://glygen.org/publication/PubMed/23667559" }, { "database": "PubMed", "id": "16996265", "url": "https://glygen.org/publication/PubMed/16996265" } ] }, { "annotation": "Regulates mitochondrial electron transport chain integrity and promotes oxidative phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450#function" }, { "database": "PubMed", "id": "25215488", "url": "https://glygen.org/publication/PubMed/25215488" } ] } ], "disease": [ { "disease_id": "DOID:0060366", "recommended_name": { "id": "DOID:0060366", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060366", "name": "Hennekam syndrome", "description": "A lymphatic system disease characterized by he presence of intestinal lymphangiectasia, mental retardation, and characteristic facial anomalies. It is inherited in an autosomal recessive pattern. Most individuals with Hennekam syndrome have characteristic facial abnormalities, such as a flat face with accompanying puffy eyelids and hypertelorism; the nasal bridge is typically flat and the ears are typically small. Congenital extremity and genital lymphedema is present in most patients." }, "synonyms": [ { "id": "DOID:0060366", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060366", "name": "Hennekam lymphangiectasia-lymphedema syndrome", "description": "" }, { "id": "DOID:0060366", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060366", "name": "lymphedem-lymphangiectasia-intellectual disability syndrome", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "Hennekam lymphangiectasia-lymphedema syndrome 2", "description": "Any Hennekam syndrome in which the cause of the disease is a mutation in the FAT4 gene." }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "FAT4 Hennekam syndrome", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "Hennekam lymphangiectasia-lymphedema syndrome 2", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "Hennekam lymphangiectasia-lymphedema syndrome type 2", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "Hennekam syndrome caused by mutation in FAT4", "description": "" }, { "id": "MONDO:0014454", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014454", "name": "HKLLS2", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam lymphangiectasia-lymphedema syndrome 1", "description": "Any Hennekam syndrome in which the cause of the disease is a mutation in the CCBE1 gene." }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "CCBE1 Hennekam syndrome", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam lymphangiectasia-lymphedema syndrome 1", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam lymphangiectasia-lymphedema syndrome type 1", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam syndrome caused by mutation in CCBE1", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "HKLLS1", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "Hennekam lymphangiectasia-lymphedema syndrome", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "lymphatic dysplasia, generalised", "description": "" }, { "id": "MONDO:0009337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009337", "name": "lymphatic dysplasia, generalized", "description": "" }, { "id": "MIM:616006", "resource": "MIM", "url": "https://www.omim.org/entry/616006", "name": "Hennekam lymphangiectasia-lymphedema syndrome 2", "description": "Hennekam