{ "uniprot_canonical_ac": "P31373-1", "uniprot_ac": "P31373", "uniprot_id": "CYS3_YEAST", "mass": { "chemical_mass": 42542.0, "monoisotopic_mass": 42542.0 }, "refseq": { "ac": "NP_009390", "name": "cystathionine gamma-lyase CYS3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009390" }, "gene_names": [ { "name": "CYS3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P31373", "id": "P31373" }, { "name": "CYI1; FUN35; STR1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009390", "id": "NP_009390" }, { "name": "CYI1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P31373", "id": "P31373" }, { "name": "CYS3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009390", "id": "NP_009390" }, { "name": "FUN35", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P31373", "id": "P31373" }, { "name": "STR1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P31373", "id": "P31373" } ], "protein_names": [ { "name": "Cystathionine gamma-lyase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P31373" }, { "name": "4.4.1.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P31373" }, { "name": "Gamma-cystathionase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P31373" }, { "name": "Sulfur transfer protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P31373" }, { "name": "cystathionine gamma-lyase CYS3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009390", "id": "NP_009390" }, { "name": "gamma-CTLase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P31373" } ], "function": [ { "annotation": "Catalyzes the production of cysteine from cystathionine in the reverse transsulfuration pathway for the biosynthesis of sulfur-containing amino acids cysteine and methionine. In this pathway, homocysteine sulfur is converted to cysteine sulfur (Probable). Also has cystathionine beta-lyase and cystathionine gamma-synthase activities in vitro. Cystathionine beta-lyase may be physiological, while cystathionine gamma-synthase activity is not, as the required substrate O-succinyl-L-homoserine(OSH) does not occur naturally in S.cerevisiae (PubMed:8335636).", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373#function" }, { "database": "PubMed", "id": "8335636", "url": "https://glygen.org/publication/PubMed/8335636" }, { "database": "PubMed", "id": "1577698", "url": "https://glygen.org/publication/PubMed/1577698" } ] } ], "disease": [ { "disease_id": "DOID:0090142", "recommended_name": { "id": "DOID:0090142", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090142", "name": "cystathioninuria", "description": "An amino acid metabolic disorder that is characterized by elevated plasma and urinary cystathionine levels that has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding cystathionine gamma-lyase (CTH) on chromosome 1p31." }, "synonyms": [ { "id": "DOID:0090142", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090142", "name": "cystathionase deficiency", "description": "" }, { "id": "DOID:0090142", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090142", "name": "cystathione gamma-lyase deficiency syndrome", "description": "" }, { "id": "DOID:0090142", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090142", "name": "gamma-cystathionase deficiency", "description": "" }, { "id": "MONDO:0009058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009058", "name": "cystathioninuria", "description": "Cystathioninuria is an autosomal recessive disorder caused by cystathionine gamma-lyase deficiency. It is usually pyridoxine-dependent, but in very rare cases it may be non-dependent. It is generally considered to be a benign condition without pathogenic relevance. However, association of cystathioninuria with intellectual impairment has been reported in several cases." }, { "id": "MONDO:0009058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009058", "name": "Cystathione gamma-lyase deficiency syndrome", "description": "" }, { "id": "MONDO:0009058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009058", "name": "cystathionase deficiency", "description": "" }, { "id": "MONDO:0009058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009058", "name": "cystathione gamma-lyase deficiency syndrome", "description": "" }, { "id": "MONDO:0009058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009058", "name": "cystathioninuria", "description": "" }, { "id": "MONDO:0009058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009058", "name": "cystathioninuria (disease)", "description": "" }, { "id": "MONDO:0009058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009058", "name": "gamma-cystathionase deficiency", "description": "" }, { "id": "MIM:219500", "resource": "MIM", "url": "https://www.omim.org/entry/219500", "name": "Cystathioninuria", "description": "Cystathioninuria" } ], "evidence": [ { "id": "0090142", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0090142" } ] }, { "disease_id": "DOID:83", "recommended_name": { "id": "DOID:83", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:83", "name": "cataract", "description": "A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision." }, "synonyms": [ { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1 multiple types", "description": "Any cataract (disease) in which the cause of the disease is a mutation in the GJA8 gene." }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CTRCT1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "Duffy