{ "uniprot_canonical_ac": "P33174-1", "uniprot_ac": "P33174", "uniprot_id": "KIF4_MOUSE", "mass": { "chemical_mass": 139519.0, "monoisotopic_mass": 139519.0 }, "refseq": { "ac": "NP_032472", "name": "chromosome-associated kinesin KIF4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" }, "gene_names": [ { "name": "Kif4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P33174", "id": "P33174" }, { "name": "D330050K22Rik; Kns4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472", "id": "NP_032472" }, { "name": "Kif4a", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P33174", "id": "P33174" }, { "name": "Kif4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472", "id": "NP_032472" }, { "name": "Kns4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P33174", "id": "P33174" } ], "protein_names": [ { "name": "Chromosome-associated kinesin KIF4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P33174" }, { "name": "Chromokinesin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P33174" }, { "name": "chromokinesin; kinesin heavy chain member 4; N-5 kinesin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472", "id": "NP_032472" }, { "name": "chromosome-associated kinesin KIF4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472", "id": "NP_032472" } ], "function": [ { "annotation": "CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.", "evidence": [ { "database": "RefSeq", "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" }, { "database": "PubMed", "id": "35579738", "url": "https://glygen.org/publication/PubMed/35579738" } ] }, { "annotation": "Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Required for mitotic chromosomal positioning and bipolar spindle stabilization.", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174#function" }, { "database": "PubMed", "id": "7929562", "url": "https://glygen.org/publication/PubMed/7929562" }, { "database": "UniProtKB", "id": "O95239", "url": "https://www.uniprot.org/uniprot/O95239#function" } ] }, { "annotation": "KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" }, { "database": "PubMed", "id": "36482480", "url": "https://glygen.org/publication/PubMed/36482480" } ] }, { "annotation": "This work reveals essential roles for Kif4 during the meiotic divisions.", "evidence": [ { "database": "RefSeq", "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" }, { "database": "PubMed", "id": "31067151", "url": "https://glygen.org/publication/PubMed/31067151" } ] }, { "annotation": "Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.", "evidence": [ { "database": "RefSeq", "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" }, { "database": "PubMed", "id": "31486502", "url": "https://glygen.org/publication/PubMed/31486502" } ] } ], "disease": [ { "disease_id": "DOID:0112040", "recommended_name": { "id": "DOID:0112040", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112040", "name": "non-syndromic X-linked intellectual disability 100", "description": "A non-syndromic X-linked intellectual disability characterized by mild to moderate intellectual disability that has_material_basis_in hemizygous mutation in the KIF4A gene on chromosome Xq13.1." }, "synonyms": [ { "id": "DOID:0112040", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112040", "name": "MRX100", "description": "" }, { "id": "DOID:0112040", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112040", "name": "X-linked mental retardation 100", "description": "" }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "intellectual disability, X-linked 100", "description": "Any non-syndromic X-linked intellectual disability in which the cause of the disease is a mutation in the KIF4A gene." }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "KIF4A non-syndromic X-linked intellectual disability", "description": "" }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "intellectual developmental disorder, X-linked 100, X-linked recessive", "description": "" }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "intellectual disability, X-linked 100", "description": "" }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "intellectual disability, X-linked type 100", "description": "" }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "mental retardation, X-linked type 100", "description": "" }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "non-syndromic X-linked intellectual disability caused by mutation in KIF4A", "description": "" }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "MRX100", "description": "" }, { "id": "MONDO:0010488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010488", "name": "mental retardation, X-linked 100", "description": "" }, { "id": "MIM:300923", "resource": "MIM", "url": "https://www.omim.org/entry/300923", "name": "Intellectual developmental disorder, X-linked 100", "description": "Intellectual developmental disorder, X-linked 100" } ], "evidence": [ { "id": "0112040", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112040" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "evidence": [ { "id": "1826", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Kif4", "url": "https://www.uniprot.org/uniprot/P33174", "locus": { "chromosome": "X", "start_pos": 99770820, "end_pos": 99669343, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000034311", "url": "https://www.ensembl.org/id/ENSMUSG00000034311" } ] } } ], "crossref": [ { "id": "ENSMUSG00000034311", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034311", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "5.6.1.3", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.6.1.3&UniProtAcc=P33174", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd01372", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01372", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "16571", "url": "https://www.ncbi.nlm.nih.gov/gene/16571", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P33174", "url": "https://www.ebi.ac.uk/intact/interactors/id:P33174*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:16571", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16571", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "108389", "url": "http://www.informatics.jax.org/marker/MGI:108389", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "P33174", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P33174", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PAFNKQH", "url": "https://omabrowser.org/oma/group/PAFNKQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "602895at2759", "url": "http://www.orthodb.org/?query=602895at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47969:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47969:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3ZFC", "url": "https://www.rcsb.org/structure/3ZFC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3ZFD", "url": "https://www.rcsb.org/structure/3ZFD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00225", "url": "http://pfam.xfam.org/family/PF00225", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P33174", "url": "http://purl.obolibrary.org/obo/PR_P33174", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2132295", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-437239", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-437239", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6811434", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6811434", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-983189", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983189", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P33174-1", "url": "https://www.uniprot.org/uniprot/P33174-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKEEVKGIPVRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLPGDINVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHAACKVDLQKLVETLEDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQSSPDTSRSSDVFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQLQPIQFQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQEQSKLLKLKESTEHTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQKEVAEKRKETQSRGMESTAARMKNWLGNEIEVMVSTEEAKRHLNGLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELELRSAQIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVSKLESSLNQSKASCIDVQKMLFEEQNHFAKIETELKEELVKVEQQHQEKVLYLLSQLQQSQMTEKQLEESVSEKEQQLLSTLKCQEEELRKMQEVCEQNQQLLQENSAIKQKLTLLQVASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCLEQSFAVEGLQYYSEPSVAEQDNEDSDDHADEEWIPTKLVKVSKKSIQGCSCKGWCGNKQCGCRKQKSDCNVSCSCDPTKCRNRHQNQDNSDAIELNQDSENSFKLEDPTEVTSGLSFFHPICATPSSKILKEMCDADQVQLKQPVFVSSSDHPELKSIASESQENKAIGKKKKRALASNTSFFSGCSPIQEESH", "length": 1231, "header": "sp|P33174-1|KIF4_MOUSE Isoform 1 of Chromosome-associated kinesin KIF4 OS=Mus musculus OX=10090 GN=Kif4 PE=1 SV=3 CANONICAL=P33174-1" }, "isoforms": [ { "isoform_ac": "P33174-1", "url": "", "sequence": { "sequence": "MKEEVKGIPVRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLPGDINVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHAACKVDLQKLVETLEDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQSSPDTSRSSDVFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQLQPIQFQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQEQSKLLKLKESTEHTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQKEVAEKRKETQSRGMESTAARMKNWLGNEIEVMVSTEEAKRHLNGLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELELRSAQIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVSKLESSLNQSKASCIDVQKMLFEEQNHFAKIETELKEELVKVEQQHQEKVLYLLSQLQQSQMTEKQLEESVSEKEQQLLSTLKCQEEELRKMQEVCEQNQQLLQENSAIKQKLTLLQVASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCLEQSFAVEGLQYYSEPSVAEQDNEDSDDHADEEWIPTKLVKVSKKSIQGCSCKGWCGNKQCGCRKQKSDCNVSCSCDPTKCRNRHQNQDNSDAIELNQDSENSFKLEDPTEVTSGLSFFHPICATPSSKILKEMCDADQVQLKQPVFVSSSDHPELKSIASESQENKAIGKKKKRALASNTSFFSGCSPIQEESH", "length": 1231, "header": "sp|P33174-1|KIF4_MOUSE Isoform 1 of Chromosome-associated kinesin KIF4 OS=Mus musculus OX=10090 GN=Kif4 PE=1 SV=3 CANONICAL=P33174-1" }, "locus": { "chromosome": "X", "start_pos": 99770262, "end_pos": 99670075, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000048962", "url": "https://www.ensembl.org/id/ENSMUST00000048962" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000048383", "url": "https://www.ensembl.org/id/ENSMUSP00000048383" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P33174", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P33174" }, { "id": "28528544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28528544" }, { "id": "34887587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34887587" } ] } ], "phosphorylation": [ { "start_pos": 1224, "end_pos": 