{
"uniprot_canonical_ac": "P33261-1",
"uniprot_ac": "P33261",
"uniprot_id": "CP2CJ_HUMAN",
"mass": {
"chemical_mass": 55945.0,
"monoisotopic_mass": 55945.0
},
"refseq": {
"ac": "NP_000760",
"name": "cytochrome P450 2C19 precursor",
"summary": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760"
},
"gene_names": [
{
"name": "CYP2C19",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P33261",
"id": "P33261"
},
{
"name": "CPCJ; CYP2C; CYPIIC17; CYPIIC19; P450C2C; P450IIC19",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760",
"id": "NP_000760"
},
{
"name": "CYP2C19",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760",
"id": "NP_000760"
}
],
"protein_names": [
{
"name": "Cytochrome P450 2C19",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P33261"
},
{
"name": "(R)-limonene 6-monooxygenase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "(S)-limonene 6-monooxygenase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "(S)-limonene 7-monooxygenase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "1.14.14.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "1.14.14.51",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "1.14.14.52",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "1.14.14.53",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "1.14.14.75",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "CYPIIC17",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "CYPIIC19",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "Cytochrome P450-11A",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "Cytochrome P450-254C",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "Fenbendazole monooxygenase (4'-hydroxylating)",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "Mephenytoin 4-hydroxylase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P33261"
},
{
"name": "cytochrome P450 2C19 precursor",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760",
"id": "NP_000760"
},
{
"name": "microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; mephenytoin 4'-hydroxylase; cytochrome P450 2C19; S-mephenytoin 4-hydroxylase; cytochrome P-450 II C; cytochrome P450-11A; cytochrome P450-254C; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; cytochrome P450, family 2, subfamily C, polypeptide 19; fenbendazole monooxygenase (4'-hydroxylating)",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760",
"id": "NP_000760"
}
],
"function": [
{
"annotation": "A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261#function"
},
{
"database": "PubMed",
"id": "11950794",
"url": "https://glygen.org/publication/PubMed/11950794"
},
{
"database": "PubMed",
"id": "23959307",
"url": "https://glygen.org/publication/PubMed/23959307"
},
{
"database": "PubMed",
"id": "19965576",
"url": "https://glygen.org/publication/PubMed/19965576"
},
{
"database": "PubMed",
"id": "20972997",
"url": "https://glygen.org/publication/PubMed/20972997"
},
{
"database": "PubMed",
"id": "18577768",
"url": "https://glygen.org/publication/PubMed/18577768"
}
]
},
{
"annotation": "Association of CYP2C19 Loss-of-Function Metabolizer Status With Stroke Risk Among Chinese Patients Treated With Ticagrelor-Aspirin vs Clopidogrel-Aspirin: A Prespecified Secondary Analysis of a Randomized Clinical Trial. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000760",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760"
},
{
"database": "PubMed",
"id": "37279000",
"url": "https://glygen.org/publication/PubMed/37279000"
}
]
},
{
"annotation": "Population pharmacokinetics of voriconazole and the role of CYP2C19 genotype on treatment optimization in pediatric patients. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000760",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760"
},
{
"database": "PubMed",
"id": "37695751",
"url": "https://glygen.org/publication/PubMed/37695751"
}
]
},
{
"annotation": "The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000760",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760"
},
{
"database": "PubMed",
"id": "37584614",
"url": "https://glygen.org/publication/PubMed/37584614"
}
]
},
{
"annotation": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000760",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760"
}
]
},
{
"annotation": "VARIANTS OF THE FORMATION AND COURSE OF DRUG-RESISTANT EPILEPSY IN CHILDREN WITH GENETIC POLYMORPHISMS OF CYP2C9, CYP2C19, CYP3A4.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000760",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000760"
},
{
"database": "PubMed",
"id": "37326083",
"url": "https://glygen.org/publication/PubMed/37326083"
}
]
}
],
"disease": [
{
"disease_id": "MONDO:0012294",
"recommended_name": {
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "obsolete drug metabolism, poor, Cyp2C19-related",
"description": ""
},
"synonyms": [
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "clopidogrel, impaired responsiveness to",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "drug metabolism, poor, Cyp2C19-related",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "mephenytoin poor metabolizer",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "omeprazole poor metabolizer",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "proguanil poor metabolizer",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "Mephenytoin, poor metabolism of",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "Omeprazole, poor metabolism of",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "Opremazole, poor metabolism of",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "Proguanil, poor metabolism of",
"description": ""
},
{
"id": "MONDO:0012294",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012294",
"name": "clopidogrel, poor metabolism of",
"description": ""
}
],
"evidence": [
{
"id": "609535",
"database": "MIM",
"url": "https://www.omim.org/entry/609535"
}
]
}
],
"snv": [],
"mutagenesis": [],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "29.47",
"present": "ABSENT",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "77.86",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "17.43",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "51.68",