lymphangiectasia-lymphedema syndrome 2" }, { "id": "MIM:235510", "resource": "MIM", "url": "https://www.omim.org/entry/235510", "name": "Hennekam lymphangiectasia-lymphedema syndrome 1", "description": "Hennekam lymphangiectasia-lymphedema syndrome 1" } ], "evidence": [ { "id": "0060366", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060366" } ] }, { "disease_id": "DOID:0080586", "recommended_name": { "id": "DOID:0080586", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080586", "name": "Van Maldergem syndrome 2", "description": "A Van Malergem syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the FAT4 gene on chromosome 4q28." }, "synonyms": [ { "id": "MONDO:0014242", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014242", "name": "van Maldergem syndrome 2", "description": "Any van Maldergem syndrome in which the cause of the disease is a mutation in the FAT4 gene." }, { "id": "MONDO:0014242", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014242", "name": "FAT4 van Maldergem syndrome", "description": "" }, { "id": "MONDO:0014242", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014242", "name": "Van Maldergem syndrome type 2", "description": "" }, { "id": "MONDO:0014242", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014242", "name": "van Maldergem syndrome 2", "description": "" }, { "id": "MONDO:0014242", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014242", "name": "van Maldergem syndrome caused by mutation in FAT4", "description": "" }, { "id": "MONDO:0014242", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014242", "name": "VAN Maldergem syndrome 2", "description": "" }, { "id": "MONDO:0014242", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014242", "name": "VMLDS2", "description": "" }, { "id": "MIM:615546", "resource": "MIM", "url": "https://www.omim.org/entry/615546", "name": "Van Maldergem syndrome 2", "description": "Van Maldergem syndrome 2" } ], "evidence": [ { "id": "0080586", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080586" } ] }, { "disease_id": "DOID:1289", "recommended_name": { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons." }, "synonyms": [ { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "degenerative disease", "description": "" } ], "evidence": [ { "id": "1289", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1289" } ] }, { "disease_id": "DOID:305", "recommended_name": { "id": "DOID:305", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:305", "name": "carcinoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:305", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:305", "name": "epithelial cancer", "description": "" }, { "id": "DOID:305", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:305", "name": "epithelioma", "description": "" }, { "id": "DOID:305", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:305", "name": "malignant Epithelioma", "description": "" } ], "evidence": [ { "id": "305", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:305" } ] }, { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 273, "end_pos": 273, "sequence_org": "S", "sequence_mut": "A", "comment": "Blocks ability of fj to enhance binding to ds.", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" }, { "database": "PubMed", "id": "20434335", "url": "https://glygen.org/publication/PubMed/20434335" } ] }, { "start_pos": 