{ "uniprot_canonical_ac": "P32785-1", "uniprot_ac": "P32785", "uniprot_id": "FMT_YEAST", "mass": { "chemical_mass": 44617.0, "monoisotopic_mass": 44617.0 }, "refseq": { "ac": "NP_009540", "name": "methionyl-tRNA formyltransferase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009540" }, "gene_names": [ { "name": "FMT1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P32785", "id": "P32785" }, { "name": "FMT1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009540", "id": "NP_009540" }, { "name": "YBL0311", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P32785", "id": "P32785" }, { "name": "YBL0313", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P32785", "id": "P32785" } ], "protein_names": [ { "name": "Methionyl-tRNA formyltransferase, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P32785" }, { "name": "2.1.2.9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32785" }, { "name": "MtFMT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32785" }, { "name": "methionyl-tRNA formyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009540", "id": "NP_009540" } ], "function": [ { "annotation": "Formylates methionyl-tRNA in mitochondria and the cytoplasm (PubMed:10781559, PubMed:30409808). Responsible for the formylation of the 8 N-terminally formylated (Nt-formylated) mitochondrial matrix proteins that are encoded by mitochondrial DNA (PubMed:10781559, PubMed:12549912). Nt-formylated proteins in the cytoplasm are strongly up-regulated in stationary phase or upon starvation for specific amino acids (His or Lys) and are targeted for degradation by a PSH1 E3 ubiquitin ligase-mediated fMet/N-end rule pathway. Increased Nt-formylation of cytosolic proteins appears to be important for adaptation to these stresses. Stationary phase-degraded Nt-formylated proteins include histone H3-like centromeric protein CSE4, Mediator complex subunit 3 (PGD1) and small ribosomal subunit protein uS8-A (RPS22A) (PubMed:30409808).", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785#function" }, { "database": "PubMed", "id": "30409808", "url": "https://glygen.org/publication/PubMed/30409808" }, { "database": "PubMed", "id": "12549912", "url": "https://glygen.org/publication/PubMed/12549912" }, { "database": "PubMed", "id": "10781559", "url": "https://glygen.org/publication/PubMed/10781559" } ] } ], "disease": [ { "disease_id": "DOID:0111491", "recommended_name": { "id": "DOID:0111491", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111491", "name": "combined oxidative phosphorylation deficiency 15", "description": "A combined oxidative phosphorylation deficiency that has_material_basis_in homozygous or compound heterozygous mutation] in the MTFMT gene on chromosome 15q22.31." }, "synonyms": [ { "id": "DOID:0111491", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111491", "name": "COXPD15", "description": "" }, { "id": "MONDO:0013987", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013987", "name": "combined oxidative phosphorylation defect type 15", "description": "Combined oxidative phosphorylation defect type 15 is a rare mitochondrial disease due to a defect in mitochondrial protein synthesis characterized by onset in infancy or early childhood of muscular hypotonia, gait ataxia, mild bilateral pyramidal tract signs, developmental delay (affecting mostly speech and coordination) and subsequent intellectual disability. Short stature, obesity, microcephaly, strabismus, nystagmus, reduced visual acuity, lactic acidosis, and a brain neuropathology consistent with Leigh syndrome are also reported." }, { "id": "MONDO:0013987", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013987", "name": "COXPD15", "description": "" }, { "id": "MONDO:0013987", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013987", "name": "MTFMT combined oxidative phosphorylation deficiency", "description": "" }, { "id": "MONDO:0013987", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013987", "name": "combined oxidative phosphorylation defect type 15", "description": "" }, { "id": "MONDO:0013987", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013987", "name": "combined oxidative phosphorylation deficiency caused by mutation in MTFMT", "description": "" }, { "id": "MONDO:0013987", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013987", "name": "combined oxidative phosphorylation deficiency type 15", "description": "" }, { "id": "MONDO:0013987", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013987", "name": "combined oxidative phosphorylation deficiency 15", "description": "" }, { "id": "MIM:614947", "resource": "MIM", "url": "https://www.omim.org/entry/614947", "name": "Combined oxidative phosphorylation deficiency 15", "description": "Combined oxidative phosphorylation deficiency 15" } ], "evidence": [ { "id": "0111491", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111491" } ] }, { "disease_id": "DOID:0112090", "recommended_name": { "id": "DOID:0112090", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112090", "name": "nuclear type mitochondrial