{ "uniprot_canonical_ac": "P32660-1", "uniprot_ac": "P32660", "uniprot_id": "ATC5_YEAST", "mass": { "chemical_mass": 177798.0, "monoisotopic_mass": 177798.0 }, "refseq": { "ac": "NP_011093", "name": "aminophospholipid-translocating P4-type ATPase DNF1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011093" }, "gene_names": [ { "name": "DNF1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P32660", "id": "P32660" }, { "name": "DNF1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011093", "id": "NP_011093" }, { "name": "SYGP-ORF7", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P32660", "id": "P32660" } ], "protein_names": [ { "name": "Phospholipid-transporting ATPase DNF1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P32660" }, { "name": "7.6.2.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32660" }, { "name": "Flippase DNF1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32660" }, { "name": "aminophospholipid-translocating P4-type ATPase DNF1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011093", "id": "NP_011093" } ], "function": [ { "annotation": "Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide, phosphatidylcholine, phosphatidylethanolamine, and small amounts of phosphatidylserine from the lumenal to the cytosolic leaflet of the cell membrane and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:22791719, PubMed:33320091, PubMed:12631737, PubMed:35294892, PubMed:31786280, PubMed:33060204, PubMed:22308393, PubMed:23302692). Does not appear to transport sphingomyelin, inositol phosphoceramide, or phosphatidic acid (PubMed:33320091, PubMed:12631737, PubMed:22308393). Required for efficient endocytosis (PubMed:12631737).", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660#function" }, { "database": "PubMed", "id": "22791719", "url": "https://glygen.org/publication/PubMed/22791719" }, { "database": "PubMed", "id": "35294892", "url": "https://glygen.org/publication/PubMed/35294892" }, { "database": "PubMed", "id": "33320091", "url": "https://glygen.org/publication/PubMed/33320091" }, { "database": "PubMed", "id": "33060204", "url": "https://glygen.org/publication/PubMed/33060204" }, { "database": "PubMed", "id": "12631737", "url": "https://glygen.org/publication/PubMed/12631737" }, { "database": "PubMed", "id": "31786280", "url": "https://glygen.org/publication/PubMed/31786280" }, { "database": "PubMed", "id": "22308393", "url": "https://glygen.org/publication/PubMed/22308393" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] } ], "disease": [ { "disease_id": "DOID:0070226", "recommended_name": { "id": "DOID:0070226", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070226", "name": "progressive familial intrahepatic cholestasis 1", "description": "A progressive familial intrahepatic cholestasis characterized by autosomal recessive inheritance that has_material_basis_in mutation in the ATP8B1 gene on chromosome 18q21." }, "synonyms": [ { "id": "DOID:0070226", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070226", "name": "FIC1 deficiency", "description": "" }, { "id": "DOID:0070226", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070226", "name": "PFIC1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "progressive familial intrahepatic cholestasis type 1", "description": "PFIC1, a type of progressive familial intrahepathic cholestasis (PFIC), is an infantile hereditary disorder in bile formation that is hepatocellular in origin and associated with extrahepatic features." }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "Byler disease", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "FIC1 deficiency", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "PFIC1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "cholestasis, progressive familial intrahepatic 1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "cholestasis, progressive familial intrahepatic, type 1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "Byler's disease", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "cholestasis, fatal intrahepatic", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "cholestasis, progressive familial intrahepatic, 1", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "progressive familial intrahepatic cholestasis", "description": "" }, { "id": "MONDO:0008892", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008892", "name": "severe ATP8B1 deficiency", "description": "" }, { "id": "MIM:211600", "resource": "MIM", "url": "https://www.omim.org/entry/211600", "name": "Cholestasis, progressive familial intrahepatic, 1", "description": "Cholestasis, progressive familial intrahepatic, 1" } ], "evidence": [ { "id": "0070226", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070226" } ] }, { "disease_id": "DOID:0070228", "recommended_name": { "id": "DOID:0070228", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070228", "name": "intrahepatic cholestasis of pregnancy 1", "description": "An intrahepatic cholestasis of pregnancy characterized by autosomal dominant inheritance that has_material_basis_in mutation in the ATP8B1 gene on chromosome 18q21." }, "synonyms": [ { "id": "DOID:0070228", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070228", "name": "ICP1", "description": "" }, { "id": "DOID:0070228", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070228", "name": "pregnancy related cholestasis 1", "description": "" }, { "id": "MONDO:0007829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007829", "name": "cholestasis, intrahepatic, of pregnancy, 1", "description": "" }, { "id": "MONDO:0007829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007829", "name": "cholestasis, intrahepatic, of pregnancy, 