273, "end_pos": 273, "sequence_org": "S", "sequence_mut": "D", "comment": "Blocks ability of fj to enhance binding to ds.", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" }, { "database": "PubMed", "id": "20434335", "url": "https://glygen.org/publication/PubMed/20434335" } ] }, { "start_pos": 4854, "end_pos": 4854, "sequence_org": "T", "sequence_mut": "I", "comment": "In ft61; strong overgrowth of eye imaginal disks. Binding to Fbxl7 is not affected.", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" }, { "database": "PubMed", "id": "25107277", "url": "https://glygen.org/publication/PubMed/25107277" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "ft", "url": "https://www.uniprot.org/uniprot/P33450", "locus": { "chromosome": "2L", "start_pos": 4198404, "end_pos": 4221796, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0001075", "url": "https://www.ensembl.org/id/FBgn0001075" } ] } } ], "crossref": [ { "id": "FBgn0001075", "url": "https://bgee.org/?page=gene&gene_id=FBgn0001075", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0001075", "url": "https://flybase.org/reports/FBgn0001075", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "33627", "url": "https://www.ncbi.nlm.nih.gov/gene/33627", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P33450", "url": "https://www.ebi.ac.uk/intact/interactors/id:P33450*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG3352", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG3352", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YREAGGM", "url": "https://omabrowser.org/oma/group/YREAGGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2961370at2759", "url": "http://www.orthodb.org/?query=2961370at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24026:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24026:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "http://pfam.xfam.org/family/PF00008", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "http://pfam.xfam.org/family/PF00028", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00054", "url": "http://pfam.xfam.org/family/PF00054", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02210", "url": "http://pfam.xfam.org/family/PF02210", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P33450", "url": "http://purl.obolibrary.org/obo/PR_P33450", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-350379", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-350379", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-390023", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-390023", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-390150", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-390150", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_477497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477497", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P33450-1", "url": "https://www.uniprot.org/uniprot/P33450-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERLLLLFFLLLAGRESLCQTGDTKLELLAPRGRSYATTYEQYAAFPRRRSSSSSPSGEMQSRAVDTSADFEVLEGQPRGTTVGFIPTKPKFSYRFNEPPREFTLDPVTGEVKTNVVLDREGMRDHYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSESATSGTRLLLDAATDADVGENGVTDQYEIVAGNVDNKFRLVTTANPSGDTSYLHLETTGNLDRESRGSYQLNISARDGGSPPRFGYLQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDNDLGDNSKITYYLAETEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDHGSPRQDGRTYVTVNLLDTNDHDPIISFRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNELGHFRLEEAADLHIVRVNGVLDREEIGKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDHEPVFEKSEYSAVLSELAPTGSFVASITATDEDTGVNAQVHYDILSGNELKWFSMDPLTGLIVTTGPLDREIRDTVELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVTLGEDAPPQTIVALMTATDHDQGTNGSVTFALAPSVERLYPLQFALDALTGQLTTRRPLDREKMSQYEISVIARDQGAPTPQSATATVWLNVADVNDNDPQFYPRHYIYSLADDDDDIKLKKEVEKERILLHVTASDKDDGDNALIEYRLESGGEGLFQLDARSGAISLRGDAPASMHWKPHYKLLVSARDAGQRRSQQDAIVEIVLKSKLEMLECGQAQAGGYEFQMVEDHEQQRNSQPNREVGIVQVKSTNGKANSHIEYDIIQGDRAQNFRIDTRSGRITTARPLDREEQANYRLTILASSSSSSSAAASSVSYGQCIVNIAIIDLNDNAPVFALDRESEPTISLPENAAVGQEIYLSRVRDRDAGVNSRISYSLTNNPNQQFRIGPVTGVLYLQRPIRAEPGSLIHVELMATDAGSPPLSSKLSLSVLIADVNDHTPVFDHTSYETSLPETTKVNTRFFALAATDIDLGDNGRISYEIIEGNTERMFGVFPDGYLFVRAPLDREERDYYALTVSCRDAGQPSRSSVVPVVIHVIDENDNAPQFTNSTFTFSIPENAPADTFVGKLTAVDRDIGRNAELSFTLSSQTQDFTIDTRNGFIKTLRPFDREALVKVSRNAEASGEDGSLRGSMAGNYMLLEATVSDNGIPRLQDKVKVKVIVTDVNDNAPEFLRAPYHVTISEGASEGTHITHVFTQDADEGLNGDVYYSLAKGNEAGQFNLDSATGQLSLGRRLDRESQEIHHLIVVAKDAALKHPLSSNASITIVVLDENDNAPEFTQSSSEVSVLETSPTGTELMRFRASDADQGVNSQVVFSISAGNRRDTFHIDSITGSLYLHKPLDYEDITSYTLNITASDCGTPSLSTTVLYNVLVVDDNDNPPIFPSTAIVRQIKEGIPLKTPIVTVTADDPDSGLNGKVSYAISKQEPQLPQGRHFGINTETGVIHTLREIDRESIDTFRLTVVATDRAQPSERQLSTEKLVTVIVEDINDNAPVFVSMNAAILPPKFSTSKGSSTAVMQVHAKDADSSSNGLVTYEIVSGPQELFKLQRNTGIITFTPGPQFKQEVRYQLTLKSTDEAVQSERRSSEVYITIITPGSGGSESSVPQFEQRSKLSGSVYENEPIGTSILTVTAHLASAEIEYFVTNVTATGSRGQVDRLFDIDAKLGILSTAAELDREAGPEEYEVEVYAIALGGQPRTSRTKVRVTVLDKNDSPPQFLDTPFVYNVSEDLQIGHTISTLRAHDPDTLGSVTFLLMDGHDGKFLLEPSTGKLILNDTLDRETKSKYELRIRVSDGVQYTEAYATIQVSDTNDNPPLFEDTVYSFDIPENAQRGYQVGQIVARDADLGQNAQLSYGVVSDWANDVFSLNPQTGMLTLTARLDYEEVQHYILIVQAQDNGQPSLSTTITVYCNVLDLNDNAPIFDPMSYSSEVFENVPIATEVVTVSAKDIDSGNNGLIEYSITAGDVDSEFGIDSNGTIRTRRNLDREHRSTYTLTVTARDCADEFASFSELEETQLKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVTILIKDVNDEVPVFISANETAIMENVAINTVVIAVKAVDNDEGRNGYIDYLMKEARDEDMGQSDPLPFSLNPTDGQLRVVDALDRELRSSYLLNITARDRGEPPQSTESQLLIRILDENDNSPVFDPKQYSASVAENASIGAMVLQVSATDVDEGANGRIRYSIVLGDQNHDFSISEDTGVVRVAKNLNYERLSRYSLTVRAEDCALENPAGDTAELTINILDINDNRPTFLDSPYLARVMENTVPPNGGYVLTVNAYDADTPPLNSQVRYFLKEGDSDLFRINASSGDIALLKPLDREQQSEYTLTLVAMDTGSPPLTGTGIVRVEVQDINDNDPVFELQSYHATVRENLPSGTHVLTPRATDKDEGLNAKLRFNLLGEHMHRFHIDSETGEISTATTLDREETSVYHLTLMAQDSSITEPRASSVNLTISVSDVNDNIPKFDSTTYNVAVPERISKGEFVFGARALDLDDGENAVVHYTISGRDQHYFDINTKTGVVSTKLELKTKTKSHDDLTYTIVISAMDQGEQSLSSKAELTVILRPPELFPTFAYMANSHFAMSEDVRPGKMITKVSATSPKKGLVGKIRYAIAGGIMGDSLRVDPNSGLLSVGQDGLDYELTHLYEIWIEAADGDTPSLRSVTLITLNVTDANDNAPVMEQLIYNAEVLEEESPPQLIAVVKASDRDSGDNGNVIYRLQNDFDGTFEITESGEIYTRMRLDREEIGDYAFVVEAVDQGVPHMTGTASVLLHLLDKNDNPPKFTRLFSLNVTENAEIGSFVIRVTSSDLDLGANANASYSFSENPGEKFRIEPQSGNITVAGHLDREQQDEYILKVVASDGAWRAETPITITIQDQNDNAPEFEHSFYSFSFPELQQSIALVGQIIATDRDKQGPNSVISYSLQQPSPMFSIDPATGEVFSKKAVRFKHSQYVRSPENMYALTVLATDNGKPPLYSECLVNINIVDAHNNPPKFEQAEYLAPLPQDAVRGQRIVRVHANDKQDLGTNEMDYSLMTFNLSSIFSVGRHDGWITLVKPIQVPPNTRYELVVRATDRGVPPQSDETRVVIVVTGENMDTPRFSVNSYQVIVPENEPVGSTILTVGATDDDTGPNGMLRYSISGGNERQDFSVDERTGGIVIQQQLDYDLIQEYHLNITVQDLGYHPLSSVAMLTIILTDVNDNPPVFNHKEYHCYIPENKPVGTFVFQAHAADKDSPKNAIIHYAFLPSGPDRHFFIMNQSNGTISSAVSFDYEERRIYTLQIKAKNPDSSMESYANLYVHVLGVNEFYPQFLQPVFHFDVSETSAVGTRVGAVQATDKDSGEDGRVYYLLVGSSNDKGFRIDTNTGLIYVARHLDRETQNRVVLTVMAKNYGSIRGNDTDEAQVIISIQDGNDPPEFIKHYYTSTISEAAPVGTKVTTVKAIDKDVRTQNNQFSYSIINGNLKQSFKIDVQTGEISTASRLDREETSTYNLVIGAIDTGLPPQTGSATVHIELEDVNDNGPTFTPEGLNGYISENEPAGTSIMTLIASDPDLPRNGGPFTYQLIGGKHKSWLSVDRNSGVVRSTTSFDREMTPILEAIIEVEDSGKPKQKSQHLLTITVLDQNDNPSTTRSLHIAVSLFNGDLPSNVKLADVRPNDIDIVGDYRCRLQKNPAQSQLQLAIPRACDLITTSHTTPIASVFSYTGNDGKHGDVSSKVSVAFQSFNNETLANSVSIMVRNMTAYHFLANHYRPILEMIKSRMSNEDEVILYSLLEGGSGNSTNLQLLMAVRLAKTSYQQPKYLIERLREKRSAFSELLQKEVIVGYEPCSEPDVCENGGVCSATMRLLDAHSFVIQDSPALVLSGPRVVHDYSCQCTSGFSGEQCSRRQDPCLPNPCHSQVQCRRLGSDFQCMCPANRDGKHCEKERSDVCYSKPCRNGGSCQRSPDGSSYFCLCRPGFRGNQCESVSDSCRPNPCLHGGLCVSLKPGYKCNCTPGRYGRHCERFSYGFQPLSYMTFPALDVTTNDISIVFATTKPNSLLLYNYGMQSGGRSDFLAIELVHGRAYFSSGGARTAISTVIAGRNLADGGWHKVTATRNGRVMSLSVAKCADSGDVCTECLPGDSSCYADEVGPVGTLNFNKQPLMIGGLSSADPILERPGQVHSDDLVGCLHSVHIGGRALNLSLPLQQKGILAGCNRQACQPALAAERCGGFAGQCIDRWSSSLCQCGGHLQSPDCSDSLEPITLGEGAFVEFRISEIYRRMQLLDNLYNSKSAWLDNQQMRERRAVSNFSTASQIYEAPKMLSMLFRTYKDQGQILYAATNQMFTSLSLREGRLVYYSKQHLTINMTVQETSTLNDGKWHNVSLFSESRSLRLIVDGRQVGDELDIAGVHDFLDPYLTILNVGGEAFVGCLANVTVNNELQPLNGSGSIFPEVRYHGKIESGCRGDIGQDAAQVADPLSIGFTLVIVFFVILVVAILGSYVIYRFRGKQEKIGSLSCGVPGFKIKHPGGPVTQSQVDHVLVRNLHPSEAPSPPVGAGDHMRPPVGSHHLVGPELLTKKFKEPTAEMPQPQQQQQRPQRPDIIERESPLIREDHHLPIPPLHPLPLEHASSVDMGSEYPEHYDLENASSIAPSDIDIVYHYKGYREAAGLRKYKASVPPVSAYTHHKHQNSGSQQQQQQHRHTAPFVTRNQGGQPPPPPTSASRTHQSTPLARLSPSSELSSQQPRILTLHDISGKPLQSALLATTSSSGGVGKDVHSNSERSLNSPVMSQLSGQSSSASRQKPGVPQQQAQQTSMGLTAEEIERLNGRPRTCSLISTLDAVSSSSEAPRVSSSALHMSLGGDVDAHSSTSTDESGNDSFTCSEIEYDNNSLSGDGKYSTSKSLLDGRSPVSRALSGGETSRNPPTTVVKTPPIPPHAYDGFESSFRGSLSTLVASDDDIANHLSGIYRKANGAASPSATTLGWEYLLNWGPSYENLMGVFKDIAELPDTNGPSQQQQQQTQVVSTLRMPSSNGPAAPEEYV", "length": 5147, "header": "sp|P33450-1|FAT_DROME Isoform 1 of Cadherin-related tumor suppressor OS=Drosophila melanogaster OX=7227 GN=ft PE=1 SV=3 CANONICAL=P33450-1" }, "isoforms": [ { "isoform_ac": "P33450-1", "url": "", "sequence": { "sequence": "MERLLLLFFLLLAGRESLCQTGDTKLELLAPRGRSYATTYEQYAAFPRRRSSSSSPSGEMQSRAVDTSADFEVLEGQPRGTTVGFIPTKPKFSYRFNEPPREFTLDPVTGEVKTNVVLDREGMRDHYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSESATSGTRLLLDAATDADVGENGVTDQYEIVAGNVDNKFRLVTTANPSGDTSYLHLETTGNLDRESRGSYQLNISARDGGSPPRFGYLQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDNDLGDNSKITYYLAETEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDHGSPRQDGRTYVTVNLLDTNDHDPIISFRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNELGHFRLEEAADLHIVRVNGVLDREEIGKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDHEPVFEKSEYSAVLSELAPTGSFVASITATDEDTGVNAQVHYDILSGNELKWFSMDPLTGLIVTTGPLDREIRDTVELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVTLGEDAPPQTIVALMTATDHDQGTNGSVTFALAPSVERLYPLQFALDALTGQLTTRRPLDREKMSQYEISVIARDQGAPTPQSATATVWLNVADVNDNDPQFYPRHYIYSLADDDDDIKLKKEVEKERILLHVTASDKDDGDNALIEYRLESGGEGLFQLDARSGAISLRGDAPASMHWKPHYKLLVSARDAGQRRSQQDAIVEIVLKSKLEMLECGQAQAGGYEFQMVEDHEQQRNSQPNREVGIVQVKSTNGKANSHIEYDIIQGDRAQNFRIDTRSGRITTARPLDREEQANYRLTILASSSSSSSAAASSVSYGQCIVNIAIIDLNDNAPVFALDRESEPTISLPENAAVGQEIYLSRVRDRDAGVNSRISYSLTNNPNQQFRIGPVTGVLYLQRPIRAEPGSLIHVELMATDAGSPPLSSKLSLSVLIADVNDHTPVFDHTSYETSLPETTKVNTRFFALAATDIDLGDNGRISYEIIEGNTERMFGVFPDGYLFVRAPLDREERDYYALTVSCRDAGQPSRSSVVPVVIHVIDENDNAPQFTNSTFTFSIPENAPADTFVGKLTAVDRDIGRNAELSFTLSSQTQDFTIDTRNGFIKTLRPFDREALVKVSRNAEASGEDGSLRGSMAGNYMLLEATVSDNGIPRLQDKVKVKVIVTDVNDNAPEFLRAPYHVTISEGASEGTHITHVFTQDADEGLNGDVYYSLAKGNEAGQFNLDSATGQLSLGRRLDRESQEIHHLIVVAKDAALKHPLSSNASITIVVLDENDNAPEFTQSSSEVSVLETSPTGTELMRFRASDADQGVNSQVVFSISAGNRRDTFHIDSITGSLYLHKPLDYEDITSYTLNITASDCGTPSLSTTVLYNVLVVDDNDNPPIFPSTAIVRQIKEGIPLKTPIVTVTADDPDSGLNGKVSYAISKQEPQLPQGRHFGINTETGVIHTLREIDRESIDTFRLTVVATDRAQPSERQLSTEKLVTVIVEDINDNAPVFVSMNAAILPPKFSTSKGSSTAVMQVHAKDADSSSNGLVTYEIVSGPQELFKLQRNTGIITFTPGPQFKQEVRYQLTLKSTDEAVQSERRSSEVYITIITPGSGGSESSVPQFEQRSKLSGSVYENEPIGTSILTVTAHLASAEIEYFVTNVTATGSRGQVDRLFDIDAKLGILSTAAELDREAGPEEYEVEVYAIALGGQPRTSRTKVRVTVLDKNDSPPQFLDTPFVYNVSEDLQIGHTISTLRAHDPDTLGSVTFLLMDGHDGKFLLEPSTGKLILNDTLDRETKSKYELRIRVSDGVQYTEAYATIQVSDTNDNPPLFEDTVYSFDIPENAQRGYQVGQIVARDADLGQNAQLSYGVVSDWANDVFSLNPQTGMLTLTARLDYEEVQHYILIVQAQDNGQPSLSTTITVYCNVLDLNDNAPIFDPMSYSSEVFENVPIATEVVTVSAKDIDSGNNGLIEYSITAGDVDSEFGIDSNGTIRTRRNLDREHRSTYTLTVTARDCADEFASFSELEETQLKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVTILIKDVNDEVPVFISANETAIMENVAINTVVIAVKAVDNDEGRNGYIDYLMKEARDEDMGQSDPLPFSLNPTDGQLRVVDALDRELRSSYLLNITARDRGEPPQSTESQLLIRILDENDNSPVFDPKQYSASVAENASIGAMVLQVSATDVDEGANGRIRYSIVLGDQNHDFSISEDTGVVRVAKNLNYERLSRYSLTVRAEDCALENPAGDTAELTINILDINDNRPTFLDSPYLARVMENTVPPNGGYVLTVNAYDADTPPLNSQVRYFLKEGDSDLFRINASSGDIALLKPLDREQQSEYTLTLVAMDTGSPPLTGTGIVRVEVQDINDNDPVFELQSYHATVRENLPSGTHVLTPRATDKDEGLNAKLRFNLLGEHMHRFHIDSETGEISTATTLDREETSVYHLTLMAQDSSITEPRASSVNLTISVSDVNDNIPKFDSTTYNVAVPERISKGEFVFGARALDLDDGENAVVHYTISGRDQHYFDINTKTGVVSTKLELKTKTKSHDDLTYTIVISAMDQGEQSLSSKAELTVILRPPELFPTFAYMANSHFAMSEDVRPGKMITKVSATSPKKGLVGKIRYAIAGGIMGDSLRVDPNSGLLSVGQDGLDYELTHLYEIWIEAADGDTPSLRSVTLITLNVTDANDNAPVMEQLIYNAEVLEEESPPQLIAVVKASDRDSGDNGNVIYRLQNDFDGTFEITESGEIYTRMRLDREEIGDYAFVVEAVDQGVPHMTGTASVLLHLLDKNDNPPKFTRLFSLNVTENAEIGSFVIRVTSSDLDLGANANASYSFSENPGEKFRIEPQSGNITVAGHLDREQQDEYILKVVASDGAWRAETPITITIQDQNDNAPEFEHSFYSFSFPELQQSIALVGQIIATDRDKQGPNSVISYSLQQPSPMFSIDPATGEVFSKKAVRFKHSQYVRSPENMYALTVLATDNGKPPLYSECLVNINIVDAHNNPPKFEQAEYLAPLPQDAVRGQRIVRVHANDKQDLGTNEMDYSLMTFNLSSIFSVGRHDGWITLVKPIQVPPNTRYELVVRATDRGVPPQSDETRVVIVVTGENMDTPRFSVNSYQVIVPENEPVGSTILTVGATDDDTGPNGMLRYSISGGNERQDFSVDERTGGIVIQQQLDYDLIQEYHLNITVQDLGYHPLSSVAMLTIILTDVNDNPPVFNHKEYHCYIPENKPVGTFVFQAHAADKDSPKNAIIHYAFLPSGPDRHFFIMNQSNGTISSAVSFDYEERRIYTLQIKAKNPDSSMESYANLYVHVLGVNEFYPQFLQPVFHFDVSETSAVGTRVGAVQATDKDSGEDGRVYYLLVGSSNDKGFRIDTNTGLIYVARHLDRETQNRVVLTVMAKNYGSIRGNDTDEAQVIISIQDGNDPPEFIKHYYTSTISEAAPVGTKVTTVKAIDKDVRTQNNQFSYSIINGNLKQSFKIDVQTGEISTASRLDREETSTYNLVIGAIDTGLPPQTGSATVHIELEDVNDNGPTFTPEGLNGYISENEPAGTSIMTLIASDPDLPRNGGPFTYQLIGGKHKSWLSVDRNSGVVRSTTSFDREMTPILEAIIEVEDSGKPKQKSQHLLTITVLDQNDNPSTTRSLHIAVSLFNGDLPSNVKLADVRPNDIDIVGDYRCRLQKNPAQSQLQLAIPRACDLITTSHTTPIASVFSYTGNDGKHGDVSSKVSVAFQSFNNETLANSVSIMVRNMTAYHFLANHYRPILEMIKSRMSNEDEVILYSLLEGGSGNSTNLQLLMAVRLAKTSYQQPKYLIERLREKRSAFSELLQKEVIVGYEPCSEPDVCENGGVCSATMRLLDAHSFVIQDSPALVLSGPRVVHDYSCQCTSGFSGEQCSRRQDPCLPNPCHSQVQCRRLGSDFQCMCPANRDGKHCEKERSDVCYSKPCRNGGSCQRSPDGSSYFCLCRPGFRGNQCESVSDSCRPNPCLHGGLCVSLKPGYKCNCTPGRYGRHCERFSYGFQPLSYMTFPALDVTTNDISIVFATTKPNSLLLYNYGMQSGGRSDFLAIELVHGRAYFSSGGARTAISTVIAGRNLADGGWHKVTATRNGRVMSLSVAKCADSGDVCTECLPGDSSCYADEVGPVGTLNFNKQPLMIGGLSSADPILERPGQVHSDDLVGCLHSVHIGGRALNLSLPLQQKGILAGCNRQACQPALAAERCGGFAGQCIDRWSSSLCQCGGHLQSPDCSDSLEPITLGEGAFVEFRISEIYRRMQLLDNLYNSKSAWLDNQQMRERRAVSNFSTASQIYEAPKMLSMLFRTYKDQGQILYAATNQMFTSLSLREGRLVYYSKQHLTINMTVQETSTLNDGKWHNVSLFSESRSLRLIVDGRQVGDELDIAGVHDFLDPYLTILNVGGEAFVGCLANVTVNNELQPLNGSGSIFPEVRYHGKIESGCRGDIGQDAAQVADPLSIGFTLVIVFFVILVVAILGSYVIYRFRGKQEKIGSLSCGVPGFKIKHPGGPVTQSQVDHVLVRNLHPSEAPSPPVGAGDHMRPPVGSHHLVGPELLTKKFKEPTAEMPQPQQQQQRPQRPDIIERESPLIREDHHLPIPPLHPLPLEHASSVDMGSEYPEHYDLENASSIAPSDIDIVYHYKGYREAAGLRKYKASVPPVSAYTHHKHQNSGSQQQQQQHRHTAPFVTRNQGGQPPPPPTSASRTHQSTPLARLSPSSELSSQQPRILTLHDISGKPLQSALLATTSSSGGVGKDVHSNSERSLNSPVMSQLSGQSSSASRQKPGVPQQQAQQTSMGLTAEEIERLNGRPRTCSLISTLDAVSSSSEAPRVSSSALHMSLGGDVDAHSSTSTDESGNDSFTCSEIEYDNNSLSGDGKYSTSKSLLDGRSPVSRALSGGETSRNPPTTVVKTPPIPPHAYDGFESSFRGSLSTLVASDDDIANHLSGIYRKANGAASPSATTLGWEYLLNWGPSYENLMGVFKDIAELPDTNGPSQQQQQQTQVVSTLRMPSSNGPAAPEEYV", "length": 