complex I deficiency 27", "description": "A nuclear type mitochondrial complex I deficiency that has_material_basis_in homozygous or compound heterozygous mutation in the MTFMT gene on chromosome 15q22.31." }, "synonyms": [ { "id": "DOID:0112090", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112090", "name": "MC1DN27", "description": "" }, { "id": "MONDO:0032631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032631", "name": "mitochondrial complex 1 deficiency, nuclear type 27", "description": "" }, { "id": "MONDO:0032631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032631", "name": "MC1DN27", "description": "" }, { "id": "MONDO:0032631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032631", "name": "MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 27", "description": "" }, { "id": "MIM:618248", "resource": "MIM", "url": "https://www.omim.org/entry/618248", "name": "Mitochondrial complex I deficiency, nuclear type 27", "description": "Mitochondrial complex I deficiency, nuclear type 27" } ], "evidence": [ { "id": "0112090", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112090" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "common_name": "Yeast" } ], "gene": [ { "name": "FMT1", "url": "https://www.uniprot.org/uniprot/P32785", "locus": {} } ], "crossref": [ { "id": "2.1.2.9", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.2.9&UniProtAcc=P32785", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd08646", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08646", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "852270", "url": "https://www.ncbi.nlm.nih.gov/gene/852270", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P32785", "url": "https://www.ebi.ac.uk/intact/interactors/id:P32785*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041711", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YBL013W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YBL013W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MWIIPGP", "url": "https://omabrowser.org/oma/group/MWIIPGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "179280at2759", "url": "http://www.orthodb.org/?query=179280at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11138", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11138", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11138:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11138:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00551", "url": "http://pfam.xfam.org/family/PF00551", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02911", "url": "http://pfam.xfam.org/family/PF02911", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P32785", "url": "http://purl.obolibrary.org/obo/PR_P32785", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_009540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009540", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000109", "url": "https://www.yeastgenome.org/locus/S000000109", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P32785-1", "url": "https://www.uniprot.org/uniprot/P32785-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKMRRITPTRLLFTCRYISNNASPPVQPLNVLFFGSDTFSNFSLQALNELRQNNGSCGIVDNIQVVTRSPKWCGRQKSILKYPPIFDMAEKLQLPRPITCDTKQEMLALSKLTPSRQGNPENDGSGAPFNAIIAVSFGKLIPGDLIRAVPLALNVHPSLLPRHKGSAPIQRALLEGDTYTGVTIQTLHPDRFDHGAIVAQTEPLAIATMLSKGRVNDSTADFNSEGLPRRTAILMDQLGALGAQLLGQTLRERLYLPQNRVQAPTAYKPSYAHRITTEDKRIHWARDSAAELLNKLETLGPLHAFKEATAARKDAQNSVLKRILFHECKVMRDARLDNGSKPGMFKYDDIKDCILVTCRGNLLLCVSRLQFEGFAVERAGQFMARLRKRCGALSEKLVFL", "length": 401, "header": "sp|P32785-1|FMT_YEAST Isoform 1 of Methionyl-tRNA formyltransferase, mitochondrial OS=Saccharomyces cerevisiae S288C OX=559292 GN=FMT1 PE=1 SV=2 CANONICAL=P32785-1" }, "isoforms": [ { "isoform_ac": "P32785-1", "url": "", "sequence": { "sequence": "MVKMRRITPTRLLFTCRYISNNASPPVQPLNVLFFGSDTFSNFSLQALNELRQNNGSCGIVDNIQVVTRSPKWCGRQKSILKYPPIFDMAEKLQLPRPITCDTKQEMLALSKLTPSRQGNPENDGSGAPFNAIIAVSFGKLIPGDLIRAVPLALNVHPSLLPRHKGSAPIQRALLEGDTYTGVTIQTLHPDRFDHGAIVAQTEPLAIATMLSKGRVNDSTADFNSEGLPRRTAILMDQLGALGAQLLGQTLRERLYLPQNRVQAPTAYKPSYAHRITTEDKRIHWARDSAAELLNKLETLGPLHAFKEATAARKDAQNSVLKRILFHECKVMRDARLDNGSKPGMFKYDDIKDCILVTCRGNLLLCVSRLQFEGFAVERAGQFMARLRKRCGALSEKLVFL", "length": 401, "header": "sp|P32785-1|FMT_YEAST Isoform 1 of Methionyl-tRNA formyltransferase, mitochondrial OS=Saccharomyces cerevisiae S288C OX=559292 GN=FMT1 PE=1 SV=2 CANONICAL=P32785-1" }, "locus": { "chromosome": "II", "start_pos": 203258, "end_pos": 202056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YBL013W_mRNA", "url": "https://www.ensembl.org/id/YBL013W_mRNA" }, { "database": "Ensembl Peptide", "id": "YBL013W", "url": "https://www.ensembl.org/id/YBL013W" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA.", "journal": "J. Bacteriol.", "date": "2000", "authors": "Li Y., Appling D.R., RajBhandary U.L., Holmes W.B.", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "reference": [ { "type": "PubMed", "id": "10781559", "url": "https://glygen.org/publication/PubMed/10781559" } ] }, { "title": "Mitochondrial methionyl-tRNAfMet