1224, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "site_lbl": "Ser1224" }, { "start_pos": 1230, "end_pos": 1230, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "site_lbl": "Ser1230" }, { "start_pos": 395, "end_pos": 395, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "site_lbl": "Ser395" }, { "start_pos": 800, "end_pos": 800, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" }, { "database": "PubMed", "id": "28125646", "url": "https://glygen.org/publication/PubMed/28125646" } ], "site_lbl": "Thr800" }, { "start_pos": 802, "end_pos": 802, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "site_lbl": "Ser802" }, { "start_pos": 811, "end_pos": 811, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "site_lbl": "Ser811" }, { "start_pos": 816, "end_pos": 816, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "site_lbl": "Ser816" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Kinesin family in murine central nervous system.", "journal": "J. Cell Biol.", "date": "1992", "authors": "Zhang Z., Sekine Y., Aizawa H., Hirokawa N., Nangaku M., Takemura R.", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" } ], "reference": [ { "type": "PubMed", "id": "1447303", "url": "https://glygen.org/publication/PubMed/1447303" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" }, { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Kif4 Is Essential for Mouse Oocyte Meiosis.", "journal": "PloS one", "date": "2017", "authors": "Camlin NJ, McLaughlin EA, Holt JE", "evidence": [ { "database": "iPTMnet", "id": "P33174", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P33174" } ], "reference": [ { "type": "PubMed", "id": "28125646", "url": "https://glygen.org/publication/PubMed/28125646" } ] }, { "title": "The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.", "journal": "Journal of the American Chemical Society", "date": "2017", "authors": "Chuh KN, Batt AR, Zaro BW, Darabedian N, Marotta NP, Brennan CK, Amirhekmat A, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "P33174", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P33174" } ], "reference": [ { "type": "PubMed", "id": "28528544", "url": "https://glygen.org/publication/PubMed/28528544" } ] }, { "title": "Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.", "journal": "Molecular biology of the cell", "date": "2019", "authors": "Heath CM, Wignall SM", "evidence": [ { "database": "RefSeq", "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" } ], "reference": [ { "type": "PubMed", "id": "31067151", "url": "https://glygen.org/publication/PubMed/31067151" } ] }, { "title": "Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.", "journal": "European review for medical and pharmacological sciences", "date": "2019", "authors": "Luan YJ, Liu SH, Sun YG, Qu X, Wei FC, Xu Y, Yang PS", "evidence": [ { "database": "RefSeq", "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" } ], "reference": [ { "type": "PubMed", "id": "31486502", "url": "https://glygen.org/publication/PubMed/31486502" } ] }, { "title": "Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.", "journal": "Nature chemical biology", "date": "2022", "authors": "Shu XE, Mao Y, Jia L, Qian SB", "evidence": [ { "database": "O-GlcNAc Database", "id": "P33174", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P33174" } ], "reference": [ { "type": "PubMed", "id": "34887587", "url": "https://glygen.org/publication/PubMed/34887587" } ] }, { "title": "CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.", "journal": "Molecular biology reports", "date": "2022", "authors": "He P, Liu F, Wang Z, Gong H, Zhang M, Jia Z, Zhai X", "evidence": [ { "database": "RefSeq", "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" } ], "reference": [ { "type": "PubMed", "id": "35579738", "url": "https://glygen.org/publication/PubMed/35579738" } ] }, { "title": "KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.", "journal": "The Journal of cell biology", "date": "2023-02-06", "authors": "Wan Yuansong, Morikawa Momo, Morikawa Manatsu, Iwata Suguru, Naseer Muhammad Imran, Ahmed Chaudhary Adeel Gulzar, Tanaka Yosuke, Hirokawa Nobutaka", "evidence": [ { "database": "RefSeq", "id": "NP_032472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032472" } ], "reference": [ { "type": "PubMed", "id": "36482480", "url": "https://glygen.org/publication/PubMed/36482480" } ] }, { "title": "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.", "journal": "J. Cell Biol.", "date": "1994", "authors": "Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N", "evidence": [ { "database": "UniProtKB", "id": "P33174", "url": "https://www.uniprot.org/uniprot/P33174" } ], "reference": [ { "type": "PubMed", "id": "7929562", "url": "https://glygen.org/publication/PubMed/7929562" } ] } ], "pathway": [ { "id": "mmu:16571", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16571", "resource": "KEGG Pathway" }, { "id": "R-MMU-2132295", "name": "MHC class II antigen presentation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-MMU-437239", "name": "Recycling pathway of L1", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-437239", "resource": "Reactome", "description": "Recycling pathway of L1" }, { "id": "R-MMU-6811434", "name": "COPI-dependent Golgi-to-ER retrograde traffic", "url": 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