{ "uniprot_canonical_ac": "P32179-1", "uniprot_ac": "P32179", "uniprot_id": "MET22_YEAST", "mass": { "chemical_mass": 39149.0, "monoisotopic_mass": 39149.0 }, "refseq": { "ac": "NP_014577", "name": "3'(2'),5'-bisphosphate nucleotidase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014577" }, "gene_names": [ { "name": "MET22", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P32179", "id": "P32179" }, { "name": "HAL2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014577", "id": "NP_014577" }, { "name": "HAL2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P32179", "id": "P32179" }, { "name": "MET22", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014577", "id": "NP_014577" } ], "protein_names": [ { "name": "3'(2'),5'-bisphosphate nucleotidase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P32179" }, { "name": "3'(2'),5'-bisphosphate nucleotidase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014577", "id": "NP_014577" }, { "name": "3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32179" }, { "name": "3.1.3.7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32179" }, { "name": "DPNPase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32179" }, { "name": "Halotolerance protein HAL2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32179" }, { "name": "Methionine-requiring protein 22", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P32179" } ], "function": [ { "annotation": "Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance. Confers resistance to lithium.", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179#function" } ] } ], "disease": [ { "disease_id": "DOID:0112224", "recommended_name": { "id": "DOID:0112224", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112224", "name": "chondrodysplasia with joint dislocations gPAPP type", "description": "An osteochondrodysplasia characterized by prenatal onset of disproportionate short stature, shortening of the limbs, joint hyperlaxity and/or dislocations, micrognathia, cleft palate, brachydactyly, short metacarpals, supernumerary carpal ossification centers and dysmorphic facial features that has_material_basis_in homozygous or compound heterozygous mutation in the IMPAD1 gene on chromosome 8q12." }, "synonyms": [ { "id": "DOID:0112224", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112224", "name": "gPAPP deficiency", "description": "" }, { "id": "MONDO:0013561", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013561", "name": "chondrodysplasia with joint dislocations, gPAPP type", "description": "" }, { "id": "MONDO:0013561", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013561", "name": "chondrodysplasia with joint dislocations, gPAPP type", "description": "" }, { "id": "MONDO:0013561", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013561", "name": "gPAPP deficiency", "description": "" }, { "id": "MIM:614078", "resource": "MIM", "url": "https://www.omim.org/entry/614078", "name": "Chondrodysplasia with joint dislocations, GPAPP type", "description": "Chondrodysplasia with joint dislocations, GPAPP type" } ], "evidence": [ { "id": "0112224", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112224" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "common_name": "Yeast" } ], "gene": [ { "name": "MET22", "url": "https://www.uniprot.org/uniprot/P32179", "locus": { "chromosome": "XV", "start_pos": 206103, "end_pos": 207176, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "YOL064C", "url": "https://www.ensembl.org/id/YOL064C" } ] } } ], "crossref": [ { "id": "3.1.3.7", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.7&UniProtAcc=P32179", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd01517", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01517", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "854090", "url": "https://www.ncbi.nlm.nih.gov/gene/854090", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P32179", "url": "https://www.ebi.ac.uk/intact/interactors/id:P32179*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020550", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020550", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YOL064C", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOL064C", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MSYQQER", "url": "https://omabrowser.org/oma/group/MSYQQER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5486961at2759", "url": "http://www.orthodb.org/?query=5486961at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43200", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43200", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43200:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43200:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1K9Y", "url": "https://www.rcsb.org/structure/1K9Y", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1K9Z", "url": "https://www.rcsb.org/structure/1K9Z", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1KA0", "url": "https://www.rcsb.org/structure/1KA0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1KA1", "url": "https://www.rcsb.org/structure/1KA1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1QGX", "url": "https://www.rcsb.org/structure/1QGX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00459", "url": "http://pfam.xfam.org/family/PF00459", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P32179", "url": "http://purl.obolibrary.org/obo/PR_P32179", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_014577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014577", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000005425", "url": "https://www.yeastgenome.org/locus/S000005425", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P32179-1", "url": "https://www.uniprot.org/uniprot/P32179-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALERELLVATQAVRKASLLTKRIQSEVISHKDSTTITKNDNSPVTTGDYAAQTIIINAIKSNFPDDKVVGEESSSGLSDAFVSGILNEIKANDEVYNKNYKKDDFLFTNDQFPLKSLEDVRQIIDFGNYEGGRKGRFWCLDPIDGTKGFLRGEQFAVCLALIVDGVVQLGCIGCPNLVLSSYGAQDLKGHESFGYIFRAVRGLGAFYSPSSDAESWTKIHVRHLKDTKDMITLEGVEKGHSSHDEQTAIKNKLNISKSLHLDSQAKYCLLALGLADVYLRLPIKLSYQEKIWDHAAGNVIVHEAGGIHTDAMEDVPLDFGNGRTLATKGVIASSGPRELHDLVVSTSCDVIQSRNA", "length": 357, "header": "sp|P32179-1|MET22_YEAST Isoform 1 of 3'(2'),5'-bisphosphate nucleotidase OS=Saccharomyces cerevisiae S288C OX=559292 GN=MET22 PE=1 SV=1 CANONICAL=P32179-1" }, "isoforms": [ { "isoform_ac": "P32179-1", "url": "", "sequence": { "sequence": "MALERELLVATQAVRKASLLTKRIQSEVISHKDSTTITKNDNSPVTTGDYAAQTIIINAIKSNFPDDKVVGEESSSGLSDAFVSGILNEIKANDEVYNKNYKKDDFLFTNDQFPLKSLEDVRQIIDFGNYEGGRKGRFWCLDPIDGTKGFLRGEQFAVCLALIVDGVVQLGCIGCPNLVLSSYGAQDLKGHESFGYIFRAVRGLGAFYSPSSDAESWTKIHVRHLKDTKDMITLEGVEKGHSSHDEQTAIKNKLNISKSLHLDSQAKYCLLALGLADVYLRLPIKLSYQEKIWDHAAGNVIVHEAGGIHTDAMEDVPLDFGNGRTLATKGVIASSGPRELHDLVVSTSCDVIQSRNA", "length": 357, "header": "sp|P32179-1|MET22_YEAST Isoform 1 of 3'(2'),5'-bisphosphate nucleotidase OS=Saccharomyces cerevisiae S288C OX=559292 GN=MET22 PE=1 SV=1 CANONICAL=P32179-1" }, "locus": { "chromosome": "XV", "start_pos": 207176, "end_pos": 206106, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YOL064C_mRNA", "url": "https://www.ensembl.org/id/YOL064C_mRNA" }, { "database": "Ensembl Peptide", "id": "YOL064C", "url": "https://www.ensembl.org/id/YOL064C" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "SGD", "id": "P32179", "url": "https://www.yeastgenome.org/locus/P32179" }, { "database": "iPTMnet", "id": "P32179", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32179" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser26" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "X-ray structure of yeast Hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity.", "journal": "J. Mol. Biol.", "date": "2000", "authors": "Blundell T.L., Patel S., Rodriguez P.L., Serrano R., Yenush L., Martinez-Ripoll M., Albert A., Gil-Mascarell M.R.", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "reference": [ { "type": "PubMed", "id": "10656801", "url": "https://glygen.org/publication/PubMed/10656801" } ] }, { "title": "Structural enzymology of Li(+)-sensitive/Mg(2+)-dependent phosphatases.", "journal": "J. Mol. Biol.", "date": "2002", "authors": "Blundell T.L., Patel S., Martinez-Ripoll M., Albert A.", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "reference": [ { "type": "PubMed", "id": "12126627", "url": "https://glygen.org/publication/PubMed/12126627" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", "evidence": [ { "database": "iPTMnet", "id": "P32179", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P32179" } ], "reference": [ { "type": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene.", "journal": "EMBO J.", "date": "1993", "authors": "Thomas D., Serrano R., Surdin-Kerjan Y., Gaxiola R., Glaeser H.