formyltransferase from Saccharomyces cerevisiae: gene disruption and tRNA substrate specificity.", "journal": "Biochemistry", "date": "2003", "authors": "Schmitt E., Gomez P., Blanquet S., Mechulam Y., Panvert M., Vial L.", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "reference": [ { "type": "PubMed", "id": "12549912", "url": "https://glygen.org/publication/PubMed/12549912" } ] }, { "title": "The sequence of an 8 kb segment on the left arm of chromosome II from Saccharomyces cerevisiae identifies five new open reading frames of unknown functions, two tRNA genes and two transposable elements.", "journal": "Yeast", "date": "1992", "authors": "Goffeau A., van Dyck L., Purnelle B., Skala J.", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "reference": [ { "type": "PubMed", "id": "1332308", "url": "https://glygen.org/publication/PubMed/1332308" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "The proteome of Saccharomyces cerevisiae mitochondria.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Sickmann A., Zahedi R.P., Rehling P., Chacinska A., Guiard B., Meyer H.E., Meisinger C., Reinders J., Pfanner N., Joppich C., Perschil I., Schoenfisch B., Wagner Y.", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "reference": [ { "type": "PubMed", "id": "14576278", "url": "https://glygen.org/publication/PubMed/14576278" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Complete DNA sequence of yeast chromosome II.", "journal": "EMBO J.", "date": "1994", "authors": "Gassenhuber J., Mewes H.-W., Obermaier B., Stucka R., Rose M., Wagner G., Boles E., Brueckner M., Jacquet M., Rieger M., Mueller S., Molemans F., Zagulski M., Brandt T., Christiansen C., Barthe C., Feldmann H., Kleine K., Cziepluch C., Fiers W., Mallet L., Jauniaux J.-C., Dubois E., Andre B., Li Z.Y., Koetter P., Hein C., Entian K.-D., Slonimski P.P., Vetter I., Nasr F., Louis E.J., Delaveau T., Hollenberg C.P., Contreras R., Domdey H., Pohl T.M., Brendel M., Becam A.-M., Bussereau F., Crouzet M., Doignon F., Dujon B., El Bakkoury M., Feuermann M., Glansdorff N., Goffeau A., Grivell L.A., Herbert C.J., Jacq C., Mannhaupt G., Messenguy F., Miosga T., Perea J., Pierard A., Potier S., Proft M., Schaaff-Gerstenschlaeger I., Scherens B., Souciet J.-L., Steensma H.Y., Vissers S., Zimmermann F.K., Aljinovic G., Duesterhus S., Jonniaux J.-L., Kirchrath L., Purnelle B., Ramezani Rad M., Skala J., Urrestarazu L.A., Vierendeels F., de Wergifosse P., Aigle M., Baclet M.C., Baur A., Biteau N., Demolis N., Fobo G.M., Fritz C., Holmstroem K., Kallesoee T., Kiesau P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Maat M.J., Piravandi E., Pohl F.M., Schwarzlose C., Smits P.H.M., Van Dyck L., Vassarotti A., Wolfe K.H., de Haan M., van der Aart Q.J.M.", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "reference": [ { "type": "PubMed", "id": "7813418", "url": "https://glygen.org/publication/PubMed/7813418" } ] } ], "pathway": [ { "id": "sce:YBL013W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YBL013W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "methionyl-tRNA formyltransferase activity", "id": "GO:0004479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004479", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "conversion of methionyl-tRNA to N-formyl-methionyl-tRNA", "id": "GO:0071951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071951", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated by GCN2 in response to nutrient deprivation. Phosphorylation mediates retention of FMT1 in the cytoplasm.", "evidence": [ { "database": "UniProtKB", "id": "P32785", "url": "https://www.uniprot.org/uniprot/P32785" }, { "database": "PubMed", "id": "30409808", "url": "https://glygen.org/publication/PubMed/30409808" } ] } ], "interactions": [], "reactions": [ { "id": "24380", "name": "", "equation": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I0C5-1", "Q96DP5-1", "Q9D799-1", "P32785-1" ], "evidence": [ { "id": "24380", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24380" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P32785", "gene_name": "FMT1", "activity": [ { "ec_number": "2.1.2.9", "activity": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet).", "evidence": [ { "id": "P32785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32785" } ] }, { "ec_number": "2.1.2.9", "activity": "", "evidence": [ { "id": "P32785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32785" } ] } ] }, { "uniprot_ac": "Q5I0C5", "gene_name": "Mtfmt", "activity": [ { "ec_number": "2.1.2.9", "activity": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet).", "evidence": [ { "id": "Q5I0C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0C5" } ] }, { "ec_number": "2.1.2.9", "activity": "", "evidence": [ { "id": "Q5I0C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0C5" } ] } ] }, { "uniprot_ac": "Q96DP5", "gene_name": "MTFMT", "activity": [ { "ec_number": "2.1.2.9", "activity": "(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = 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