5147, "header": "sp|P33450-1|FAT_DROME Isoform 1 of Cadherin-related tumor suppressor OS=Drosophila melanogaster OX=7227 GN=ft PE=1 SV=3 CANONICAL=P33450-1" }, "locus": { "chromosome": "2L", "start_pos": 4217840, "end_pos": 4199135, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0077478", "url": "https://www.ensembl.org/id/FBtr0077478" }, { "database": "Ensembl Peptide", "id": "FBpp0077167", "url": "https://www.ensembl.org/id/FBpp0077167" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1155, "start_aa": "Asn", "end_pos": 1155, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1155", "evidence": [ { "id": "P33450", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33450#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1367, "start_aa": "Asn", "end_pos": 1367, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1367", "evidence": [ { "id": "P33450", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33450#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1458, "start_aa": "Asn", "end_pos": 1458, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1458", "evidence": [ { "id": "P33450", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33450#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1751, "start_aa": "Asn", "end_pos": 1751, "end_aa": "Asn", 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"length": 4981 }, "evidence": [ { "id": "P33450", "url": "https://omabrowser.org/oma/group/P33450/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 32, "go_terms": [ { "name": "negative regulation of organ growth", "id": "GO:0046621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046621", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "regulation of growth", "id": "GO:0040008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040008", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "regulation of protein localization", "id": "GO:0032880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0007157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007157", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0016339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016339", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "tissue development", "id": "GO:0009888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009888", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "establishment of body hair planar orientation", "id": "GO:0048105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048105", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "regulation of establishment of planar polarity", "id": "GO:0090175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090175", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "positive regulation of hippo signaling", "id": "GO:0035332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035332", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "negative