linked cataract", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "GJA8 cataract (disease)", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract (disease) caused by mutation in GJA8", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1, multiple types, with or without microcornea", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CAE1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "CZP1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "zonular pulverulent cataract 1", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract 1, multiple types", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract, Duffy-linked", "description": "" }, { "id": "MONDO:0007285", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007285", "name": "cataract, zonular pulverulent, 1", "description": "" }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "early-onset non-syndromic cataract", "description": "Early-onset non-syndromic cataract is a rare, genetic, non-syndromic developmental defect of the eye, with high clinical and genetic heterogeneity, most frequently characterized by bilateral, symmetrical, non-progressive cataracts which present at birth or in early-childhood. Additional ocular manifestations (e.g. anterior segment dysgenesis, colobomas, nystagmus, microcornea, microphthalmia, myopia) may be associated, however other organs/systems are usually not affected." }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "cataract, age-related nuclear", "description": "" }, { "id": "MONDO:0011060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011060", "name": "nuclear sclerosis of the lens", "description": "" }, { "id": "MIM:116200", "resource": "MIM", "url": "https://www.omim.org/entry/116200", "name": "Cataract 1, multiple types", "description": "Cataract 1, multiple types" } ], "evidence": [ { "id": "83", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:83" } ] }, { "disease_id": "DOID:9252", "recommended_name": { "id": "DOID:9252", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9252", "name": "amino acid metabolic disorder", "description": "An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids." }, "synonyms": [ { "id": "DOID:9252", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9252", "name": "inborn errors of amino acid metabolism", "description": "" } ], "evidence": [ { "id": "9252", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9252" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Saccharomyces cerevisiae S288C", "taxid": 559292, "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "common_name": "Yeast" } ], "gene": [ { "name": "CYS3", "url": "https://www.uniprot.org/uniprot/P31373", "locus": { "chromosome": "I", "start_pos": 131983, "end_pos": 130799, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "YAL012W", "url": "https://www.ensembl.org/id/YAL012W" } ] } } ], "crossref": [ { "id": "4.4.1.1", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.4.1.1&UniProtAcc=P31373", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd00614", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00614", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "851221", "url": "https://www.ncbi.nlm.nih.gov/gene/851221", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "P31373", "url": "https://www.ebi.ac.uk/intact/interactors/id:P31373*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "sce:YAL012W", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YAL012W", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YKQDGVG", "url": "https://omabrowser.org/oma/group/YKQDGVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "6018at2759", "url": "http://www.orthodb.org/?query=6018at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11808", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11808", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11808:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11808:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1N8P", "url": "https://www.rcsb.org/structure/1N8P", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01053", "url": "http://pfam.xfam.org/family/PF01053", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P31373", "url": "http://purl.obolibrary.org/obo/PR_P31373", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_009390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009390", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000000010", "url": "https://www.yeastgenome.org/locus/S000000010", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P31373-1", "url": "https://www.uniprot.org/uniprot/P31373-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLQESDKFATKAIHAGEHVDVHGSVIEPISLSTTFKQSSPANPIGTYEYSRSQNPNRENLERAVAALENAQYGLAFSSGSATTATILQSLPQGSHAVSIGDVYGGTHRYFTKVANAHGVETSFTNDLLNDLPQLIKENTKLVWIETPTNPTLKVTDIQKVADLIKKHAAGQDVILVVDNTFLSPYISNPLNFGADIVVHSATKYINGHSDVVLGVLATNNKPLYERLQFLQNAIGAIPSPFDAWLTHRGLKTLHLRVRQAALSANKIAEFLAADKENVVAVNYPGLKTHPNYDVVLKQHRDALGGGMISFRIKGGAEAASKFASSTRLFTLAESLGGIESLLEVPAVMTHGGIPKEAREASGVFDDLVRISVGIEDTDDLLEDIKQALKQATN", "length": 394, "header": "sp|P31373-1|CYS3_YEAST Isoform 1 of Cystathionine gamma-lyase OS=Saccharomyces cerevisiae S288C OX=559292 GN=CYS3 PE=1 SV=2 CANONICAL=P31373-1" }, "isoforms": [ { "isoform_ac": "P31373-1", "url": "", "sequence": { "sequence": "MTLQESDKFATKAIHAGEHVDVHGSVIEPISLSTTFKQSSPANPIGTYEYSRSQNPNRENLERAVAALENAQYGLAFSSGSATTATILQSLPQGSHAVSIGDVYGGTHRYFTKVANAHGVETSFTNDLLNDLPQLIKENTKLVWIETPTNPTLKVTDIQKVADLIKKHAAGQDVILVVDNTFLSPYISNPLNFGADIVVHSATKYINGHSDVVLGVLATNNKPLYERLQFLQNAIGAIPSPFDAWLTHRGLKTLHLRVRQAALSANKIAEFLAADKENVVAVNYPGLKTHPNYDVVLKQHRDALGGGMISFRIKGGAEAASKFASSTRLFTLAESLGGIESLLEVPAVMTHGGIPKEAREASGVFDDLVRISVGIEDTDDLLEDIKQALKQATN", "length": 394, "header": "sp|P31373-1|CYS3_YEAST Isoform 1 of Cystathionine gamma-lyase OS=Saccharomyces cerevisiae S288C OX=559292 GN=CYS3 PE=1 SV=2 CANONICAL=P31373-1" }, "locus": { "chromosome": "I", "start_pos": 131980, "end_pos": 130799, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "YAL012W_mRNA", "url": "https://www.ensembl.org/id/YAL012W_mRNA" }, { "database": "Ensembl Peptide", "id": "YAL012W", "url": "https://www.ensembl.org/id/YAL012W" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "SGD", "id": "P31373", "url": "https://www.yeastgenome.org/locus/P31373" }, { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ], "site_lbl": "Thr2" }, { "start_pos": 362, "end_pos": 362, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" }, { "database": "SGD", "id": "P31373", "url": "https://www.yeastgenome.org/locus/P31373" } ], "site_lbl": "Ser362" }, { "start_pos": 39, "end_pos": 39, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" }, { "database": "SGD", "id": "P31373", "url": "https://www.yeastgenome.org/locus/P31373" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser39" }, { "start_pos": 40, "end_pos": 40, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" }, { "database": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" }, { "database": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" }, { "database": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" }, { "database": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" }, { "database": "SGD", "id": "P31373", "url": "https://www.yeastgenome.org/locus/P31373" }, { "database": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ], "site_lbl": "Ser40" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison.", "journal": "Biol. Chem.", "date": "2003", "authors": "Steegborn C., Huber R., Clausen T., Wahl M.C., Worbs M., Laber B., Messerschmidt A.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "12715888", "url": "https://glygen.org/publication/PubMed/12715888" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.", "journal": "Molecular & cellular proteomics : MCP", "date": "2005-03", "authors": "Gruhler Albrecht, Olsen Jesper V, Mohammed Shabaz, Mortensen Peter, Faergeman Nils J, Mann Matthias, Jensen Ole N", "evidence": [ { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" } ], "reference": [ { "type": "PubMed", "id": "15665377", "url": "https://glygen.org/publication/PubMed/15665377" } ] }, { "title": "Cloning and characterization of the CYS3 (CYI1) gene of Saccharomyces cerevisiae.", "journal": "J. Bacteriol.", "date": "1992", "authors": "Tanaka K., Yamamoto S., Ohmori S., Oshima T., Naito K., Toh-e A., Shinoda S., Heike C., Ono B.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "1577698", "url": "https://glygen.org/publication/PubMed/1577698" } ] }, { "title": "A multidimensional chromatography technology for in-depth phosphoproteome analysis.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008-07", "authors": "Albuquerque Claudio P, Smolka Marcus B, Payne Samuel H, Bafna Vineet, Eng Jimmy, Zhou Huilin", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" }, { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" } ], "reference": [ { "type": "PubMed", "id": "18407956", "url": "https://glygen.org/publication/PubMed/18407956" } ] }, { "title": "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.", "journal": "Science (New York, N.Y.)", "date": "2009-09-25", "authors": "Holt Liam J, Tuch Brian B, Vill\u00e9n Judit, Johnson Alexander D, Gygi Steven P, Morgan David O", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" }, { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" } ], "reference": [ { "type": "PubMed", "id": "19779198", "url": "https://glygen.org/publication/PubMed/19779198" } ] }, { "title": "The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates.", "journal": "Molecular biology of the cell", "date": "2010-10-01", "authors": "Soulard Alexandre, Cremonesi Alessio, Moes Suzette, Sch\u00fctz Fr\u00e9d\u00e9ric, Jen\u00f6 Paul, Hall Michael N", "evidence": [ { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" } ], "reference": [ { "type": "PubMed", "id": "20702584", "url": "https://glygen.org/publication/PubMed/20702584" } ] }, { "title": "Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.", "journal": "BMC genomics", "date": "2010-12-02", "authors": "Helbig Andreas O, Rosati Sara, Pijnappel Pim W W M, van Breukelen Bas, Timmers Marc H T H, Mohammed Shabaz, Slijper Monique, Heck Albert J R", "evidence": [ { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" } ], "reference": [ { "type": "PubMed", "id": "21126336", "url": "https://glygen.org/publication/PubMed/21126336" } ] }, { "title": "Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.", "journal": "Nature methods", "date": "2013-07", "authors": "Swaney Danielle L, Beltrao Pedro, Starita Lea, Guo Ailan, Rush John, Fields Stanley, Krogan Nevan J, Vill\u00e9n Judit", "evidence": [ { "database": "iPTMnet", "id": "P31373", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P31373" } ], "reference": [ { "type": "PubMed", "id": "23749301", "url": "https://glygen.org/publication/PubMed/23749301" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1995", "authors": "Hall J., Su Y., Ouellette B.F.F., Bussey H., Davies C.J., Clark M.W., Keng T., Barton A.B., Fortin N., Kaback D.B., Storms R.K., Vo D.H., Zhong W.