1", "description": "" }, { "id": "MONDO:0007829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007829", "name": "cholestasis, intrahepatic, of pregnancy, type 1", "description": "" }, { "id": "MONDO:0007829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007829", "name": "ICP1", "description": "" }, { "id": "MONDO:0007829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007829", "name": "cholestasis, pregnancy-related, 1", "description": "" }, { "id": "MIM:147480", "resource": "MIM", "url": "https://www.omim.org/entry/147480", "name": "Cholestasis of pregnancy, intrahepatic 1", "description": "Cholestasis of pregnancy, intrahepatic 1" } ], "evidence": [ { "id": "0070228", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070228" } ] }, { "disease_id": "DOID:0070231", "recommended_name": { "id": "DOID:0070231", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070231", "name": "benign recurrent intrahepatic cholestasis 1", "description": "A benign recurrent intrahepatic cholestasis characterized by typically autosomal recessive inheritance that has_material_basis_in mutation in the ATP8B1 gene on chromosome 18q." }, "synonyms": [ { "id": "DOID:0070231", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070231", "name": "BRIC type 1", "description": "" }, { "id": "DOID:0070231", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070231", "name": "BRIC1", "description": "" }, { "id": "DOID:0070231", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070231", "name": "Summerskill syndrome", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "benign recurrent intrahepatic cholestasis type 1", "description": "Benign recurrent intrahepatic cholestasis 1 (BRIC1) is characterized by episodes of liver dysfunction called cholestasis, during which the liver cells have a reduced ability to release a digestive fluid called bile. These episodes can last from weeks to months, and the time between them, during which there are usually no symptoms, can vary from weeks to years.Most people with BRIC1have their first episode of cholestasisintheir teens or twenties. Symptoms oftenpresent with severe itchiness, followed by yellowing of the skin and whites of the eyes (jaundice) a few weeks later. BRIC1 is caused by mutations in the ATP8B1 gene. This condition is inherited in an autosomal recessive pattern.BRIC1generally does not cause lasting damage to the liver. However, in rare cases, episodes of liver dysfunction may develop into a more severe, permanent form of liver disease known as progressive familial intrahepatic cholestasis (PFIC). BRIC and PFIC are sometimes considered to be part of a spectrum of intrahepatic cholestasis disorders of varying severity." }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "cholestasis, benign recurrent intrahepatic", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "ATP8B1 benign recurrent intrahepatic cholestasis", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "BRIC1", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "Bric type 1", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "benign recurrent intrahepatic cholestasis caused by mutation in ATP8B1", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "cholestasis, benign recurrent intrahepatic, type 1", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "Summerskill syndrome", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "benign recurrent intrahepatic cholestasis 1", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "cholestasis, benign recurrent intrahepatic 1", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "cholestasis, benign recurrent intrahepatic, 1", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "mild ATP8B1 deficiency", "description": "" }, { "id": "MONDO:0009469", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009469", "name": "recurrent familial intrahepatic cholestasis 1", "description": "" }, { "id": "MIM:243300", "resource": "MIM", "url": "https://www.omim.org/entry/243300", "name": "Cholestasis, benign recurrent intrahepatic, 1", "description": "Cholestasis, benign recurrent intrahepatic, 1" } ], "evidence": [ { "id": "0070231", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070231" } ] }, { "disease_id": "DOID:1852", "recommended_name": { "id": "DOID:1852", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1852", "name": "intrahepatic cholestasis", "description": "A cholestasis characterized by impairment of the bile flow caused by obstruction located_in liver." }, "synonyms": [ { "id": "DOID:1852", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1852", "name": "neonatal intrahepatic cholestasis", "description": "" } ], "evidence": [ { "id": "1852", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1852" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 1194, "end_pos": 1194, "sequence_org": "K", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 1194, "end_pos": 1194, "sequence_org": "K", "sequence_mut": "R", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 1226, "end_pos": 1226, "sequence_org": "N", "sequence_mut": "A", "comment": "Decreases glucosylceramide, phosphatidylethanolamine, and phosphatidylcholine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "33320091", "url": "https://glygen.org/publication/PubMed/33320091" } ] }, { "start_pos": 1235, "end_pos": 1235, "sequence_org": "I", "sequence_mut": "F", "comment": "Increases phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine and sphingomyelin uptake, but not phosphatidic acid uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 230, "end_pos": 231, "sequence_org": "GA", "sequence_mut": "QQ", "comment": "Increases phosphatidylserine uptake but not phosphatidic acid or sphingomyelin uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 234, "end_pos": 