"present": "ABSENT",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "29.4",
"present": "ABSENT",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "16.51",
"present": "ABSENT",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "89.03",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "23.62",
"present": "ABSENT",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "23.62",
"present": "ABSENT",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165841",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165841"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "down",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P33261",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P33261"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "P33261",
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{
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{
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{
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},
{
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{
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{
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{
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},
{
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{
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{
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{
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},
{
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{
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{
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{
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{
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{
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},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "malignant tumour of bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
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},
{
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"name": "malignant tumour of the urinary bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant tumour of urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "malignant urinary bladder neoplasm",
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},
{
"id": "MONDO:0001187",
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"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
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},
{
"id": "MIM:109800",
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}
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},
{
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{
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{
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{
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{
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{
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{
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},
{
"id": "MONDO:0012942",
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},
{
"id": "MONDO:0012942",
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},
{
"id": "MONDO:0012955",
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},
{
"id": "MONDO:0012955",
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},
{
"id": "MONDO:0012955",
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},
{
"id": "MONDO:0013631",
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},
{
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},
{
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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"name": "malignant lung tumor",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"name": "malignant tumour of the lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"name": "alveolar cell carcinoma",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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{
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}
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},
{
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{
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{
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},
{
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{
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
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},
{
"id": "MONDO:0016419",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
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"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0016419",
"resource": "MONDO",
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"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0016419",
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"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0016419",
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"name": "breast cancer, somatic",
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},
{
"id": "MONDO:0016419",
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},
{
"id": "MONDO:0016419",
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
"id": "MONDO:0016419",
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"name": "breast cancer, familial",
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},
{
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},
{
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}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P33261",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P33261"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P33261",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P33261"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P33261",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P33261"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
"resource": "MIM",
"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
"database": "BioXpress",
"id": "P33261",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P33261"
}
],
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