-W.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "7731988", "url": "https://glygen.org/publication/PubMed/7731988" } ] }, { "title": "Cloning and bacterial expression of the CYS3 gene encoding cystathionine gamma-lyase of Saccharomyces cerevisiae and the physicochemical and enzymatic properties of the protein.", "journal": "J. Bacteriol.", "date": "1993", "authors": "Nakamura K., D'Andrea R.J., Isaji M., Yamagata S., Fujisaki S.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "8335636", "url": "https://glygen.org/publication/PubMed/8335636" } ] }, { "title": "Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes.", "journal": "Genome", "date": "1993", "authors": "Ouellette B.F.F., Zeng B., Bussey H., Clark M.W., Keng T., Barton A.B., Fortin N., Kaback D.B., Storms R.K., Zhong W.-W., Delaney S.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "8458570", "url": "https://glygen.org/publication/PubMed/8458570" } ] }, { "title": "Physical localization of yeast CYS3, a gene whose product resembles the rat gamma-cystathionase and Escherichia coli cystathionine gamma-synthase enzymes.", "journal": "Yeast", "date": "1993", "authors": "Ouellette B.F.F., Zeng B., Bussey H., Clark M.W., Keng T., Barton A.B., Fortin N., Kaback D.B., Storms R.K., Zhong W.W., Delaney S.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "8511966", "url": "https://glygen.org/publication/PubMed/8511966" } ] }, { "title": "Cystathionine gamma-lyase of Saccharomyces cerevisiae: structural gene and cystathionine gamma-synthase activity.", "journal": "Yeast", "date": "1993", "authors": "Yamamoto S., Ishii N., Ohmori S., Naito K., Miyoshi S., Shinoda S., Ono B.", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "reference": [ { "type": "PubMed", "id": "8511969", "url": "https://glygen.org/publication/PubMed/8511969" } ] } ], "pathway": [ { "id": "sce:YAL012W", "name": "", "url": 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080146", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "pmid": "" }, { "name": "cysteine-S-conjugate beta-lyase activity", "id": "GO:0047804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047804", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of hydrogen sulfide biosynthetic process", "id": "GO:1904828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904828", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "pmid": "" }, { "name": "transsulfuration", "id": "GO:0019346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019346", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "pmid": "" }, { "name": "cysteine biosynthetic process via cystathionine", "id": "GO:0019343", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019343", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "pmid": "" }, { "name": "cysteine biosynthetic process", "id": "GO:0019344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019344", "evidence": [ { "database": "UniProtKB", "id": "P31373", "url": "https://www.uniprot.org/uniprot/P31373" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14005", "name": "", "equation": "H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18757-1", "P32929-1", "Q8VCN5-1", "P31373-1", "Q55DV9-1" ], "evidence": [ { "id": "14005", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14005" } ] }, { "id": "R-SCE-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1614594" ], "enzyme_list": [ "P31373-1" ], "evidence": [ { "id": "R-SCE-1614567", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-1614567" } ] }, { "id": "R-SCE-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P31373-1" ], "evidence": [ { "id": "R-SCE-1614583", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-1614583" } ] }, { "id": "R-SCE-1614591", "name": "Excess cysteine yields lanthionine and H2S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1614532", "R-ALL-1614582" ], "enzyme_list": [ "P31373-1" ], "evidence": [ { "id": "R-SCE-1614591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-1614591" } ] }, { "id": "R-SCE-1614614", "name": "Cysteine is degraded to serine and H2S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-200736" ], "enzyme_list": [ "P31373-1" ], "evidence": [ { "id": "R-SCE-1614614", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-1614614" } ] }, { "id": "R-SCE-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-174369" ], "output_participant_list": [ "R-ALL-29382", "R-ALL-936714" ], "enzyme_list": [ "P31373-1" ], "evidence": [ { "id": "R-SCE-1614631", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SCE-1614631" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1614532", "participant_name": "H2S [cytosol]", "crossref": [ { "id": "29919", "database": "ChEBI", "url": "" }, { "id": "29919", "database": "ChEBI", "url": "" }, { "id": "29919", "database": "ChEBI", "url": "" }, { "id": "29919", "database": "ChEBI", "url": "" }, { "id": "29919", "database": "ChEBI", "url": "" }, { "id": "29919", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1614582", "participant_name": "L-Lanthionine [cytosol]", "crossref": [ { "id": "21347", "database": "ChEBI", "url": "" }, { "id": "HMDB0240656", "database": "HMDB 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