235, "sequence_org": "IF", "sequence_mut": "HV", "comment": "Decreases phosphatidylcholine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 240, "end_pos": 241, "sequence_org": "PG", "sequence_mut": "RY", "comment": "Decreases phosphatidylcholine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": 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"PubMed", "id": "30824614", "url": "https://glygen.org/publication/PubMed/30824614" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 550, "end_pos": 550, "sequence_org": "N", "sequence_mut": "K", "comment": "Increases phosphatidylserine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "30824614", "url": "https://glygen.org/publication/PubMed/30824614" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 550, "end_pos": 550, "sequence_org": "N", "sequence_mut": "S", "comment": "Does not alter phosphatidic acid or sphingomyelin uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "30824614", "url": "https://glygen.org/publication/PubMed/30824614" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 550, "end_pos": 550, "sequence_org": "N", "sequence_mut": "S", "comment": "Increases phosphatidylserine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "30824614", "url": "https://glygen.org/publication/PubMed/30824614" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 550, "end_pos": 550, "sequence_org": "N", "sequence_mut": "Y", "comment": "Increases phosphatidylserine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "30824614", "url": "https://glygen.org/publication/PubMed/30824614" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { 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"https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 565, "end_pos": 565, "sequence_org": "F", "sequence_mut": "L", "comment": "Decreases phosphatidylcholine and phosphatidylehtanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 568, "end_pos": 568, "sequence_org": "G", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 571, "end_pos": 571, "sequence_org": "N", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 574, "end_pos": 574, "sequence_org": "Y", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 575, "end_pos": 575, "sequence_org": "Y", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 575, "end_pos": 575, "sequence_org": "Y", "sequence_mut": "N", "comment": "Decreases phosphatidylcholine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 575, "end_pos": 575, "sequence_org": "Y", "sequence_mut": "S", "comment": "Decreases phosphatidylcholine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 578, "end_pos": 578, "sequence_org": "K", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 578, "end_pos": 578, "sequence_org": "K", "sequence_mut": "E", "comment": "Increases phosphatidylserine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 586, "end_pos": 586, "sequence_org": "E", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 587, "end_pos": 587, "sequence_org": "F", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 587, "end_pos": 587, "sequence_org": "F", "sequence_mut": "L", "comment": "Decreases phosphatidylcholine uptake, but not phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "22308393", "url": "https://glygen.org/publication/PubMed/22308393" } ] }, { "start_pos": 587, "end_pos": 587, "sequence_org": "F", "sequence_mut": "Y", "comment": "Decreases phosphatidylcholine uptake, but not phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "22308393", "url": "https://glygen.org/publication/PubMed/22308393" } ] }, { "start_pos": 588, "end_pos": 588, "sequence_org": "G", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine and phosphatidylserine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 604, "end_pos": 604, "sequence_org": "V", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 606, "end_pos": 606, "sequence_org": "V", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 609, "end_pos": 611, "sequence_org": "YQS", "sequence_mut": "FSN", "comment": "Decreases glucosylceramide and phosphatidylethanolamine uptake, but not phosphatidylcholine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "33320091", "url": "https://glygen.org/publication/PubMed/33320091" } ] }, { "start_pos": 610, "end_pos": 610, "sequence_org": "Q", "sequence_mut": "A", "comment": "Decreases glucosylceramide and phosphatidylethanolamine uptake, but not phosphatidylcholine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "33320091", "url": "https://glygen.org/publication/PubMed/33320091" } ] }, { "start_pos": 611, "end_pos": 611, "sequence_org": "S", "sequence_mut": "A", "comment": "Increases glucosylceramide, phosphatidylethanolamine, and phosphatidylcholine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "33320091", "url": "https://glygen.org/publication/PubMed/33320091" } ] }, { "start_pos": 618, "end_pos": 618, "sequence_org": "Y", "sequence_mut": "C", "comment": "Decreases phosphatidylcholine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 618, "end_pos": 618, "sequence_org": "Y", "sequence_mut": "F", "comment": "Increases phosphatidylserine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "22308393", "url": "https://glygen.org/publication/PubMed/22308393" } ] }, { "start_pos": 618, "end_pos": 620, "sequence_org": "YIS", "sequence_mut": "FVT", "comment": "Increases phosphatidylserine, phosphatidylcholine, and sphingomyelin uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "22308393", "url": "https://glygen.org/publication/PubMed/22308393" } ] }, { "start_pos": 621, "end_pos": 621, "sequence_org": "V", "sequence_mut": "A", "comment": "Decreases phosphatidylcholine and phosphatidylethanolamine uptake, and increases phosphatidylserine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 