{
    "uniprot_canonical_ac": "P32304-1",
    "uniprot_ac": "P32304",
    "uniprot_id": "5HT7R_MOUSE",
    "mass": {
        "chemical_mass": 49916.0,
        "monoisotopic_mass": 49916.0
    },
    "refseq": {
        "ac": "NP_032341",
        "name": "5-hydroxytryptamine receptor 7 isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341"
    },
    "gene_names": [
        {
            "name": "Htr7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P32304",
            "id": "P32304"
        },
        {
            "name": "5-HT-X; 5-HT7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341",
            "id": "NP_032341"
        },
        {
            "name": "Htr7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341",
            "id": "NP_032341"
        }
    ],
    "protein_names": [
        {
            "name": "5-hydroxytryptamine receptor 7",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P32304"
        },
        {
            "name": "5-HT-7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P32304"
        },
        {
            "name": "5-HT-X",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P32304"
        },
        {
            "name": "5-HT7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P32304"
        },
        {
            "name": "5-hydroxytryptamine receptor 7 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341",
            "id": "NP_032341"
        },
        {
            "name": "5-hydroxytryptamine receptor 7 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334371",
            "id": "NP_001334371"
        },
        {
            "name": "5-hydroxytryptamine receptor 7; serotonin receptor 7",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334371",
            "id": "NP_001334371"
        },
        {
            "name": "Serotonin receptor 7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P32304"
        }
    ],
    "function": [
        {
            "annotation": "Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain are reported.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_032341",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341"
                },
                {
                    "database": "PubMed",
                    "id": "18793707",
                    "url": "https://glygen.org/publication/PubMed/18793707"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001334371",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334371"
                }
            ]
        },
        {
            "annotation": "Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_032341",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341"
                },
                {
                    "database": "PubMed",
                    "id": "33081564",
                    "url": "https://glygen.org/publication/PubMed/33081564"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001334371",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334371"
                }
            ]
        },
        {
            "annotation": "Serotonin 5-HT7 receptor overexpression in the raphe nuclei area produces antidepressive effect and affects brain serotonin system in male mice.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_032341",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341"
                },
                {
                    "database": "PubMed",
                    "id": "35443076",
                    "url": "https://glygen.org/publication/PubMed/35443076"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001334371",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334371"
                }
            ]
        },
        {
            "annotation": "This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P32304",
                    "url": "https://www.uniprot.org/uniprot/P32304#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:10914",
            "recommended_name": {
                "id": "DOID:10914",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:10914",
                "name": "amnestic disorder",
                "description": "A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information."
            },
            "synonyms": [
                {
                    "id": "DOID:10914",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10914",
                    "name": "Amnestic syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:10914",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10914",
                    "name": "Korsakoff's psychosis or syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:10914",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10914",
                    "name": "amnesia",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "10914",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:10914"
                }
            ]
        },
        {
            "disease_id": "DOID:1561",
            "recommended_name": {
                "id": "DOID:1561",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1561",
                "name": "cognitive disorder",
                "description": "A disease of mental health that affects cognitive functions including memory processing, perception and problem solving."
            },
            "synonyms": [
                {
                    "id": "DOID:1561",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1561",
                    "name": "cognitive disease",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "1561",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1561"
                }
            ]
        },
        {
            "disease_id": "DOID:1574",
            "recommended_name": {
                "id": "DOID:1574",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1574",
                "name": "alcohol use disorder",
                "description": "A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences."
            },
            "synonyms": [
                {
                    "id": "DOID:1574",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1574",
                    "name": "Ethanol abuse",
                    "description": ""
                },
                {
                    "id": "DOID:1574",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1574",
                    "name": "alcohol abuse",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "1574",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1574"
                }
            ]
        },
        {
            "disease_id": "DOID:1825",
            "recommended_name": {
                "id": "DOID:1825",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1825",
                "name": "childhood absence epilepsy",
                "description": "A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years."
