{ "uniprot_canonical_ac": "P32578-1", "uniprot_ac": "P32578", "uniprot_id": "SIP1_YEAST", "mass": { "chemical_mass": 91071.0, "monoisotopic_mass": 91071.0 }, "refseq": { "ac": "NP_010710", "name": "Sip1p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010710" }, "gene_names": [ { "name": "SIP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P32578", "id": "P32578" }, { "name": "D9461.11", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P32578", "id": "P32578" }, { "name": "SIP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010710", "id": "NP_010710" } ], "protein_names": [ { "name": "SNF1 protein kinase subunit beta-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P32578" }, { "name": "SNF1-interacting protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32578" }, { "name": "Sip1p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010710", "id": "NP_010710" } ], "function": [ { "annotation": "Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Promotes the PKA-regulated relocalization of the SNF1 kinase complex to the vacuolar membrane in response to various types of carbon stress.", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578#function" }, { "database": "PubMed", "id": "10990457", "url": "https://glygen.org/publication/PubMed/10990457" }, { "database": "PubMed", "id": "8088514", "url": "https://glygen.org/publication/PubMed/8088514" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 2, "end_pos": 2, "sequence_org": "G", "sequence_mut": "A", "comment": "Prevents relocalization to the vacuolar membrane.", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" }, { "database": "PubMed", "id": "14966266", "url": "https://glygen.org/publication/PubMed/14966266" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" } ], "common_name": "Yeast" } ], "gene": [ { "name": "SIP1", "url": "https://www.uniprot.org/uniprot/P32578", "locus": {} } ], "crossref": [ { "id": "2.7.11.31", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.31&UniProtAcc=P32578", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd02859", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02859", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "852032", "url": "https://www.ncbi.nlm.nih.gov/gene/852032", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P32578", "url": "https://www.ebi.ac.uk/intact/interactors/id:P32578*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037256", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037256", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YDR422C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YDR422C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INHIIPH", "url": "https://omabrowser.org/oma/group/INHIIPH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "120305at2759", "url": "http://www.orthodb.org/?query=120305at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10343", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10343", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10343:SF87", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10343:SF87", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04739", "url": "http://pfam.xfam.org/family/PF04739", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16561", "url": "http://pfam.xfam.org/family/PF16561", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P32578", "url": "http://purl.obolibrary.org/obo/PR_P32578", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_010710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010710", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000002830", "url": "https://www.yeastgenome.org/locus/S000002830", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P32578-1", "url": "https://www.uniprot.org/uniprot/P32578-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNSPSTQDPSHSTKKEHGHHFHDAFNKDRQGSITSQLFNNRKSTHKRRASHTSEHNGAIPPRMQLLASHDPSTDCDGRMSSDTTIDKGPSHLFKKDYSLSSAADVNDTTLANLTLSDDHDVGAPEEQVKSPSFLSPGPSMATVKRTKSDLDDLSTLNYTMVDETTENERNDKPHHERHRSSIIALKKNLLESSATASPSPTRSSSVHSASLPALTKTDSIDIPVRQPYSKKPSIHAYQYQYLNNDETFSENSQMDKEGNSDSVDAEAGVLQSEDMVLNQSLLQNALKKDMQRLSRVNSSNSMYTAERISHANNNGNIENNTRNKGNAGGSNDDFTAPISATAKMMMKLYGDKTLMERDLNKHHNKTKKAQNKKIRSVSNSRRSSFASLHSLQSRKSILTNGLNLQPLHPLHPIINDNESQYSAPQHREISHHSNSMSSMSSISSTNSTENTLVVLKWKDDGTVAATTEVFIVSTDIASALKEQRELTLDENASLDSEKQLNPRIRMVYDDVHKEWFVPDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEVLPGYHTIEPFRNEADIDSQVEPTLDEELPKRPELKRFPSSSRKSSYYSAKGVERPSTPFSDYRGLSRSSSINMRDSFVRLKASSLDLMAEVKPERLVYSNEIPNLFNIGDGSTISVKGDSDDVHPQEPPSFTHRVVDCNQDDLFATLQQGGNIDAETAEAVFLSRYPVPDLPIYLNSSYLNRILNQSNQNSESHERDEGAINHIIPHVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAPCYYKTQKSQISN", "length": 815, "header": "sp|P32578-1|SIP1_YEAST Isoform 1 of SNF1 protein kinase subunit beta-1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SIP1 PE=1 SV=2 CANONICAL=P32578-1" }, "isoforms": [ { "isoform_ac": "P32578-1", "url": "", "sequence": { "sequence": "MGNSPSTQDPSHSTKKEHGHHFHDAFNKDRQGSITSQLFNNRKSTHKRRASHTSEHNGAIPPRMQLLASHDPSTDCDGRMSSDTTIDKGPSHLFKKDYSLSSAADVNDTTLANLTLSDDHDVGAPEEQVKSPSFLSPGPSMATVKRTKSDLDDLSTLNYTMVDETTENERNDKPHHERHRSSIIALKKNLLESSATASPSPTRSSSVHSASLPALTKTDSIDIPVRQPYSKKPSIHAYQYQYLNNDETFSENSQMDKEGNSDSVDAEAGVLQSEDMVLNQSLLQNALKKDMQRLSRVNSSNSMYTAERISHANNNGNIENNTRNKGNAGGSNDDFTAPISATAKMMMKLYGDKTLMERDLNKHHNKTKKAQNKKIRSVSNSRRSSFASLHSLQSRKSILTNGLNLQPLHPLHPIINDNESQYSAPQHREISHHSNSMSSMSSISSTNSTENTLVVLKWKDDGTVAATTEVFIVSTDIASALKEQRELTLDENASLDSEKQLNPRIRMVYDDVHKEWFVPDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEVLPGYHTIEPFRNEADIDSQVEPTLDEELPKRPELKRFPSSSRKSSYYSAKGVERPSTPFSDYRGLSRSSSINMRDSFVRLKASSLDLMAEVKPERLVYSNEIPNLFNIGDGSTISVKGDSDDVHPQEPPSFTHRVVDCNQDDLFATLQQGGNIDAETAEAVFLSRYPVPDLPIYLNSSYLNRILNQSNQNSESHERDEGAINHIIPHVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAPCYYKTQKSQISN", "length": 815, "header": "sp|P32578-1|SIP1_YEAST Isoform 1 of SNF1 protein kinase subunit beta-1 OS=Saccharomyces cerevisiae S288C OX=559292 GN=SIP1 PE=1 SV=2 CANONICAL=P32578-1" }, "locus": { "chromosome": "IV", "start_pos": 1317773, "end_pos": 1315329, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YDR422C_mRNA", "url": "https://www.ensembl.org/id/YDR422C_mRNA" }, { "database": "Ensembl Peptide", "id": "YDR422C", "url": "https://www.ensembl.org/id/YDR422C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ], "site_lbl": "Ser101" }, { "start_pos": 102, "end_pos": 102, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" } ], "site_lbl": "Ser102" }, { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" } ], "site_lbl": "Ser133" }, { "start_pos": 136, "end_pos": 136, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" } ], "site_lbl": "Ser136" }, { "start_pos": 149, "end_pos": 149, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ], "site_lbl": "Ser149" }, { "start_pos": 181, "end_pos": 181, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" } ], "site_lbl": "Ser181" }, { "start_pos": 193, "end_pos": 193, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" } ], "site_lbl": "Ser193" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser194" }, { "start_pos": 196, "end_pos": 196, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ], "site_lbl": "Thr196" }, { "start_pos": 198, "end_pos": 198, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser198" }, { "start_pos": 200, "end_pos": 200, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser200" }, { "start_pos": 206, "end_pos": 206, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser206" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" } ], "site_lbl": "Ser209" }, { "start_pos": 211, "end_pos": 211, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ], "site_lbl": "Ser211" }, { "start_pos": 220, "end_pos": 220, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19795423", "url": "https://glygen.org/publication/PubMed/19795423" }, { "database": "PubMed", "id": "19823750", "url": "https://glygen.org/publication/PubMed/19823750" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "PubMed", "id": "21177495", "url": "https://glygen.org/publication/PubMed/21177495" }, { "database": "SGD", "id": "P32578", "url": "https://www.yeastgenome.org/locus/P32578" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser220" }, { "start_pos": 229, "end_pos": 229, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ], "site_lbl": "Tyr229" }, { "start_pos": 230, "end_pos": 230, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": 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"date": "2007-03", "authors": "Li Xue, Gerber Scott A, Rudner Adam D, Beausoleil Sean A, Haas Wilhelm, Vill\u00e9n Judit, Elias Joshua E, Gygi Steve P", "evidence": [ { "database": "UniProtKB", "id": "P32578", "url": "https://www.uniprot.org/uniprot/P32578" }, { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" } ], "reference": [ { "type": "PubMed", "id": "17330950", "url": "https://glygen.org/publication/PubMed/17330950" } ] }, { "title": "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007-06-19", "authors": "Smolka Marcus B, Albuquerque Claudio P, Chen Sheng-hong, Zhou Huilin", "evidence": [ { "database": "iPTMnet", "id": "P32578", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32578" } ], "reference": [ { "type": "PubMed", "id": "17563356", "url": 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