-U., Montrichard F.", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "reference": [ { "type": "PubMed", "id": "8393782", "url": "https://glygen.org/publication/PubMed/8393782" } ] }, { "title": "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.", "journal": "Nature", "date": "1997", "authors": "Ansorge W., Mewes H.-W., Wambutt R., Wedler H., Wiemann S., Pujol A., Uhlen M., Camasses A., Poch O., Benes V., Durand P., Vlcek C., Winsor B., Landt O., Portetelle D., Casas C., Lafuente M.J., Paces V., Delius H., Michaux G., Schweizer M., Feldmann H., Kleine K., Martin R.P., Hofmann B., Schwager C., Voss H., Cziepluch C., Jauniaux J.-C., Hughes B., Galisson F., Volckaert G., Hattenhorst U., Cheret G., Sor F., Herrero E., Arino J., Vetter I., Casamayor A., Bordonne R., Perrin A., Thierry A., Kordes E., Louis E.J., Hollenberg C.P., Maarse A.C., Marck C., Vandenbol M., Pohl T.M., Tobiasch E., Pearson B.M., Poirey R., Hand N.J., Goulding S.E., Daignan-Fornier B., Dujon B., Goffeau A., Grivell L.A., Hani J., Hernando Y., Hilger F., Madania A., Mannhaupt G., Zollner A., Aldea M., Alexandraki D., Bolotin-Fukuhara M., Fairhead C., Gancedo C., Purnelle B., Ramezani Rad M., Tarassov I.A., Tzermia M., Voet M., Albermann K., Bohn C., Boyer J., Dang V.-D., Gaillon L., Gamo F.-J., Habbig B., Hebling U., Heumann K., Hiesel R., Kalogeropoulos A., Katsoulou C., Parle-McDermott A.G., Pettersson B., Rechmann S., Sterky F., Teodoru C., Tettelin H., Unseld M., Valens M., Wolfe K.H., Zumstein E., de Haan M.", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "reference": [ { "type": "PubMed", "id": "9169874", "url": "https://glygen.org/publication/PubMed/9169874" } ] }, { "title": "Sequence analysis of a 33.2 kb segment from the left arm of yeast chromosome XV reveals eight known genes and ten new open reading frames including homologues of ABC transporters, inositol phosphatases and human expressed sequence tags.", "journal": "Yeast", "date": "1997", "authors": "Alexandraki D., Tzermia M., Katsoulou C.", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "reference": [ { "type": "PubMed", "id": "9178509", "url": "https://glygen.org/publication/PubMed/9178509" } ] } ], "pathway": [ { "id": "sce:YOL064C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YOL064C", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "pmid": "" }, { "name": "3'(2'),5'-bisphosphate nucleotidase activity", "id": "GO:0008441", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008441", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "hyperosmotic salinity response", "id": "GO:0042538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042538", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate biosynthetic process", "id": "GO:0046854", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046854", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "pmid": "" }, { "name": "methionine biosynthetic process", "id": "GO:0009086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009086", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "pmid": "" }, { "name": "sulfate assimilation", "id": "GO:0000103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000103", "evidence": [ { "database": "UniProtKB", "id": "P32179", "url": "https://www.uniprot.org/uniprot/P32179" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10040", "name": "", "equation": "adenosine 3',5'-bisphosphate + H2O = AMP + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9Z1N4-1", "D4AD37-1", "O95861-1", "Q9NX62-1", "Q9Z0S1-1", "Q80V26-1", "P32179-1", "Q55F34-1", "Q869K3-1" ], "evidence": [ { "id": "10040", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10040" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "D4AD37", 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