            },
            "synonyms": [
                {
                    "id": "DOID:1825",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1825",
                    "name": "petit mal seizure",
                    "description": ""
                },
                {
                    "id": "DOID:1825",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1825",
                    "name": "pyknolepsy",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "1825",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1825"
                }
            ]
        },
        {
            "disease_id": "DOID:2030",
            "recommended_name": {
                "id": "DOID:2030",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:2030",
                "name": "anxiety disorder",
                "description": "A cognitive disorder that involves an excessive, irrational dread of everyday situations."
            },
            "synonyms": [
                {
                    "id": "DOID:2030",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2030",
                    "name": "anxiety",
                    "description": ""
                },
                {
                    "id": "DOID:2030",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2030",
                    "name": "anxiety state",
                    "description": ""
                },
                {
                    "id": "MONDO:0011918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011918",
                    "name": "anxiety",
                    "description": ""
                },
                {
                    "id": "MONDO:0011918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011918",
                    "name": "anxiety",
                    "description": ""
                },
                {
                    "id": "MONDO:0011918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011918",
                    "name": "anxiety-related personality traits",
                    "description": ""
                },
                {
                    "id": "MONDO:0011918",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011918",
                    "name": "harm avoidance",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "2030",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:2030"
                }
            ]
        },
        {
            "disease_id": "DOID:6364",
            "recommended_name": {
                "id": "DOID:6364",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:6364",
                "name": "migraine",
                "description": "A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing."
            },
            "synonyms": [
                {
                    "id": "DOID:6364",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:6364",
                    "name": "migraine disorder",
                    "description": ""
                },
                {
                    "id": "DOID:6364",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:6364",
                    "name": "migraine variant",
                    "description": ""
                },
                {
                    "id": "DOID:6364",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:6364",
                    "name": "migraine with or without aura",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "migraine with or without aura, susceptibility to, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "migraine with or without aura, susceptibility to, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "migraine with or without aura, susceptibility to, type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "migraine without aura, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "migraine, resistance to",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "migraine, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "Mgau",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "Mgr1",
                    "description": ""
                },
                {
                    "id": "MONDO:0008000",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008000",
                    "name": "migraine",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "6364",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:6364"
                }
            ]
        },
        {
            "disease_id": "DOID:9778",
            "recommended_name": {
                "id": "DOID:9778",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9778",
                "name": "irritable bowel syndrome",
                "description": "An intestinal disease that is characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause."
            },
            "synonyms": [
                {
                    "id": "DOID:9778",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9778",
                    "name": "IBD",
                    "description": ""
                },
                {
                    "id": "DOID:9778",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9778",
                    "name": "Irritable colon",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "9778",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9778"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P32304",
                    "url": "https://www.uniprot.org/uniprot/P32304"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Htr7",
            "url": "https://www.uniprot.org/uniprot/P32304",
            "locus": {
                "chromosome": "19",
                "start_pos": 35936134,
                "end_pos": 36034907,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000024798",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000024798"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000024798",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024798",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd15329",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15329",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "CHEMBL4764",
            "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4764",
            "database": "ChEMBL",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "15566",
            "url": "https://www.ncbi.nlm.nih.gov/gene/15566",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000276",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001069",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001069",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002231",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002231",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017452",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:15566",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:15566",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "99841",
            "url": "http://www.informatics.jax.org/marker/MGI:99841",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "GFPRPEK",