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"name": "heme binding",
"id": "GO:0020037",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "monooxygenase activity",
"id": "GO:0004497",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",
"id": "GO:0016705",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "(S)-limonene 6-monooxygenase activity",
"id": "GO:0018675",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018675",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "(S)-limonene 7-monooxygenase activity",
"id": "GO:0018676",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018676",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "(R)-limonene 6-monooxygenase activity",
"id": "GO:0052741",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052741",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "aromatase activity",
"id": "GO:0070330",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "enzyme binding",
"id": "GO:0019899",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "oxidoreductase activity",
"id": "GO:0016491",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
"id": "GO:0016712",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "arachidonic acid epoxygenase activity",
"id": "GO:0008392",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008392",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "steroid hydroxylase activity",
"id": "GO:0008395",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008395",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "oxygen binding",
"id": "GO:0019825",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "long-chain fatty acid omega-1 hydroxylase activity",
"id": "GO:0120319",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120319",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 8,
"go_terms": [
{
"name": "monoterpenoid metabolic process",
"id": "GO:0016098",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016098",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "heterocycle metabolic process",
"id": "GO:0046483",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046483",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "omega-hydroxylase P450 pathway",
"id": "GO:0097267",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097267",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "long-chain fatty acid metabolic process",
"id": "GO:0001676",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001676",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "xenobiotic metabolic process",
"id": "GO:0006805",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "xenobiotic catabolic process",
"id": "GO:0042178",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042178",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "steroid metabolic process",
"id": "GO:0008202",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "epoxygenase P450 pathway",
"id": "GO:0019373",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 4,
"go_terms": [
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "intracellular membrane-bounded organelle",
"id": "GO:0043231",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum membrane",
"id": "GO:0005789",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
"evidence": [
{
"database": "UniProtKB",
"id": "P33261",
"url": "https://www.uniprot.org/uniprot/P33261"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 334,
"end_pos": 336,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 56,
"end_pos": 58,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [],
"interactions": [],
"reactions": [
{
"id": "17149",
"name": "",
"equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11711-1",
"P05182-1",
"A0A8I6A0P6-1",
"P10633-1",
"P51538-1",
"P00176-1",
"P05178-1",
"P10610-1",
"P13107-1",
"P20812-1",
"P33272-1",
"P51870-1",
"P00185-1",
"Q64581-1",
"P05179-1",
"P51871-1",
"P04167-1",
"P04800-1",
"P05183-1",
"P10634-1",
"P11510-1",
"P12938-1",
"P12939-1",
"P15129-1",
"P15149-1",
"P20814-1",
"P33273-1",
"P51590-1",
"Q64583-1",
"Q64680-1",
"P04799-1",
"Q64678-1",
"P08683-1",
"P24464-1",
"D4A820-1",
"A0A0G2K5K4-1",
"F1LT33-1",
"G3V9D2-1",
"Q9QXF7-1",
"A0A8I5ZZ08-1",
"P05181-1",
"A0A087X1C5-1",
"P08684-1",
"P20853-1",
"P04798-1",
"P05177-1",
"P33261-1",
"Q86W10-1",
"Q16678-1",
"P98187-1",
"P10632-1",
"P11712-1",
"P24462-1",
"Q9HB55-1",
"P13584-1",
"Q16696-1",
"Q9HCS2-1",
"P33260-1",
"Q02928-1",
"Q08477-1",
"Q9HBI6-1",
"P78329-1",
"P24903-1",
"P20815-1",
"Q6V0L0-1",
"P20852-1",
"O09158-1",
"O55071-1",
"Q64459-1",
"Q64481-1",
"O54749-1",
"P11714-1",
"P15392-1",
"Q8CIM7-1",
"P24456-1",
"P56654-1",
"P56655-1",
"P56656-1",
"P12791-1",
"P56593-1",
"O54750-1",
"Q91WL5-1",
"Q91X77-1",
"Q64458-1",
"P00186-1",
"P00184-1",
"Q05421-1",
"Q6XVG2-1",
"Q9D816-1",
"P12790-1",
"P24457-1",
"Q9JMA7-1",
"Q64462-1",
"Q64464-1",
"Q64429-1",
"D3YYZ0-1",
"D3Z2W7-1",
"Q9WV19-1",
"Q9DBX6-1",
"B2RXZ2-1",
"E9Q593-1",
"A2A974-1",
"A6H6J2-1",
"Q9EQW4-1",
"B2RXA7-1"
],
"evidence": [
{
"id": "17149",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17149"
}
]
},
{
"id": "17945",
"name": "",
"equation": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P11712-1"
],
"evidence": [
{
"id": "17945",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17945"
}
]
},
{
"id": "18957",
"name": "",
"equation": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P11712-1"
],
"evidence": [
{
"id": "18957",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/18957"
}
]
},
{
"id": "23432",
"name": "",
"equation": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P11712-1"
],
"evidence": [
{
"id": "23432",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/23432"
}
]
},
{
"id": "39759",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q4V8D1-1",
"Q9QXF7-1",
"P04798-1",
"P05177-1",
"P33261-1",
"P11712-1",
"Q7Z449-1",
"P00186-1",
"P00184-1",
"Q91WL5-1",
"Q9CX98-1",
"A2A974-1"
],
"evidence": [
{
"id": "39759",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39759"
}
]
},
{
"id": "39779",
"name": "",
"equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"P08683-1",
"P24470-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P00186-1",
"P00184-1",
