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"PR_P30657", "url": "http://purl.obolibrary.org/obo/PR_P30657", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_116708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116708", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "S000001946", "url": "https://www.yeastgenome.org/locus/S000001946", "database": "SGD", "categories": [ "Organism-specific" ] }, { "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P30657-1", "url": "https://www.uniprot.org/uniprot/P30657-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI", "length": 266, "header": "sp|P30657-1|PSB7_YEAST Isoform 1 of Proteasome subunit beta type-7 OS=Saccharomyces cerevisiae S288C OX=559292 GN=PRE4 PE=1 SV=1 CANONICAL=P30657-1" }, "isoforms": [ { "isoform_ac": "P30657-1", "url": "", "sequence": { "sequence": "MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI", "length": 266, "header": "sp|P30657-1|PSB7_YEAST Isoform 1 of Proteasome subunit beta type-7 OS=Saccharomyces cerevisiae S288C OX=559292 GN=PRE4 PE=1 SV=1 CANONICAL=P30657-1" }, "locus": { "chromosome": "VI", "start_pos": 249866, "end_pos": 249069, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "YFR050C_mRNA", "url": "https://www.ensembl.org/id/YFR050C_mRNA" }, { "database": "Ensembl Peptide", "id": "YFR050C", "url": "https://www.ensembl.org/id/YFR050C" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "A gated channel into the proteasome core particle.", "journal": "Nat. Struct. Biol.", "date": "2000", "authors": "Huber R., Finley D., Moroder L., Koehler A., Bajorek M., Glickman M.H., Groll M., Rubin D.M.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "11062564", "url": "https://glygen.org/publication/PubMed/11062564" } ] }, { "title": "Structural basis for the activation of 20S proteasomes by 11S regulators.", "journal": "Nature", "date": "2000", "authors": "Whitby F.G., Yao Y., Hill C.P., Wang C.C., Knowlton J.R., Kramer L., Masters E.I.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "11081519", "url": "https://glygen.org/publication/PubMed/11081519" } ] }, { "title": "Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.", "journal": "EMBO J.", "date": "2001", "authors": "Jaeger S., Heinemeyer W., Wolf D.H., Strayle J.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "11500370", "url": "https://glygen.org/publication/PubMed/11500370" } ] }, { "title": "Global analysis of protein localization in budding yeast.", "journal": "Nature", "date": "2003", "authors": "Weissman J.S., Carroll A.S., Howson R.W., Huh W.-K., O'Shea E.K., Falvo J.V., Gerke L.C.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "14562095", "url": "https://glygen.org/publication/PubMed/14562095" } ] }, { "title": "Global analysis of protein expression in yeast.", "journal": "Nature", "date": "2003", "authors": "Dephoure N., Weissman J.S., Howson R.W., Huh W.-K., O'Shea E.K., Belle A., Bower K., Ghaemmaghami S.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "14562106", "url": "https://glygen.org/publication/PubMed/14562106" } ] }, { "title": "Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome.", "journal": "Structure", "date": "2006", "authors": "Ploegh H.L., Ovaa H., Berkers C.R., Groll M.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "16531229", "url": "https://glygen.org/publication/PubMed/16531229" } ] }, { "title": "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.", "journal": "J. Am. Chem. Soc.", "date": "2006", "authors": "Huber R., Groll M., Potts B.C.M.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "16608349", "url": "https://glygen.org/publication/PubMed/16608349" } ] }, { "title": "TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome.", "journal": "Chem. Biol.", "date": "2006", "authors": "Moroder L., Kaiser M., Goetz M., Groll M., Weyher E.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "16793518", "url": "https://glygen.org/publication/PubMed/16793518" } ] }, { "title": "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.", "journal": "Genome Res.", "date": "2007", "authors": "Hu Y., LaBaer J., Moreira D., Raphael J., Rolfs A., Zuo D., Richardson A., Simpson A.J.G., Zhu C., Harlow E., Camargo A.A., Jepson D., Kelley F., McCarron S., Taycher E., Kolodner R.D., Kane M.F., Williamson J., Berger M.F., Bulyk M.L., Bhullar B., Mohr S., Marsischky G., Murthy T.V.S.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "17322287", "url": "https://glygen.org/publication/PubMed/17322287" } ] }, { "title": "Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.", "journal": "Mol. Cell", "date": "2010", "authors": "Sadre-Bazzaz Kianoush, Whitby Frank G, Robinson Howard, Formosa Tim, Hill Christopher P", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "20227375", "url": "https://glygen.org/publication/PubMed/20227375" } ] }, { "title": "Near-atomic resolution structural model of the yeast 26S proteasome.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2012", "authors": "Villa E., Baumeister W., Beck F., Pfeifer G., Plitzko J.M., Sakata E., Schweitzer A., Forster F., Bohn S., Nickell S., Unverdorben P.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "22927375", "url": "https://glygen.org/publication/PubMed/22927375" } ] }, { "title": "The reference genome sequence of Saccharomyces cerevisiae: Then and now.", "journal": "G3 (Bethesda)", "date": "2014", "authors": "Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "24374639", "url": "https://glygen.org/publication/PubMed/24374639" } ] }, { "title": "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.", "journal": "Nat. Genet.", "date": "1995", "authors": "Soeda E., Tashiro H., Yamazaki M., Yokoyama K., Hagiwara H., Murakami Y., Shibata T., Ozawa M., Eki T., Tsuchiya Y., Sasanuma S., Naitou M., Sasanuma M.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "7670463", "url": "https://glygen.org/publication/PubMed/7670463" } ] }, { "title": "The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.", "journal": "J. Biol. Chem.", "date": "1993", "authors": "Gruhler A., Wolf D.H., Enenkel C., Hilt W., Singer T.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "8381431", "url": "https://glygen.org/publication/PubMed/8381431" } ] }, { "title": "Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae.", "journal": "Yeast", "date": "1996", "authors": "Hagiwara H., Murakami Y., Shibata T., Hanaoka F., Ozawa M., Eki T., Tsuchiya Y., Sasanuma S., Naitou M., Sasanuma M.", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "8686379", "url": "https://glygen.org/publication/PubMed/8686379" } ] }, { "title": "Structure of 20S proteasome from yeast at 2.4-A resolution.", "journal": "Nature", "date": "1997", "authors": "Groll M, Ditzel L, L\u00f6we J, Stock D, Bochtler M, Bartunik H D, Huber R", "evidence": [ { "database": "UniProtKB", "id": "P30657", "url": "https://www.uniprot.org/uniprot/P30657" } ], "reference": [ { "type": "PubMed", "id": "9087403", "url": "https://glygen.org/publication/PubMed/9087403" } ] } ], "pathway": [ { "id": "sce:YFR050C", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+sce:YFR050C", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P28070-1", "protein_name": "Proteasome subunit beta type-4", "gene_name": "PSMB4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMISGFE", "length": 264 }, "evidence": [ { "id": "P30657", "url": "https://omabrowser.org/oma/group/P30657/", "database": "OMA" } 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