            "url": "https://omabrowser.org/oma/group/GFPRPEK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2999405at2759",
            "url": "http://www.orthodb.org/?query=2999405at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24247",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24247",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24247:SF116",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24247:SF116",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24248",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR24248:SF66",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248:SF66",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00001",
            "url": "http://pfam.xfam.org/family/PF00001",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P32304",
            "url": "http://purl.obolibrary.org/obo/PR_P32304",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-390666",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-390666",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-418555",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418555",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-9706019",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9706019",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_032341",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B6VJS2",
            "url": "https://www.uniprot.org/uniprot/B6VJS2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B6VJS2-1",
            "url": "https://www.uniprot.org/uniprot/B6VJS2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B6VJS3",
            "url": "https://www.uniprot.org/uniprot/B6VJS3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B6VJS3-1",
            "url": "https://www.uniprot.org/uniprot/B6VJS3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9Q1X2",
            "url": "https://www.uniprot.org/uniprot/E9Q1X2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9Q1X2-1",
            "url": "https://www.uniprot.org/uniprot/E9Q1X2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9Q4Q7",
            "url": "https://www.uniprot.org/uniprot/E9Q4Q7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "E9Q4Q7-1",
            "url": "https://www.uniprot.org/uniprot/E9Q4Q7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P32304",
            "url": "https://www.uniprot.org/uniprot/P32304",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P32304-1",
            "url": "https://www.uniprot.org/uniprot/P32304-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFSGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNCDHCGKKGHDT",
        "length": 448,
        "header": "sp|P32304-1|5HT7R_MOUSE Isoform 1 of 5-hydroxytryptamine receptor 7  OS=Mus musculus OX=10090 GN=Htr7 PE=2 SV=2 CANONICAL=P32304-1"
    },
    "isoforms": [
        {
            "isoform_ac": "B6VJS2-1",
            "url": "",
            "sequence": {
                "sequence": "MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFSGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVL",
                "length": 435,
                "header": "tr|B6VJS2-1|B6VJS2_MOUSE Computationally mapped isoform of 5-hydroxytryptamine receptor 7  OS=Mus musculus OX=10090 GN=Htr7 PE=2 SV=1 CANONICAL=P32304-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 36034653,
                "end_pos": 35946708,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000166074.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000166074.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000126150.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000126150.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "B6VJS3-1",
            "url": "",
            "sequence": {
                "sequence": "MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFSGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLMTGASGVQKALENLPWGNGVNTGIKAVNSVALTKL",
                "length": 470,
                "header": "tr|B6VJS3-1|B6VJS3_MOUSE Computationally mapped isoform of 5-hydroxytryptamine receptor 7  OS=Mus musculus OX=10090 GN=Htr7 PE=2 SV=1 CANONICAL=P32304-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 36034653,
                "end_pos": 35937791,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000099505.4",
                        "url": "https://www.ensembl.org/id/ENSMUST00000099505.4"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000097105.4",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000097105.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9Q1X2-1",
            "url": "",
            "sequence": {
                "sequence": "MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVARRWKSVRTFRDCSNTKGKTFPSSRGNRKQPLPWGSSWEPSRCAGCRFSSCPQQGPLSVAPPVAASRCGWRGHVCGWAMQTLSLTLLYMPSSTGT",
                "length": 344,
                "header": "tr|E9Q1X2-1|E9Q1X2_MOUSE Computationally mapped isoform of 5-hydroxytryptamine receptor 7  OS=Mus musculus OX=10090 GN=Htr7 PE=3 SV=1 CANONICAL=P32304-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 36034653,
                "end_pos": 35946833,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000170360.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000170360.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000131517.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000131517.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9Q4Q7-1",
            "url": "",
            "sequence": {
                "sequence": "MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRESIAGHRRIGSLRKY",
                "length": 198,
                "header": "tr|E9Q4Q7-1|E9Q4Q7_MOUSE Computationally mapped isoform of 5-hydroxytryptamine receptor 7  OS=Mus musculus OX=10090 GN=Htr7 PE=4 SV=1 CANONICAL=P32304-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 36034653,
                "end_pos": 36018967,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000164781.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000164781.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000131912.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000131912.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "P32304-1",
            "url": "",
            "sequence": {
                "sequence": "MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFSGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNCDHCGKKGHDT",
                "length": 448,
                "header": "sp|P32304-1|5HT7R_MOUSE Isoform 1 of 5-hydroxytryptamine receptor 7  OS=Mus musculus OX=10090 GN=Htr7 PE=2 SV=2 CANONICAL=P32304-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 36034653,
                "end_pos": 35937760,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000164639",
                        "url": "https://www.ensembl.org/id/ENSMUST00000164639"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000126847",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000126847"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 5,
            "start_aa": "Asn",