622, "end_pos": 622, "sequence_org": "E", "sequence_mut": "V", "comment": "Decreases phosphatidylcholine and increases phosphatidylserine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 623, "end_pos": 623, "sequence_org": "I", "sequence_mut": "F", "comment": "Decreases phosphatidylcholine and phosphatidylethanolamine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "23302692", "url": "https://glygen.org/publication/PubMed/23302692" } ] }, { "start_pos": 652, "end_pos": 652, "sequence_org": "W", "sequence_mut": "A", "comment": "Decreases glucosylceramide, phosphatidylethanolamine, and phosphatidylcholine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "33320091", "url": "https://glygen.org/publication/PubMed/33320091" } ] }, { "start_pos": 652, "end_pos": 652, "sequence_org": "W", "sequence_mut": "S", "comment": "Decreases glucosylceramide, phosphatidylethanolamine, and phosphatidylcholine uptake.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "33320091", "url": "https://glygen.org/publication/PubMed/33320091" } ] }, { "start_pos": 667, "end_pos": 667, "sequence_org": "D", "sequence_mut": "E", "comment": "Decreases interaction with LEM3.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "19411703", "url": "https://glygen.org/publication/PubMed/19411703" } ] }, { "start_pos": 667, "end_pos": 667, "sequence_org": "D", "sequence_mut": "N", "comment": "Decreases interaction with LEM3.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "19411703", "url": "https://glygen.org/publication/PubMed/19411703" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "common_name": "Yeast" } ], "gene": [ { "name": "DNF1", "url": "https://www.uniprot.org/uniprot/P32660", "locus": {} } ], "crossref": [ { "id": "7.6.2.1", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.1&UniProtAcc=P32660", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd02073", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02073", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "856913", "url": "https://www.ncbi.nlm.nih.gov/gene/856913", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P32660", "url": "https://www.ebi.ac.uk/intact/interactors/id:P32660*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YER166W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YER166W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QALRCGR", "url": "https://omabrowser.org/oma/group/QALRCGR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "275833at2759", "url": "http://www.orthodb.org/?query=275833at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092:SF180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092:SF180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7DRX", "url": "https://www.rcsb.org/structure/7DRX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7DSH", "url": "https://www.rcsb.org/structure/7DSH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7DSI", "url": "https://www.rcsb.org/structure/7DSI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7F7F", "url": "https://www.rcsb.org/structure/7F7F", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KY6", "url": "https://www.rcsb.org/structure/7KY6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KYB", "url": "https://www.rcsb.org/structure/7KYB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KYC", "url": "https://www.rcsb.org/structure/7KYC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7WHV", "url": "https://www.rcsb.org/structure/7WHV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7WHW", "url": "https://www.rcsb.org/structure/7WHW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF13246", "url": "http://pfam.xfam.org/family/PF13246", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16209", "url": "http://pfam.xfam.org/family/PF16209", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16212", "url": "http://pfam.xfam.org/family/PF16212", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P32660", "url": "http://purl.obolibrary.org/obo/PR_P32660", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_011093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011093", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000968", "url": "https://www.yeastgenome.org/locus/S000000968", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P32660-1", "url": "https://www.uniprot.org/uniprot/P32660-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN", "length": 1571, "header": "sp|P32660-1|ATC5_YEAST Isoform 1 of Phospholipid-transporting ATPase DNF1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=DNF1 PE=1 SV=2 CANONICAL=P32660-1" }, "isoforms": [ { "isoform_ac": "P32660-1", "url": "", "sequence": { "sequence": "MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN", 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"publication": [ { "title": "Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis.", "journal": "Mol. Biol. Cell", "date": "2003", "authors": "Devaux P.F., Holthuis J.C., Lombardi R., Riezman H., van Meer G., Pomorski T.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "reference": [ { "type": "PubMed", "id": "12631737", "url": "https://glygen.org/publication/PubMed/12631737" } ] }, { "title": "A global topology map of the Saccharomyces cerevisiae membrane proteome.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Kim H., von Heijne G., Melen K., Oesterberg M.