{ "uniprot_canonical_ac": "P32344-1", "uniprot_ac": "P32344", "uniprot_id": "COX24_YEAST", "mass": { "chemical_mass": 12772.0, "monoisotopic_mass": 12772.0 }, "refseq": { "ac": "NP_013305", "name": "Qri5p", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013305" }, "gene_names": [ { "name": "QRI5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P32344", "id": "P32344" }, { "name": "COX24; mS38", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013305", "id": "NP_013305" }, { "name": "COX24", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P32344", "id": "P32344" }, { "name": "QRI5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013305", "id": "NP_013305" } ], "protein_names": [ { "name": "Small ribosomal subunit protein mS38", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P32344" }, { "name": "Mitochondrial mRNA-processing protein COX24", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32344" }, { "name": "Qri5p", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013305", "id": "NP_013305" } ], "function": [ { "annotation": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). mS38 is also involved in the splicing of the COX1 mRNA (PubMed:16339141).", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344#function" }, { "database": "PubMed", "id": "25609543", "url": "https://glygen.org/publication/PubMed/25609543" }, { "database": "PubMed", "id": "28154081", "url": "https://glygen.org/publication/PubMed/28154081" }, { "database": "PubMed", "id": "16339141", "url": "https://glygen.org/publication/PubMed/16339141" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "common_name": "Yeast" } ], "gene": [ { "name": "QRI5", "url": "https://www.uniprot.org/uniprot/P32344", "locus": { "chromosome": "XII", "start_pos": 552605, "end_pos": 552270, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "YLR204W", "url": "https://www.ensembl.org/id/YLR204W" } ] } } ], "crossref": [ { "id": "850901", "url": "https://www.ncbi.nlm.nih.gov/gene/850901", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P32344", "url": "https://www.ebi.ac.uk/intact/interactors/id:P32344*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR013177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YLR204W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YLR204W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AINTTMP", "url": "https://omabrowser.org/oma/group/AINTTMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2035927at2759", "url": "http://www.orthodb.org/?query=2035927at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32035", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32035", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32035:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32035:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5MRC", "url": "https://www.rcsb.org/structure/5MRC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5MRE", "url": "https://www.rcsb.org/structure/5MRE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5MRF", "url": "https://www.rcsb.org/structure/5MRF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF08213", "url": "http://pfam.xfam.org/family/PF08213", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P32344", "url": "http://purl.obolibrary.org/obo/PR_P32344", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_013305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013305", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000004194", "url": "https://www.yeastgenome.org/locus/S000004194", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P32344-1", "url": "https://www.uniprot.org/uniprot/P32344-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGRALRPGWLGITRTVVKKPSCGSYFNRTFQTAINTTMPPMQEGMLSTMMMMTATATRITGTVSEPLNGSNIVMQLDSVMRKRKKKMKKHKLRKRRKREKAERRKLSQGR", "length": 111, "header": "sp|P32344-1|COX24_YEAST Isoform 1 of Small ribosomal subunit protein mS38 OS=Saccharomyces cerevisiae S288C OX=559292 GN=QRI5 PE=1 SV=1 CANONICAL=P32344-1" }, "isoforms": [ { "isoform_ac": "P32344-1", "url": "", "sequence": { "sequence": "MLGRALRPGWLGITRTVVKKPSCGSYFNRTFQTAINTTMPPMQEGMLSTMMMMTATATRITGTVSEPLNGSNIVMQLDSVMRKRKKKMKKHKLRKRRKREKAERRKLSQGR", "length": 111, "header": "sp|P32344-1|COX24_YEAST Isoform 1 of Small ribosomal subunit protein mS38 OS=Saccharomyces cerevisiae S288C OX=559292 GN=QRI5 PE=1 SV=1 CANONICAL=P32344-1" }, "locus": { "chromosome": "XII", "start_pos": 552602, "end_pos": 552270, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YLR204W_mRNA", "url": "https://www.ensembl.org/id/YLR204W_mRNA" }, { "database": "Ensembl Peptide", "id": "YLR204W", "url": "https://www.ensembl.org/id/YLR204W" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Analysis of the MSS51 region on chromosome XII of Saccharomyces cerevisiae.", "journal": "Yeast", "date": "1992", "authors": "Simon M., Sor F., Faye G., della Seta F.", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "1523888", "url": "https://glygen.org/publication/PubMed/1523888" } ] }, { "title": "COX24 codes for a mitochondrial protein required for processing of the COX1 transcript.", "journal": "J. Biol. Chem.", "date": "2006", "authors": "Tzagoloff A., Barros M.H., Myers A.M., Van Driesche S.", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "16339141", "url": "https://glygen.org/publication/PubMed/16339141" } ] }, { "title": "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.", "journal": "Genome Res.", "date": "2007", "authors": "Hu Y., LaBaer J., Moreira D., Raphael J., Rolfs A., Zuo D., Richardson A., Simpson A.J.G., Zhu C., Harlow E., Camargo A.A., Jepson D., Kelley F., McCarron S., Taycher E., Kolodner R.D., Kane M.F., Williamson J., Berger M.F., Bulyk M.L., Bhullar B., Mohr S., Marsischky G., Murthy T.V.S.", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "17322287", "url": "https://glygen.org/publication/PubMed/17322287" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography.", "journal": "Nat. Commun.", "date": "2015", "authors": "Herrmann J.M., Woellhaf M.W., Pfeffer S., Forster F.", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "25609543", "url": "https://glygen.org/publication/PubMed/25609543" } ] }, { "title": "The structure of the yeast mitochondrial ribosome.", "journal": "Science", "date": "2017", "authors": "Brown A., Amunts A., Ramakrishnan V., Desai N.", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "28154081", "url": "https://glygen.org/publication/PubMed/28154081" } ] }, { "title": "Analysis of a yeast nuclear gene involved in the maturation of mitochondrial pre-messenger RNA of the cytochrome oxidase subunit I.", "journal": "Cell", "date": "1983", "authors": "Simon M., Faye G.", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "6297789", "url": "https://glygen.org/publication/PubMed/6297789" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Duesterhoeft A., Hillier L.W., Mewes H.-W., Obermaier B., Scharfe M., Wambutt R., Wedler H., Verhasselt P., Rose M., Benes V., Brueckner M., Rieger M., Portetelle D., Delius H., Schwarz S., Kleine K., Floeth M., Schwager C., Voss H., Hoheisel J.D., Dubois E., Volckaert G., Andre B., Koetter P., Entian K.-D., Louis E.J., Vandenbol M., Johnston M., Pohl T.M., Goffeau A., Hani J., Hilger F., Messenguy F., Miosga T., Mueller-Auer S., Scherens B., Zimmermann F.K., Zollner A., Purnelle B., Urrestarazu L.A., Vierendeels F., Voet M., Albermann K., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H., Moestl D., Nentwich U., Piravandi E., Rechmann S., Riles L., Rinke M., Scholler P., Underwood A.P., Wedler E.", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "reference": [ { "type": "PubMed", "id": "9169871", "url": "https://glygen.org/publication/PubMed/9169871" } ] } ], "pathway": [ { "id": "sce:YLR204W", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YLR204W", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial small ribosomal subunit", "id": "GO:0005763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005763", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P32344", "url": "https://www.uniprot.org/uniprot/P32344" } ], "pmid": "" }, { "name": 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