            "end_pos": 5,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn5",
            "evidence": [
                {
                    "id": "P32304",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P32304#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 69,
            "start_aa": "Asn",
            "end_pos": 69,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn69",
            "evidence": [
                {
                    "id": "P32304",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/P32304#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain.",
            "journal": "Gene",
            "date": "2008",
            "authors": "Gellynck E, Laenen K, Andressen KW, Lintermans B, De Martelaere K, Matthys A, Levy FO, Haegeman G, Vanhoenacker P, Van Craenenbroeck K",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001334371",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334371"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_032341",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18793707",
                    "url": "https://glygen.org/publication/PubMed/18793707"
                }
            ]
        },
        {
            "title": "Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane.",
            "journal": "Chronobiology international",
            "date": "2021",
            "authors": "Liu B, Chu S, Liu T, Song J, Ma Z, Gu X, Xia T",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001334371",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334371"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_032341",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33081564",
                    "url": "https://glygen.org/publication/PubMed/33081564"
                }
            ]
        },
        {
            "title": "Serotonin 5-HT(7) receptor overexpression in the raphe nuclei area produces antidepressive effect and affects brain serotonin system in male mice.",
            "journal": "Journal of neuroscience research",
            "date": "2022",
            "authors": "Rodnyy AY, Kondaurova EM, Bazovkina DV, Kulikova EA, Ilchibaeva TV, Kovetskaya AI, Baraboshkina IA, Bazhenova EY, Popova NK, Naumenko VS",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_032341",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032341"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001334371",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334371"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "35443076",
                    "url": "https://glygen.org/publication/PubMed/35443076"
                }
            ]
        },
        {
            "title": "Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.",
            "journal": "Mol. Pharmacol.",
            "date": "1993",
            "authors": "Plassat JL, Amlaiky N, Hen R",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P32304",
                    "url": "https://www.uniprot.org/uniprot/P32304"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8394987",
                    "url": "https://glygen.org/publication/PubMed/8394987"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:15566",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:15566",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-390666",
            "name": "Serotonin receptors",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-390666",
            "resource": "Reactome",
            "description": "Serotonin receptors"
        },
        {
            "id": "R-MMU-418555",
            "name": "G alpha (s) signalling events",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418555",
            "resource": "Reactome",
            "description": "G alpha (s) signalling events"
        },
        {
            "id": "R-MMU-9706019",
            "name": "RHOBTB3 ATPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9706019",
            "resource": "Reactome",
            "description": "RHOBTB3 ATPase cycle"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P32305-1",
            "protein_name": "5-hydroxytryptamine receptor 7",
            "gene_name": "Htr7",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT",
                "length": 448
            },
            "evidence": [
                {
                    "id": "45235975",
                    "url": "http://www.informatics.jax.org/homology/45235975",
                    "database": "MGI"
                },
                {
                    "id": "P32304",
                    "url": "https://omabrowser.org/oma/group/P32304/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P34969-1",
            "protein_name": "5-hydroxytryptamine receptor 7",
            "gene_name": "HTR7",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD",
                "length": 479
            },
            "evidence": [
                {
                    "id": "45235975",
                    "url": "http://www.informatics.jax.org/homology/45235975",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 8,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synapse",
                        "id": "GO:0045202",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite",
                        "id": "GO:0030425",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuronal cell body",
                        "id": "GO:0043025",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "axon terminus",
                        "id": "GO:0043679",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "postsynaptic membrane",
                        "id": "GO:0045211",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "synaptic vesicle",
                        "id": "GO:0008021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "presynaptic membrane",
                        "id": "GO:0042734",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 18,
                "go_terms": [
                    {
                        "name": "smooth muscle contraction",
                        "id": "GO:0006939",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006939",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chemical synaptic transmission",
                        "id": "GO:0007268",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "circadian rhythm",
                        "id": "GO:0007623",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007623",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "vasoconstriction",
                        "id": "GO:0042310",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042310",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "memory",
                        "id": "GO:0007613",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of neuron projection development",
                        "id": "GO:0010976",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P32304",
                                "url": "https://www.uniprot.org/uniprot/P32304"
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