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "reference": [ { "type": "PubMed", "id": "16847258", "url": "https://glygen.org/publication/PubMed/16847258" } ] }, { "title": "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-02-13", "authors": "Chi An, Huttenhower Curtis, Geer Lewis Y, Coon Joshua J, Syka John E P, Bai Dina L, Shabanowitz Jeffrey, Burke Daniel J, Troyanskaya Olga G, Hunt Donald F", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "17287358", "url": "https://glygen.org/publication/PubMed/17287358" } ] }, { "title": "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.", "journal": "Journal of proteome research", "date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": "https://glygen.org/publication/PubMed/17563356" } ] }, { "title": "Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry.", "journal": "Mol. 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Cell", "date": "2008", "authors": "Nakano Kenzi, Yamamoto Takaharu, Kishimoto Takuma, Noji Takehiro, Tanaka Kazuma", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "reference": [ { "type": "PubMed", "id": "18199685", "url": "https://glygen.org/publication/PubMed/18199685" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008-07", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter Drs2p.", "journal": "J. 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Chem.", "date": "2009", "authors": "Lenoir Guillaume, Williamson Patrick, Puts Catheleyne F, Holthuis Joost C M", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "reference": [ { "type": "PubMed", "id": "19411703", "url": "https://glygen.org/publication/PubMed/19411703" } ] }, { "title": "Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.", "journal": "Genes & development", "date": "2009-08-15", "authors": "Huber Alexandre, Bodenmiller Bernd, Uotila Aino, Stahl Michael, Wanka Stefanie, Gerrits Bertran, Aebersold Ruedi, Loewith Robbie", "evidence": [ { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "19684113", "url": "https://glygen.org/publication/PubMed/19684113" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast.", "journal": "Proteomics", "date": "2009-10", "authors": "Gnad Florian, de Godoy Lyris M F, Cox J\u00fcrgen, Neuhauser Nadin, Ren Shubin, Olsen Jesper V, Mann Matthias", "evidence": [ { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" } ] }, { "title": "Global analysis of the yeast osmotic stress response by quantitative proteomics.", "journal": "Molecular bioSystems", "date": "2009-11", "authors": "Soufi Boumediene, Kelstrup Christian D, Stoehr Gabriele, Fr\u00f6hlich Florian, Walther Tobias C, Olsen Jesper V", "evidence": [ { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" } ] }, { "title": "A protein kinase network regulates the function of aminophospholipid flippases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010-01-05", "authors": "Roelants Fran\u00e7oise M, Baltz Alexander G, Trott Amy E, Fereres Sol, Thorner Jeremy", "evidence": [ { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "19966303", "url": "https://glygen.org/publication/PubMed/19966303" } ] }, { "title": "The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates.", "journal": "Molecular biology of the cell", "date": "2010-10-01", "authors": "Soulard Alexandre, Cremonesi Alessio, Moes Suzette, Sch\u00fctz Fr\u00e9d\u00e9ric, Jen\u00f6 Paul, Hall Michael N", "evidence": [ { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" } ] }, { "title": "Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.", "journal": "Science signaling", "date": "2010-12-21", "authors": "Bodenmiller Bernd, Wanka Stefanie, Kraft Claudine, Urban J\u00f6rg, Campbell David, Pedrioli Patrick G, Gerrits Bertran, Picotti Paola, Lam Henry, Vitek Olga, Brusniak Mi-Youn, Roschitzki Bernd, Zhang Chao, Shokat Kevan M, Schlapbach Ralph, Colman-Lerner Alejandro, Nolan Garry P, Nesvizhskii Alexey I, Peter Matthias, Loewith Robbie, von Mering Christian, Aebersold Ruedi", "evidence": [ { "database": "iPTMnet", "id": "P32660", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32660" } ], "reference": [ { "type": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" } ] }, { "title": "Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases.", "journal": "Proc. 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"GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "phosphatidylethanolamine flippase activity", "id": "GO:0090555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090555", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "phosphatidylcholine floppase activity", "id": "GO:0090554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090554", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "phosphatidylserine floppase activity", "id": "GO:0090556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090556", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "ATPase-coupled intramembrane lipid 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"pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "phospholipid-translocating ATPase complex", "id": "GO:1990531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990531", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "cell septum", "id": "GO:0030428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030428", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "cellular bud neck", "id": "GO:0005935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005935", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "mating projection tip membrane", "id": "GO:0070867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070867", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" }, { "name": "establishment or maintenance of cell polarity", "id": "GO:0007163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007163", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1046, "end_pos": 1048, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1245, "end_pos": 1247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1461, "end_pos": 1463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" }, { "start_pos": 