"Q91WL5-1",
"E9Q5K4-1",
"A2A974-1"
],
"evidence": [
{
"id": "39779",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39779"
}
]
},
{
"id": "39787",
"name": "",
"equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P05182-1",
"P05181-1",
"P04798-1",
"P33261-1",
"Q08477-1",
"P00184-1",
"Q05421-1",
"Q91WL5-1",
"A2A974-1"
],
"evidence": [
{
"id": "39787",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39787"
}
]
},
{
"id": "49860",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P33261-1",
"Q16678-1",
"P10632-1",
"P11712-1",
"P00186-1",
"P00184-1",
"Q64429-1",
"P56657-1"
],
"evidence": [
{
"id": "49860",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49860"
}
]
},
{
"id": "49876",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P51589-1",
"P33261-1",
"Q16678-1",
"P10632-1",
"P11712-1",
"Q64429-1"
],
"evidence": [
{
"id": "49876",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49876"
}
]
},
{
"id": "49880",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P10635-1",
"P51589-1",
"P04798-1",
"P33261-1",
"Q16678-1",
"P10632-1",
"P11712-1",
"P00184-1",
"Q64429-1",
"E9Q5K4-1"
],
"evidence": [
{
"id": "49880",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49880"
}
]
},
{
"id": "49884",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P10635-1",
"P51589-1",
"P04798-1",
"P33261-1",
"Q16678-1",
"P11712-1",
"P00184-1",
"Q64429-1",
"E9Q5K4-1"
],
"evidence": [
{
"id": "49884",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49884"
}
]
},
{
"id": "50076",
"name": "",
"equation": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P05182-1",
"P05181-1",
"P04798-1",
"P33261-1",
"P00184-1",
"Q05421-1"
],
"evidence": [
{
"id": "50076",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/50076"
}
]
},
{
"id": "50088",
"name": "",
"equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P05182-1",
"P05181-1",
"P33261-1",
"Q08477-1",
"Q05421-1"
],
"evidence": [
{
"id": "50088",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/50088"
}
]
},
{
"id": "52120",
"name": "",
"equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"P10635-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P33261-1",
"P10632-1",
"P00186-1",
"P00184-1"
],
"evidence": [
{
"id": "52120",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52120"
}
]
},
{
"id": "52124",
"name": "",
"equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P10635-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P33261-1",
"P10632-1",
"P00184-1"
],
"evidence": [
{
"id": "52124",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52124"
}
]
},
{
"id": "56292",
"name": "",
"equation": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1"
],
"evidence": [
{
"id": "56292",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/56292"
}
]
},
{
"id": "R-HSA-143468",
"name": "MEOS oxidizes ethanol to acetaldehyde",
"equation": "",
"summary": "The MEOS (microsomal ethanol oxidizing system) is an accessory pathway in the liver which increases in activity on chronic alcohol induction. The MEOS utilizes a cytochrome P450 which has since been deciphered to be CYP2E1, an ethanol-inducible form of P450. CYP2E1 also increases acetaldehyde formation and free radicals which can initiate lipid peroxidation. CYP2E1 can also activate many over-the-counter medicines and solvents to toxic metabolites and deplete retinoids resulting in their depletion and deletrious effects. This is because, being a cytochrome P450 and using NADPH and oxygen, it has the ability to biotransform drugs when it has been induced by ethanol.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-113748"
],
"output_participant_list": [
"R-ALL-113564",
"R-ALL-113745"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-143468",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-143468"
}
]
},
{
"id": "R-HSA-211881",
"name": "Coumarin is 7-hydroxylated by CYP2A13",
"equation": "",
"summary": "CYP2A13 can also 7-hydroxylate coumarin. It shares a 93.5% identity with CYP2A6 in the amino acid sequence but it is only about one-tenth as active as CYP2A6 in catalyzing coumarin 7-hydroxylation.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-76328"
],
"output_participant_list": [
"R-ALL-76452"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"P11509-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211881",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211881"
}
]
},
{
"id": "R-HSA-211910",
"name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation",
"equation": "",
"summary": "Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211906"
],
"output_participant_list": [
"R-ALL-211894"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211910",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211910"
}
]
},
{
"id": "R-HSA-211929",
"name": "CYP2C19 5-hydroxylates omeprazole",
"equation": "",
"summary": "Omeprazole is a potent long-acting inhibitor of gastric acid secretion by irreversible binding to the proton pump (H+,K+) ATPase in the gastric parietal cell. CYP2C19 is the major P450 which involved in 5-hydroxylation of omeprazole.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211892"
],
"output_participant_list": [
"R-ALL-211944"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211929",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211929"
}
]
},
{
"id": "R-HSA-211966",
"name": "CYP2D6 4-hydroxylates debrisoquine",
"equation": "",
"summary": "CYP2D6 (debrisoquine 4-hydroxylase) has a wide substrate specificity and is an important cytochrme P450 in drug metabolism. It has extensive genetic polymorphism (called the debrisoquine/sparteine oxidation polymorphism) that influences its expression and function.The polymorphism is responsible for populations being poor metabolizers (PM) or extensive metabolizers (EM, normal). Approximately 10% of Caucasians and less than 1% of Asians lack the CYP2D6 protein because of two null alleles which do not encode the functional product. Further polymorphisms discovered recently have identified ultrarapid metabolizers (PM) (alleles with multiple gene copies) and intermediate metabolizers (IM) (deficiency in their metabolism capacity) (Zanger UM et al, 2004).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211993"