regulation of growth", "id": "GO:0045926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045926", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "cell-cell adhesion mediated by cadherin", "id": "GO:0044331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044331", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "establishment of planar polarity", "id": "GO:0001736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001736", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization involved in establishment of planar polarity", "id": "GO:0090176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090176", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "protein localization involved in establishment of planar polarity", "id": "GO:0090251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090251", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "establishment of tissue polarity", "id": "GO:0007164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007164", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "pupal development", "id": "GO:0035209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035209", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "establishment of imaginal disc-derived wing hair orientation", "id": "GO:0001737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001737", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "imaginal disc growth", "id": "GO:0007446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007446", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "imaginal disc-derived wing morphogenesis", "id": "GO:0007476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007476", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "regulation of tube length, open tracheal system", "id": "GO:0035159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035159", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "wing disc development", "id": "GO:0035220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035220", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "establishment of ommatidial planar polarity", "id": "GO:0042067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042067", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "equator specification", "id": "GO:0045317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045317", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "regulation of imaginal disc growth", "id": "GO:0045570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045570", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "negative regulation of imaginal disc growth", "id": "GO:0045571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045571", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "imaginal disc pattern formation", "id": "GO:0007447", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007447", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "establishment or maintenance of polarity of larval imaginal disc epithelium", "id": "GO:0016336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016336", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P33450", "url": "https://www.uniprot.org/uniprot/P33450" } ], "pmid": "" }, { "name": "apical 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