653, "end_pos": 655, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" }, { "start_pos": 843, "end_pos": 845, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated by FPK1 and KIN82.", "evidence": [ { "database": "UniProtKB", "id": "P32660", "url": "https://www.uniprot.org/uniprot/P32660" }, { "database": "PubMed", "id": "18199685", "url": "https://glygen.org/publication/PubMed/18199685" } ] } ], "interactions": [], "reactions": [ { "id": "38567", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D4AA47-1", "O95477-1", "Q8IZY2-1", "Q9Y2G3-1", "Q8NB49-1", "P98196-1", "Q9NTI2-4", "Q9Y2Q0-1", "O43520-1", "O60423-2", "P41233-1", "P98197-1", "Q9QZW0-1", "Q6DFW5-1", "Q148W0-1", "P70704-1", "P98200-1", "Q6UQ17-1", "P39524-1", "P32660-1", "P40527-1", "Q12675-1" ], "evidence": [ { "id": "38567", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38567" } ] }, { "id": "38583", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P43245-1", "D4AA47-1", "O95477-1", "Q8IZY2-1", "P08183-1", "O43520-1", "P98198-1", "O60312-1", "P41233-1", "P21447-1", "P06795-1", "O54827-1", "P98199-1", "Q148W0-1", "P32660-1", "Q12675-1", "Q12674-1" ], "evidence": [ { "id": "38583", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38583" } ] }, { "id": "66036", "name": "", "equation": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9P241-1", "O60312-1", "O94823-1", "O54827-1", "Q8K2X1-1", "B1AWN4-1", "P32660-1", "Q12675-1" ], "evidence": [ { "id": "66036", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66036" } ] }, { "id": "66132", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Y2G3-1", "Q8NB49-1", "P98196-1", "P78363-1", "P98197-1", "Q9QZW0-1", "O35600-1", "Q6DFW5-1", "P39524-1", "P32660-1", "P40527-1", "Q12675-1", "Q12674-1" ], "evidence": [ { "id": "66132", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66132" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "B1AWN4", "gene_name": "Atp10b", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "B1AWN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "B1AWN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWN4" } ] } ] }, { "uniprot_ac": "D4AA47", "gene_name": "Atp8b1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "D4AA47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AA47" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "D4AA47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AA47" } ] } ] }, { "uniprot_ac": "O35600", "gene_name": "Abca4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O35600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35600" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O35600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35600" } ] } ] }, { "uniprot_ac": "O43520", "gene_name": "ATP8B1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O43520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43520" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O43520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43520" } ] } ] }, { "uniprot_ac": "O54827", "gene_name": "Atp10a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O54827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54827" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O54827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54827" } ] } ] }, { "uniprot_ac": "O60312", "gene_name": "ATP10A", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O60312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60312" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O60312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60312" } ] } ] }, { "uniprot_ac": "O60423", "gene_name": "ATP8B3", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O60423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60423" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O60423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60423" } ] } ] }, { "uniprot_ac": "O94823", "gene_name": "ATP10B", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O94823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94823" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O94823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94823" } ] } ] }, { "uniprot_ac": "O95477", "gene_name": "ABCA1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "O95477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95477" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "O95477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95477" } ] } ] }, { "uniprot_ac": "P06795", "gene_name": "Abcb1b", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P06795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06795" } ] }, { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "P06795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06795" } ] } ] }, { "uniprot_ac": "P08183", "gene_name": "ABCB1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P08183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08183" } ] }, { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "P08183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08183" } ] } ] }, { "uniprot_ac": "P21447", "gene_name": "Abcb1a", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P21447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21447" } ] }, { "ec_number": "7.6.2.2", "activity": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate.", "evidence": [ { "id": "P21447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21447" } ] } ] }, { "uniprot_ac": "P32660", "gene_name": "DNF1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "P32660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32660" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "P32660", "database": "UniProtKB", 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