],
"output_participant_list": [
"R-ALL-211952"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P51589-1",
"Q8TAV3-1",
"P10632-1",
"P11712-1"
],
"evidence": [
{
"id": "R-HSA-211966",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211966"
}
]
},
{
"id": "R-HSA-211988",
"name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation",
"equation": "",
"summary": "Tolbutamide is an oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety. The reaction is catalyzed by CYP2C9.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9838902"
],
"output_participant_list": [
"R-ALL-211937"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211988",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211988"
}
]
},
{
"id": "R-HSA-211991",
"name": "Cyclophosphamide is 4-hydroxylated by CYP2B6",
"equation": "",
"summary": "Cyclophosphamide (CPA) is an alkylating agent used in cancer chemotherapy and an immunosuppressant. CYP2B6 converts CPA to the active metabolite 4-hydroxy-CPA.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211977"
],
"output_participant_list": [
"R-ALL-211967"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211991",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211991"
}
]
},
{
"id": "R-HSA-212004",
"name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation",
"equation": "",
"summary": "Phenytoin is a widely used anti-epileptic drug which can be hydroxylated by several P450s including CYP2C18 to its major metabolite, (5-(4-hydroxyphenyl)-phenylhydantoin (HPPH).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211939"
],
"output_participant_list": [
"R-ALL-211927"
],
"enzyme_list": [
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P33260-1"
],
"evidence": [
{
"id": "R-HSA-212004",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212004"
}
]
},
{
"id": "R-HSA-212005",
"name": "CYP2F1 dehydrogenates 3-methylindole",
"equation": "",
"summary": "3-methylindole (3MI) is a fermentation product of tryptophan. It is usually formed in the rumen of goats and cattle and in the large intestine of humans. CYP2F1 shows the highest activity towards the dehydrogenation of 3MI to form a methylene imine-reactive intermediate.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-213162"
],
"output_participant_list": [
"R-ALL-213163"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-212005",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212005"
}
]
},
{
"id": "R-HSA-2161814",
"name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)",
"equation": "",
"summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE). The CYPs and their references are as follows: CYP2C8 (Bylund et al. 1998); CYP2C9 (Bylund et al. 1998); CYP2C19 (Bylund et al. 1998); CYP4A11 (Gainer et al. 2005); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-2142836"
],
"enzyme_list": [
"P33261-1",
"Q16678-1",
"Q7Z449-1",
"P04798-1",
"P10632-1",
"P11712-1",
"Q02928-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161814",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161814"
}
]
},
{
"id": "R-HSA-2161899",
"name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)",
"equation": "",
"summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (8,9-, 11,12-, 14,15-EETs). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P51589-1",
"Q16678-1",
"P04798-1",
"P10632-1",
"P11712-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161899",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161899"
}
]
},
{
"id": "R-HSA-76354",
"name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide",
"equation": "",
"summary": "CYP2E1 can catalyze the oxidation of the vinyl halide vinyl chloride to the epoxide 2-chloroethylene oxide. The epoxide is very unstable and rearranges quickly to 2-chloroacetaldehyde. Both these products can interact with DNA and proteins.",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-39417"
],
"output_participant_list": [
"R-ALL-156524"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76354",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76354"
}
]
},
{
"id": "R-HSA-76397",
"name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)",
"equation": "",
"summary": "N-acetyl-p-benzoquinone imine (NAPQI) is the reactive intermediate of the analgesic and antipyretic, acetaminophen (INN, paracetamol). At usual doses, NAPQI is quickly detoxified by conjugation but in overdose situations, NAPQI is extremely toxic to liver tissue.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-113555",
"R-ALL-39427"
],
"output_participant_list": [
"R-ALL-113519",
"R-ALL-113601",
"R-ALL-76396"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76397",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76397"
}
]
},
{
"id": "R-HSA-76416",
"name": "Benzene is hydroxylated to phenol",
"equation": "",
"summary": "Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-31711"
],
"output_participant_list": [
"R-ALL-29630"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76416",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76416"
}
]
},
{
"id": "R-HSA-76434",
"name": "Dehalogenation of carbon tetrachloride to form a free radical",
"equation": "",
"summary": "Carbon tetrachloride (CCl4) has been widely used as a dry-cleaning agent, in fire extinguishers and in the manufacture of other halogenated hydrocarbons. At toxic doses, CCl4 exposure can damage the liver and kidneys. This toxicity results from CYP2E1-dependant reduction of CCl4 to the reactive trichloromethyl radical (CCl3.).",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-40887"
],
"output_participant_list": [
"R-ALL-29572",
"R-ALL-76433"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76434",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76434"
}
]
},
{
"id": "R-HSA-76456",
"name": "O-atom dealkylation of dextromethorphan",
"equation": "",
"summary": "At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of 'Dextromethorphan', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of 'Dextrorphan', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.
This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 2D6 '.
",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-39703"
],
"output_participant_list": [
"R-ALL-143501",
"R-ALL-76455"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P51589-1",
"Q8TAV3-1",
"P10632-1",
"P11712-1"
],
"evidence": [
{
"id": "R-HSA-76456",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76456"
}
]
},
{
"id": "R-HSA-76475",
"name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide",
"equation": "",
"summary": "The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis (\\halothane hepatitis\\).",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-40795"
],
"output_participant_list": [
"R-ALL-76473",
"R-ALL-76474"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76475",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76475"
}
]
},
{
"id": "R-HSA-9749986",
"name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA",
"equation": "",
"summary": "2,3-Dihydroxybenzoate (2,3-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015)",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-113534"
],
"output_participant_list": [
"R-ALL-9750011"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9749986",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749986"
}
]
},
{
"id": "R-HSA-9750016",
"name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA",
"equation": "",
"summary": "2,5-Dihydroxybenzoate (gentisic acid, 2,5-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-9750014"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9750016",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9750016"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-ALL-113519",
"participant_name": "H2O [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "C00001",
"database": "COMPOUND",
"url": ""
},
{
"id": "15377",
"database": "ChEBI",
"url": ""
},
{
"id": "8145132",
"database": "PubChem Substance",
"url": ""
},
{
"id": "HMDB0002111",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "15377",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0002111",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8145132",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C00001",
"database": "COMPOUND",
"url": ""
},
{
"id": "15377",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0002111",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8145132",
"database": "PubChem Substance",
"url": ""
},
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}
]
},
{
"ec_number": "1.14.13.n7",
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{
"id": "P05181",
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}
]
}
]
},
{
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{
"ec_number": "1.14.13.n7",
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"id": "P05182",
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}
]
},
{
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{
"id": "P05182",
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}
]
},
{
"ec_number": "1.14.13.n7",
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{
"id": "P05182",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P05182",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P05183",
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}
]
},
{
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{
"id": "P05183",
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}
]
}
]
},
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"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P08683",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P08683",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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"id": "P08684",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.55",
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{
"id": "P08684",
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}
]
},
{
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{
"id": "P08684",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.73",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P08684",
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}
]
},
{
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}
]
},
{
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}
]
}
]
},
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}
]
},
{
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}
]
}
]
},
{
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}
]
},
{
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"id": "P10632",
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}
]
}
]
},
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}
]
},
{
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}
]
},
{
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}
]
}
]
},
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"ec_number": "1.14.14.1",
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"id": "P10634",
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}
]
},
{
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"id": "P10634",
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}
]
}
]
},
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"id": "P10635",
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}
]
}
]
},
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{
"ec_number": "1.14.14.-",
"activity": "",
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"id": "P11509",
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}
]
}
]
},
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}
]
},
{
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}
]
}
]
},
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}
]
},
{
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}
]
}
]
},
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{
"ec_number": "1.14.14.1",
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{
"id": "P11712",
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}
]
},
{
"ec_number": "1.14.14.51",
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{
"id": "P11712",
"database": "UniProtKB",
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}
]
},
{
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{
"id": "P11712",
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}
]
},
{
"ec_number": "1.14.14.53",
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{
"id": "P11712",
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}
]
},
{
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{
"id": "P11712",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.-",
"activity": "",
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{
"id": "P11714",
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}
]
},
{
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{
"id": "P11714",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P11714",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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"id": "P12790",
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}
]
},
{
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{
"id": "P12790",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P12791",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P12791",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P12938",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P12938",
"database": "UniProtKB",
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}
]
}
]
},
{
"uniprot_ac": "P12939",
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{
"ec_number": "1.14.14.-",
"activity": "",
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{
"id": "P12939",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P12939",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P12939",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P13107",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P13107",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13107"
}
]
}
]
},
{
"uniprot_ac": "P13584",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P13584",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13584"
}
]
},
{
"ec_number": "1.14.14.1",
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"evidence": [
{
"id": "P13584",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P15129",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P15129",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P15149",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P15149",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P15392",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P15392",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P20812",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P20812",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.13.-",
"activity": "",
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{
"id": "P20813",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P20814",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20814"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P20814",
"database": "UniProtKB",
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}
]
}
]
},
{
"uniprot_ac": "P20815",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P20815",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20815"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
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{
"id": "P20815",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P20852",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20852"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P20852",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20852"
}
]
}
]
},
{
"uniprot_ac": "P20853",
"gene_name": "CYP2A7",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P20853",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20853"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P20853",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20853"
}
]
}
]
},
{
"uniprot_ac": "P24456",
"gene_name": "Cyp2d10",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P24456",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24456"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24456",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24456"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24456",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24456"
}
]
}
]
},
{
"uniprot_ac": "P24457",
"gene_name": "Cyp2d11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24457",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24457"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24457",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24457"
}
]
}
]
},
{
"uniprot_ac": "P24462",
"gene_name": "CYP3A7",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24462"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24462"
}
]
}
]
},
{
"uniprot_ac": "P24464",
"gene_name": "Cyp4a12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24464"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24464"
}
]
}
]
},
{
"uniprot_ac": "P24470",
"gene_name": "Cyp2c23",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P24470",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24470"
}
]
}
]
},
{
"uniprot_ac": "P24903",
"gene_name": "CYP2F1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24903",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24903"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24903",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24903"
}
]
}
]
},
{
"uniprot_ac": "P33260",
"gene_name": "CYP2C18",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33260"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P33260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33260"
}
]
}
]
},
{
"uniprot_ac": "P33261",
"gene_name": "CYP2C19",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.51",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.52",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.53",
"activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.75",
"activity": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
}
]
},
{
"uniprot_ac": "P33272",
"gene_name": "Cyp2b12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33272",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33272"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P33272",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33272"
}
]
}
]
},
{
"uniprot_ac": "P33273",
"gene_name": "Cyp2c55",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33273",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33273"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P33273",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33273"
}
]
}
]
},
{
"uniprot_ac": "P51538",
"gene_name": "Cyp3a9",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P51538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51538"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51538"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51538"
}
]
}
]
},
{
"uniprot_ac": "P51589",
"gene_name": "CYP2J2",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P51589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51589"
}
]
},
{
"ec_number": "5.4.4.7",
"activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.",
"evidence": [
{
"id": "P51589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51589"
}
]
},
{
"ec_number": "1.14.14.73",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51589"
}
]
},
{
"ec_number": "1.14.14.74",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51589"
}
]
}
]
},
{
"uniprot_ac": "P51590",
"gene_name": "Cyp2j3",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51590",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51590"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51590",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51590"
}
]
}
]
},
{
"uniprot_ac": "P51870",
"gene_name": "Cyp4f5",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51870",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51870"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51870",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51870"
}
]
}
]
},
{
"uniprot_ac": "P51871",
"gene_name": "Cyp4f6",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51871"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51871"
}
]
}
]
},
{
"uniprot_ac": "P56593",
"gene_name": "Cyp2a12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56593"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56593"
}
]
}
]
},
{
"uniprot_ac": "P56654",
"gene_name": "Cyp2c37",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56654"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56654"
}
]
}
]
},
{
"uniprot_ac": "P56655",
"gene_name": "Cyp2c38",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56655"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56655"
}
]
}
]
},
{
"uniprot_ac": "P56656",
"gene_name": "Cyp2c39",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56656"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56656"
}
]
}
]
},
{
"uniprot_ac": "P56657",
"gene_name": "Cyp2c40",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P56657",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56657"
}
]
}
]
},
{
"uniprot_ac": "P78329",
"gene_name": "CYP4F2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.78",
"activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.79",
"activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.94",
"activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
}
]
},
{
"uniprot_ac": "P98187",
"gene_name": "CYP4F8",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P98187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98187"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P98187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98187"
}
]
}
]
},
{
"uniprot_ac": "Q02928",
"gene_name": "CYP4A11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
},
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
}
]
},
{
"uniprot_ac": "Q05421",
"gene_name": "Cyp2e1",
"activity": [
{
"ec_number": "1.14.13.n7",
"activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).",
"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "",
"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
}
]
},
{
"uniprot_ac": "Q08477",
"gene_name": "CYP4F3",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
},
{
"ec_number": "1.14.14.79",
"activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
},
{
"ec_number": "1.14.14.94",
"activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
}
]
},
{
"uniprot_ac": "Q16678",
"gene_name": "CYP1B1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q16678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16678"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q16678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16678"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q16678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16678"
}
]
}
]
},
{
"uniprot_ac": "Q16696",
"gene_name": "CYP2A13",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q16696",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16696"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q16696",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16696"
}
]
}
]
},
{
"uniprot_ac": "Q4V8D1",
"gene_name": "Cyp2u1",
"activity": [
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q4V8D1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4V8D1"
}
]
}
]
},
{
"uniprot_ac": "Q64429",
"gene_name": "Cyp1b1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64429",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64429"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q64429",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64429"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64429",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64429"
}
]
}
]
},
{
"uniprot_ac": "Q64458",
"gene_name": "Cyp2c29",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64458"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64458"
}
]
}
]
},
{
"uniprot_ac": "Q64459",
"gene_name": "Cyp3a11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64459"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64459"
}
]
}
]
},
{
"uniprot_ac": "Q64462",
"gene_name": "Cyp4b1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64462"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64462"
}
]
}
]
},
{
"uniprot_ac": "Q64464",
"gene_name": "Cyp3a13",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64464"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64464"
}
]
}
]
},
{
"uniprot_ac": "Q64481",
"gene_name": "Cyp3a16",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64481",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64481"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64481",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64481"
}
]
}
]
},
{
"uniprot_ac": "Q64581",
"gene_name": "Cyp3a18",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q64581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64581"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64581"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64581"
}
]
}
]
},
{
"uniprot_ac": "Q64583",
"gene_name": "Cyp2b15",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64583",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64583"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64583",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64583"
}
]
}
]
},
{
"uniprot_ac": "Q64678",
"gene_name": "Cyp1b1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q64678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
}
]
},
{
"uniprot_ac": "Q64680",
"gene_name": "Cyp2d4",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64680"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64680"
}
]
}
]
},
{
"uniprot_ac": "Q6V0L0",
"gene_name": "CYP26C1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q6V0L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V0L0"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q6V0L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V0L0"
}
]
}
]
},
{
"uniprot_ac": "Q6XVG2",
"gene_name": "Cyp2c54",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q6XVG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XVG2"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q6XVG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XVG2"
}
]
}
]
},
{
"uniprot_ac": "Q7Z449",
"gene_name": "CYP2U1",
"activity": [
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q7Z449",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z449"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q7Z449",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z449"
}
]
}
]
},
{
"uniprot_ac": "Q86W10",
"gene_name": "CYP4Z1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q86W10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86W10"
}
]
},
{
"ec_number": "1.14.14.130",
"activity": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q86W10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86W10"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q86W10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86W10"
}
]
}
]
},
{
"uniprot_ac": "Q8CIM7",
"gene_name": "Cyp2d26",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q8CIM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIM7"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q8CIM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIM7"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q8CIM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIM7"
}
]
}
]
},
{
"uniprot_ac": "Q8TAV3",
"gene_name": "CYP2W1",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q8TAV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TAV3"
}
]
}
]
},
{
"uniprot_ac": "Q91WL5",
"gene_name": "Cyp4a12a",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q91WL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WL5"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q91WL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WL5"
}
]
}
]
},
{
"uniprot_ac": "Q91X77",
"gene_name": "Cyp2c50",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q91X77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91X77"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q91X77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91X77"
}
]
}
]
},
{
"uniprot_ac": "Q96SQ9",
"gene_name": "CYP2S1",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q96SQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96SQ9"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q96SQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96SQ9"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "prostaglandin H2 = thromboxane A2.",
"evidence": [
{
"id": "Q96SQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96SQ9"
}
]
}
]
},
{
"uniprot_ac": "Q9CX98",
"gene_name": "Cyp2u1",
"activity": [
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9CX98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CX98"
}
]
}
]
},
{
"uniprot_ac": "Q9D816",
"gene_name": "Cyp2c55",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9D816",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D816"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9D816",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D816"
}
]
}
]
},
{
"uniprot_ac": "Q9DBX6",
"gene_name": "Cyp2s1",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "prostaglandin H2 = thromboxane A2.",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
}
]
},
{
"uniprot_ac": "Q9EQW4",
"gene_name": "Cyp3a44",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q9EQW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EQW4"
}
]
}
]
},
{
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]
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